This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell.... See more...

Aliases for CD86 Gene

Aliases for CD86 Gene

  • CD86 Molecule 2 3 5
  • CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen) 2 3
  • T-Lymphocyte Activation Antigen CD86 3 4
  • CTLA-4 Counter-Receptor B7.2 3 4
  • CD28LG2 3 4
  • FUN-1 3 4
  • B7-2 2 3
  • B7.2 2 3
  • BU63 3 4
  • B70 3 4
  • B-Lymphocyte Activation Antigen B7-2 3
  • B-Lymphocyte Antigen B7-2 2
  • Activation B7-2 Antigen 4
  • CD86 Antigen 4
  • LAB72 3
  • CD86 5

External Ids for CD86 Gene

Previous HGNC Symbols for CD86 Gene

  • CD28LG2

Previous GeneCards Identifiers for CD86 Gene

  • GC03P118451
  • GC03P121633
  • GC03P123055
  • GC03P123095
  • GC03P123256
  • GC03P121774
  • GC03P119148

Summaries for CD86 Gene

Entrez Gene Summary for CD86 Gene

  • This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

GeneCards Summary for CD86 Gene

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Myocarditis and Acute Myocarditis. Among its related pathways are RET signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. An important paralog of this gene is CD80.

UniProtKB/Swiss-Prot Summary for CD86 Gene

  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
  • [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD86 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD86 Gene

Genomics for CD86 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD86 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J122073 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 262.7 +22.1 22068 7.1 BCLAF1 SP1 CEBPA BCL11A SIN3A TRIM22 NR2C1 FOXA2 RXRA IRF4 CD86 ILDR1 ENSG00000202388 DTX3L PARP9 FAM162A MIX23 IQCB1 EAF2 CSTA
GH03J122054 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 261.8 +2.3 2336 5.8 BCLAF1 POLR2A BCL11A ZNF592 IRF4 CBFB TAF1 BHLHE40 SPI1 BATF CD86 ENSG00000202388 IQCB1 HCLS1 EAF2 HSALNG0028476 ILDR1
GH03J121979 Promoter 0.3 EPDnew 250.2 -75.9 -75862 0.1 piR-32023-143 piR-36588-293 CD86 SLC15A2 LOC101927010
GH03J122099 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +46.4 46421 5.2 BCLAF1 SP1 ZNF654 BCL11A CTCF REST ZNF592 TRIM22 ZNF217 RXRA CSTA CD86 ILDR1 ENSG00000202388 CASR POLQ PARP9 DTX3L HCLS1 EAF2
GH03J122002 Enhancer 1 FANTOM5 ENCODE 13.9 -51.5 -51527 2.4 ZNF207 BCL11A TRIM22 SMC3 IRF4 ZNF316 BHLHE40 ELF1 ZNF24 STAT5A IQCB1 SLC15A2 CD86 ENSG00000202388 ILDR1 CSTA EAF2 HCLS1 piR-58929-067 LOC101927010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD86 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD86

Top Transcription factor binding sites by QIAGEN in the CD86 gene promoter:
  • AP-1
  • STAT3

Genomic Locations for CD86 Gene

Latest Assembly
chr3:122,055,362-122,121,139
(GRCh38/hg38)
Size:
65,778 bases
Orientation:
Plus strand

Previous Assembly
chr3:121,774,209-121,839,983
(GRCh37/hg19 by Entrez Gene)
Size:
65,775 bases
Orientation:
Plus strand

chr3:121,774,213-121,839,983
(GRCh37/hg19 by Ensembl)
Size:
65,771 bases
Orientation:
Plus strand

Genomic View for CD86 Gene

Genes around CD86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD86 Gene

Proteins for CD86 Gene

  • Protein details for CD86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42081-CD86_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD86
    Protein Accession:
    P42081
    Secondary Accessions:
    • A0N0P0
    • B7Z2F3
    • B7Z702
    • E7ETN5
    • E9PC27
    • Q13655
    • Q6FHB1
    • Q6GTS4
    • Q7M4L5

    Protein attributes for CD86 Gene

    Size:
    329 amino acids
    Molecular mass:
    37682 Da
    Quaternary structure:
    • Homodimer. Interacts with MARCH8. Interacts (via cytoplasmic domain) with PHB and PHB2; the interactions increases after priming with CD40 (By similarity).
    • (Microbial infection) Interacts with adenovirus subgroup b fiber protein.

    Three dimensional structures from OCA and Proteopedia for CD86 Gene

    Alternative splice isoforms for CD86 Gene

neXtProt entry for CD86 Gene

Post-translational modifications for CD86 Gene

  • Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
  • Glycosylation at Asn135, Asn33, Asn146, Asn47, Asn154, Asn177, Asn192, and Asn213
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for CD86

Protein products for research

  • Abcam proteins for CD86

No data available for DME Specific Peptides for CD86 Gene

Domains & Families for CD86 Gene

Gene Families for CD86 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD86 Gene

InterPro:
Blocks:
  • Immunoglobulin V-type

Suggested Antigen Peptide Sequences for CD86 Gene

GenScript: Design optimal peptide antigens:
  • FUN-1 (CD86_HUMAN)
genes like me logo Genes that share domains with CD86: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD86 Gene

Function for CD86 Gene

Molecular function for CD86 Gene

UniProtKB/Swiss-Prot Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
GENATLAS Biochemistry:
cell differentiation antigen CD86,80kDa,identified by monoclonal antibody FUN1,B7.2 expressed on monocytes,dendritic cells and activated B,T and natural killer cells (antigen presenting cells)

