CD80 Gene (Protein Coding)

CD80 Molecule

GC03M119524
GIFtS:
43
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] See more...

Aliases for CD80 Gene

Aliases for CD80 Gene

  • CD80 Molecule 2 3 5
  • CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) 2 3
  • T-Lymphocyte Activation Antigen CD80 3 4
  • B-Lymphocyte Activation Antigen B7 2 3
  • CTLA-4 Counter-Receptor B7.1 3 4
  • Activation B7-1 Antigen 3 4
  • CD28LG1 3 4
  • CD28LG 3 4
  • LAB7 3 4
  • BB1 3 4
  • B7 3 4
  • Costimulatory Molecule Variant IgV-CD80 3
  • Costimulatory Factor CD80 3
  • CD80 Molecule 2
  • CD80 Antigen 4
  • B7-1 3
  • B7.1 3

External Ids for CD80 Gene

Previous HGNC Symbols for CD80 Gene

  • CD28LG
  • CD28LG1

Previous GeneCards Identifiers for CD80 Gene

  • GC03M115885
  • GC03M118875
  • GC03M120524
  • GC03M120564
  • GC03M120725
  • GC03M119243
  • GC03M116618

Summaries for CD80 Gene

Entrez Gene Summary for CD80 Gene

  • The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD80 Gene

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PI3K/AKT activation and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot Summary for CD80 Gene

  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD80 Gene

Additional gene information for CD80 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD80 Gene

Genomics for CD80 Gene

GeneHancer (GH) Regulatory Elements for CD80 Gene

Promoters and enhancers for CD80 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03J119557 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 775.8 -0.9 -899 5.8 ZNF24 SP1 CTCF HCFC1 RELA CEBPB RAD21 NKRF POLR2A MLLT1 CD80 lnc-ADPRH-1 ADPRH ARHGAP31 TMEM39A
GH03J119578 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 -20.2 -20212 2.4 ETV6 RELA L3MBTL2 POLR2A ZNF148 ZBTB33 NKRF ZFX MLLT1 MYC ADPRH ENSG00000272967 CD80 MAATS1 lnc-CD80-5
GH03J119595 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 15.4 -37.2 -37196 3 RELA RAD21 SP1 MLLT1 ZNF687 ZNF639 ZBED1 POLR2A IKZF1 RXRA PLA1A CD80 ADPRH COX17 ARHGAP31 TMEM39A POGLUT1 lnc-PLA1A-1
GH03J119675 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -117.4 -117364 2.8 PPP1R10 FOXK2 E2F8 SIN3A SP1 ZBTB40 LCORL FOXA1 RBPJ POLR2A COX17 POPDC2 lnc-POPDC2-4 MAATS1 CD80
GH03J119497 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 +60.4 60433 4 SP1 ZBTB40 SIX5 ZBTB6 RBPJ POLR2A NR2F1 NR2F6 ATF1 CREB1 TIMMDC1 ENSG00000272662 piR-40514 POGLUT1 TMEM39A MAATS1 CD80 ADPRH POPDC2 RPS26P21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD80 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • ISGF-3
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • STAT1

Genomic Locations for CD80 Gene

Genomic Locations for CD80 Gene
chr3:119,523,948-119,559,634
(GRCh38/hg38)
Size:
35,687 bases
Orientation:
Minus strand
chr3:119,243,140-119,278,481
(GRCh37/hg19)
Size:
35,342 bases
Orientation:
Minus strand

Genomic View for CD80 Gene

Genes around CD80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD80 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD80 Gene

Proteins for CD80 Gene

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  1. Antibody
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  • Protein details for CD80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33681-CD80_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD80
    Protein Accession:
    P33681
    Secondary Accessions:
    • Q5DTA9
    • Q5DTB0

    Protein attributes for CD80 Gene

    Size:
    288 amino acids
    Molecular mass:
    33048 Da
    Quaternary structure:
    • Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
    • (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.

    Three dimensional structures from OCA and Proteopedia for CD80 Gene

    Alternative splice isoforms for CD80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD80 Gene

Post-translational modifications for CD80 Gene

  • Glycosylation at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, and Asn232
  • Modification sites at PhosphoSitePlus

Other Protein References for CD80 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CD80
  • Santa Cruz Biotechnology (SCBT) Antibodies for CD80

Protein Products

  • Abcam proteins for CD80

No data available for DME Specific Peptides for CD80 Gene

Domains & Families for CD80 Gene

Gene Families for CD80 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD80 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD80 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA (A0N0P2_HUMAN)
  • CTLA-4 counter-receptor B7.1 (CD80_HUMAN)
  • B7 isoform (Q5MD59_HUMAN)
genes like me logo Genes that share domains with CD80: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD80 Gene

