Aliases for CD80 Gene
Aliases for CD80 Gene
External Ids for CD80 Gene
- HGNC: 1700
- Entrez Gene: 941
- Ensembl: ENSG00000121594
- OMIM: 112203
- UniProtKB: P33681
Previous HGNC Symbols for CD80 Gene
- CD28LG
- CD28LG1
Previous GeneCards Identifiers for CD80 Gene
- GC03M115885
- GC03M118875
- GC03M120524
- GC03M120564
- GC03M120725
- GC03M119243
- GC03M116618
Summaries for CD80 Gene
-
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot for CD80 Gene
-
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
-
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Additional gene information for CD80 Gene
- Monarch Initiative
- Search for CD80 at DataMed
- Search for CD80 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene
Genomics for CD80 Gene
GeneHancer (GH) Regulatory Elements for CD80 Gene
Promoters and enhancers for CD80 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD80 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
-
- STAT1
- AP-1
- c-Jun
- ATF-2
- NF-kappaB2
- NF-kappaB1
- NF-kappaB
- AREB6
- ISGF-3
Regulatory Element Products
Genomic Locations for CD80 Gene
Genomic Locations for CD80 Gene
- chr3:119,523,948-119,559,634
- (GRCh38/hg38)
- Size:
- 35,687 bases
- Orientation:
- Minus strand
- chr3:119,243,140-119,278,481
- (GRCh37/hg19)
- Size:
- 35,342 bases
- Orientation:
- Minus strand
Genomic View for CD80 Gene
Genes around CD80 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC
- 3q13.33 by Ensembl
CD80 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD80 Gene
Proteins for CD80 Gene
-
Protein details for CD80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33681-CD80_HUMAN
- Recommended name:
- T-lymphocyte activation antigen CD80
- Protein Accession:
- P33681
- Q5DTA9
- Q5DTB0
Protein attributes for CD80 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33048 Da
- Quaternary structure:
-
- Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
- (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.
Post-translational modifications for CD80 Gene
Other Protein References for CD80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD80 (B7-1/CD80)
-
Custom Antibody ServicesOriGene Antibodies for CD80
- AM05201PU-N
- AM05570FC-N
- AM05570FC-T
- AM05570LE-N
- AM05570PU-L
- AM05570PU-N
- AM05570PU-T
- AM05570RP-N
- AM05570RP-T
- AM05682RC5-N
- AM05686PU-N
- AM06332SU-N
- AM08052AC-N
- AM08052BT-N
- AM08052FC-N
- AM08052LE-N
- AM08052PU-N
- AM08052RP-N
- AM08052RP-S
- AM26002PU-N
- AM31878PU-N
- AM31878RP-L
- AM31878RP-N
- AM33405PU-N
- AP23702PU-N
- PP1132B1
- PP1132B2
- PP1132P1
- PP1132P2
- SM1742A
- SM1742AC
- SM1742F
- SM1742P
- SM1742PP
- SM1742PS
- SM1742RP
- TA320291
- TA320292
- TA350999
- TA501575
- CF501575
- TA501576
- CF501576
- TA501577
- CF501577
- TA501578
- CF501578
- TA501667
- CF501667
- TA501668
- CF501668
- TA501669
- CF501669
- TA501679
- CF501679
- TA501680
- CF501680
- TA501681
- CF501681
- TA501682
- CF501682
- TA600489
- TA600490
- TA600491
- TA700489
- TA700490
- UM500055
- UM570055
- TA501576S
- Novus Biologicals Antibodies for CD80
-
Abcam antibodies for CD80
- Invitrogen Antibodies for CD80
- antibodies-online: Search results for 772 available CD80 Antibodies ranked by validation data
- Compare Top CD80 Antibodies
-
Recommended
- 171 WB Antibodies (anti-human)
- 129 FACS Antibodies (anti-human)
- 31 IP Antibodies (anti-human)
- 28 IF Antibodies (anti-human)
- 20 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 LMNX Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 15 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 98 FACS Antibodies (anti-mouse)
- 48 IP Antibodies (anti-mouse)
- 32 WB Antibodies (anti-mouse)
- 28 IHC (p) Antibodies (anti-mouse)
- 25 IHC (fro) Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- GeneTex CD80 Antibody for CD80
-
Custom Antibody ServicesProSci Antibodies for CD80
- CD80 molecule [8679]
- CD80 molecule [RF16041]
- CD80 molecule [RF16041-HRP]
- CD80 molecule [RF16042]
- CD80 molecule [RF16042-HRP]
- CD80 molecule [RF16043]
- CD80 molecule [RF16043-HRP]
- CD80 molecule [RF16044]
- CD80 molecule [RF16044-HRP]
- CD80 molecule [RF16045]
- CD80 molecule [RF16045-HRP]
- CD80 molecule [RF16046]
- CD80 molecule [RF16046-HRP]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Sino Biological Antibodies for CD80
Protein Products
- R&D Systems Proteins and Enzymes for CD80 (B7-1/CD80)
-
OriGene Purified Proteins for CD80
- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
