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Aliases for CD82 Gene

Aliases for CD82 Gene

  • CD82 Molecule 2 3 5
  • CD82 Antigen 2 3 4
  • Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
  • Metastasis Suppressor Kangai-1 3 4
  • Inducible Membrane Protein R2 3 4
  • Tetraspanin-27 3 4
  • C33 Antigen 3 4
  • Tspan-27 3 4
  • TSPAN27 3 4
  • KAI1 3 4
  • SAR2 3 4
  • ST6 3 4
  • IA4 3 4
  • Suppressor Of Tumorigenicity 6 Protein 4
  • Suppression Of Tumorigenicity 6 2
  • R2 Leukocyte Antigen 2
  • GR15 3
  • 4F9 3
  • C33 3
  • R2 3

External Ids for CD82 Gene

Previous HGNC Symbols for CD82 Gene

  • ST6
  • KAI1

Previous GeneCards Identifiers for CD82 Gene

  • GC11P044544
  • GC11P044296

Summaries for CD82 Gene

Entrez Gene Summary for CD82 Gene

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD82 Gene

CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include Prostate Cancer and Bladder Cancer. Among its related pathways are Direct p53 effectors and NF-kappaB Signaling. An important paralog of this gene is CD37.

UniProtKB/Swiss-Prot for CD82 Gene

  • Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Gene Wiki entry for CD82 Gene

Additional gene information for CD82 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD82 Gene

Genomics for CD82 Gene

GeneHancer (GH) Regulatory Elements for CD82 Gene

Promoters and enhancers for CD82 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J044560 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.3 +1.7 1699 10.5 HDGF PKNOX1 SIN3A IRF4 YY1 ZNF143 FOS KLF13 SP3 NFYC CD82 ALKBH3 SEC14L1P1 ENSG00000254693 ENSG00000255092 EXT2
GH11J044590 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +30.1 30103 7.5 HDGF PKNOX1 KLF5 IRF4 YY1 EGR1 IKZF2 RUNX3 CREM SMARCA5 CD82 RPL34P22 ENSG00000254693 GC11M044589
GH11J044572 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +11.9 11876 7.9 HDGF PKNOX1 BATF IRF4 EGR1 ZFP91 FOS ETV6 IKZF2 RUNX3 CD82 ENSG00000254693 ENSG00000255092 SEC14L1P1
GH11J044606 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +46.8 46831 8.9 HDGF PKNOX1 SMAD1 YBX1 ZNF207 ZNF143 ATF7 FOS RUNX3 ZNF623 CD82 TSPAN18 PRDM11 ENSG00000255092 RPL34P22 GC11M044589
GH11J044559 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13 -4.5 -4509 1.5 HDGF SIN3A STAT5A BMI1 BATF IRF4 ETS1 ZNF143 ATF7 ETV6 EXT2 SEC14L1P1 ALKBH3 CD82 ENSG00000255092 ENSG00000254693 GC11M044543
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD82 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD82 gene promoter:
  • AP-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for CD82 Gene

Genomic Locations for CD82 Gene
55,937 bases
Plus strand
55,937 bases
Plus strand

Genomic View for CD82 Gene

Genes around CD82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD82 Gene

Proteins for CD82 Gene

  • Protein details for CD82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD82 antigen
    Protein Accession:
    Secondary Accessions:
    • D3DQN6
    • E9PC70
    • Q7Z2D4
    • Q7Z5N2

    Protein attributes for CD82 Gene

    267 amino acids
    Molecular mass:
    29626 Da
    Quaternary structure:
    • Interacts directly with IGSF8.

    Alternative splice isoforms for CD82 Gene


neXtProt entry for CD82 Gene

Post-translational modifications for CD82 Gene

  • Glycosylation at Asn198, posLast=157157, and Asn129
  • Ubiquitination at posLast=190190
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD82 Gene

Domains & Families for CD82 Gene

Gene Families for CD82 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CD82 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD82: view

Function for CD82 Gene

Molecular function for CD82 Gene

UniProtKB/Swiss-Prot Function:
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Phenotypes From GWAS Catalog for CD82 Gene

Gene Ontology (GO) - Molecular Function for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15205336
genes like me logo Genes that share ontologies with CD82: view
genes like me logo Genes that share phenotypes with CD82: view

Animal Models for CD82 Gene

MGI Knock Outs for CD82:
  • Cd82 Cd82<tm1.1Xaz>

Animal Model Products

  • Taconic Biosciences Mouse Models for CD82

Clone Products

  • Addgene plasmids for CD82

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD82 Gene

Localization for CD82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD82 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
nucleus 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7754374
GO:0005887 integral component of plasma membrane TAS 1842498
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with CD82: view

Pathways & Interactions for CD82 Gene

genes like me logo Genes that share pathways with CD82: view

Pathways by source for CD82 Gene

1 BioSystems pathway for CD82 Gene
1 KEGG pathway for CD82 Gene
1 Cell Signaling Technology pathway for CD82 Gene

Gene Ontology (GO) - Biological Process for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CD82: view

No data available for SIGNOR curated interactions for CD82 Gene

Drugs & Compounds for CD82 Gene

(2) Drugs for CD82 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CD82 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD82: view

Transcripts for CD82 Gene

Unigene Clusters for CD82 Gene

CD82 molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for CD82

Alternative Splicing Database (ASD) splice patterns (SP) for CD82 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP7: - -

Relevant External Links for CD82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD82 Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for CD82 Gene

This gene is overexpressed in Nasal epithelium (54.6) and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD82 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD82 Gene:


SOURCE GeneReport for Unigene cluster for CD82 Gene:


mRNA Expression by UniProt/SwissProt for CD82 Gene:

Tissue specificity: Lymphoid specific.

Evidence on tissue expression from TISSUES for CD82 Gene

  • Intestine(4.6)
  • Blood(4.4)
  • Liver(4.4)
  • Lymph node(3.1)
  • Lung(2.8)
  • Nervous system(2.6)
  • Bone marrow(2.3)
  • Skin(2.2)
  • Spleen(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with CD82: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD82 Gene

Orthologs for CD82 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD82 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD82 34 33
  • 99.5 (n)
(Canis familiaris)
Mammalia CD82 34 33
  • 86.64 (n)
(Bos Taurus)
Mammalia LOC100335281 33
  • 84.77 (n)
CD82 34
  • 77 (a)
(Mus musculus)
Mammalia Cd82 16 34 33
  • 79.45 (n)
(Rattus norvegicus)
Mammalia Cd82 33
  • 78.57 (n)
(Monodelphis domestica)
Mammalia CD82 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CD82 34
  • 61 (a)
(Gallus gallus)
Aves CD82 34 33
  • 64.36 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
-- 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd82 33
  • 65.6 (n)
MGC76214 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24083 33
(Danio rerio)
Actinopterygii cd82b 34 33
  • 63.24 (n)
cd82a 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 34 33
  • 49.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004861 33
  • 44.54 (n)
(Caenorhabditis elegans)
Secernentea tsp-8 33
  • 44.54 (n)
tsp-11 34
  • 23 (a)
tsp-13 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
-- 34
  • 16 (a)
Species where no ortholog for CD82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD82 Gene

Gene Tree for CD82 (if available)
Gene Tree for CD82 (if available)
Evolutionary constrained regions (ECRs) for CD82: view image

Paralogs for CD82 Gene

(22) SIMAP similar genes for CD82 Gene using alignment to 10 proteins:

  • CD82_HUMAN
  • E9PJ45_HUMAN
  • E9PJ59_HUMAN
  • E9PM43_HUMAN
  • E9PP61_HUMAN
  • H0YD57_HUMAN
genes like me logo Genes that share paralogs with CD82: view

Variants for CD82 Gene

Sequence variations from dbSNP and Humsavar for CD82 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000000095 -- 44,565,674(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000024424 -- 44,602,264(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000091277 -- 44,579,669(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000106516 -- 44,609,252(+) T/G intron_variant
rs1000140828 -- 44,586,406(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD82 Gene

Variant ID Type Subtype PubMed ID
esv3626163 CNV loss 21293372
nsv522766 CNV loss 19592680
nsv525321 CNV gain 19592680

Variation tolerance for CD82 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene

Disorders for CD82 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD82 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CD82 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD82

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD82: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD82 Gene

Publications for CD82 Gene

  1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T … Morange PE (British journal of haematology 2012) 3 44 58
  2. Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PMID: 20144992) Danglot L … Galli T (Journal of cell science 2010) 3 22 58
  3. Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance. (PMID: 19148553) Malik FA … Jiang WG (International journal of molecular medicine 2009) 3 22 58
  4. Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. (PMID: 19371633) Ruseva Z … Reuning U (Experimental cell research 2009) 3 22 58
  5. [Role of KAI1 gene expression and loss of heterozygosity of KAI1 in metastatic potential and prognosis of pancreatic cancer]. (PMID: 19489224) Fan LX … Zhang Y (Zhonghua bing li xue za zhi = Chinese journal of pathology 2009) 3 22 58

Products for CD82 Gene

Sources for CD82 Gene

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