The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This enc... See more...

Aliases for CD81 Gene

Aliases for CD81 Gene

  • CD81 Molecule 2 3 5
  • CD81 Antigen (Target Of Antiproliferative Antibody 1) 2 3
  • 26 KDa Cell Surface Protein TAPA-1 3 4
  • Tetraspanin-28 3 4
  • CD81 Antigen 3 4
  • Tspan-28 3 4
  • TSPAN28 3 4
  • TAPA1 3 4
  • Target Of The Antiproliferative Antibody 1 4
  • CVID6 3
  • S5.7 3

External Ids for CD81 Gene

Previous HGNC Symbols for CD81 Gene

  • TAPA1

Previous GeneCards Identifiers for CD81 Gene

  • GC11P002460
  • GC11P002599
  • GC11P002356
  • GC11P002363
  • GC11P002355
  • GC11P002397
  • GC11P002188

Summaries for CD81 Gene

Entrez Gene Summary for CD81 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD81 Gene

CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is CD9.

UniProtKB/Swiss-Prot Summary for CD81 Gene

  • Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
  • (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
  • (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1.
  • (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.

Gene Wiki entry for CD81 Gene

Additional gene information for CD81 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD81 Gene

Genomics for CD81 Gene

GeneHancer (GH) Regulatory Elements for CD81 Gene

Promoters and enhancers for CD81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002376 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 508.7 +8.5 8469 16.2 HNRNPK CTCF PHF8 ZFX ZIC2 ZBTB10 POLR2A ZNF423 ZBTB26 RFX1 CD81 ENSG00000199550 KCNQ1 CD81-AS1 lnc-TSSC4-2 NONHSAG007426.2
GH11J002374 Enhancer 0.8 VISTA ENCODE dbSUPER 508.6 -1.3 -1293 1.4 CTCF JUND RAD21 KLF1 MAX RXRA YY1 GABPA CD81 LOC105376520 lnc-TSSC4-2 ENSG00000199550 CD81-AS1
GH11J002375 Enhancer 0.7 ENCODE dbSUPER 500.7 -0.1 -111 0.2 CTCF FOXA2 JUND RXRA REST MAX SP1 YY1 GABPA CD81 CD81-AS1 LOC105376520 lnc-TSSC4-2
GH11J002131 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -234.1 -234071 21.1 CTCF NRF1 POLR2G USF1 NCOR1 FOS ZIC2 ZBTB10 FOXA1 ZBTB26 IGF2 IGF2-AS RF00483 INS-IGF2 CD81 ENSG00000199550 LSP1 FAM99B LINC02708 KRTAP5-6
GH11J002398 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 +24.3 24267 4.5 RXRA FOXK2 ZBTB40 ZNF217 EP300 CTCF TCF12 SIN3A NRF1 POLR2G TSSC4 lnc-TRPM5-1 OSBPL5 CD81 piR-57818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD81 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD81

Top Transcription factor binding sites by QIAGEN in the CD81 gene promoter:
  • Brachyury
  • Gfi-1
  • Lmo2
  • MAZR
  • Pax-4a
  • Pax-5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZIC2

Genomic Locations for CD81 Gene

Genomic Locations for CD81 Gene
chr11:2,376,177-2,397,419
(GRCh38/hg38)
Size:
21,243 bases
Orientation:
Plus strand
chr11:2,397,407-2,418,649
(GRCh37/hg19)
Size:
21,243 bases
Orientation:
Plus strand

Genomic View for CD81 Gene

Genes around CD81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD81 Gene

Proteins for CD81 Gene

  • Protein details for CD81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60033-CD81_HUMAN
    Recommended name:
    CD81 antigen
    Protein Accession:
    P60033
    Secondary Accessions:
    • P18582
    • Q5U0J6

