Aliases for CD86 Gene
External Ids for CD86 Gene
Previous HGNC Symbols for CD86 Gene
Previous GeneCards Identifiers for CD86 Gene
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
GeneCards Summary for CD86 Gene
CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Myocarditis and Acute Myocarditis. Among its related pathways are RET signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity. An important paralog of this gene is CD80.
UniProtKB/Swiss-Prot Summary for CD86 Gene
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
[Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.