Aliases for CD8B2 Gene

Aliases for CD8B2 Gene

  • CD8b2 Molecule 2 3 5
  • T-Cell Surface Glycoprotein CD8 Beta-2 Chain 3 4
  • CD8b Molecule Pseudogene 2 3
  • CD8b Pseudogene 3 4
  • CD8BP 3 4
  • Putative T-Cell Surface Glycoprotein CD8 Beta-2 Chain 3
  • CD8 Antigen, Beta Polypeptide 2, Pseudogene (P37) 2
  • CD8 Antigen, Beta Polypeptide Pseudogene 3

External Ids for CD8B2 Gene

Previous HGNC Symbols for CD8B2 Gene

  • CD8BP

Previous GeneCards Identifiers for CD8B2 Gene

  • GC02U990013
  • GC02P106708
  • GC02P106725
  • GC02P106562

Summaries for CD8B2 Gene

GeneCards Summary for CD8B2 Gene

CD8B2 (CD8b2 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage and Cell adhesion molecules (CAMs). An important paralog of this gene is CD8B.

UniProtKB/Swiss-Prot Summary for CD8B2 Gene

  • Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).

Additional gene information for CD8B2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD8B2 Gene

Genomics for CD8B2 Gene

GeneHancer (GH) Regulatory Elements for CD8B2 Gene

Promoters and enhancers for CD8B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J106484 Promoter/Enhancer 0.6 Ensembl dbSUPER 500.7 -0.1 -64 0.6 EZH2 CD8B2 ENSG00000237666
GH02J106488 Enhancer 0.3 Ensembl dbSUPER 512.1 +1.5 1537 0.6 CD8B2 ENSG00000232001
GH02J106542 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 7.1 +55.7 55709 0.7 CTCF REST RAD21 TRIM22 EZH2 TEAD1 SMC3 YY1 NR2F1 POU2F2 piR-49254 CD8B2 ENSG00000231505 ENSG00000232001
GH02J106536 Enhancer 0.8 Ensembl ENCODE 8.1 +50.3 50337 2.6 CREB1 SPI1 ELF1 IKZF1 NR2F1 RXRA ATF2 JUND ATF7 ATF3 ENSG00000231505 CD8B2 ENSG00000235486 ENSG00000232001
GH02J106546 Enhancer 0.6 Ensembl ENCODE 9 +59.7 59737 3 GABPA GATA3 ATF4 HLF TCF7L2 FOS CD8B2 ENSG00000235486 piR-49254 HSALNG0017648
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD8B2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD8B2

Genomic Locations for CD8B2 Gene

Genomic Locations for CD8B2 Gene
chr2:106,487,364-106,544,297
(GRCh38/hg38)
Size:
56,934 bases
Orientation:
Plus strand
chr2:107,103,824-107,124,137
(GRCh37/hg19)
Size:
20,314 bases
Orientation:
Plus strand

Genomic View for CD8B2 Gene

Genes around CD8B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD8B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD8B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8B2 Gene

Proteins for CD8B2 Gene

  • Protein details for CD8B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJW9-CD8B2_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 beta-2 chain
    Protein Accession:
    A6NJW9
    Secondary Accessions:
    • A0A2R8Y7N9

    Protein attributes for CD8B2 Gene

    Size:
    210 amino acids
    Molecular mass:
    23703 Da
    Quaternary structure:
    • In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.

neXtProt entry for CD8B2 Gene

Post-translational modifications for CD8B2 Gene

  • Glycosylation at Asn102

Other Protein References for CD8B2 Gene

No data available for DME Specific Peptides for CD8B2 Gene

Domains & Families for CD8B2 Gene

Gene Families for CD8B2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CD8B2 Gene

Suggested Antigen Peptide Sequences for CD8B2 Gene

GenScript: Design optimal peptide antigens:
  • CD8b pseudogene (CD8BL_HUMAN)
genes like me logo Genes that share domains with CD8B2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD8B2 Gene

Function for CD8B2 Gene

Molecular function for CD8B2 Gene

UniProtKB/Swiss-Prot Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).
GENATLAS Biochemistry:
cell differentiation antigen CD8B2

Phenotypes From GWAS Catalog for CD8B2 Gene

Gene Ontology (GO) - Molecular Function for CD8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015026 coreceptor activity IEA --
GO:0042288 MHC class I protein binding IEA --
genes like me logo Genes that share ontologies with CD8B2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD8B2 Gene

Localization for CD8B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8B2 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for CD8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD8B2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CD8B2 Gene

Pathways & Interactions for CD8B2 Gene

genes like me logo Genes that share pathways with CD8B2: view

Interacting Proteins for CD8B2 Gene

;

Gene Ontology (GO) - Biological Process for CD8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0050776 regulation of immune response IEA --
genes like me logo Genes that share ontologies with CD8B2: view

No data available for SIGNOR curated interactions for CD8B2 Gene

Drugs & Compounds for CD8B2 Gene

No Compound Related Data Available

Transcripts for CD8B2 Gene

mRNA/cDNA for CD8B2 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CD8B2 Gene

No ASD Table

Relevant External Links for CD8B2 Gene

GeneLoc Exon Structure for
CD8B2

Expression for CD8B2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD8B2 Gene

Orthologs for CD8B2 Gene

Evolution for CD8B2 Gene

ENSEMBL:
Gene Tree for CD8B2 (if available)
TreeFam:
Gene Tree for CD8B2 (if available)

No data available for Orthologs for CD8B2 Gene

Paralogs for CD8B2 Gene

Paralogs for CD8B2 Gene

genes like me logo Genes that share paralogs with CD8B2: view

Variants for CD8B2 Gene

Additional dbSNP identifiers (rs#s) for CD8B2 Gene

Additional Variant Information for CD8B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD8B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CD8B2 Gene

Disorders for CD8B2 Gene

Additional Disease Information for CD8B2

No disorders were found for CD8B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD8B2 Gene

Publications for CD8B2 Gene

  1. Recent duplication of the two human CD8 beta-chain genes. (PMID: 1541829) Nakayama K … Nakauchi H (Journal of immunology (Baltimore, Md. : 1950) 1992) 2 3 4 54
  2. Transcriptional diversity at the duplicated human CD8 beta loci. (PMID: 8436166) DiSanto JP … Flomenberg N (European journal of immunology 1993) 3 4 54
  3. Transcriptional fates of human-specific segmental duplications in brain. (PMID: 30228200) Dougherty ML … Eichler EE (Genome research 2018) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 54

Products for CD8B2 Gene

Sources for CD8B2 Gene