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Aliases for CDA Gene

Aliases for CDA Gene

  • Cytidine Deaminase 2 3 3 5
  • Cytidine Aminohydrolase 3 4
  • CDD 3 4
  • Cytosine Nucleoside Deaminase 3
  • Small Cytidine Deaminase 3
  • EC 3.5.4.5 4

External Ids for CDA Gene

Previous GeneCards Identifiers for CDA Gene

  • GC01P020485
  • GC01P019951
  • GC01P020061
  • GC01P020385
  • GC01P020660
  • GC01P020788
  • GC01P020915
  • GC01P019161

Summaries for CDA Gene

Entrez Gene Summary for CDA Gene

  • This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDA Gene

CDA (Cytidine Deaminase) is a Protein Coding gene. Diseases associated with CDA include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia. Among its related pathways are Metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity.

UniProtKB/Swiss-Prot for CDA Gene

  • This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis.

Gene Wiki entry for CDA Gene

Additional gene information for CDA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDA Gene

Genomics for CDA Gene

GeneHancer (GH) Regulatory Elements for CDA Gene

Promoters and enhancers for CDA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020588 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 678 +1.1 1083 3.5 HDAC1 PKNOX1 ATF1 FOXA2 KLF17 ZBTB7B RAD21 YY1 ZNF335 EGR1 CDA PINK1 FAM43B MUL1 GC01P020619
GH01J020587 Enhancer 1.2 Ensembl ENCODE dbSUPER 655.1 -1.2 -1247 0.6 BCOR HDAC1 MEIS2 KLF1 PTBP1 ATF1 ARNT JUN KLF17 ZMYM3 CDA MUL1 FAM43B
GH01J020632 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.8 +45.1 45066 2.5 PKNOX1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF213 ZNF143 KLF13 PINK1 MIR6084 CDA PIR40855
GH01J020610 Enhancer 1.3 Ensembl ENCODE dbSUPER 34.2 +24.0 24037 4.2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 FOS DEK PINK1 CDA OTUD3 FAM43B DDOST GC01P020619
GH01J020601 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.9 +14.4 14367 4.2 USF1 FOXA2 NFRKB JUN ZNF266 MAX YY1 EGR1 POLR2A NFYB CDA PINK1 HP1BP3 DDOST GC01P020619
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDA gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • Pax-5
  • COUP-TF
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5

Genomic Locations for CDA Gene

Genomic Locations for CDA Gene
chr1:20,588,948-20,618,908
(GRCh38/hg38)
Size:
29,961 bases
Orientation:
Plus strand
chr1:20,915,441-20,945,401
(GRCh37/hg19)
Size:
29,961 bases
Orientation:
Plus strand

Genomic View for CDA Gene

Genes around CDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDA Gene

Proteins for CDA Gene

  • Protein details for CDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32320-CDD_HUMAN
    Recommended name:
    Cytidine deaminase
    Protein Accession:
    P32320

    Protein attributes for CDA Gene

    Size:
    146 amino acids
    Molecular mass:
    16185 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CDA Gene

neXtProt entry for CDA Gene

Post-translational modifications for CDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDA Gene

Domains & Families for CDA Gene

Gene Families for CDA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32320

UniProtKB/Swiss-Prot:

CDD_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with CDA: view

Function for CDA Gene

Molecular function for CDA Gene

UniProtKB/Swiss-Prot Function:
This enzyme scavenges exogenous and endogenous cytidine and 2-deoxycytidine for UMP synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Cytidine + H(2)O = uridine + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxycytidine + H(2)O = 2-deoxyuridine + NH(3).
GENATLAS Biochemistry:
cytidine deaminase,pyrimidine catabolic pathway

Enzyme Numbers (IUBMB) for CDA Gene

Phenotypes From GWAS Catalog for CDA Gene

Gene Ontology (GO) - Molecular Function for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001882 nucleoside binding IDA 15689149
GO:0003824 catalytic activity IEA --
GO:0004126 cytidine deaminase activity EXP,IDA 7923172
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding TAS 9596658
genes like me logo Genes that share ontologies with CDA: view
genes like me logo Genes that share phenotypes with CDA: view

Animal Model Products

miRNA for CDA Gene

miRTarBase miRNAs that target CDA

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDA Gene

Localization for CDA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDA gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9596658
GO:0005829 cytosol TAS 9596658
GO:0034774 secretory granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with CDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDA Gene

Pathways & Interactions for CDA Gene

genes like me logo Genes that share pathways with CDA: view

Gene Ontology (GO) - Biological Process for CDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway NAS 9596658
GO:0008655 pyrimidine-containing compound salvage NAS 9596658
GO:0009972 cytidine deamination IDA 9596658
GO:0019858 cytosine metabolic process TAS 7923172
GO:0030308 negative regulation of cell growth IDA 9596658
genes like me logo Genes that share ontologies with CDA: view

No data available for SIGNOR curated interactions for CDA Gene

Drugs & Compounds for CDA Gene

(21) Drugs for CDA Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1166
Gemcitabine Approved Pharma Enzyme, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100
Capecitabine Approved, Investigational Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1402
Azacitidine Approved, Investigational Pharma Enzyme, substrate 581
Gemzar Approved May 1996 Pharma 0

