This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] See more...

Aliases for CD99L2 Gene

Aliases for CD99L2 Gene

  • CD99 Molecule Like 2 2 3 5
  • CD99 Antigen-Like Protein 2 3 4
  • MIC2-Like Protein 1 3 4
  • MIC2 Like 1 2 3
  • MIC2L1 3 4
  • CD99B 2 3
  • CD99 Molecule-Like 2 2
  • CD99 Antigen-Like 2 2
  • CD99 Antigen 4
  • CD99L2 5

External Ids for CD99L2 Gene

Previous HGNC Symbols for CD99L2 Gene

  • MIC2L1

Previous GeneCards Identifiers for CD99L2 Gene

  • GC0XM146617
  • GC0XM147705
  • GC0XM148576
  • GC0XM148577
  • GC0XM149605
  • GC0XM149934
  • GC0XM138794

Summaries for CD99L2 Gene

Entrez Gene Summary for CD99L2 Gene

  • This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for CD99L2 Gene

CD99L2 (CD99 Molecule Like 2) is a Protein Coding gene. Diseases associated with CD99L2 include Chorioangioma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cell surface interactions at the vascular wall. An important paralog of this gene is CD99.

UniProtKB/Swiss-Prot Summary for CD99L2 Gene

  • Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Wiki entry for CD99L2 Gene

Additional gene information for CD99L2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD99L2 Gene

Genomics for CD99L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD99L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ150897 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 608.7 +0.3 315 3.4 ZNF692 BACH1 LARP7 PRDM1 ZIC2 ZSCAN4 RBFOX2 POLR2A PATZ1 REST CD99L2 ENSG00000230153 lnc-CXorf40B-2 piR-60051-115 MTMR1
GH0XJ150841 Enhancer 1.3 FANTOM5 Ensembl ENCODE 25.8 +52.2 52216 12.4 CREB1 GATAD2A IKZF1 RCOR2 TARDBP FOXA1 REST SP1 HDAC1 SOX6 piR-60051-115 CD99L2 MTMR1 HMGB3 lnc-CXorf40B-2
GH0XJ150870 Enhancer 1 FANTOM5 Ensembl ENCODE 29.5 +26.6 26615 4.4 IKZF1 JUND NFE2 ZNF316 MAFG FOSL2 MAFK DPF2 KDM1A FOS CD99L2 HMGB3 lnc-CXorf40B-2 piR-60051-115 MTMR1
GH0XJ150772 Enhancer 0.9 Ensembl ENCODE 12.2 +126.5 126510 0.6 CTCF PATZ1 REST RAD21 POLR2A TRIM22 GTF2F1 ZNF341 ZXDB ATF3 CD99L2 piR-32680 SNODB1707 MTMR1
GH0XJ150833 Enhancer 0.5 Ensembl 13.8 +64.7 64715 0.6 YY1 KDM1A ATF2 CEBPG CEBPB HDAC2 CD99L2 piR-60051-115 lnc-MTMR1-2 PPIAP91 lnc-CXorf40B-2 MTMR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD99L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD99L2

Top Transcription factor binding sites by QIAGEN in the CD99L2 gene promoter:
  • AML1a
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GATA-1
  • ITF-2
  • Pax-6
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for CD99L2 Gene

Genomic Locations for CD99L2 Gene
chrX:150,766,336-150,898,816
(GRCh38/hg38)
Size:
132,481 bases
Orientation:
Minus strand
chrX:149,934,809-150,067,289
(GRCh37/hg19)
Size:
132,481 bases
Orientation:
Minus strand

Genomic View for CD99L2 Gene

Genes around CD99L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD99L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD99L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99L2 Gene

Proteins for CD99L2 Gene

  • Protein details for CD99L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCZ2-C99L2_HUMAN
    Recommended name:
    CD99 antigen-like protein 2
    Protein Accession:
    Q8TCZ2
    Secondary Accessions:
    • A8K2D5
    • A8K5R0
    • B3KWG2
    • B4DDL7
    • E7EMK5
    • E9PD27
    • Q8TAW2
    • Q8TCZ0
    • Q8TCZ1
    • Q9BQG9

    Protein attributes for CD99L2 Gene

    Size:
    262 amino acids
    Molecular mass:
    27986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66515.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CD99L2 Gene

neXtProt entry for CD99L2 Gene

Post-translational modifications for CD99L2 Gene

No data available for DME Specific Peptides for CD99L2 Gene

Domains & Families for CD99L2 Gene

Gene Families for CD99L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD99L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99L2 Gene

GenScript: Design optimal peptide antigens:
  • MIC2-like protein 1 (C99L2_HUMAN)
  • CD99L2 protein (Q96E20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCZ2

UniProtKB/Swiss-Prot:

C99L2_HUMAN :
  • Belongs to the CD99 family.
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99L2: view

Function for CD99L2 Gene

Molecular function for CD99L2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

Gene Ontology (GO) - Molecular Function for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD99L2: view
genes like me logo Genes that share phenotypes with CD99L2: view

Animal Models for CD99L2 Gene

MGI Knock Outs for CD99L2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD99L2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD99L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD99L2 Gene

Localization for CD99L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99L2 Gene

Cell membrane. Single-pass type I membrane protein. Extracellular side. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD99L2 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
golgi apparatus 2
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IEA --
GO:0005925 focal adhesion HDA 21423176
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD99L2: view

Pathways & Interactions for CD99L2 Gene

genes like me logo Genes that share pathways with CD99L2: view

Pathways by source for CD99L2 Gene

Gene Ontology (GO) - Biological Process for CD99L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0050904 diapedesis IEA --
GO:2000391 positive regulation of neutrophil extravasation IEA --
GO:2000409 positive regulation of T cell extravasation IEA --
genes like me logo Genes that share ontologies with CD99L2: view

No data available for SIGNOR curated interactions for CD99L2 Gene

Drugs & Compounds for CD99L2 Gene

No Compound Related Data Available

Transcripts for CD99L2 Gene

mRNA/cDNA for CD99L2 Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD99L2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CD99L2 Gene

GeneLoc Exon Structure for
CD99L2

Expression for CD99L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD99L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD99L2 Gene

This gene is overexpressed in Fetal Brain (18.4), Urine (18.2), and Cerebrospinal fluid (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD99L2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD99L2

SOURCE GeneReport for Unigene cluster for CD99L2 Gene:

Hs.522805

mRNA Expression by UniProt/SwissProt for CD99L2 Gene:

Q8TCZ2-C99L2_HUMAN
Tissue specificity: Expressed in many tissues, with low expression in thymus.

Evidence on tissue expression from TISSUES for CD99L2 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Muscle(4.4)
  • Blood(4.4)
  • Heart(2.5)
  • Kidney(2.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with CD99L2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD99L2 Gene

Orthologs for CD99L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99L2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD99L2 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CD99L2 30 31
  • 85.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD99L2 30 31
  • 84.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd99l2 30 17 31
  • 76.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1559441 30
  • 73.42 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CD99L2 31
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD99L2 31
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD99L2 31
  • 49 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CD99L2 31
  • 50 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii cd99l2 30 31
  • 36 (a)
OneToOne
Species where no ortholog for CD99L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD99L2 Gene

ENSEMBL:
Gene Tree for CD99L2 (if available)
TreeFam:
Gene Tree for CD99L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD99L2: view image

Paralogs for CD99L2 Gene

Paralogs for CD99L2 Gene

(1) SIMAP similar genes for CD99L2 Gene using alignment to 3 proteins:

  • C99L2_HUMAN
  • H0Y4H3_HUMAN
  • Q96E20_HUMAN
genes like me logo Genes that share paralogs with CD99L2: view

Variants for CD99L2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD99L2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
732081 Benign: not provided 150,777,456(-) C/T MISSENSE_VARIANT
746998 Benign: not provided 150,769,064(-) C/T SYNONYMOUS_VARIANT
764770 Likely Benign: not provided 150,769,041(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CD99L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD99L2 Gene

Variant ID Type Subtype PubMed ID
dgv1405e199 CNV deletion 23128226
dgv2528e212 CNV loss 25503493
esv1216901 CNV deletion 17803354
esv1531534 CNV deletion 17803354
esv2740598 CNV deletion 23290073
esv2740599 CNV deletion 23290073
esv3559461 CNV deletion 23714750
esv3574980 CNV loss 25503493
esv3574981 CNV loss 25503493
esv3577530 CNV gain 25503493
nsv1124525 CNV deletion 24896259
nsv508813 CNV insertion 20534489
nsv510567 OTHER sequence alteration 20534489
nsv525661 CNV gain 19592680
nsv7150 CNV insertion 18451855
nsv7151 CNV deletion 18451855

Variation tolerance for CD99L2 Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD99L2 Gene

Human Gene Mutation Database (HGMD)
CD99L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD99L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99L2 Gene

Disorders for CD99L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD99L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chorioangioma
  • placental hemangioma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CD99L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD99L2 Gene

Publications for CD99L2 Gene

  1. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PMID: 12706889) Suh YH … Park SH (Gene 2003) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CD99L2 Gene

Sources for CD99L2 Gene