Aliases for CD96 Gene
Aliases for CD96 Gene
External Ids for CD96 Gene
- HGNC: 16892
- Entrez Gene: 10225
- Ensembl: ENSG00000153283
- OMIM: 606037
- UniProtKB: P40200
Previous GeneCards Identifiers for CD96 Gene
- GC00U906250
- GC03P112542
- GC03P112581
- GC03P112743
- GC03P111260
- GC03P108635
- GC03P111012
Summaries for CD96 Gene
-
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CD96 Gene
CD96 (CD96 Molecule) is a Protein Coding gene. Diseases associated with CD96 include Cat Eye Syndrome and Valproate Embryopathy. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
UniProtKB/Swiss-Prot for CD96 Gene
-
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Additional gene information for CD96 Gene
- Monarch Initiative
- Search for CD96 at DataMed
- Search for CD96 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD96 Gene
Genomics for CD96 Gene
GeneHancer (GH) Regulatory Elements for CD96 Gene
Promoters and enhancers for CD96 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J111541 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE dbSUPER | 650.1 | +253.2 | 253157 | 9 | PKNOX1 EBF1 BMI1 BATF ATF7 IKZF2 RUNX3 ZNF639 CBFA2T3 JUNB | CD96 ZBED2 PLCXD2 GC03M111365 ENSG00000239311 | |
| GH03J111607 | Enhancer | 1.1 | FANTOM5 ENCODE dbSUPER | 18.9 | +317.0 | 316981 | 3.8 | DPF2 ATF2 JUND TARDBP IKZF1 ATF7 ETV6 RUNX3 IKZF2 SPI1 | CD96 PLCXD2 ZBED2 LOC100420394 | |
| GH03J111615 | Enhancer | 1 | FANTOM5 ENCODE dbSUPER | 12.1 | +324.1 | 324065 | 2.3 | CTCF SRF ZNF680 SPI1 | CD96 PLCXD2 LOC100420394 ZBED2 | |
| GH03J111577 | Enhancer | 0.8 | ENCODE dbSUPER | 10.8 | +285.3 | 285270 | 0.2 | CTCF ZNF654 FOXA2 FOXA3 TRIM22 RAD21 FOXA1 SMC3 FOSL2 | CD96 PLCXD2 ENSG00000240787 ZBED2 | |
| GH03J112002 | Enhancer | 0.5 | ENCODE | 5.6 | +709.9 | 709936 | 1.2 | ZFHX2 JUND EGR1 HLF FOS EGR2 | ABHD10 CD96 TAGLN3 RFKP2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CD96 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD96 gene promoter:
Regulatory Element Products
Genomic Locations for CD96 Gene
Genomic Locations for CD96 Gene
- chr3:111,292,719-111,665,996
- (GRCh38/hg38)
- Size:
- 373,278 bases
- Orientation:
- Plus strand
- chr3:111,011,566-111,384,597
- (GRCh37/hg19)
Genomic View for CD96 Gene
Genes around CD96 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.13-q13.2 by Entrez Gene
- 3q13.13-q13.2 by HGNC
- 3q13.13 by Ensembl
CD96 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD96 Gene
Proteins for CD96 Gene
-
Protein details for CD96 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40200-TACT_HUMAN
- Recommended name:
- T-cell surface protein tactile
- Protein Accession:
- P40200
- Q5JPB3
Protein attributes for CD96 Gene
- Size:
- 585 amino acids
- Molecular mass:
- 65634 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with PVR.
Protein Expression for CD96 Gene
Post-translational modifications for CD96 Gene
Other Protein References for CD96 Gene
Antibody Products
- R&D Systems Antibodies for CD96 (CD96)
-
Custom Antibody ServicesOriGene Antibodies for CD96
- Novus Biologicals Antibodies for CD96
- Invitrogen Antibodies for CD96
- GeneTex CD96 Antibody for CD96
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD96
- Sino Biological Antibodies for CD96
Protein Products
- R&D Systems Proteins and Enzymes for CD96
-
OriGene Purified Proteins for CD96
- Search Origene for MassSpec and Protein Over-expression Lysates for CD96
- Origene Custom Protein Services for CD96
- Sino Biological Cell Lysates for CD96
- Sino Biological Recombinant Proteins for CD96
- ProSpec Recombinant Proteins for CD96
- Search GeneTex for Proteins for CD96
Assay Products
- antibodies-online: Search results for 3 available CD96 Elisa Kits ranked by validation data
- Compare Top CD96 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CD96 Gene
Domains & Families for CD96 Gene
Gene Families for CD96 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD96 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD96 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD96 Gene
Function for CD96 Gene
Molecular function for CD96 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Phenotypes From GWAS Catalog for CD96 Gene
Phenotypes for CD96 Gene
- GenomeRNAi human phenotypes for CD96:
-
- Increased HPV18 LCR reporter activity
- Decreased HPV16-GFP infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased IL-8 secretion
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD96
-
CRISPR Products
-
OriGene CRISPR knockouts for CD96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD96
