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The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] See more...
Aliases for CD80 Gene
Aliases for CD80 Gene
External Ids for CD80 Gene
- HGNC: 1700
- Entrez Gene: 941
- Ensembl: ENSG00000121594
- OMIM: 112203
- UniProtKB: P33681
Previous HGNC Symbols for CD80 Gene
- CD28LG
- CD28LG1
Previous GeneCards Identifiers for CD80 Gene
- GC03M115885
- GC03M118875
- GC03M120524
- GC03M120564
- GC03M120725
- GC03M119243
- GC03M116618
Summaries for CD80 Gene
-
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Focal Segmental Glomerulosclerosis. Among its related pathways are Nur77 Signaling in T-Cell and RET signaling. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot Summary for CD80 Gene
-
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
-
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Additional gene information for CD80 Gene
- HGNC(1700)
- Entrez Gene(941)
- Ensembl(ENSG00000121594)
- OMIM(112203)
- UniProtKB(P33681)
- Open Targets Platform(ENSG00000121594)
- Monarch Initiative
- Search for CD80 at DataMed
- Search for CD80 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD80 Gene
Genomics for CD80 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD80 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD80 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD80
- Top Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
-
- AP-1
- AREB6
- ATF-2
- c-Jun
- ISGF-3
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- STAT1
Genomic Locations for CD80 Gene
Genomic Locations for CD80 Gene
- chr3:119,524,293-119,559,614
- (GRCh38/hg38)
- Size:
- 35,322 bases
- Orientation:
- Minus strand
- chr3:119,243,140-119,278,481
- (GRCh37/hg19)
- Size:
- 35,342 bases
- Orientation:
- Minus strand
Genomic View for CD80 Gene
Genes around CD80 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by HGNC
- 3q13.33 by Entrez Gene
- 3q13.33 by Ensembl
CD80 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD80 Gene
Proteins for CD80 Gene
-
Protein details for CD80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33681-CD80_HUMAN
- Recommended name:
- T-lymphocyte activation antigen CD80
- Protein Accession:
- P33681
- Q5DTA9
- Q5DTB0
Protein attributes for CD80 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33048 Da
- Quaternary structure:
-
- Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
- (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.
- Miscellaneous:
-
- [Isoform 2]: Soluble isoform. Expressed in unstimulated B-cells and monocytes, but not T-cells.
- [Isoform 3]: Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c.
Post-translational modifications for CD80 Gene
Other Protein References for CD80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD80 Antibody
- NSJ Bioreagents CD80 Antibody / B7-1 (Mouse Monoclonal)
-
BioLegend
- CD80 Antibody (305202)
- CD80 Antibody (305207)
- CD80 Antibody (305205)
- CD80 Antibody (305204)
- CD80 Antibody (305206)
- CD80 Antibody (305201)
- CD80 Antibody (305209)
- CD80 Antibody (305208)
- CD80 Antibody (305210)
- CD80 Antibody (305214)
- CD80 Antibody (305213)
- CD80 Antibody (305215)
- CD80 Antibody (305216)
- CD80 Antibody (305218)
- CD80 Antibody (305217)
- CD80 Antibody (305220)
- CD80 Antibody (305219)
- CD80 Antibody (305221)
- CD80 Antibody (305225)
- CD80 Antibody (305227)
- CD80 Antibody (305222)
- CD80 Antibody (305229)
- PerCP/Cyanine5.5 CD80 Antibody (305231)
- PerCP/Cyanine5.5 CD80 Antibody (305232)
- CD80 Antibody (305230)
- CD80 Antibody (305234)
- CD80 Antibody (305233)
- CD80 Antibody (305235)
- CD80 Antibody (305236)
- CD80 Antibody (305237)
- CD80 Antibody (305238)
- TotalSeq(TM)-A0005 CD80 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD80
- AM05570FC-N
- AM05570FC-T
- AM05570PU-L
- AM05570PU-N
- AM05570PU-T
- AM05570RP-N
- AM06332SU-N
- AM08052AC-N
- AM08052BT-N
- AM08052FC-N
- AM08052LE-N
- AM08052PU-N
- AM08052RP-N
- AM08052RP-S
- AM26002PU-N
- AM31878PU-N
- AM31878RP-L
- AM31878RP-N
- AM33405PU-N
- AP23702PU-N
- CF501575
- CF501576
- CF501577
- CF501578
- CF501667
- CF501668
- CF501669
- CF501679
- CF501680
- CF501681
- CF501682
- DDX0160P-100
- PP1132B1
- PP1132B2
- PP1132P1
- PP1132P2
- SM1742A
- SM1742AC
- SM1742F
- SM1742P
- SM1742PP
- SM1742PS
- SM1742RP
- TA320291
- TA320292
- TA350999
- TA355032
- TA355072
- TA355074
- TA355076
- TA355078
- TA355080
- TA355082
- TA501575
- TA501575S
- TA501576
- TA501576S
- TA501577
- TA501577S
- TA501578
- TA501578S
- TA501667
- TA501667S
- TA501668
- TA501668S
- TA501669
- TA501669S
- TA501679
- TA501679S
- TA501680
- TA501680S
- TA501681
- TA501681S
- TA501682
- TA501682S
- TA600489
- TA600490
- TA600491
- TA700489
- TA700490
- TA812241
- TA812241S
- TA812242
- TA812242S
- TA812243
- TA812243S
- TA812244
- TA812244S
- TA812246
- TA812246S
- TA812361
- TA812361S
- UM500055
- UM500055CF
- UM570055
- Novus Biologicals Antibodies for CD80
-
Abcam antibodies for CD80
- Invitrogen Antibodies for CD80 (AFLGC-CD80)
- antibodies-online: Show 209 available CD80 Antibodies ranked by validation data
- Compare Top CD80 Antibodies
-
Recommended
- 172 WB Antibodies (anti-human)
- 92 FACS Antibodies (anti-human)
- 48 IF Antibodies (anti-human)
- 37 IHC (p) Antibodies (anti-human)
- 32 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 5 LMNX Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 14 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 137 FACS Antibodies (anti-mouse)
- 45 IP Antibodies (anti-mouse)
- 37 WB Antibodies (anti-mouse)
