CD8A Gene (Protein Coding)

CD8a Molecule

GC02M086784
GIFtS:
46
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a ... See more...

Aliases for CD8A Gene

Aliases for CD8A Gene

  • CD8a Molecule 2 3 5
  • T-Cell Surface Glycoprotein CD8 Alpha Chain 2 3 4
  • T-Lymphocyte Differentiation Antigen T8/Leu-2 3 4
  • CD8 Antigen, Alpha Polypeptide (P32) 2 3
  • Leu2 T-Lymphocyte Antigen 3
  • OKT8 T-Cell Antigen 3
  • T-Cell Antigen Leu2 3
  • T Cell Co-Receptor 3
  • T8 T-Cell Antigen 3
  • CD8a Antigen 4
  • Leu2 3
  • CD8A 5
  • CD8 3
  • P32 3
  • MAL 4

External Ids for CD8A Gene

Previous HGNC Symbols for CD8A Gene

  • CD8

Previous GeneCards Identifiers for CD8A Gene

  • GC02M086907
  • GC02M087305
  • GC02M086986
  • GC02M086923
  • GC02M086865

Summaries for CD8A Gene

Entrez Gene Summary for CD8A Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

GeneCards Summary for CD8A Gene

CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Herpes Zoster. Among its related pathways are TCR Signaling (Qiagen) and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.

UniProtKB/Swiss-Prot Summary for CD8A Gene

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Gene Wiki entry for CD8A Gene

Additional gene information for CD8A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD8A Gene

Genomics for CD8A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CD8A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD8A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD8A

Top Transcription factor binding sites by QIAGEN in the CD8A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • STAT1

Genomic Locations for CD8A Gene

Genomic Locations for CD8A Gene
chr2:86,784,605-86,808,396
(GRCh38/hg38)
Size:
23,792 bases
Orientation:
Minus strand
chr2:87,011,728-87,035,519
(GRCh37/hg19)
Size:
23,792 bases
Orientation:
Minus strand

Genomic View for CD8A Gene

Genes around CD8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD8A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD8A Gene

Proteins for CD8A Gene

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  • Protein details for CD8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01732-CD8A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 alpha chain
    Protein Accession:
    P01732
    Secondary Accessions:
    • B4DT80
    • D6W5M8
    • Q13970
    • Q4ZG17

    Protein attributes for CD8A Gene

    Size:
    235 amino acids
    Molecular mass:
    25729 Da
    Quaternary structure:
    • Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop) (PubMed:2784196, PubMed:9177355). Interacts with LCK in a zinc-dependent manner. Interacts with HLA-G; this interaction is direct and might down-regulate T cell receptor signaling.

    Three dimensional structures from OCA and Proteopedia for CD8A Gene

    Alternative splice isoforms for CD8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD8A Gene

Protein Expression for CD8A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD8A Gene

  • Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
  • O-glycosylated.
  • Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD8A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD8A Gene

Domains & Families for CD8A Gene

Gene Families for CD8A Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD8A Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin V-type
ProtoNet:

Suggested Antigen Peptide Sequences for CD8A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61164, highly similar to T-cell surface glycoprotein CD8 alpha chain (B4DT80_HUMAN)
  • T-lymphocyte differentiation antigen T8/Leu-2 (CD8A_HUMAN)
  • CD8a molecule (Q8TAW8_HUMAN)
  • Mutant CD8 alpha antigen (Q96QR6_HUMAN)
genes like me logo Genes that share domains with CD8A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD8A Gene

Function for CD8A Gene

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Molecular function for CD8A Gene

UniProtKB/Swiss-Prot Function:
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
GENATLAS Biochemistry:
cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes

Phenotypes From GWAS Catalog for CD8A Gene

Gene Ontology (GO) - Molecular Function for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2470098
GO:0015026 coreceptor activity NAS 11131152
GO:0023024 MHC class I protein complex binding IDA 2784196
GO:0042288 MHC class I protein binding NAS 11131152
genes like me logo Genes that share ontologies with CD8A: view
genes like me logo Genes that share phenotypes with CD8A: view

Human Phenotype Ontology for CD8A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD8A Gene

MGI Knock Outs for CD8A:

Animal Model Products

CRISPR Products

miRNA for CD8A Gene

miRTarBase miRNAs that target CD8A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD8A

Clone Products

  • Addgene plasmids for CD8A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD8A Gene

Localization for CD8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8A Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269 PubMed:17341584}.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD8A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
golgi apparatus 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane NAS 2496167
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD8A: view

Pathways & Interactions for CD8A Gene

genes like me logo Genes that share pathways with CD8A: view

SIGNOR curated interactions for CD8A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity IBA 21873635
GO:0006955 immune response NAS 11131152
GO:0007166 cell surface receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CD8A: view

Drugs & Compounds for CD8A Gene

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  1. Drug

(1) Drugs for CD8A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CD8A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD8A: view

Transcripts for CD8A Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for CD8A Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD8A

Clone Products

  • Addgene plasmids for CD8A

Alternative Splicing Database (ASD) splice patterns (SP) for CD8A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b
SP1:
SP2:
SP3: - -

Relevant External Links for CD8A Gene

GeneLoc Exon Structure for
CD8A

Expression for CD8A Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD8A Gene

mRNA expression in normal human tissues for CD8A Gene
mRNA expression by BioGPS for CD8A GenemRNA expression by GTEx for CD8A Gene

mRNA differential expression in normal tissues according to GTEx for CD8A Gene

This gene is overexpressed in Whole Blood (x15.7) and Spleen (x14.7).

