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Aliases for CDADC1 Gene

Aliases for CDADC1 Gene

  • Cytidine And DCMP Deaminase Domain Containing 1 2 3 5
  • Testis Development Protein NYD-SP15 3 4
  • Cytidine And DCMP Deaminase Domain-Containing Protein 1 3
  • Protein Kinase NYD-SP15 3
  • BA103J18.1 3
  • NYD-SP15 3

External Ids for CDADC1 Gene

Previous GeneCards Identifiers for CDADC1 Gene

  • GC13P047620
  • GC13P048720
  • GC13P049822
  • GC13P030615

Summaries for CDADC1 Gene

GeneCards Summary for CDADC1 Gene

CDADC1 (Cytidine And DCMP Deaminase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for CDADC1 Gene

  • May play an important role in testicular development and spermatogenesis.

Additional gene information for CDADC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDADC1 Gene

Genomics for CDADC1 Gene

GeneHancer (GH) Regulatory Elements for CDADC1 Gene

Promoters and enhancers for CDADC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I049247 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 407 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 CDADC1 LOC105370203 CAB39L GC13M049249 GC13M049248
GH13I048974 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.6 -270.2 -270173 6.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B ZNF213 FNDC3A GC13M048972 ENSG00000275202 CDADC1 GC13P048988
GH13I049292 Enhancer 0.8 Ensembl ENCODE 10.6 +45.0 44993 1 ZSCAN18 NFIA NFIB ZNF195 ZNF16 ZNF662 ZIC2 NFIC LCORL ZNF544 SETDB2 TRIM13 CDADC1 CAB39L GC13P049296 GC13M049248
GH13I049303 Enhancer 0.8 ENCODE 10.5 +56.0 56021 0.5 ELF3 MLX ARID4B DMAP1 RAD21 THRB RARA ETS1 CREM RXRA CDADC1 CAB39L GC13P049296 GC13P049390
GH13I049277 Enhancer 0.3 dbSUPER 23.2 +30.4 30393 1 SCRT2 CDADC1 MLNR CAB39L GC13P049296 GC13M049248
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDADC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDADC1 gene promoter:

Genomic Locations for CDADC1 Gene

Genomic Locations for CDADC1 Gene
chr13:49,247,875-49,293,486
(GRCh38/hg38)
Size:
45,612 bases
Orientation:
Plus strand
chr13:49,822,047-49,867,622
(GRCh37/hg19)

Genomic View for CDADC1 Gene

Genes around CDADC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDADC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDADC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDADC1 Gene

Proteins for CDADC1 Gene

  • Protein details for CDADC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWV3-CDAC1_HUMAN
    Recommended name:
    Cytidine and dCMP deaminase domain-containing protein 1
    Protein Accession:
    Q9BWV3
    Secondary Accessions:
    • Q49A08
    • Q4G119
    • Q5TAW9
    • Q7Z764
    • Q9NT36

    Protein attributes for CDADC1 Gene

    Size:
    514 amino acids
    Molecular mass:
    58455 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDADC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDADC1 Gene

Post-translational modifications for CDADC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDADC1 Gene

Domains & Families for CDADC1 Gene

Gene Families for CDADC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9BWV3

UniProtKB/Swiss-Prot:

CDAC1_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with CDADC1: view

Function for CDADC1 Gene

Molecular function for CDADC1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in testicular development and spermatogenesis.

Gene Ontology (GO) - Molecular Function for CDADC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004126 cytidine deaminase activity IDA 26945630
GO:0008270 zinc ion binding IMP,IEA 26945630
GO:0016787 hydrolase activity IEA --
GO:0042803 protein homodimerization activity IDA 26945630
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDADC1: view
genes like me logo Genes that share phenotypes with CDADC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDADC1 Gene

Localization for CDADC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDADC1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDADC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 26945630
GO:0005737 cytoplasm IMP 26945630
genes like me logo Genes that share ontologies with CDADC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDADC1 Gene

Pathways & Interactions for CDADC1 Gene

SuperPathways for CDADC1 Gene

No Data Available

Interacting Proteins for CDADC1 Gene

Gene Ontology (GO) - Biological Process for CDADC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009972 cytidine deamination IDA 26945630
GO:0070383 DNA cytosine deamination IDA 26945630
genes like me logo Genes that share ontologies with CDADC1: view

No data available for Pathways by source and SIGNOR curated interactions for CDADC1 Gene

Drugs & Compounds for CDADC1 Gene

No Compound Related Data Available

Transcripts for CDADC1 Gene

Unigene Clusters for CDADC1 Gene

Cytidine and dCMP deaminase domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDADC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - - - - - -

Relevant External Links for CDADC1 Gene

GeneLoc Exon Structure for
CDADC1
ECgene alternative splicing isoforms for
CDADC1

Expression for CDADC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDADC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CDADC1 Gene:

CDADC1

SOURCE GeneReport for Unigene cluster for CDADC1 Gene:

Hs.388220

mRNA Expression by UniProt/SwissProt for CDADC1 Gene:

Q9BWV3-CDAC1_HUMAN
Tissue specificity: Widely expressed. Expressed at high levels in the testis.

Evidence on tissue expression from TISSUES for CDADC1 Gene

  • Nervous system(4.4)
  • Bone marrow(4.3)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with CDADC1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDADC1 Gene

Orthologs for CDADC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDADC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDADC1 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia CDADC1 33 34
  • 91.89 (n)
cow
(Bos Taurus)
Mammalia CDADC1 33 34
  • 90.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CDADC1 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdadc1 33 16 34
  • 87.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDADC1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDADC1 33 34
  • 78.32 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdadc1 33
  • 71.07 (n)
zebrafish
(Danio rerio)
Actinopterygii cdadc1 33 34
  • 60.61 (n)
Species where no ortholog for CDADC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDADC1 Gene

ENSEMBL:
Gene Tree for CDADC1 (if available)
TreeFam:
Gene Tree for CDADC1 (if available)

Paralogs for CDADC1 Gene

No data available for Paralogs for CDADC1 Gene

Variants for CDADC1 Gene

Sequence variations from dbSNP and Humsavar for CDADC1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000008698 -- 49,272,501(+) G/C intron_variant
rs1000110453 -- 49,280,210(+) G/T intron_variant
rs1000215895 -- 49,263,673(+) T/C intron_variant
rs1000300808 -- 49,264,889(+) T/G intron_variant
rs1000317075 -- 49,287,878(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDADC1 Gene

Variant ID Type Subtype PubMed ID
esv2007070 CNV deletion 18987734
esv2747389 CNV deletion 23290073
esv2747390 CNV deletion 23290073
esv3632042 CNV loss 21293372
nsv1144676 CNV deletion 24896259
nsv64013 CNV deletion 16902084
nsv832607 CNV loss 17160897

Variation tolerance for CDADC1 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDADC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDADC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDADC1 Gene

Disorders for CDADC1 Gene

Additional Disease Information for CDADC1

No disorders were found for CDADC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDADC1 Gene

Publications for CDADC1 Gene

  1. NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis. (PMID: 16955368) Liu Q … Li J (Biochemical genetics 2006) 3 4 58
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  3. Structural and biological function of NYD-SP15 as a new member of cytidine deaminases. (PMID: 26945630) Xu Y … Liu Q (Gene 2016) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 44 58

Products for CDADC1 Gene

Sources for CDADC1 Gene

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