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The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
CD83 (CD83 Molecule) is a Protein Coding gene. Diseases associated with CD83 include Sulfamethoxazole Allergy and Plague. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and T cell receptor signaling pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20374249 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | 9310491 |
GO:0005887 | integral component of plasma membrane | TAS | 8422464 |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NF-kappaB Signaling | ||
2 | Dendritic Cells Developmental Lineage Pathway | ||
3 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
4 | T cell receptor signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006952 | defense response | TAS | 1378080 |
GO:0006959 | humoral immune response | TAS | 8422464 |
GO:0007165 | signal transduction | TAS | 9310491 |
GO:0014070 | response to organic cyclic compound | IEA | -- |
GO:0032713 | negative regulation of interleukin-4 production | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD83 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD83 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD83 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd83 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd83 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CD83 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD83 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD83 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3327144 | CNV | insertion | 20981092 |
nsv1133627 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sulfamethoxazole allergy |
|
|
plague |
|
|
rift valley fever |
|
|
skin sarcoidosis |
|
|
cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction |
|
|