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The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Herpes Zoster. Among its related pathways are TCR Signaling (Qiagen) and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 2470098 |
GO:0015026 | coreceptor activity | NAS | 11131152 |
GO:0023024 | MHC class I protein complex binding | IDA | 2784196 |
GO:0042288 | MHC class I protein binding | NAS | 11131152 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0005887 | integral component of plasma membrane | NAS | 2496167 |
GO:0009897 | external side of plasma membrane | IDA | 17213291 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | T cell receptor signaling pathway | ||
2 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
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TCR Signaling
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3 | NF-kappaB Signaling | ||
4 | Allograft rejection | ||
5 | Cell adhesion molecules (CAMs) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002456 | T cell mediated immunity | IBA | 21873635 |
GO:0006955 | immune response | NAS | 11131152 |
GO:0007166 | cell surface receptor signaling pathway | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||
SP2: | |||||||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD8A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD8A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD8A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd8a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd8a 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD8A 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD8A 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
639504 | Uncertain Significance: Cd8 deficiency, familial | 86,790,324(-) | G/C | INTRON_VARIANT | |
644495 | Uncertain Significance: Cd8 deficiency, familial | 86,790,394(-) | A/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
645068 | Uncertain Significance: Cd8 deficiency, familial | 86,789,379(-) | G/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
648401 | Uncertain Significance: Cd8 deficiency, familial | 86,789,660(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
649582 | Uncertain Significance: Cd8 deficiency, familial | 86,790,361(-) | ACAT/TGCTCAG | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INDEL |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3886n100 | CNV | gain | 25217958 |
dgv714e214 | CNV | gain | 21293372 |
esv25494 | CNV | gain | 19812545 |
esv3591559 | CNV | gain | 21293372 |
nsv10063 | CNV | gain | 18304495 |
nsv458585 | CNV | gain | 19166990 |
nsv477145 | CNV | novel sequence insertion | 20440878 |
nsv582373 | CNV | gain | 21841781 |
nsv7316 | OTHER | inversion | 18451855 |
nsv997982 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cd8 deficiency, familial |
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herpes zoster |
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alveolar echinococcosis |
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primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma |
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inflammatory linear verrucous epidermal nevus |
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