Phenotypes From GWAS Catalog for CD86 Gene

Gene Ontology (GO) - Molecular Function for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
GO:0038023 signaling receptor activity TAS 7694363
genes like me logo Genes that share ontologies with CD86: view
genes like me logo Genes that share phenotypes with CD86: view

Animal Models for CD86 Gene

MGI Knock Outs for CD86:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD86

Clone products for research

  • Addgene plasmids for CD86

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD86 Gene

Localization for CD86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD86 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD86 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
endosome 3
cytosol 3
lysosome 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface HDA 23981064
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD86: view

Pathways & Interactions for CD86 Gene

genes like me logo Genes that share pathways with CD86: view

Pathways by source for CD86 Gene

4 GeneGo (Thomson Reuters) pathways for CD86 Gene
  • Immune response CD28 signaling
  • Immune response ICOS pathway in T-helper cell
  • Immune response IL-22 signaling pathway
  • Immune response NFAT in immune response
8 Qiagen pathways for CD86 Gene
  • CD28 Signaling in T-Helper Cell
  • CTLA4 Signaling
  • ICos-ICosL Pathway in T-Helper Cell
  • NFAT in Immune Response
  • Nur77 Signaling in T-Cell

Gene Ontology (GO) - Biological Process for CD86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production ISS --
GO:0006955 immune response TAS,IBA 21873635
GO:0007166 cell surface receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CD86: view

No data available for SIGNOR curated interactions for CD86 Gene

Drugs & Compounds for CD86 Gene

(19) Drugs for CD86 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma Target, antagonist, binder 267
Belatacept Approved, Investigational Pharma Target, antagonist, inhibitor 0
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target, binder 0
Bryostatin 1 Investigational Pharma Target, inducer 43
antithymocyte globulin Pharma binder 0

(10) Additional Compounds for CD86 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD86: view

Transcripts for CD86 Gene

mRNA/cDNA for CD86 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD86

Clone products for research

  • Addgene plasmids for CD86

Alternative Splicing Database (ASD) splice patterns (SP) for CD86 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for CD86 Gene

GeneLoc Exon Structure for
CD86

Expression for CD86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD86 Gene

mRNA differential expression in normal tissues according to GTEx for CD86 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for CD86 Gene

This gene is overexpressed in Heart (31.5), Monocytes (26.3), and Retina (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD86 Gene



Protein tissue co-expression partners for CD86 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD86

SOURCE GeneReport for Unigene cluster for CD86 Gene:

Hs.171182

mRNA Expression by UniProt/SwissProt for CD86 Gene:

P42081-CD86_HUMAN
Tissue specificity: Expressed by activated B-lymphocytes and monocytes.

Evidence on tissue expression from TISSUES for CD86 Gene

  • Nervous system(4.6)
  • Spleen(3.9)
  • Lymph node(3.8)
  • Blood(3.7)
  • Bone marrow(3.2)
  • Intestine(3.1)
  • Lung(3)
  • Skin(2.8)
  • Heart(2.8)
  • Liver(2.7)
  • Stomach(2.4)
  • Kidney(2.4)
  • Pancreas(2.4)
  • Bone(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CD86: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD86 Gene

Orthologs for CD86 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD86 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD86 29 30
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD86 29 30
  • 78.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD86 29 30
  • 74.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd86 29
  • 68.86 (n)
Mouse
(Mus musculus)
Mammalia Cd86 29 16 30
  • 68.37 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CD86 30
  • 34 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD86 30
  • 34 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD86 29 30
  • 51.17 (n)
OneToOne
Species where no ortholog for CD86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD86 Gene

ENSEMBL:
Gene Tree for CD86 (if available)
TreeFam:
Gene Tree for CD86 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD86: view image
Alliance of Genome Resources:
Additional Orthologs for CD86

Paralogs for CD86 Gene

genes like me logo Genes that share paralogs with CD86: view

Variants for CD86 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD86 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs9282648 Benign: not provided 122,119,511(+) G/Ap.Asp323Asn
NM_175862.5(CD86):c.967G>A (p.Asp323Asn)
MISSENSE
rs1129055 -- p.Ala310Thr
rs2681417 -- p.Val185Ile
rs9282642 -- p.Ser170Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CD86 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CD86 Gene

Variant ID Type Subtype PubMed ID
esv1959984 CNV deletion 18987734
esv2500835 CNV deletion 19546169
esv33139 CNV loss 17666407
nsv3972 CNV insertion 18451855
nsv528646 CNV loss 19592680

Variation tolerance for CD86 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD86 Gene

Human Gene Mutation Database (HGMD)
CD86
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD86
Leiden Open Variation Database (LOVD)
CD86

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD86 Gene

Disorders for CD86 Gene

MalaCards: The human disease database

(54) MalaCards diseases for CD86 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
myocarditis
  • myocardial inflammation
acute myocarditis
plague
  • yersiniosis
cowpox
  • yaba
allergic disease
  • allergic hypersensitivity disease
- elite association - COSMIC cancer census association via MalaCards
Search CD86 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD86

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CD86: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD86 Gene

Publications for CD86 Gene

  1. A functional CD86 polymorphism associated with asthma and related allergic disorders. (PMID: 17513529) Corydon TJ … Børglum AD (Journal of medical genetics 2007) 3 22 40
  2. A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis. (PMID: 16712644) Abdallah AM … Welsh KI (International journal of immunogenetics 2006) 3 22 40
  3. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 22 40
  4. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PMID: 16223675) Marín LA … Alvarez-López MR (Transplant immunology 2005) 3 22 40
  5. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PMID: 14975605) Teutsch SM … Stewart GJ (Journal of neuroimmunology 2004) 3 22 40

Products for CD86 Gene

  • Addgene plasmids for CD86

Sources for CD86 Gene