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The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternativel... See more...
Aliases for CD79B Gene
Aliases for CD79B Gene
External Ids for CD79B Gene
- HGNC: 1699
- NCBI Entrez Gene: 974
- Ensembl: ENSG00000007312
- OMIM®: 147245
- UniProtKB/Swiss-Prot: P40259
Previous HGNC Symbols for CD79B Gene
- IGB
Previous GeneCards Identifiers for CD79B Gene
- GC17M061643
- GC17M064432
- GC17M062346
- GC17M062479
- GC17M059359
- GC17M062006
- GC17M057373
Summaries for CD79B Gene
-
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD79B Gene
CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Fc-GammaR Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD79A.
UniProtKB/Swiss-Prot Summary for CD79B Gene
-
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Additional gene information for CD79B Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD79B Gene
Genomics for CD79B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD79B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD79B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD79B
- Top Transcription factor binding sites by QIAGEN in the CD79B gene promoter:
-
- E47
- Elk-1
- GATA-2
- Hand1
- HOXA9
- HOXA9B
- LUN-1
- Meis-1
- Meis-1b
- SEF-1 (1)
Genomic Locations for CD79B Gene
Latest Assembly
- chr17:63,928,740-63,932,336
- (GRCh38/hg38)
- Size:
- 3,597 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:62,006,100-62,009,691
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,592 bases
- Orientation:
- Minus strand
Genomic View for CD79B Gene
Genes around CD79B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.3 by HGNC
- 17q23.3 by Entrez Gene
- 17q23.3 by Ensembl
CD79B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD79B Gene
Proteins for CD79B Gene
-
Protein details for CD79B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40259-CD79B_HUMAN
- Recommended name:
- B-cell antigen receptor complex-associated protein beta chain
- Protein Accession:
- P40259
- Q53FS2
- Q9BU06
Protein attributes for CD79B Gene
- Size:
- 229 amino acids
- Molecular mass:
- 26048 Da
- Quaternary structure:
-
- Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).
Protein Expression for CD79B Gene
Post-translational modifications for CD79B Gene
- Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
-
Glycosylation at Asn73, Asn101, Asn127, and Asn128
- NX_P40259 (NX_P40259-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CD79B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CD79B / CD79 Beta Monoclonal Antibody
- G Biosciences Immunotag™ CD79B Antibody
-
BioLegend
- CD79b (Igbeta) Antibody (341404)
- PerCP/Cyanine5.5 CD79b (Igbeta) Antibody (341408)
- CD79b (Igbeta) Antibody (341406)
- PerCP/Cyanine5.5 CD79b (Igbeta) Antibody (341407)
- CD79b (Igbeta) Antibody (341410)
- CD79b (Igbeta) Antibody (341409)
- APC/Fire(TM) 750 CD79b (Igbeta) Antibody (341412)
- CD79b (Igbeta) Antibody (341414)
- CD79b (Igbeta) Antibody (341413)
- APC/Fire(TM) 750 CD79b (Igbeta) Antibody (341411)
- TotalSeq(TM)-A0187 CD79b (Igbeta) Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD79B
- AM08072BT-N
- AM08072FC-N
- AM08072LE-N
- AM08072PU-N
- AM08072RP-N
- AM08164AC-N
- AM08164BT-N
- AM08164FC-N
- AM08164PU-N
- AM08164RP-N
- CF810462
- CF810463
- CF810480
- CF810481
- CF810482
- CF810502
- CF810503
- CF810561
- SM1576F
- SM1576PS
- SM1576R
- SM1873F
- SM1873FT
- SM1873P
- SM1873PT
- SM1899P
- SM1899PT
- SM1899R
- TA323605
- TA327234
- TA353066L
- TA810462
- TA810462S
- TA810463
- TA810463S
- TA810480
- TA810480S
- TA810481
- TA810481S
- TA810482
- TA810482S
- TA810502
- TA810502S
- TA810503
- TA810503S
- TA810561
- TA810561S
- Novus Biologicals Antibodies for CD79B
-
Abcam antibodies for CD79B
- Invitrogen Antibodies for CD79B (AFLGC-Cd79b)
-
Custom Antibody ServicesProSci Antibodies for CD79B
- B-cell antigen receptor complex-associated protein beta chain [18-457]
- B-cell antigen receptor complex-associated protein beta chain [58-647]
- CD79b molecule, immunoglobulin-associated beta [70-263]
- CD79B antigen [98-996]
- CD79B antigen [98-997]
- CD79B antigen [98-998]
- CD79B antigen [98-999]
- CD79B antigen [99-001]
- B-cell antigen receptor complex-associated protein beta chain [99-570]
- B-cell antigen receptor complex-associated protein beta chain [99-571]
- B-cell antigen receptor complex-associated protein beta chain [99-572]
- B-cell antigen receptor complex-associated protein beta chain [99-573]
- B-cell antigen receptor complex-associated protein beta chain [99-574]
- B-cell antigen receptor complex-associated protein beta chain [99-575]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD79B
- Sino Biological Antibodies for CD79B
Protein products for research
- G Biosciences Human CD79B/B29, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for CD79B
- Origene Custom Protein Services for CD79B
- Sino Biological Recombinant Proteins for CD79B
- Sino Biological Cell Lysates for CD79B
- ProSpec Recombinant Proteins for CD79B
-
ProSci Proteins for CD79B
-
Abcam proteins for CD79B
Assay products for research
- RayBiotech Custom Human CD79B ELISA
- antibodies-online: Show 5 available CD79B Elisa Kits ranked by validation data
- Compare Top CD79B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CD79B Gene
Domains & Families for CD79B Gene
Gene Families for CD79B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Predicted membrane proteins
Protein Domains for CD79B Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Immunoglobulin subtype
- Phosphorylated immunoreceptor signaling ITAM
Suggested Antigen Peptide Sequences for CD79B Gene
- GenScript: Design optimal peptide antigens:
-
- Immunoglobulin-associated B29 protein (CD79B_HUMAN)
- CD79B protein (Q6PIS4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD79B Gene
Function for CD79B Gene
Molecular function for CD79B Gene
- UniProtKB/Swiss-Prot Function:
- Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
- GENATLAS Biochemistry:
- cell differentiation antigen CD79B,expressed on B cells
Phenotypes From GWAS Catalog for CD79B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042802 | identical protein binding | IDA | 14967045 |
Phenotypes for CD79B Gene
- MGI mutant phenotypes for CD79B:
- inferred from 9 alleles
- GenomeRNAi human phenotypes for CD79B:
Animal Models for CD79B Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for CD79B
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CD79B - Starting at $85 >
- * CD79B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CD79B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD79B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD79B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD79B
- Browse OriGene Inhibitory RNA Products For CD79B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD79B
Clone products for research
- Applied Biological Materials (abm): Clones for CD79B - Starting at $45 >
- * CD79B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202725
- MR202725
- MR202725L3
- MR202725L4
- RC200665
- RC200665L1
- RC200665L2
- RC200665L3
- RC200665L4
- RC215340
- RC215340L1
- RC215340L2
- RC215340L3
- RC215340L4
- RC217693
- RC217693L3
- RC217693L4
- RG200665
- RG215340
- RG217693
- RR207564
- RR207564L3
- RR207564L4
- MR202725L3V
- MR202725L4V
- RC200665L1V
- RC200665L2V
- RC200665L3V
- RC200665L4V
- RC215340L1V
- RC215340L2V
- RC215340L3V
- RC215340L4V
- RC217693L3V
- RC217693L4V
- RR207564L3V
- RR207564L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD79B
- Addgene plasmids for CD79B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD79B
Cell Lines for research
-
Horizon Cell Lines for CD79B
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CD79B Gene
Localization for CD79B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD79B Gene
- Cell membrane. Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
- Plasma membrane (3)
- Cytosol (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8486355 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
Pathways & Interactions for CD79B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | B cell receptor signaling pathway (KEGG) | ||
| 2 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
B-Cell Receptor Complex
.01
|
|
| 3 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
| 4 | Fc-GammaR Pathway |
Fc-Gamma-RIIB Signaling in B-Cells
.55
|
|
| 5 | CREB Pathway |
IP3 Pathway
.68
|
|
Pathways by source for CD79B Gene
2 BioSystems pathways for CD79B Gene
5 Reactome pathways for CD79B Gene
1 KEGG pathway for CD79B Gene
3 GeneGo (Thomson Reuters) pathways for CD79B Gene
- Immune response BCR pathway
- Immune response NFAT in immune response
- Signal transduction IP3 signaling
1 R&D Systems pathway for CD79B Gene
6 Qiagen pathways for CD79B Gene
- B-Cell Receptor Complex
- Fc-Gamma-RIIB Signaling in B-Cells
- IP3 Pathway
- NFAT in Immune Response
- Phospholipase-C Pathway
Interacting Proteins for CD79B Gene
Selected Interacting proteins:
P40259-CD79B_HUMAN
ENSP00000376544
for CD79B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD79B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006955 | immune response | TAS | 8486355 |
| GO:0007165 | signal transduction | TAS | 8486355 |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
Drugs & Compounds for CD79B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Polatuzumab vedotin | Approved, Investigational | Pharma | Target, Transporter | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human CD79B/B29, Lyophilized
Transcripts for CD79B Gene
mRNA/cDNA for CD79B Gene
- 4 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000006750 1246 nts (view in UCSC)
- ENST00000349817 378 nts (view in UCSC)
- ENST00000392795 1254 nts (view in UCSC)
- ENST00000558969 563 nts (view in UCSC)
- ENST00000559358 1159 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CD79B - Starting at $85 >
- * CD79B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CD79B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD79B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD79B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD79B
- Browse OriGene Inhibitory RNA Products For CD79B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD79B
Clone products for research
- Applied Biological Materials (abm): Clones for CD79B - Starting at $45 >
- * CD79B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202725
- MR202725
- MR202725L3
- MR202725L4
- RC200665
- RC200665L1
- RC200665L2
- RC200665L3
- RC200665L4
- RC215340
- RC215340L1
- RC215340L2
- RC215340L3
- RC215340L4
- RC217693
- RC217693L3
- RC217693L4
- RG200665
- RG215340
- RG217693
- RR207564
- RR207564L3
- RR207564L4
- MR202725L3V
- MR202725L4V
- RC200665L1V
- RC200665L2V
- RC200665L3V
- RC200665L4V
- RC215340L1V
- RC215340L2V
- RC215340L3V
- RC215340L4V
- RC217693L3V
- RC217693L4V
- RR207564L3V
- RR207564L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD79B
- Addgene plasmids for CD79B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD79B
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for CD79B Gene
- GeneLoc Exon Structure for
- CD79B
Expression for CD79B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Adipose (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CD79B Gene
This gene is overexpressed in Spleen (x12.6), Whole Blood (x7.6), Pituitary (x5.0), and Small Intestine - Terminal Ileum (x4.2).
This gene is overexpressed in Blymphocyte (36.0), Monocytes (16.0), and Lymph node (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD79B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD79B
SOURCE GeneReport for Unigene cluster for CD79B Gene:
Hs.89575mRNA Expression by UniProt/SwissProt for CD79B Gene:
P40259-CD79B_HUMAN
Tissue specificity:
B-cells.
Evidence on tissue expression from TISSUES for CD79B Gene
- Spleen(4.7)
- Intestine(4.5)
- Lymph node(3.4)
- Bone marrow(3)
- Blood(2.9)
- Nervous system(2.3)
- Stomach(2.3)
- Kidney(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD79B Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- eyelid
- face
- head
- jaw
- mandible
- maxilla
- meninges
- middle ear
- mouth
- neck
- outer ear
- sinus
- skull
Thorax:
- bronchus
- chest wall
- clavicle
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- biliary tract
- gallbladder
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
Pelvis:
- pelvis
- rectum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- skin
- spinal column
- vertebrae
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for CD79B
-
OriGene qPCR primer pairs and template standards for CD79B
Gene Expression Assays for research
Orthologs for CD79B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD79B 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD79B 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CD79B 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd79b 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd79b 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CD79b 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CD79B 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CD79B 29 30 |
|
OneToOne |
- Species where no ortholog for CD79B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD79B Gene
- ENSEMBL:
- Gene Tree for CD79B (if available)
- TreeFam:
- Gene Tree for CD79B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD79B: view image
- Alliance of Genome Resources:
- Additional Orthologs for CD79B
Paralogs for CD79B Gene
Variants for CD79B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD79B Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1005019 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,163(-) |
A/C NM_000626.4(CD79B):c.341T>G (p.Phe114Cys) |
MISSENSE_VARIANT,INTRON | |
| 1019051 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,929,777(-) |
A/T NM_000626.4(CD79B):c.542T>A (p.Leu181Gln) |
MISSENSE | |
| 1038551 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,931,354(-) |
GTCC/G NM_000626.4(CD79B):c.93GGA[1] (p.Glu32del) |
INFRAME_DELETION | |
| 1046774 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,930,373(-) |
G/A NM_000626.4(CD79B):c.131C>T (p.Ser44Leu) |
MISSENSE_VARIANT,INTRON | |
| 837161 | Uncertain Significance: Agammaglobulinemia 6, autosomal recessive | 63,929,772(-) |
T/C NM_000626.4(CD79B):c.547A>G (p.Lys183Glu) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD79B Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD79B Gene
Disorders for CD79B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| agammaglobulinemia 6, autosomal recessive |
|
|
| agammaglobulinemia, non-bruton type |
|
|
| agammaglobulinemia |
|
|
| relapsed/refractory diffuse large b-cell lymphoma |
|
|
| lambda 5 deficiency |
|
|
Search CD79B in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CD79B_HUMAN- Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:17675462}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for CD79B
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for CD79B Gene
Publications for CD79B Gene
- Mutations of the Igbeta gene cause agammaglobulinemia in man. (PMID: 17709424) Ferrari S … Plebani A (The Journal of experimental medicine 2007) 3 22 72
- Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PMID: 9545642) Nakazato S … Ono M (Genomics 1998) 2 3 22
- The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. (PMID: 7913081) Hashimoto S … Gregersen PK (Immunogenetics 1994) 3 4 22
- The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. (PMID: 8419481) Hashimoto S … Chiorazzi N (Journal of immunology (Baltimore, Md. : 1950) 1993) 3 4 22
- Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). (PMID: 8486355) Wood WJ … Denny CT (Genomics 1993) 3 4 22
ExternalLinks
Products for CD79B Gene
- View all 19 R&D Systems CD79B (CD79B) Products
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- B-cell antigen receptor complex-associated protein beta chain [18-457]
- B-cell antigen receptor complex-associated protein beta chain [58-647]
- CD79b molecule, immunoglobulin-associated beta [70-263]
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- CD79B antigen [98-997]
- CD79B antigen [98-998]
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Sources for CD79B Gene
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