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Aliases for CD8A Gene

Aliases for CD8A Gene

  • CD8a Molecule 2 3 5
  • T-Lymphocyte Differentiation Antigen T8/Leu-2 3 4
  • T-Cell Surface Glycoprotein CD8 Alpha Chain 2 3
  • CD8 Antigen, Alpha Polypeptide (P32) 2 3
  • MAL 3 4
  • Leu2 T-Lymphocyte Antigen 3
  • OKT8 T-Cell Antigen 3
  • T-Cell Antigen Leu2 3
  • T Cell Co-Receptor 3
  • T8 T-Cell Antigen 3
  • CD8a Antigen 4
  • Leu2 3
  • P32 3
  • CD8 3

External Ids for CD8A Gene

Previous HGNC Symbols for CD8A Gene

  • CD8

Previous GeneCards Identifiers for CD8A Gene

  • GC02M086907
  • GC02M087305
  • GC02M086986
  • GC02M086923
  • GC02M086865

Summaries for CD8A Gene

Entrez Gene Summary for CD8A Gene

  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CD8A Gene

CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Lymphoid Interstitial Pneumonia. Among its related pathways are T cell receptor signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.

UniProtKB/Swiss-Prot for CD8A Gene

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Gene Wiki entry for CD8A Gene

Additional gene information for CD8A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD8A Gene

Genomics for CD8A Gene

GeneHancer (GH) Regulatory Elements for CD8A Gene

Promoters and enhancers for CD8A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J086783 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 691.9 +19.0 18959 12.6 PKNOX1 ATF1 ZSCAN4 FEZF1 ZNF335 ZNF366 SCRT2 ZNF143 ATF7 BCLAF1 CD8A CD8B CHMP3 RNU6-640P REEP1 ENSG00000231259 RMND5A KDM3A RNF103 LOC105374846
GH02J086805 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 684.8 +0.5 542 5.3 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 CD8A CD8B SNORD94 CHMP3 RNU6-640P REEP1 PLGLB1 LOC105374846
GH02J086719 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 5.5 +87.8 87758 2.5 PKNOX1 ATF1 FOXA2 ARNT SIN3A POLR2B GLIS2 ZNF207 ATF7 SP3 RMND5A RNF103-CHMP3 CD8A ENSG00000231259 GC02M086689
GH02J086694 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +113.0 113001 1.5 FOXA2 GLI4 ETS1 TCF12 ZNF280A FOS ATF7 SP3 NFYC NCOA1 SNORD94 LOC102724642 RNF103-CHMP3 RNF103 POLR1A CHMP3 RNU6-640P RMND5A CD8A ENSG00000231259
GH02J086764 Enhancer 0.8 ENCODE dbSUPER 7.7 +43.3 43318 0.8 CTCF ZNF654 USF1 NR2F1 TRIM22 EBF1 RAD21 ATF2 MITF SMC3 CHMP3 RNU6-640P CD8A GC02M086689 LOC105374846 RMND5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD8A gene promoter:
  • c-Jun
  • ATF-2
  • STAT1
  • AP-1
  • p53

Genomic Locations for CD8A Gene

Genomic Locations for CD8A Gene
chr2:86,784,605-86,808,396
(GRCh38/hg38)
Size:
23,792 bases
Orientation:
Minus strand
chr2:87,011,728-87,035,519
(GRCh37/hg19)
Size:
23,792 bases
Orientation:
Minus strand

Genomic View for CD8A Gene

Genes around CD8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD8A Gene

Proteins for CD8A Gene

  • Protein details for CD8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01732-CD8A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD8 alpha chain
    Protein Accession:
    P01732
    Secondary Accessions:
    • B4DT80
    • D6W5M8
    • Q13970
    • Q4ZG17

    Protein attributes for CD8A Gene

    Size:
    235 amino acids
    Molecular mass:
    25729 Da
    Quaternary structure:
    • Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD8A Gene

    Alternative splice isoforms for CD8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD8A Gene

Post-translational modifications for CD8A Gene

  • Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
  • O-glycosylated.
  • Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD8A Gene

Antibody Products

No data available for DME Specific Peptides for CD8A Gene

Domains & Families for CD8A Gene

Gene Families for CD8A Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD8A: view

No data available for UniProtKB/Swiss-Prot for CD8A Gene

Function for CD8A Gene

Molecular function for CD8A Gene

UniProtKB/Swiss-Prot Function:
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
GENATLAS Biochemistry:
cell differentiation antigen CD8A (p32),class I receptor,identified by monoclonal antibodies T8,Leu2a,M236,UCHT4,T811,enhancing formation of stable T-cell receptor/MHC class I complexes

Phenotypes From GWAS Catalog for CD8A Gene

Gene Ontology (GO) - Molecular Function for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2470098
GO:0015026 coreceptor activity NAS 11131152
GO:0019901 protein kinase binding IEA --
GO:0042288 MHC class I protein binding NAS 11131152
genes like me logo Genes that share ontologies with CD8A: view
genes like me logo Genes that share phenotypes with CD8A: view

Human Phenotype Ontology for CD8A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD8A Gene

MGI Knock Outs for CD8A:

Animal Model Products

miRNA for CD8A Gene

miRTarBase miRNAs that target CD8A

Clone Products

  • Addgene plasmids for CD8A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD8A Gene