    Protein attributes for CD81 Gene

    Size:
    236 amino acids
    Molecular mass:
    25809 Da
    Quaternary structure:
    • Homodimer (PubMed:20375010). Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B cells. Interacts (via the second extracellular domain) with CD19; this interaction is initiated early during biosynthesis in the ER and enables trafficking of only properly folded CD19 (PubMed:16449649, PubMed:1383329). Part of a complex that includes MHC class II/HLA-DR molecules and IFITM1 (PubMed:8409388). Interacts with IFITM1 (PubMed:2398277). Interacts with IFITM2 and IFITM3 (By similarity). Part of integrin-tetraspanin complex composed of CD9, CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (PubMed:12796480). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:27993971). Interacts with CD247/CD3 zeta, ICAM1 and CD9 at the immune synapse on T cell membrane (PubMed:23858057). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, possibly CD9, and GNA11 in which CD81 enhances the association of ADGRG1 with GNA11 (PubMed:15004227). Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8 (PubMed:11504738). Interacts with CD53 and SCIMP (PubMed:21930792). Interacts with SAMHD1 (via its C-terminus) (PubMed:28871089). Interacts with glypican GPC3 and with the transcriptional repressor HHEX; binding to GPC3 decreases the availability of free CD81 for binding to HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Interacts with CLDN1 (PubMed:20375010, PubMed:21516087). Interacts with CLDN6 and CLDN9 (PubMed:20375010).
    • (Microbial infection) Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.

    Three dimensional structures from OCA and Proteopedia for CD81 Gene

neXtProt entry for CD81 Gene

Post-translational modifications for CD81 Gene

  • Not glycosylated.
  • Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts.
  • Ubiquitination at Lys124, Lys144, and Lys148
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD81 Gene

Domains & Families for CD81 Gene

Gene Families for CD81 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for CD81 Gene

Suggested Antigen Peptide Sequences for CD81 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin-28 (CD81_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60033

UniProtKB/Swiss-Prot:

CD81_HUMAN :
  • Binds cholesterol in a cavity lined by the transmembrane spans.
  • Belongs to the tetraspanin (TM4SF) family.
Domain:
  • Binds cholesterol in a cavity lined by the transmembrane spans.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD81: view

Function for CD81 Gene

Molecular function for CD81 Gene

UniProtKB/Swiss-Prot Function:
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.
GENATLAS Biochemistry:
integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of an antiproliferative antibody

Phenotypes From GWAS Catalog for CD81 Gene

Gene Ontology (GO) - Molecular Function for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IMP 20375010
GO:0005178 integrin binding IDA 12796480
GO:0005515 protein binding IPI 2398277
GO:0008289 lipid binding IEA --
GO:0015485 cholesterol binding IDA 27881302
genes like me logo Genes that share ontologies with CD81: view
genes like me logo Genes that share phenotypes with CD81: view

Human Phenotype Ontology for CD81 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD81 Gene

MGI Knock Outs for CD81:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD81

CRISPR Products

Clone Products

  • Addgene plasmids for CD81

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD81 Gene

Localization for CD81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD81 Gene

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269 PubMed:20375010}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD81 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 3
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA,IBA 14676841
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with CD81: view

Pathways & Interactions for CD81 Gene

genes like me logo Genes that share pathways with CD81: view

Pathways by source for CD81 Gene

1 GeneGo (Thomson Reuters) pathway for CD81 Gene
  • Immune response BCR pathway
1 Qiagen pathway for CD81 Gene
  • PI3K Signaling in B-Lymphocyte

Gene Ontology (GO) - Biological Process for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 14676841
GO:0001771 immunological synapse formation IMP 23858057
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002455 humoral immune response mediated by circulating immunoglobulin IMP 20237408
genes like me logo Genes that share ontologies with CD81: view

No data available for SIGNOR curated interactions for CD81 Gene

Drugs & Compounds for CD81 Gene

(5) Drugs for CD81 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CD81 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD81: view

Transcripts for CD81 Gene

mRNA/cDNA for CD81 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CD81

Alternative Splicing Database (ASD) splice patterns (SP) for CD81 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - - - -
SP12: -

Relevant External Links for CD81 Gene

GeneLoc Exon Structure for
CD81

Expression for CD81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD81 Gene

This gene is overexpressed in Frontal cortex (7.5) and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD81 Gene



Protein tissue co-expression partners for CD81 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD81

SOURCE GeneReport for Unigene cluster for CD81 Gene:

Hs.54457

mRNA Expression by UniProt/SwissProt for CD81 Gene:

P60033-CD81_HUMAN
Tissue specificity: Expressed on B cells (at protein level) (PubMed:20237408). Expressed in hepatocytes (at protein level) (PubMed:12483205). Expressed in monocytes/macrophages (at protein level) (PubMed:12796480). Expressed on both naive and memory CD4-positive T cells (at protein level) (PubMed:22307619).

