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This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expressio... See more...
Aliases for CD82 Gene
Aliases for CD82 Gene
- CD82 Molecule 2 3 5
- CD82 Antigen 2 3 4
- TSPAN27 2 3 4
- IA4 2 3 4
- Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
- Metastasis Suppressor Kangai-1 3 4
- Inducible Membrane Protein R2 3 4
- Tetraspanin-27 3 4
- C33 Antigen 3 4
- Tspan-27 3 4
External Ids for CD82 Gene
- HGNC: 6210
- Entrez Gene: 3732
- Ensembl: ENSG00000085117
- OMIM: 600623
- UniProtKB: P27701
Previous HGNC Symbols for CD82 Gene
- ST6
- KAI1
Previous GeneCards Identifiers for CD82 Gene
- GC11P044544
- GC11P044296
Summaries for CD82 Gene
-
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD82 Gene
CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include Penile Cancer and Renal Oncocytoma. Among its related pathways are Direct p53 effectors and NF-kappaB Signaling. An important paralog of this gene is CD37.
UniProtKB/Swiss-Prot Summary for CD82 Gene
-
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Additional gene information for CD82 Gene
- HGNC(6210)
- Entrez Gene(3732)
- Ensembl(ENSG00000085117)
- OMIM(600623)
- UniProtKB(P27701)
- Open Targets Platform(ENSG00000085117)
- Monarch Initiative
- Search for CD82 at DataMed
- Search for CD82 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD82 Gene
Genomics for CD82 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD82 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD82 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD82
- Top Transcription factor binding sites by QIAGEN in the CD82 gene promoter:
-
- AP-1
- NF-kappaB
- NF-kappaB1
Genomic Locations for CD82 Gene
Genomic Locations for CD82 Gene
- chr11:44,564,427-44,620,363
- (GRCh38/hg38)
- Size:
- 55,937 bases
- Orientation:
- Plus strand
- chr11:44,585,977-44,641,913
- (GRCh37/hg19)
- Size:
- 55,937 bases
- Orientation:
- Plus strand
Genomic View for CD82 Gene
Genes around CD82 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
CD82 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD82 Gene
Proteins for CD82 Gene
-
Protein details for CD82 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27701-CD82_HUMAN
- Recommended name:
- CD82 antigen
- Protein Accession:
- P27701
- D3DQN6
- E9PC70
- Q7Z2D4
- Q7Z5N2
Protein attributes for CD82 Gene
- Size:
- 267 amino acids
- Molecular mass:
- 29626 Da
- Quaternary structure:
-
- Interacts directly with IGSF8.
Protein Expression for CD82 Gene
Post-translational modifications for CD82 Gene
Other Protein References for CD82 Gene
Antibody Products
- LifeSpan BioSciences CD82 Antibody and CD82 Monoclonal Antibody
- G Biosciences Immunotag™ CD82 Antibody
- NSJ Bioreagents CD82 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD82
- Novus Biologicals Antibodies for CD82
-
Abcam antibodies for CD82
- Invitrogen Antibodies for CD82 (AFLGC-CD82)
- antibodies-online: Show 56 available CD82 Antibodies ranked by validation data
- Compare Top CD82 Antibodies
-
Recommended
- 39 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 100 WB Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CD82
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD82
- Sino Biological Antibodies for CD82
Protein Products
-
OriGene Purified Proteins for CD82
- Search Origene for MassSpec and Protein Over-expression Lysates for CD82
- Origene Custom Protein Services for CD82
- Sino Biological Cell Lysates for CD82
- Sino Biological Recombinant Proteins for CD82
-
Abcam proteins for CD82
Assay Products
- Novus Biologicals ELISA Kits for CD82
- antibodies-online: Show 5 available CD82 Elisa Kits ranked by validation data
- Compare Top CD82 Elisa Kits
-
Quality Products:
- Sino Biological Assays for CD82
No data available for DME Specific Peptides for CD82 Gene
Domains & Families for CD82 Gene
Gene Families for CD82 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD82 Gene
- InterPro:
- Blocks:
-
- Transmembrane four family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CD82 Gene
- GenScript: Design optimal peptide antigens:
-
- Tetraspanin-27 (CD82_HUMAN)
- KAI1 protein (Q6LET0_HUMAN)
- Kangai 1 (Q7Z5N2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P27701- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for CD82 Gene
Molecular function for CD82 Gene
- UniProtKB/Swiss-Prot Function:
- Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Phenotypes From GWAS Catalog for CD82 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15205336 |
Phenotypes for CD82 Gene
- MGI mutant phenotypes for CD82:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CD82:
Animal Models for CD82 Gene
- MGI Knock Outs for CD82:
-
- Cd82 Cd82<tm1.1Xaz>
Animal Model Products
-
Taconic Biosciences Mouse Models for CD82
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD82 - Select products 50% OFF >
- * CD82 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD82
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD82
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD82
miRNA for CD82 Gene
- miRTarBase miRNAs that target CD82
-
- hsa-miR-362-3p (MIRT054277)
- hsa-miR-197-3p (MIRT054634)
- hsa-miR-129-5p (MIRT650678)
- hsa-miR-8055 (MIRT650679)
- hsa-miR-4652-3p (MIRT650680)
- hsa-miR-4743-3p (MIRT650681)
- hsa-miR-6864-3p (MIRT650682)
- hsa-miR-3672 (MIRT650683)
- hsa-miR-6888-3p (MIRT650684)
- hsa-miR-4753-3p (MIRT650685)
- hsa-miR-4294 (MIRT650686)
- hsa-miR-130b-5p (MIRT650687)
- hsa-miR-1470 (MIRT783846)
- hsa-miR-4667-3p (MIRT786357)
- hsa-miR-6793-3p (MIRT788758)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD82
- Browse OriGene Inhibitory RNA Products For CD82
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD82
Clone Products
- Applied Biological Materials (abm): Clones for CD82 - Select products 50% OFF >
- * CD82 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG219757
- MG225036
- MR219757
- MR219757L3
- MR219757L4
- MR225036
- MR225036L3
- MR225036L4
- MR228894
- MR228895
- MR228896
- MR228897
- MR228898
- RC200457
- RC200457L1
- RC200457L2
- RC200457L3
- RC200457L4
- RC220072
- RC220072L1
- RC220072L2
- RC220072L3
- RC220072L4
- RG200457
- RG220072
- RR200770
- RR200770L3
- RR200770L4
- MR219757L3V
- MR219757L4V
- MR225036L3V
- MR225036L4V
- RC200457L1V
- RC200457L2V
- RC200457L3V
- RC200457L4V
- RC220072L1V
- RC220072L2V
- RC220072L3V
- RC220072L4V
- RR200770L3V
- RR200770L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD82
- Addgene plasmids for CD82
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD82
Cell Line Products
-
Horizon Cell Lines for CD82
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD82 Gene
Localization for CD82 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,IDA | 30463011 |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19199708 |
Pathways & Interactions for CD82 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-kappaB Signaling | ||
| 2 | DNA Damage Response | ||
| 3 | Direct p53 effectors | ||
Pathways by source for CD82 Gene
1 BioSystems pathway for CD82 Gene
1 KEGG pathway for CD82 Gene
1 Cell Signaling Technology pathway for CD82 Gene
Interacting Proteins for CD82 Gene
Selected Interacting proteins:
P27701-CD82_HUMAN
ENSP00000227155
for CD82 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD82
Transcripts for CD82 Gene
mRNA/cDNA for CD82 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000526958 538 nts (view in UCSC)
- ENST00000227155 2212 nts (view in UCSC)
- ENST00000342935 967 nts (view in UCSC)
- ENST00000532544 580 nts (view in UCSC)
- ENST00000529277 582 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD82 - Select products 50% OFF >
- * CD82 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD82
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD82
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD82
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD82
- Browse OriGene Inhibitory RNA Products For CD82
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD82
Clone Products
- Applied Biological Materials (abm): Clones for CD82 - Select products 50% OFF >
- * CD82 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG219757
- MG225036
- MR219757
- MR219757L3
- MR219757L4
- MR225036
- MR225036L3
- MR225036L4
- MR228894
- MR228895
- MR228896
- MR228897
- MR228898
- RC200457
- RC200457L1
- RC200457L2
- RC200457L3
- RC200457L4
- RC220072
- RC220072L1
- RC220072L2
- RC220072L3
- RC220072L4
- RG200457
- RG220072
- RR200770
- RR200770L3
- RR200770L4
- MR219757L3V
- MR219757L4V
- MR225036L3V
- MR225036L4V
- RC200457L1V
- RC200457L2V
- RC200457L3V
- RC200457L4V
- RC220072L1V
- RC220072L2V
- RC220072L3V
- RC220072L4V
- RR200770L3V
- RR200770L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD82
- Addgene plasmids for CD82
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD82
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for CD82 Gene
- GeneLoc Exon Structure for
- CD82
Expression for CD82 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Tonsil (Hematopoietic System)
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Cerebellum
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
- Thymus (Hematopoietic System)
- Epithelial Cells (Uncategorized)
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
- Neural Ectoderm (Nervous System)
- Neural Tube (Nervous System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CD82 Gene
This gene is overexpressed in Whole Blood (x7.2).
This gene is overexpressed in Nasal epithelium (54.6) and Amniocyte (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD82 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD82
SOURCE GeneReport for Unigene cluster for CD82 Gene:
Hs.527778mRNA Expression by UniProt/SwissProt for CD82 Gene:
P27701-CD82_HUMAN
Tissue specificity:
Lymphoid specific.
Evidence on tissue expression from TISSUES for CD82 Gene
- Intestine(4.7)
- Blood(4.5)
- Liver(4.5)
- Lymph node(3.3)
- Nervous system(3.2)
- Skin(3.1)
- Spleen(2.9)
- Lung(2.9)
- Bone marrow(2.9)
- Stomach(2.7)
- Kidney(2.7)
- Heart(2.6)
- Muscle(2.4)
- Pancreas(2.3)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD82
-
OriGene qPCR primer pairs and template standards for CD82
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD82 Gene
Orthologs for CD82 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD82 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD82 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LOC100335281 30 |
|
||
| CD82 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Cd82 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd82 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CD82 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CD82 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CD82 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cd82 30 |
|
||
| MGC76214 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24083 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cd82b 30 31 |
|
OneToMany | |
| cd82a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp66E 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004861 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | tsp-8 30 |
|
||
| tsp-11 31 |
|
ManyToMany | |||
| tsp-13 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CD82 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CD82 Gene
- ENSEMBL:
- Gene Tree for CD82 (if available)
- TreeFam:
- Gene Tree for CD82 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD82: view image
Paralogs for CD82 Gene
Paralogs for CD82 Gene
- CD37 5
- TSPAN9 5
- TSPAN4 5
- TSPAN8 5
- TSPAN3 5
- TSPAN5 5
- CD81 5
- CD53 5
- CD9 5
- TSPAN11 5
- TSPAN7 5
- TSPAN17 5
- TSPAN1 5
- CD151 5
- TSPAN33 5
- ENSG00000250349 5
- TSPAN2 5
- TSPAN19 5
- TSPAN10 5
- CD63 5
- TSPAN6 5
- TSPAN14 5
- TSPAN15 5
- TSPAN18 5
- TSPAN12 5
- TSPAN13 5
- TSPAN31 5
- UPK1B 5
- TSPAN16 5
- ROM1 5
- PRPH2 5
- TSPAN32 5
- UPK1A 5
(22) SIMAP similar genes for CD82 Gene using alignment to 10 proteins:
- CD82_HUMAN
- E9PJ45_HUMAN
- E9PJ59_HUMAN
- E9PJB7_HUMAN
- E9PJC7_HUMAN
- E9PJK9_HUMAN
- E9PM43_HUMAN
- E9PP61_HUMAN
- H0YD57_HUMAN
- Q6LET0_HUMAN
Variants for CD82 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD82 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711550 | Benign: not provided | 44,605,107(+) | G/A | SYNONYMOUS_VARIANT | |
| 786594 | Benign: not provided | 44,618,696(+) | C/T | SYNONYMOUS_VARIANT | |
| 789795 | Benign: not provided | 44,619,066(+) | G/C | SYNONYMOUS_VARIANT | |
| 806650 | Uncertain Significance: not provided | 44,605,159(+) | G/A | MISSENSE_VARIANT | |
| 806651 | Uncertain Significance: not provided | 44,618,302(+) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.50;
10.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD82 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD82
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene
Disorders for CD82 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| penile cancer |
|
|
| renal oncocytoma |
|
|
| chromophobe renal cell carcinoma |
|
|
| facial nerve disease |
|
|
| gallbladder adenocarcinoma |
|
|
Search CD82 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD82
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD82 Gene
Publications for CD82 Gene
- A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. (PMID: 30463011) Shah J … Citi S (Cell reports 2018) 3 4
- Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T … Morange PE (British journal of haematology 2012) 3 41
- Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PMID: 20144992) Danglot L … Galli T (Journal of cell science 2010) 3 23
- Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. (PMID: 19371633) Ruseva Z … Reuning U (Experimental cell research 2009) 3 23
- Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion. (PMID: 19656997) Malik FA … Jiang WG (Cancer genomics & proteomics 2009) 3 23
ExternalLinks
Products for CD82 Gene
- View all 11 R&D Systems CD82 (CD82/Kai-1) Products
- View all R&D Systems CD82 (CD82/Kai-1) Proteins and Enzymes
- View all 9 R&D Systems CD82 (CD82/Kai-1) Primary Antibodies
- View all R&D Systems CD82 (CD82/Kai-1) cDNA Clones
- Learn more about R&D Systems custom CD82 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CD82
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD82
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- OriGene qPCR primer pairs for CD82
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- OriGene CRISPR knockouts for CD82
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 56 available CD82 Antibodies ranked by validation data
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- antibodies-online: Show 5 available CD82 Elisa Kits ranked by validation data
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- antibodies-online: Show 7 available CD82 Proteins ranked by validation data
- Compare Top CD82 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CD82
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Sources for CD82 Gene
- (1) GeneCards
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