- Sino Biological Recombinant Proteins for CD80
- Sino Biological Cell Lysates for CD80
- ProSpec Recombinant Proteins for CD80
- GeneTex Proteins for CD80
-
ProSci Proteins for CD80
- CD80 molecule [96-044]
- CD80 molecule [96-045]
- CD80 molecule� [96-085]
- CD80 molecule [96-791]
- T-lymphocyte activation antigen CD80 [96-969]
- T-lymphocyte activation antigen CD80 [96-970]
- CD80 molecule [90-399]
- CD80 molecule [90-400]
- CD80 antigen [90-401]
- CD80 molecule [92-556]
- CD80 antigen [92-581]
- CD80 molecule [RF16040-01]
-
Abcam proteins for CD80
Assay Products
- R&D Systems ELISAs and other biochemical assays for CD80 (B7-1/CD80)
- Novus Biologicals ELISA Kits for CD80
- antibodies-online: Search results for available CD80 related products ranked by validation data
-
Abcam assays for CD80
No data available for DME Specific Peptides for CD80 Gene
Domains & Families for CD80 Gene
Gene Families for CD80 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD80 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD80 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD80 Gene
Function for CD80 Gene
Molecular function for CD80 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for adenovirus subgroup B.
- GENATLAS Biochemistry:
- cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
Phenotypes From GWAS Catalog for CD80 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9915850 |
| GO:0015026 | coreceptor activity | NAS | 9915850 |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for CD80 Gene
- MGI mutant phenotypes for CD80:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD80:
-
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
-
Taconic Biosciences Mouse Models for CD80
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD80
-
CRISPR Products
-
OriGene CRISPR knockouts for CD80
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
- genomics-online: gRNA clones - Search results for available CD80 gene related products
- Applied Biological Materials CRISPR for CD80
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
miRNA for CD80 Gene
- miRTarBase miRNAs that target CD80
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
- genomics-online: shRNA clones - Search results for available CD80 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD80
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
- genomics-online: cdna clones - Search results for available CD80 gene related products
- orf clones - Search results for available CD80 gene related products
- Applied Biological Materials Clones for CD80
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
Cell Line Products
-
Horizon Cell Lines for CD80
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD80 Gene
Localization for CD80 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | NAS,TAS | -- |
| GO:0009897 | external side of plasma membrane | IBA | -- |
| GO:0009986 | cell surface | HDA,IBA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD80 Gene
Pathways & Interactions for CD80 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | RET signaling |
.92
|
|
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | Allograft rejection | ||
| 5 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
Pathways by source for CD80 Gene
7 BioSystems pathways for CD80 Gene
33 Reactome pathways for CD80 Gene
3 GeneGo (Thomson Reuters) pathways for CD80 Gene
7 R&D Systems pathways for CD80 Gene
34 Qiagen pathways for CD80 Gene
Interacting Proteins for CD80 Gene
Selected Interacting proteins:
ENSP00000264246
P33681-CD80_HUMAN
for CD80 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for CD80
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IBA | -- |
| GO:0007165 | signal transduction | IEA,IBA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
| GO:0009967 | positive regulation of signal transduction | NAS | 9915850 |
| GO:0016032 | viral process | IEA | -- |
No data available for SIGNOR curated interactions for CD80 Gene
Drugs & Compounds for CD80 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Abatacept | Approved | Pharma | binder, Target, antagonist | 210 | ||
| Belatacept | Approved, Investigational | Pharma | inhibitor, Target | 0 | ||
| durvalumab | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Galiximab | Investigational | Pharma | Target | 0 | ||
| Pharmaceutical Solutions | Pharma | 9000 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD80 Gene