Function for CD80 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  6. Cell Line

Molecular function for CD80 Gene

UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
GENATLAS Biochemistry:
cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand

Phenotypes From GWAS Catalog for CD80 Gene

Gene Ontology (GO) - Molecular Function for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
genes like me logo Genes that share ontologies with CD80: view
genes like me logo Genes that share phenotypes with CD80: view

Animal Models for CD80 Gene

MGI Knock Outs for CD80:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD80

CRISPR Products

miRNA for CD80 Gene

miRTarBase miRNAs that target CD80

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD80 Gene

Localization for CD80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD80 gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD80: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD80 Gene

Pathways & Interactions for CD80 Gene

PathCards logo

SuperPathways for CD80 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
2 RET signaling
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
Signaling by EGFR
.90
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
3 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
4 Allograft rejection
Allograft rejection
.65
Type I diabetes mellitus
.65
Graft-versus-host disease
.62
Autoimmune thyroid disease
.60
Allograft Rejection
.46
Intestinal immune network for IgA production
.38
Viral myocarditis
.38
5 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
genes like me logo Genes that share pathways with CD80: view

SIGNOR curated interactions for CD80 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction IBA 21873635
GO:0007166 cell surface receptor signaling pathway IBA 21873635
GO:0009967 positive regulation of signal transduction NAS 9915850
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CD80: view

Drugs & Compounds for CD80 Gene

Products:

  1. Drug

(27) Drugs for CD80 Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma Target, antagonist, binder 243
Belatacept Approved, Investigational Pharma Target, inhibitor 0
Durvalumab Approved, Investigational Pharma Target, binder 385
Galiximab Investigational Pharma Target 7
Immunologic Factors Pharma 29938

(10) Additional Compounds for CD80 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD80: view

Transcripts for CD80 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD80 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD80 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CD80 Gene

GeneLoc Exon Structure for
CD80
ECgene alternative splicing isoforms for
CD80

Expression for CD80 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD80 Gene

mRNA expression in normal human tissues for CD80 Gene
mRNA expression by GTEx for CD80 GenemRNA expression by BioGPS for CD80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:

CD80

SOURCE GeneReport for Unigene cluster for CD80 Gene:

Hs.838

mRNA Expression by UniProt/SwissProt for CD80 Gene:

P33681-CD80_HUMAN
Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.

Evidence on tissue expression from TISSUES for CD80 Gene

  • Nervous system(4.3)
  • Spleen(3.8)
  • Lymph node(3.6)
  • Blood(3.5)
  • Bone marrow(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CD80: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene

Orthologs for CD80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD80 33 32
  • 99.54 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CD80 33 32
  • 74.85 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CD80 33 32
  • 71.53 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cd80 32
  • 70.81 (n)
mouse
(Mus musculus)
 Mammalia Cd80 17 33 32
  • 65.87 (n)
oppossum
(Monodelphis domestica)
 Mammalia CD80 33
  • 26 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CD80 33
  • 23 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CD80 33
  • 23 (a)
 OneToOne
Species where no ortholog for CD80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD80 Gene

ENSEMBL:
Gene Tree for CD80 (if available)
TreeFam:
Gene Tree for CD80 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD80: view image

Paralogs for CD80 Gene

Paralogs for CD80 Gene

genes like me logo Genes that share paralogs with CD80: view

Variants for CD80 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CD80 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000213010 -- 119,545,406(-) T/G intron_variant
rs1000244113 -- 119,543,558(-) G/A intron_variant
rs1000533706 -- 119,529,740(-) A/G intron_variant
rs1000679202 -- 119,539,635(-) G/C intron_variant
rs1000881304 -- 119,556,523(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD80 Gene

Variant ID Type Subtype PubMed ID
esv3353419 CNV insertion 20981092
nsv829695 CNV loss 17160897

Variation tolerance for CD80 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD80

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene

Disorders for CD80 Gene

MalaCards: The human disease database

(24) MalaCards diseases for CD80 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
focal segmental glomerulosclerosis
  • fgs
vaccinia
graves' disease
  • toxic diffuse goiter
autoimmune disease
  • autoimmune hypersensitivity disease
tetanus
  • clostridial tetanus
- elite association - COSMIC cancer census association via MalaCards
Search CD80 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD80

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene

Publications for CD80 Gene

  1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 23 43 56
  2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 23 43 56
  3. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A … Dupont B (Immunogenetics 1992) 3 4 23 56
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 43 56
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 43 56

ExternalLinks

View latest publications for CD80 gene in Mastermind

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