- genomics-online: gRNA clones - Search results for available CD96 gene related products
- Applied Biological Materials CRISPR for CD96
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD96
- GenScript: Design CRISPR guide RNA sequences for CD96
miRNA for CD96 Gene
- miRTarBase miRNAs that target CD96
-
- hsa-mir-335-5p (MIRT019019)
- hsa-mir-6848-3p (MIRT680055)
- hsa-mir-6843-3p (MIRT680056)
- hsa-mir-640 (MIRT680057)
- hsa-mir-378a-5p (MIRT680058)
- hsa-mir-6778-3p (MIRT680059)
- hsa-mir-6821-3p (MIRT680060)
- hsa-mir-6790-3p (MIRT680061)
- hsa-mir-1976 (MIRT680062)
- hsa-mir-3653-5p (MIRT680063)
- hsa-mir-150-5p (MIRT680064)
- hsa-mir-7107-5p (MIRT680065)
- hsa-mir-1234-3p (MIRT680066)
- hsa-mir-1224-3p (MIRT680067)
- hsa-mir-186-3p (MIRT680068)
- hsa-mir-6807-5p (MIRT682962)
- hsa-mir-4252 (MIRT682963)
- hsa-mir-1273g-3p (MIRT682964)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD96
- Browse OriGene Inhibitory RNA Products For CD96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD96
- genomics-online: shRNA clones - Search results for available CD96 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD96
- VectorBuilder custom plasmid, inducible vectors for CD96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD96
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD96
- genomics-online: cdna clones - Search results for available CD96 gene related products
- orf clones - Search results for available CD96 gene related products
- Applied Biological Materials Clones for CD96
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD96
Cell Line Products
-
Horizon Cell Lines for CD96
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CD96 Gene
Localization for CD96 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD96 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| peroxisome | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 17847009 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1313846 |
| GO:0005912 | adherens junction | IDA | 17847009 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD96 Gene
Pathways & Interactions for CD96 Gene
Pathways by source for CD96 Gene
3 Reactome pathways for CD96 Gene
1 R&D Systems pathway for CD96 Gene
Interacting Proteins for CD96 Gene
GPS-Prot Interaction Network for CD96
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002534 | cytokine production involved in inflammatory response | IEA | -- |
| GO:0002728 | negative regulation of natural killer cell cytokine production | IEA | -- |
| GO:0006955 | immune response | TAS | 1313846 |
| GO:0007155 | cell adhesion | TAS | 1313846 |
| GO:0007160 | cell-matrix adhesion | IDA | 17847009 |
No data available for SIGNOR curated interactions for CD96 Gene
Transcripts for CD96 Gene
mRNA/cDNA for CD96 Gene
- (47) Selected AceView cDNA sequences:
- (4) Additional mRNA sequences :
- (8) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000283285 4324 bps (uc003dxw.4)
- ENST00000352690 4516 bps (uc003dxx.4)
- ENST00000438817 1565 bps (uc003dxv.4)
- ENST00000460744 546 bps (uc062mio.1)
- ENST00000465428 500 bps (uc062mir.1)
CRISPR Products
-
OriGene CRISPR knockouts for CD96
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD96
- genomics-online: gRNA clones - Search results for available CD96 gene related products
- Applied Biological Materials CRISPR for CD96
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD96
- GenScript: Design CRISPR guide RNA sequences for CD96
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD96
- Browse OriGene Inhibitory RNA Products For CD96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD96
- genomics-online: shRNA clones - Search results for available CD96 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD96
- VectorBuilder custom plasmid, inducible vectors for CD96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD96
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD96
- genomics-online: cdna clones - Search results for available CD96 gene related products
- orf clones - Search results for available CD96 gene related products
- Applied Biological Materials Clones for CD96
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD96
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: |
Expression for CD96 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Brain (Nervous System)
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CD96 Gene
This gene is overexpressed in Whole Blood (x19.6), Spleen (x5.2), and Small Intestine - Terminal Ileum (x4.0).