- 22 IHC (fro) Antibodies (anti-mouse)
- 18 IHC (p) Antibodies (anti-mouse)
- 13 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Sino Biological Antibodies for CD80
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
- Novus Biologicals proteins for CD80
- Sino Biological Recombinant Proteins for CD80
- Sino Biological Cell Lysates for CD80
- ProSpec Recombinant Proteins for CD80
-
ProSci Proteins for CD80
- CD80 molecule [RF16040-01]
- CD80 molecule [96-791]
- T-lymphocyte activation antigen CD80 [96-969]
- T-lymphocyte activation antigen CD80 [96-970]
- CD80 molecule [92-556]
- CD80 antigen [92-581]
- CD80 molecule [90-399]
- CD80 molecule [90-400]
- CD80 antigen [90-401]
- CD80 molecule [96-044]
- CD80 molecule [96-045]
- CD80 molecule� [96-085]
-
Abcam proteins for CD80
Assay Products
- RayBiotech Human CD80/B7-1 ELISA
- Novus Biologicals ELISA Kits for CD80
- antibodies-online: Show 65 available CD80 Elisa Kits ranked by validation data
- Compare Top CD80 Elisa Kits
-
Quality Products:
- ABIN417627
- ABIN1672777
- ABIN858313
- ABIN4993031
- ABIN625278
- ABIN5519927
- ABIN2708169
- ABIN6719691
- ABIN2683757
- ABIN5591684
- ABIN921092
- ABIN829738
- ABIN5563441
- ABIN2702903
- ABIN2708481
- ABIN2683758
- ABIN6719854
- ABIN6384267
- ABIN1846885
- ABIN1112557
- ABIN1889314
- ABIN5563442
- ABIN577971
- ABIN4993679
- ABIN2708631
- ABIN6719695
- ABIN2683759
- ABIN1058571
- ABIN2748018
- ABIN6384268
- ABIN1058562
- ABIN990547
-
Abcam assays for CD80
No data available for DME Specific Peptides for CD80 Gene
Domains & Families for CD80 Gene
Gene Families for CD80 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD80 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for CD80 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA (A0N0P2_HUMAN)
- CTLA-4 counter-receptor B7.1 (CD80_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD80 Gene
Function for CD80 Gene
Molecular function for CD80 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for adenovirus subgroup B.
- GENATLAS Biochemistry:
- cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
Phenotypes From GWAS Catalog for CD80 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9915850 |
| GO:0015026 | coreceptor activity | NAS | 9915850 |
Phenotypes for CD80 Gene
- MGI mutant phenotypes for CD80:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD80:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability of wild-type and TP53 knockout cells
- Decreased viability in ovarian lineage
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for CD80
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD80 - Select products 50% OFF >
- * CD80 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD80
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
miRNA for CD80 Gene
- miRTarBase miRNAs that target CD80
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
Clone Products
- Applied Biological Materials (abm): Clones for CD80 - Select products 50% OFF >
- * CD80 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD80
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
Cell Line Products
-
Horizon Cell Lines for CD80
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD80 Gene
Localization for CD80 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| endosome | 3 |
| cytosol | 3 |
| lysosome | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | NAS,TAS | -- |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0009986 | cell surface | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD80 Gene
Pathways & Interactions for CD80 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | RET signaling |
.92
|
|
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Allograft rejection | ||
| 5 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
Pathways by source for CD80 Gene
7 BioSystems pathways for CD80 Gene
33 Reactome pathways for CD80 Gene
3 GeneGo (Thomson Reuters) pathways for CD80 Gene
- Immune response CD28 signaling
- Immune response ICOS pathway in T-helper cell
- Immune response NFAT in immune response
4 R&D Systems pathways for CD80 Gene
34 Qiagen pathways for CD80 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- CD28 Signaling in T-Helper Cell
- CTLA4 Signaling
Interacting Proteins for CD80 Gene
Selected Interacting proteins:
P33681-CD80_HUMAN
ENSP00000264246
for CD80 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD80
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IBA | 21873635 |
| GO:0007165 | signal transduction | IBA | 21873635 |
| GO:0007166 | cell surface receptor signaling pathway | IBA | 21873635 |
| GO:0009967 | positive regulation of signal transduction | NAS | 9915850 |
| GO:0016032 | viral process | IEA | -- |
Drugs & Compounds for CD80 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Abatacept | Approved | Pharma | Target, antagonist, binder | 251 | ||
| Belatacept | Approved, Investigational | Pharma | Target, antagonist, inhibitor | 0 | ||
| Galiximab | Investigational | Pharma | Target, antibody | 7 | ||
| Pharmaceutical Solutions | Pharma | 11855 | ||||
| Vaccines | Pharma | 8100 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD80 Gene
mRNA/cDNA for CD80 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264246 2737 nts (view in UCSC)
- ENST00000478182 1491 nts (view in UCSC)
- ENST00000463729 737 nts (view in UCSC)
- ENST00000383669 771 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD80 - Select products 50% OFF >
- * CD80 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD80