mRNA/cDNA for CD80 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000264246 2725 bps (uc003ecq.4)
- ENST00000478182 1491 bps (uc062muu.1)
- ENST00000463729 737 bps (uc062muv.1)
- ENST00000383669 771 bps (uc010hqt.2)
CRISPR Products
-
OriGene CRISPR knockouts for CD80
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
- genomics-online: gRNA clones - Search results for available CD80 gene related products
- Applied Biological Materials CRISPR for CD80
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
- genomics-online: shRNA clones - Search results for available CD80 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD80
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
- genomics-online: cdna clones - Search results for available CD80 gene related products
- orf clones - Search results for available CD80 gene related products
- Applied Biological Materials Clones for CD80
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: |
Expression for CD80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:
CD80SOURCE GeneReport for Unigene cluster for CD80 Gene:
Hs.838mRNA Expression by UniProt/SwissProt for CD80 Gene:
P33681-CD80_HUMAN
Tissue specificity:
Expressed on activated B-cells, macrophages and dendritic cells.
Evidence on tissue expression from TISSUES for CD80 Gene
- Nervous system(4.3)
- Spleen(3.8)
- Lymph node(3.6)
- Blood(3.5)
- Bone marrow(2.6)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CD80
-
OriGene qPCR primer pairs for CD80
- genomics-online: primer clones - Search results for available CD80 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene
Orthologs for CD80 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD80 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD80 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD80 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cd80 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd80 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD80 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD80 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD80 34 |
|
OneToOne |
- Species where no ortholog for CD80 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CD80 Gene
- ENSEMBL:
- Gene Tree for CD80 (if available)
- TreeFam:
- Gene Tree for CD80 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD80: view image
Paralogs for CD80 Gene
Variants for CD80 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000213010 | -- | 119,545,406(-) | T/G | intron_variant | |
| rs1000244113 | -- | 119,543,558(-) | G/A | intron_variant | |
| rs1000533706 | -- | 119,529,740(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000679202 | -- | 119,539,635(-) | G/C | intron_variant | |
| rs1000881304 | -- | 119,556,523(-) | A/C | 5_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3353419 | CNV | insertion | 20981092 |
| nsv829695 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.87;
34.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD80 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD80
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene
Disorders for CD80 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| focal segmental glomerulosclerosis |
|
|
| vaccinia |
|
|
| graves' disease |
|
|
| systemic lupus erythematosus |
|
|
| follicular lymphoma |
|
Search CD80 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD80
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene
Publications for CD80 Gene
- Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 22 44 58
- New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 22 44 58
- Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A … Dupont B (Immunogenetics 1992) 3 4 22 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58
Products for CD80 Gene
- R&D Systems Antibodies for CD80 (B7-1/CD80)
- R&D Systems Proteins and Enzymes for CD80 (B7-1/CD80)
- R&D Systems ELISAs and other biochemical assays for CD80 (B7-1/CD80)
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Custom Antibody ServicesOriGene Antibodies for CD80
- AM05201PU-N
- AM05570FC-N
- AM05570FC-T
- AM05570LE-N
- AM05570PU-L
- AM05570PU-N
- AM05570PU-T
- AM05570RP-N
- AM05570RP-T
- AM05682RC5-N
- AM05686PU-N
- AM06332SU-N
- AM08052AC-N
- AM08052BT-N
- AM08052FC-N
- AM08052LE-N
- AM08052PU-N
- AM08052RP-N
- AM08052RP-S
- AM26002PU-N
- AM31878PU-N
- AM31878RP-L
- AM31878RP-N
- AM33405PU-N
- AP23702PU-N
