Aliases for CD74 Gene
- CD74 Molecule 2 3 5
- CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated) 2 3
- CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain 2 3
- HLA Class II Histocompatibility Antigen Gamma Chain 3 4
- HLA-DR Antigens-Associated Invariant Chain 3 4
- Gamma Chain Of Class II Antigens 2 3
- Ia-Associated Invariant Chain 2 3
- MHC HLA-DR Gamma Chain 2 3
- HLA-DR-Gamma 2 3
External Ids for CD74 Gene
Previous HGNC Symbols for CD74 Gene
Previous GeneCards Identifiers for CD74 Gene
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD74 Gene
CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Mucinous Lung Adenocarcinoma and Lung Cancer Susceptibility 3. Among its related pathways are Tuberculosis and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include identical protein binding and amyloid-beta binding.
UniProtKB/Swiss-Prot Summary for CD74 Gene
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
[Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.