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
Clone Products
- Applied Biological Materials (abm): Clones for CD80 - Select products 50% OFF >
- * CD80 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD80
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: |
Relevant External Links for CD80 Gene
- GeneLoc Exon Structure for
- CD80
Expression for CD80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD80
SOURCE GeneReport for Unigene cluster for CD80 Gene:
Hs.838mRNA Expression by UniProt/SwissProt for CD80 Gene:
P33681-CD80_HUMAN
Tissue specificity:
Expressed on activated B-cells, macrophages and dendritic cells.
Evidence on tissue expression from TISSUES for CD80 Gene
- Nervous system(4.5)
- Spleen(4)
- Lymph node(3.9)
- Blood(3.8)
- Bone marrow(3.5)
- Intestine(2.9)
- Skin(2.7)
- Liver(2.7)
- Kidney(2.7)
- Lung(2.7)
- Heart(2.6)
- Bone(2.5)
- Pancreas(2.3)
- Muscle(2.3)
Primer Products
-
OriGene qPCR primer pairs for CD80
-
OriGene qPCR primer pairs and template standards for CD80
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene
Orthologs for CD80 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD80 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CD80 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD80 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd80 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd80 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CD80 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CD80 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CD80 31 |
|
OneToOne |
- Species where no ortholog for CD80 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD80 Gene
- ENSEMBL:
- Gene Tree for CD80 (if available)
- TreeFam:
- Gene Tree for CD80 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD80: view image
Paralogs for CD80 Gene
Variants for CD80 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3353419 | CNV | insertion | 20981092 |
| nsv829695 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.87;
34.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD80 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD80
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene
Disorders for CD80 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| focal segmental glomerulosclerosis |
|
|
| cowpox |
|
|
| urinary schistosomiasis |
|
|
| lymphocytic choriomeningitis |
|
|
Search CD80 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD80
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene
Publications for CD80 Gene
- Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 23 41
- Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PMID: 14975605) Teutsch SM … Stewart GJ (Journal of neuroimmunology 2004) 3 23 41
- New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 23 41
- Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A … Dupont B (Immunogenetics 1992) 3 4 23
- The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. (PMID: 1370389) Freeman GJ … Nadler LM (Blood 1992) 2 3 23
ExternalLinks
Products for CD80 Gene
- View all 26 R&D Systems CD80 (B7-1/CD80) Products
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- View all 19 R&D Systems CD80 (B7-1/CD80) Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CD80
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- Custom Assay Services
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for CD80 (AFLGC-CD80)
- VectorBuilder Custom and pre-made DNA vectors for CD80 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CD80 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for CD80
- antibodies-online: Show 209 available CD80 Antibodies ranked by validation data
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- Recommended
- 172 WB Antibodies (anti-human)
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- 48 IF Antibodies (anti-human)
- 37 IHC (p) Antibodies (anti-human)
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- 12 IF (p) Antibodies (anti-human)
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- 2 IHC (fro) Antibodies (anti-human)
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- 1 Func Antibody (anti-human)
- 14 FACS Antibodies (anti-rat)
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- 11 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
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- 1 IHC (p) Antibody (anti-rat)
- 137 FACS Antibodies (anti-mouse)
- 45 IP Antibodies (anti-mouse)
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- 3 Neut Antibodies (anti-mouse)
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- 2 ICC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- antibodies-online: Show 65 available CD80 Elisa Kits ranked by validation data
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- ABIN417627
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- antibodies-online: Show 61 available CD80 Proteins ranked by validation data
- Compare Top CD80 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Search Santa Cruz Biotechnology (SCBT) for CD80 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- Custom Antibody ServicesProSci Antibodies for CD80
- ProSci Proteins for CD80
- CD80 molecule [RF16040-01]
- CD80 molecule [96-791]
- T-lymphocyte activation antigen CD80 [96-969]
- T-lymphocyte activation antigen CD80 [96-970]
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- Horizon Cell Lines for CD80
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
Sources for CD80 Gene
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