- PP1132B1
- PP1132B2
- PP1132P1
- PP1132P2
- SM1742A
- SM1742AC
- SM1742F
- SM1742P
- SM1742PP
- SM1742PS
- SM1742RP
- TA320291
- TA320292
- TA350999
- TA501575
- CF501575
- TA501576
- CF501576
- TA501577
- CF501577
- TA501578
- CF501578
- TA501667
- CF501667
- TA501668
- CF501668
- TA501669
- CF501669
- TA501679
- CF501679
- TA501680
- CF501680
- TA501681
- CF501681
- TA501682
- CF501682
- TA600489
- TA600490
- TA600491
- TA700489
- TA700490
- UM500055
- UM570055
- TA501576S
- Custom Assay Services
- OriGene Purified Proteins for CD80
- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- OriGene qPCR primer pairs and template standards for CD80
- OriGene qPCR primer pairs for CD80
- OriGene CRISPR knockouts for CD80
- OriGene ORF clones in human for CD80
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD80
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD80 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD80
- GenScript Custom Assay Services for CD80
- GenScript CD80 - overexpressing Cell Line for Assay
- GenScript Custom overexpressing Cell Line Services for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD80
- Sino Biological Human cDNA Clone for CD80
- Sino Biological Recombinant Proteins for CD80
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- Sino Biological Antibodies for CD80
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CD80
- Novus Biologicals proteins and lysates for CD80
- Novus Biologicals ELISA Kits for CD80
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for CD80
- Abcam proteins for CD80
- Abcam assays for CD80
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for CD80
- Taconic Biosciences Mouse Models for CD80
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CD80
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD80
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 772 available CD80 Antibodies ranked by validation data
- Compare Top CD80 Antibodies
- Recommended
- 171 WB Antibodies (anti-human)
- 129 FACS Antibodies (anti-human)
- 31 IP Antibodies (anti-human)
- 28 IF Antibodies (anti-human)
- 20 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 LMNX Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 15 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 98 FACS Antibodies (anti-mouse)
- 48 IP Antibodies (anti-mouse)
- 32 WB Antibodies (anti-mouse)
- 28 IHC (p) Antibodies (anti-mouse)
- 25 IHC (fro) Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- antibodies-online: Search results for available CD80 related products ranked by validation data
- antibodies-online: Search results for 49 available CD80 Proteins ranked by validation data
- Compare Top CD80 Proteins
- GeneTex CD80 Antibody for CD80
- GeneTex Proteins for CD80
- Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Search Santa Cruz Biotechnology (SCBT) for CD80 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- Custom Antibody ServicesProSci Antibodies for CD80
- CD80 molecule [8679]
- CD80 molecule [RF16041]
- CD80 molecule [RF16041-HRP]
- CD80 molecule [RF16042]
- CD80 molecule [RF16042-HRP]
- CD80 molecule [RF16043]
- CD80 molecule [RF16043-HRP]
- CD80 molecule [RF16044]
- CD80 molecule [RF16044-HRP]
- CD80 molecule [RF16045]
- CD80 molecule [RF16045-HRP]
- CD80 molecule [RF16046]
- CD80 molecule [RF16046-HRP]
- ProSci Proteins for CD80
- CD80 molecule [96-044]
- CD80 molecule [96-045]
- CD80 molecule� [96-085]
- CD80 molecule [96-791]
- T-lymphocyte activation antigen CD80 [96-969]
- T-lymphocyte activation antigen CD80 [96-970]
- CD80 molecule [90-399]
- CD80 molecule [90-400]
- CD80 antigen [90-401]
- CD80 molecule [92-556]
- CD80 antigen [92-581]
- CD80 molecule [RF16040-01]
- Horizon Cell Lines for CD80
- genomics-online: cdna clones - Search results for available CD80 gene related products
- orf clones - Search results for available CD80 gene related products
- genomics-online: gRNA clones - Search results for available CD80 gene related products
- genomics-online: primer clones - Search results for available CD80 gene related products
- genomics-online: shRNA clones - Search results for available CD80 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD80
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD80
- GeneCopoeia miRNA 3'UTR Target clone products for CD80
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD80
Sources for CD80 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt