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The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Mucinous Lung Adenocarcinoma and Lung Cancer Susceptibility 3. Among its related pathways are Tuberculosis and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include identical protein binding and amyloid-beta binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001540 | amyloid-beta binding | IPI | 19849849 |
GO:0004896 | cytokine receptor activity | IDA | 17045821 |
GO:0005515 | protein binding | IPI | 17357109 |
GO:0019955 | cytokine binding | IPI | 17567581 |
GO:0023026 | MHC class II protein complex binding | IDA | 1448172 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005634 | nucleus | IDA | 19423618 |
GO:0005737 | cytoplasm | IDA | 22952837 |
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NF-kappaB Signaling | ||
2 | Allograft rejection | ||
3 | Herpes simplex virus 1 infection | ||
4 | Tuberculosis | ||
5 | Class I MHC mediated antigen processing and presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | IEA | -- |
GO:0001516 | prostaglandin biosynthetic process | IDA | 12782713 |
GO:0001934 | positive regulation of protein phosphorylation | IDA | 24942581 |
GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IMP | 12782713 |
GO:0002250 | adaptive immune response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
milatuzumab | Investigational | Pharma | antibody | Therapeutic Antibodies | 0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD74 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD74 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd74 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd74 30 |
|
||
Cow (Bos Taurus) |
Mammalia | CD74 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD74 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD74 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD74 30 |
|
||
II 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | CD74 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cd74 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10251 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cd74a 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs188910406 | Likely Benign: Treacher Collins Syndrome, Dominant | 150,400,217(-) | C/T | THREE_PRIME_UTR_VARIANT | |
rs533518443 | Likely Benign: Treacher Collins Syndrome, Dominant | 150,400,243(-) | G/GT | THREE_PRIME_UTR_VARIANT | |
rs55784390 | Likely Benign: Treacher Collins Syndrome, Dominant | 150,400,177(-) | C/T | THREE_PRIME_UTR_VARIANT | |
rs558770704 | Uncertain Significance: Treacher Collins Syndrome, Dominant | 150,400,178(-) | G/A | THREE_PRIME_UTR_VARIANT | |
rs886060268 | Uncertain Significance: Treacher Collins Syndrome, Dominant | 150,400,244(-) | T/G | THREE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
mucinous lung adenocarcinoma |
|
|
lung cancer susceptibility 3 |
|
|