Localization for CD8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD8A Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269 PubMed:17341584}.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD8A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2496167
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD8A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD8A Gene

Pathways & Interactions for CD8A Gene

genes like me logo Genes that share pathways with CD8A: view

Interacting Proteins for CD8A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283635%0d%0a9606.ENSP00000354782%0d%0a9606.ENSP00000316746%0d%0a9606.ENSP00000264033%0d%0a9606.ENSP00000263125%0d%0a9606.ENSP00000332049%0d%0a
Selected Interacting proteins: ENSP00000283635 P01732-CD8A_HUMAN for CD8A Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
B2M

Gene Ontology (GO) - Biological Process for CD8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity IBA --
GO:0006955 immune response NAS 11131152
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 9830036
genes like me logo Genes that share ontologies with CD8A: view

No data available for SIGNOR curated interactions for CD8A Gene

Drugs & Compounds for CD8A Gene

(1) Drugs for CD8A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CD8A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD8A: view

Transcripts for CD8A Gene

mRNA/cDNA for CD8A Gene

Unigene Clusters for CD8A Gene

CD8a molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for CD8A

Alternative Splicing Database (ASD) splice patterns (SP) for CD8A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b
SP1:
SP2:
SP3: - -

Relevant External Links for CD8A Gene

GeneLoc Exon Structure for
CD8A
ECgene alternative splicing isoforms for
CD8A

Expression for CD8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD8A Gene

mRNA differential expression in normal tissues according to GTEx for CD8A Gene

This gene is overexpressed in Whole Blood (x15.7) and Spleen (x14.7).

Protein differential expression in normal tissues from HIPED for CD8A Gene

This gene is overexpressed in Tlymphocyte (26.7) and CD8 Tcells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD8A Gene



Protein tissue co-expression partners for CD8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD8A Gene:

CD8A

SOURCE GeneReport for Unigene cluster for CD8A Gene:

Hs.85258

mRNA Expression by UniProt/SwissProt for CD8A Gene:

P01732-CD8A_HUMAN
Tissue specificity: CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.

Evidence on tissue expression from TISSUES for CD8A Gene

  • Spleen(4.3)
  • Blood(3)
  • Lymph node(2.5)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD8A Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • immune
  • respiratory
Regions:
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CD8A: view

Orthologs for CD8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD8A 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD8A 34 33
  • 79.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD8A 34 33
  • 74.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd8a 33
  • 63.67 (n)
mouse
(Mus musculus)
Mammalia Cd8a 16 34 33
  • 63.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CD8A 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD8A 34
  • 30 (a)
OneToOne
Species where no ortholog for CD8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD8A Gene

ENSEMBL:
Gene Tree for CD8A (if available)
TreeFam:
Gene Tree for CD8A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD8A: view image

Paralogs for CD8A Gene

(13) SIMAP similar genes for CD8A Gene using alignment to 5 proteins:

  • CD8A_HUMAN
  • B4DT80_HUMAN
  • B8ZZZ4_HUMAN
  • Q8TAW8_HUMAN
  • Q96QR6_HUMAN
genes like me logo Genes that share paralogs with CD8A: view

No data available for Paralogs for CD8A Gene

Variants for CD8A Gene

Sequence variations from dbSNP and Humsavar for CD8A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs115370220 benign, Cd8 deficiency, familial 86,789,707(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs121918660 pathogenic, Cd8 deficiency, familial, CD8 deficiency, familial (CD8 deficiency) [MIM:608957] 86,790,400(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs139743836 benign, Cd8 deficiency, familial 86,789,439(-) G/A/C intron_variant
rs147048705 benign, Cd8 deficiency, familial 86,790,578(-) C/A/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs746824602 likely-benign, Cd8 deficiency, familial 86,789,760(-) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD8A Gene

Variant ID Type Subtype PubMed ID
dgv3886n100 CNV gain 25217958
dgv714e214 CNV gain 21293372
esv25494 CNV gain 19812545
esv3591559 CNV gain 21293372
nsv10063 CNV gain 18304495
nsv458585 CNV gain 19166990
nsv477145 CNV novel sequence insertion 20440878
nsv582373 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv997982 CNV gain 25217958

Variation tolerance for CD8A Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD8A Gene

Human Gene Mutation Database (HGMD)
CD8A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD8A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD8A Gene

Disorders for CD8A Gene

MalaCards: The human disease database

(14) MalaCards diseases for CD8A Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cd8 deficiency, familial
  • susceptibility to respiratory infections associated with cd8alpha chain mutation
lymphoid interstitial pneumonia
  • lip
primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma
  • berti lymphoma
inflammatory linear verrucous epidermal nevus
  • ilven
immune system organ benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CD8A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD8A_HUMAN
  • CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269 PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CD8A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD8A: view

No data available for Genatlas for CD8A Gene

Publications for CD8A Gene

  1. CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. (PMID: 17341584) Pang DJ … Bijlmakers MJ (The Journal of biological chemistry 2007) 3 4 58
  2. CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses. (PMID: 17678538) Gibbings DJ … Befus AD (BMC immunology 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. (PMID: 14500983) Kim PW … Eck MJ (Science (New York, N.Y.) 2003) 3 4 58
  5. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. (PMID: 11937547) Kieffer LJ … Kavathas PB (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 22 58

Products for CD8A Gene