Protein differential expression in normal tissues from HIPED for CD8A Gene

This gene is overexpressed in Tlymphocyte (26.7) and CD8 Tcells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD8A Gene



Protein tissue co-expression partners for CD8A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD8A

SOURCE GeneReport for Unigene cluster for CD8A Gene:

Hs.85258

mRNA Expression by UniProt/SwissProt for CD8A Gene:

P01732-CD8A_HUMAN
Tissue specificity: CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.

Evidence on tissue expression from TISSUES for CD8A Gene

  • Spleen(4.8)
  • Lymph node(4.3)
  • Blood(4.2)
  • Bone marrow(4)
  • Intestine(3.7)
  • Nervous system(3.6)
  • Liver(3.6)
  • Kidney(3.6)
  • Skin(3.4)
  • Lung(3.4)
  • Heart(3.3)
  • Muscle(3)
  • Stomach(3)
  • Pancreas(3)
  • Bone(2.8)
  • Thyroid gland(2.6)
  • Eye(2.6)
  • Urine(2.5)
  • Adrenal gland(2.5)
  • Saliva(2.4)
  • Gall bladder(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD8A Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • immune
  • respiratory
Regions:
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CD8A: view

Orthologs for CD8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CD8A 30 31
  • 99.29 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CD8A 30 31
  • 79.22 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CD8A 30 31
  • 74.06 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cd8a 30
  • 63.67 (n)
Mouse
(Mus musculus)
 Mammalia Cd8a 30 17 31
  • 63.33 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CD8A 31
  • 40 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CD8A 31
  • 30 (a)
 OneToOne
Species where no ortholog for CD8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD8A Gene

ENSEMBL:
Gene Tree for CD8A (if available)
TreeFam:
Gene Tree for CD8A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD8A: view image

Paralogs for CD8A Gene

(13) SIMAP similar genes for CD8A Gene using alignment to 5 proteins:

  • CD8A_HUMAN
  • B4DT80_HUMAN
  • B8ZZZ4_HUMAN
  • Q8TAW8_HUMAN
  • Q96QR6_HUMAN
genes like me logo Genes that share paralogs with CD8A: view

No data available for Paralogs for CD8A Gene

Variants for CD8A Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD8A Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
639504 Uncertain Significance: Cd8 deficiency, familial 86,790,324(-) G/C INTRON_VARIANT
644495 Uncertain Significance: Cd8 deficiency, familial 86,790,394(-) A/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
645068 Uncertain Significance: Cd8 deficiency, familial 86,789,379(-) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
648401 Uncertain Significance: Cd8 deficiency, familial 86,789,660(-) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
649582 Uncertain Significance: Cd8 deficiency, familial 86,790,361(-) ACAT/TGCTCAG NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INDEL

Additional dbSNP identifiers (rs#s) for CD8A Gene

Structural Variations from Database of Genomic Variants (DGV) for CD8A Gene

Variant ID Type Subtype PubMed ID
dgv3886n100 CNV gain 25217958
dgv714e214 CNV gain 21293372
esv25494 CNV gain 19812545
esv3591559 CNV gain 21293372
nsv10063 CNV gain 18304495
nsv458585 CNV gain 19166990
nsv477145 CNV novel sequence insertion 20440878
nsv582373 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv997982 CNV gain 25217958

Variation tolerance for CD8A Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD8A Gene

Human Gene Mutation Database (HGMD)
CD8A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD8A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8A Gene

Disorders for CD8A Gene

MalaCards: The human disease database

(307) MalaCards diseases for CD8A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cd8 deficiency, familial
  • susceptibility to respiratory infections associated with cd8alpha chain mutation
herpes zoster
  • herpes zona
alveolar echinococcosis
  • alveolococcosis
primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma
  • berti lymphoma
inflammatory linear verrucous epidermal nevus
  • ilven
- elite association - COSMIC cancer census association via MalaCards
Search CD8A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD8A_HUMAN
  • CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269 PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CD8A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD8A: view

No data available for Genatlas for CD8A Gene

Publications for CD8A Gene

  1. CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. (PMID: 17341584) Pang DJ … Bijlmakers MJ (The Journal of biological chemistry 2007) 3 4
  2. CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses. (PMID: 17678538) Gibbings DJ … Befus AD (BMC immunology 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. (PMID: 12853576) Shiroishi M … Maenaka K (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4
  5. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. (PMID: 14500983) Kim PW … Eck MJ (Science (New York, N.Y.) 2003) 3 4

ExternalLinks

View latest publications for CD8A gene in Mastermind

Products for CD8A Gene

  • Addgene plasmids for CD8A