This gene is overexpressed in Monocytes (32.0), Heart (17.3), CD8 Tcells (11.9), and Platelet (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD96 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD96 Gene:
CD96SOURCE GeneReport for Unigene cluster for CD96 Gene:
Hs.142023mRNA Expression by UniProt/SwissProt for CD96 Gene:
P40200-TACT_HUMAN
Tissue specificity:
Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
Evidence on tissue expression from TISSUES for CD96 Gene
- Lymph node(4.3)
- Blood(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD96 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
Thorax:
- chest wall
- clavicle
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- small intestine
Pelvis:
- pelvis
- penis
- testicle
- urethra
- urinary bladder
- vagina
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for CD96
-
OriGene qPCR primer pairs and template standards for CD96
- genomics-online: primer clones - Search results for available CD96 gene related products
Gene Expression Assay Products
Orthologs for CD96 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD96 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD96 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD96 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cd96 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd96 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD96 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD96 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD96 34 |
|
OneToOne |
- Species where no ortholog for CD96 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CD96 Gene
- ENSEMBL:
- Gene Tree for CD96 (if available)
- TreeFam:
- Gene Tree for CD96 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD96: view image
Paralogs for CD96 Gene
(1) SIMAP similar genes for CD96 Gene using alignment to 7 proteins:
- TACT_HUMAN
- E9PEJ1_HUMAN
- F8WDV3_HUMAN
- H7C4F0_HUMAN
- L8EAH0_HUMAN
- Q8WUE2_HUMAN
- U3KPT0_HUMAN
No data available for Paralogs for CD96 Gene
Variants for CD96 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1035382001 | uncertain-significance, C syndrome | 111,623,817(+) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs116117825 | likely-benign, C syndrome | 111,649,931(+) | G/A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs119477056 | pathogenic, C syndrome, C syndrome (CSYN) [MIM:211750] | 111,585,362(+) | C/A/T | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs138396447 | likely-benign, C syndrome | 111,606,778(+) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs139540088 | likely-benign, C syndrome | 111,585,363(+) | G/A/T | coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2577n106 | OTHER | inversion | 24896259 |
| esv3305667 | CNV | mobile element insertion | 20981092 |
| esv3366991 | CNV | duplication | 20981092 |
| esv3374376 | CNV | insertion | 20981092 |
| esv3392024 | CNV | insertion | 20981092 |
| nsv1124873 | CNV | duplication | 24896259 |
| nsv3946 | CNV | deletion | 18451855 |
| nsv433354 | CNV | loss | 18776910 |
| nsv460821 | CNV | gain | 19166990 |
| nsv591275 | CNV | gain | 21841781 |
| nsv965196 | CNV | duplication | 23825009 |
| nsv997756 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.82;
47.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD96 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD96 Gene
Disorders for CD96 Gene
(7) MalaCards diseases for CD96 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, and DISEASES
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cat eye syndrome |
|
|
| valproate embryopathy |
|
|
| marshall-smith syndrome |
|
|
| second-degree atrioventricular block |
|
|
| carpenter syndrome 1 |
|
|
Search CD96 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TACT_HUMAN- C syndrome (CSYN) [MIM:211750]: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. {ECO:0000269 PubMed:17847009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
Additional Disease Information for CD96
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CD96 Gene
Publications for CD96 Gene
- Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome. (PMID: 17847009) Kaname T … Naritomi K (American journal of human genetics 2007) 3 4 22 44 58
- Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PMID: 15034010) Fuchs A … Colonna M (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
- Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily. (PMID: 1313846) Wang PL … Krensky AM (Journal of immunology (Baltimore, Md. : 1950) 1992) 2 3 4 58
- CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. (PMID: 19056733) Meyer D … Bernhardt G (The Journal of biological chemistry 2009) 3 22 58
- Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. (PMID: 9845376) Gramatzki M … Moldenhauer G (Experimental hematology 1998) 3 22 58
Products for CD96 Gene
- R&D Systems Antibodies for CD96 (CD96)
- R&D Systems Proteins and Enzymes for CD96
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD96
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD96
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD96
- Search Origene for MassSpec and Protein Over-expression Lysates for CD96
- Origene Custom Protein Services for CD96
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD96
- Browse OriGene Inhibitory RNA Products For CD96
- OriGene qPCR primer pairs for CD96
- OriGene qPCR primer pairs and template standards for CD96
- OriGene CRISPR knockouts for CD96
- OriGene ORF clones in human for CD96
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD96
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD96 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD96
- GenScript Custom Assay Services for CD96
- GenScript Custom overexpressing Cell Line Services for CD96
- GenScript: Design CRISPR guide RNA sequences for CD96
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD96
- Sino Biological Human cDNA Clone for CD96
- Sino Biological Cell Lysates for CD96
- Sino Biological Recombinant Proteins for CD96
- Sino Biological Antibodies for CD96
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD96
- Novus Biologicals proteins and lysates for CD96
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CD96
- VectorBuilder custom plasmid, inducible vectors for CD96
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD96
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available CD96 Antibodies ranked by validation data
- Compare Top CD96 Antibodies
- antibodies-online: Search results for 3 available CD96 Elisa Kits ranked by validation data
- Compare Top CD96 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 14 available CD96 Proteins ranked by validation data
- Compare Top CD96 Proteins
- GeneTex CD96 Antibody for CD96
- Search GeneTex for Proteins for CD96
- Santa Cruz Biotechnology (SCBT) Antibodies for CD96
- Search Santa Cruz Biotechnology (SCBT) for CD96 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD96
- Horizon Cell Lines for CD96
- genomics-online: cdna clones - Search results for available CD96 gene related products
- orf clones - Search results for available CD96 gene related products
- genomics-online: gRNA clones - Search results for available CD96 gene related products
- genomics-online: primer clones - Search results for available CD96 gene related products
- genomics-online: shRNA clones - Search results for available CD96 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD96
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD96
- GeneCopoeia miRNA 3'UTR Target clone products for CD96
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD96
Sources for CD96 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio