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The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are B cell receptor signaling pathway (KEGG) and Antigen activates B Cell Receptor (BCR) leading to generation of second messengers. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD79A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042802 | identical protein binding | IDA | 14967045 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 8486355 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | B cell receptor signaling pathway (KEGG) | ||
2 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
B-Cell Receptor Complex
.01
|
|
3 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
4 | Fc-GammaR Pathway |
Fc-Gamma-RIIB Signaling in B-Cells
.55
|
|
5 | CREB Pathway |
IP3 Pathway
.68
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006955 | immune response | TAS | 8486355 |
GO:0007165 | signal transduction | TAS | 8486355 |
GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Polatuzumab vedotin | Approved, Investigational | Pharma | Target, Transporter | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD79B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD79B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD79B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd79b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd79b 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD79b 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD79B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD79B 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
641789 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,296(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
643205 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,929,281(-) | G/A | MISSENSE_VARIANT | |
644087 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,166(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
644557 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,218(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
661158 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,138(-) | ACAGA/GC | INFRAME_DELETION,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
agammaglobulinemia 6, autosomal recessive |
|
|
agammaglobulinemia, non-bruton type |
|
|
agammaglobulinemia |
|
|
lambda 5 deficiency |
|
|
intravascular large b-cell lymphoma |
|
|