Evidence on tissue expression from TISSUES for CD81 Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Skin(3.7)
  • Liver(3.6)
  • Lymph node(3.3)
  • Pancreas(3.3)
  • Spleen(3.2)
  • Heart(3)
  • Muscle(2.9)
  • Blood(2.8)
  • Intestine(2.8)
  • Kidney(2.7)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Eye(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD81 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • meninges
  • middle ear
  • neck
  • pituitary gland
  • sinus
  • skull
  • thyroid
Thorax:
  • bronchus
  • heart
  • lung
Abdomen:
  • adrenal gland
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with CD81: view

No data available for mRNA differential expression in normal tissues for CD81 Gene

Orthologs for CD81 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD81 31 30
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD81 31 30
  • 90.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611606 30
  • 90.67 (n)
CD81 31
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd81 30
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Cd81 17 31 30
  • 86.72 (n)
chicken
(Gallus gallus)
Aves TAPA1 31
  • 83 (a)
OneToOne
CD81 30
  • 78.32 (n)
lizard
(Anolis carolinensis)
Reptilia CD81 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd81 30
  • 70.5 (n)
MGC75667 30
African clawed frog
(Xenopus laevis)
Amphibia cd81-prov 30
zebrafish
(Danio rerio)
Actinopterygii cd81 31 30 30
  • 67.53 (n)
OneToMany
CD81 (1 of 2) 31
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000823 30
  • 52.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 31 30
  • 47.58 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 31
  • 26 (a)
OneToMany
Species where no ortholog for CD81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD81 Gene

ENSEMBL:
Gene Tree for CD81 (if available)
TreeFam:
Gene Tree for CD81 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD81: view image

Paralogs for CD81 Gene

(10) SIMAP similar genes for CD81 Gene using alignment to 11 proteins:

  • CD81_HUMAN
  • A6NMH8_HUMAN
  • E9PIF1_HUMAN
  • E9PJK1_HUMAN
  • E9PM31_HUMAN
  • E9PPF5_HUMAN
  • E9PQV4_HUMAN
  • E9PRJ8_HUMAN
  • H0YDJ9_HUMAN
  • H0YDL9_HUMAN
  • H0YEE2_HUMAN
genes like me logo Genes that share paralogs with CD81: view

Variants for CD81 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD81 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
636761 Uncertain Significance: not provided 2,390,464(+) A/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
636762 Uncertain Significance: not provided 2,395,419(+) G/A MISSENSE_VARIANT
rs143644902 Likely Benign: not specified 2,395,475(+) T/C SYNONYMOUS_VARIANT
rs376883566 Uncertain Significance: not provided 2,377,547(+) G/A FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs562261414 Uncertain Significance: Common variable immunodeficiency 6 2,394,090(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CD81 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD81 Gene

Variant ID Type Subtype PubMed ID
dgv1568n54 CNV loss 21841781
dgv1569n54 CNV loss 21841781
esv1007864 CNV deletion 20482838
esv1285833 CNV deletion 17803354
esv2744006 CNV deletion 23290073
nsv1070001 CNV deletion 25765185
nsv1115318 CNV deletion 24896259
nsv1151445 CNV deletion 26484159
nsv467645 CNV gain 19166990
nsv469928 CNV loss 18288195
nsv509382 CNV insertion 20534489
nsv553047 CNV gain 21841781
nsv553089 CNV gain 21841781
nsv951286 CNV deletion 24416366
nsv951287 CNV deletion 24416366

Variation tolerance for CD81 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD81 Gene

Human Gene Mutation Database (HGMD)
CD81
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD81

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD81 Gene

Disorders for CD81 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CD81 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 6
  • cvid6
common variable immunodeficiency
  • acquired agammaglobulinemia
hepatitis c
  • chronic hepatitis c
hepatitis
  • hepatitis a
cryoglobulinemia
  • cryoimmunoglobulinaemia
- elite association - COSMIC cancer census association via MalaCards
Search CD81 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD81_HUMAN
  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CD81

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD81: view

No data available for Genatlas for CD81 Gene

Publications for CD81 Gene

  1. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PMID: 12437138) Kitadokoro K … Bolognesi M (Biological chemistry 2002) 3 4 23 54
  2. Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells. (PMID: 8766544) Secrist H … Umetsu DT (European journal of immunology 1996) 3 4 23 54
  3. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PMID: 1695320) Oren R … Levy S (Molecular and cellular biology 1990) 3 4 23 54
  4. The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. (PMID: 27993971) Yu J … Takada Y (The Biochemical journal 2017) 3 4 54
  5. Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop. (PMID: 27916518) Cunha ES … Abrescia NGA (Structure (London, England : 1993) 2017) 3 4 54

Products for CD81 Gene

  • Addgene plasmids for CD81

Sources for CD81 Gene