Aliases for CD99 Gene
External Ids for CD99 Gene
Previous HGNC Symbols for CD99 Gene
Previous GeneCards Identifiers for CD99 Gene
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]
GeneCards Summary for CD99 Gene
CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing's Sarcoma and Ewing Sarcoma. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cell surface interactions at the vascular wall. An important paralog of this gene is CD99L2.
UniProtKB/Swiss-Prot for CD99 Gene
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).