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The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Focal Segmental Glomerulosclerosis. Among its related pathways are Nur77 Signaling in T-Cell and RET signaling. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 9915850 |
GO:0015026 | coreceptor activity | NAS | 9915850 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | NAS,TAS | -- |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | RET signaling |
.92
|
|
3 | GAB1 signalosome |
.89
|
|
4 | Allograft rejection | ||
5 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006955 | immune response | IBA | 21873635 |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007166 | cell surface receptor signaling pathway | IBA | 21873635 |
GO:0009967 | positive regulation of signal transduction | NAS | 9915850 |
GO:0016032 | viral process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Abatacept | Approved | Pharma | Target, antagonist, binder | 251 | ||
Belatacept | Approved, Investigational | Pharma | Target, antagonist, inhibitor | 0 | ||
Galiximab | Investigational | Pharma | Target, antibody | 7 | ||
Pharmaceutical Solutions | Pharma | 11855 | ||||
Vaccines | Pharma | 8100 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD80 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD80 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD80 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd80 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd80 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD80 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD80 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD80 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3353419 | CNV | insertion | 20981092 |
nsv829695 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
vaccinia |
|
|
focal segmental glomerulosclerosis |
|
|
cowpox |
|
|
urinary schistosomiasis |
|
|
lymphocytic choriomeningitis |
|
|