Aliases for CDA Gene
External Ids for CDA Gene
Previous GeneCards Identifiers for CDA Gene
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDA Gene
CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia. Among its related pathways are Pyrimidine metabolism (KEGG) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity.
UniProtKB/Swiss-Prot for CDA Gene
This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis.