This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expressio... See more...

Aliases for CD82 Gene

Aliases for CD82 Gene

  • CD82 Molecule 2 3 5
  • CD82 Antigen 2 3 4
  • TSPAN27 2 3 4
  • IA4 2 3 4
  • Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
  • Metastasis Suppressor Kangai-1 3 4
  • Inducible Membrane Protein R2 3 4
  • Tetraspanin-27 3 4
  • C33 Antigen 3 4
  • Tspan-27 3 4
  • KAI1 3 4
  • SAR2 3 4
  • ST6 3 4
  • R2 2 3
  • Suppressor Of Tumorigenicity 6 Protein 4
  • Suppression Of Tumorigenicity 6 2
  • R2 Leukocyte Antigen 2
  • GR15 3
  • CD82 5
  • 4F9 3
  • C33 3

External Ids for CD82 Gene

Previous HGNC Symbols for CD82 Gene

  • ST6
  • KAI1

Previous GeneCards Identifiers for CD82 Gene

  • GC11P044544
  • GC11P044296

Summaries for CD82 Gene

Entrez Gene Summary for CD82 Gene

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD82 Gene

CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include Penile Cancer and Renal Oncocytoma. Among its related pathways are Direct p53 effectors and NF-kappaB Signaling. An important paralog of this gene is CD37.

UniProtKB/Swiss-Prot Summary for CD82 Gene

  • Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Gene Wiki entry for CD82 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD82 Gene

Genomics for CD82 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD82 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J044560 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 625.2 +1.7 1699 10.5 SP1 TEAD4 PRDM10 REST IKZF1 ZNF692 POLR2A JUND LARP7 PRDM1 CD82 ALKBH3 SEC14L1P1 ENSG00000254693 ENSG00000255092 EXT2 TSPAN18
GH11J044588 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.4 +32.1 32093 16.2 KDM1A FOXA1 ZNF143 RELA SMAD5 TCF12 IKZF2 SP1 BRD9 POLR2A CD82 RPL34P22 ENSG00000254693 TSPAN18
GH11J044572 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.2 +11.9 11876 7.9 KDM1A RELA ZIC2 IKZF2 PKNOX1 EED DPF2 HMBOX1 RELB EGR1 CD82 ENSG00000254693 ENSG00000255092 SEC14L1P1 TSPAN18
GH11J044606 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +46.9 46872 9 RFX1 KDM1A BACH1 LARP7 STAT3 ZNF143 RELA ZIC2 TCF12 IKZF2 CD82 TSPAN18 PRDM11 ENSG00000255092 MN309347
GH11J044559 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -4.5 -4509 1.5 TEAD4 RFX1 ZNF143 RELA IKZF2 POLR2A EED DPF2 RELB RUNX3 CD82 ENSG00000254693 ENSG00000255092 piR-50356-001 ALX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD82 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD82

Top Transcription factor binding sites by QIAGEN in the CD82 gene promoter:
  • AP-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for CD82 Gene

Genomic Locations for CD82 Gene
chr11:44,564,427-44,620,363
(GRCh38/hg38)
Size:
55,937 bases
Orientation:
Plus strand
chr11:44,585,977-44,641,913
(GRCh37/hg19)
Size:
55,937 bases
Orientation:
Plus strand

Genomic View for CD82 Gene

Genes around CD82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD82 Gene

Proteins for CD82 Gene

  • Protein details for CD82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27701-CD82_HUMAN
    Recommended name:
    CD82 antigen
    Protein Accession:
    P27701
    Secondary Accessions:
    • D3DQN6
    • E9PC70
    • Q7Z2D4
    • Q7Z5N2

    Protein attributes for CD82 Gene

    Size:
    267 amino acids
    Molecular mass:
    29626 Da
    Quaternary structure:
    • Interacts directly with IGSF8.

    Alternative splice isoforms for CD82 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD82 Gene

Post-translational modifications for CD82 Gene

  • Glycosylation at Asn129, Asn157, and Asn198
  • Ubiquitination at Lys190
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

  • Abcam antibodies for CD82

No data available for DME Specific Peptides for CD82 Gene

Domains & Families for CD82 Gene

Gene Families for CD82 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD82 Gene

InterPro:
Blocks:
  • Transmembrane four family signature
ProtoNet:

Suggested Antigen Peptide Sequences for CD82 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin-27 (CD82_HUMAN)
  • KAI1 protein (Q6LET0_HUMAN)
  • Kangai 1 (Q7Z5N2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27701

UniProtKB/Swiss-Prot:

CD82_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD82: view

Function for CD82 Gene

Molecular function for CD82 Gene

UniProtKB/Swiss-Prot Function:
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Phenotypes From GWAS Catalog for CD82 Gene

Gene Ontology (GO) - Molecular Function for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15205336
genes like me logo Genes that share ontologies with CD82: view
genes like me logo Genes that share phenotypes with CD82: view

Animal Models for CD82 Gene

MGI Knock Outs for CD82:
  • Cd82 Cd82<tm1.1Xaz>

Animal Model Products

  • Taconic Biosciences Mouse Models for CD82

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD82

Clone Products

  • Addgene plasmids for CD82

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD82 Gene

Localization for CD82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD82 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IDA 30463011
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with CD82: view

Pathways & Interactions for CD82 Gene

PathCards logo

SuperPathways for CD82 Gene

genes like me logo Genes that share pathways with CD82: view

Pathways by source for CD82 Gene

1 BioSystems pathway for CD82 Gene
1 KEGG pathway for CD82 Gene
1 Cell Signaling Technology pathway for CD82 Gene

SIGNOR curated interactions for CD82 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD82 Gene

None

Drugs & Compounds for CD82 Gene

(2) Drugs for CD82 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CD82 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD82: view

Transcripts for CD82 Gene

mRNA/cDNA for CD82 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD82

Clone Products

  • Addgene plasmids for CD82

Alternative Splicing Database (ASD) splice patterns (SP) for CD82 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -

Relevant External Links for CD82 Gene

GeneLoc Exon Structure for
CD82

Expression for CD82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD82 Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for CD82 Gene

This gene is overexpressed in Nasal epithelium (54.6) and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD82 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD82

SOURCE GeneReport for Unigene cluster for CD82 Gene:

Hs.527778

mRNA Expression by UniProt/SwissProt for CD82 Gene:

P27701-CD82_HUMAN
Tissue specificity: Lymphoid specific.

Evidence on tissue expression from TISSUES for CD82 Gene

  • Intestine(4.7)
  • Blood(4.5)
  • Liver(4.5)
  • Lymph node(3.3)
  • Nervous system(3.2)
  • Skin(3.1)
  • Spleen(2.9)
  • Lung(2.9)
  • Bone marrow(2.9)
  • Stomach(2.7)
  • Kidney(2.7)
  • Heart(2.6)
  • Muscle(2.4)
  • Pancreas(2.3)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with CD82: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD82 Gene

Orthologs for CD82 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD82 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD82 30 31
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD82 30 31
  • 86.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100335281 30
  • 84.77 (n)
CD82 31
  • 77 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd82 30 17 31
  • 79.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd82 30
  • 78.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia CD82 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CD82 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD82 30 31
  • 64.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 65 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cd82 30
  • 65.6 (n)
MGC76214 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24083 30
Zebrafish
(Danio rerio)
Actinopterygii cd82b 30 31
  • 63.24 (n)
OneToMany
cd82a 31
  • 53 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Tsp66E 30 31
  • 49.17 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004861 30
  • 44.54 (n)
Worm
(Caenorhabditis elegans)
Secernentea tsp-8 30
  • 44.54 (n)
tsp-11 31
  • 23 (a)
ManyToMany
tsp-13 31
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
ManyToMany
-- 31
  • 16 (a)
ManyToMany
Species where no ortholog for CD82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CD82 Gene

ENSEMBL:
Gene Tree for CD82 (if available)
TreeFam:
Gene Tree for CD82 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD82: view image

Paralogs for CD82 Gene

(22) SIMAP similar genes for CD82 Gene using alignment to 10 proteins:

  • CD82_HUMAN
  • E9PJ45_HUMAN
  • E9PJ59_HUMAN
  • E9PJB7_HUMAN
  • E9PJC7_HUMAN
  • E9PJK9_HUMAN
  • E9PM43_HUMAN
  • E9PP61_HUMAN
  • H0YD57_HUMAN
  • Q6LET0_HUMAN
genes like me logo Genes that share paralogs with CD82: view

Variants for CD82 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD82 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
711550 Benign: not provided 44,605,107(+) G/A SYNONYMOUS_VARIANT
786594 Benign: not provided 44,618,696(+) C/T SYNONYMOUS_VARIANT
789795 Benign: not provided 44,619,066(+) G/C SYNONYMOUS_VARIANT
806650 Uncertain Significance: not provided 44,605,159(+) G/A MISSENSE_VARIANT
806651 Uncertain Significance: not provided 44,618,302(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CD82 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD82 Gene

Variant ID Type Subtype PubMed ID
esv3626163 CNV loss 21293372
nsv522766 CNV loss 19592680
nsv525321 CNV gain 19592680

Variation tolerance for CD82 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD82

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene

Disorders for CD82 Gene

MalaCards: The human disease database

(15) MalaCards diseases for CD82 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
penile cancer
  • ca penis
renal oncocytoma
  • oncocytoma of kidney
chromophobe renal cell carcinoma
  • chromophobe adenocarcinoma
facial nerve disease
  • facial nerve diseases
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
- elite association - COSMIC cancer census association via MalaCards
Search CD82 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD82

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD82: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD82 Gene

Publications for CD82 Gene

  1. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. (PMID: 30463011) Shah J … Citi S (Cell reports 2018) 3 4
  2. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T … Morange PE (British journal of haematology 2012) 3 41
  3. Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PMID: 20144992) Danglot L … Galli T (Journal of cell science 2010) 3 23
  4. Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. (PMID: 19371633) Ruseva Z … Reuning U (Experimental cell research 2009) 3 23
  5. Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion. (PMID: 19656997) Malik FA … Jiang WG (Cancer genomics & proteomics 2009) 3 23

Products for CD82 Gene

Sources for CD82 Gene