(8) Additional Compounds for CDA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5'-Deoxy-5-fluorocytidine
5'-Deoxy-5-fluorouridine
  • 1-(beta-D-5-Desoxyribofuranoxyl)-5-fluoruracil
  • 5'-DFUR
  • 5'-DFUrd
  • 5-fluoro-5'-Deoxyuridine
  • Doxifluridina
genes like me logo Genes that share compounds with CDA: view

Transcripts for CDA Gene

mRNA/cDNA for CDA Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDA Gene

Cytidine deaminase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDA Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - -

Relevant External Links for CDA Gene

GeneLoc Exon Structure for
CDA
ECgene alternative splicing isoforms for
CDA

Expression for CDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDA Gene

This gene is overexpressed in Whole Blood (x32.8).

Protein differential expression in normal tissues from HIPED for CDA Gene

This gene is overexpressed in Ovary (16.2), Cervix (10.9), Neutrophil (10.7), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDA Gene



NURSA nuclear receptor signaling pathways regulating expression of CDA Gene:

CDA

SOURCE GeneReport for Unigene cluster for CDA Gene:

Hs.466910

mRNA Expression by UniProt/SwissProt for CDA Gene:

P32320-CDD_HUMAN
Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Evidence on tissue expression from TISSUES for CDA Gene

  • Blood(4.6)
  • Liver(4.5)
  • Bone marrow(2.8)
genes like me logo Genes that share expression patterns with CDA: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDA Gene

Orthologs for CDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDA 34 33
  • 99.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cda 16 34 33
  • 83.79 (n)
cow
(Bos Taurus)
Mammalia CDA 34 33
  • 83.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDA 34 33
  • 83.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909857 33
  • 82.88 (n)
oppossum
(Monodelphis domestica)
Mammalia CDA 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDA 34 33
  • 73.79 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDA 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cda 33
  • 69.61 (n)
Str.9365 33
zebrafish
(Danio rerio)
Actinopterygii cda 34 33
  • 68.99 (n)
OneToMany
CDA (3 of 3) 34
  • 63 (a)
OneToMany
CDA (1 of 3) 34
  • 57 (a)
OneToMany
Dr.16208 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7726 33
fruit fly
(Drosophila melanogaster)
Insecta CG8360 34
  • 40 (a)
OneToMany
CG8353 34
  • 37 (a)
OneToMany
CG8349 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdd-2 34
  • 38 (a)
OneToMany
cdd-1 34
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL123W 33
  • 52.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDD1 36 34 33
  • 51.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18414g 33
  • 51.36 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08359 33
  • 53.54 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdd1 33
  • 50.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
Species where no ortholog for CDA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDA Gene

ENSEMBL:
Gene Tree for CDA (if available)
TreeFam:
Gene Tree for CDA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CDA: view image

Paralogs for CDA Gene

No data available for Paralogs for CDA Gene

Variants for CDA Gene

Sequence variations from dbSNP and Humsavar for CDA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000001457 -- 20,607,890(+) G/A intron_variant
rs1000166590 -- 20,600,787(+) A/C intron_variant
rs1000177680 -- 20,603,175(+) A/G intron_variant
rs1000266307 -- 20,591,113(+) G/A intron_variant
rs1000406349 -- 20,596,412(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDA Gene

Variant ID Type Subtype PubMed ID
esv24339 CNV loss 19812545
esv2662052 CNV deletion 23128226
esv2667482 CNV deletion 23128226
esv2853125 CNV deletion 24192839
esv3305877 CNV mobile element insertion 20981092
esv3371341 CNV insertion 20981092
esv3554677 CNV deletion 23714750
esv3585425 CNV loss 21293372
esv998962 CNV deletion 20482838
nsv1112526 CNV deletion 24896259
nsv460729 CNV gain 19166990
nsv511682 CNV loss 21212237
nsv528156 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv545734 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for CDA Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDA Gene

Human Gene Mutation Database (HGMD)
CDA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDA Gene

Disorders for CDA Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDA Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
refractory hematologic cancer
  • refractory hematologic malignancy
refractory hairy cell leukemia
central nervous system leukemia
  • leukemia of the cns
immunodeficiency with hyper-igm, type 2
  • higm2
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards
Search CDA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CDA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDA Gene

Publications for CDA Gene

  1. Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. (PMID: 18600531) Giovannetti E … Peters GJ (Nucleosides, nucleotides & nucleic acids 2008) 3 22 25 44 58
  2. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T … Li D (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 22 44 58
  3. Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism. (PMID: 20213492) Maring JG … Groen HJ (European journal of clinical pharmacology 2010) 3 22 44 58
  4. Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene. (PMID: 20045991) Sugiyama E … Shin JG (Drug metabolism and pharmacokinetics 2009) 3 22 44 58
  5. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. (PMID: 18347182) Tibaldi C … Danesi R (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 22 44 58

Products for CDA Gene

Sources for CDA Gene

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