Aliases for CD80 Gene
External Ids for CD80 Gene
Previous HGNC Symbols for CD80 Gene
Previous GeneCards Identifiers for CD80 Gene
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PI3K/AKT activation and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot Summary for CD80 Gene
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.