Aliases for CD74 Gene
Aliases for CD74 Gene
- CD74 Molecule 2 3 5
- CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated) 2 3
- CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain 2 3
- HLA-DR Antigens-Associated Invariant Chain 3 4
- Gamma Chain Of Class II Antigens 2 3
- Ia-Associated Invariant Chain 2 3
- MHC HLA-DR Gamma Chain 2 3
- HLA-DR-Gamma 2 3
- DHLAG 3 4
External Ids for CD74 Gene
- HGNC: 1697
- Entrez Gene: 972
- Ensembl: ENSG00000019582
- OMIM: 142790
- UniProtKB: P04233
Previous HGNC Symbols for CD74 Gene
- DHLAG
Previous GeneCards Identifiers for CD74 Gene
- GC05M149850
- GC05M149764
- GC05M149809
- GC05M149753
- GC05M144928
Summaries for CD74 Gene
-
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD74 Gene
CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Undifferentiated Pleomorphic Sarcoma and Mantle Cell Lymphoma. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include identical protein binding and amyloid-beta binding.
UniProtKB/Swiss-Prot for CD74 Gene
-
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Additional gene information for CD74 Gene
- Monarch Initiative
- Search for CD74 at DataMed
- Search for CD74 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD74 Gene
Genomics for CD74 Gene
GeneHancer (GH) Regulatory Elements for CD74 Gene
Promoters and enhancers for CD74 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD74 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD74 gene promoter:
-
- NF-kappaB1
- Pax-6
- AP-2gamma
Regulatory Element Products
Genomic Locations for CD74 Gene
Genomic Locations for CD74 Gene
- chr5:150,401,637-150,412,936
- (GRCh38/hg38)
- Size:
- 11,300 bases
- Orientation:
- Minus strand
- chr5:149,781,200-149,792,492
- (GRCh37/hg19)
- Size:
- 11,293 bases
- Orientation:
- Minus strand
Genomic View for CD74 Gene
Genes around CD74 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.1 by Entrez Gene
- 5q33.1 by HGNC
- 5q33.1 by Ensembl
CD74 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD74 Gene
Proteins for CD74 Gene
-
Protein details for CD74 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04233-HG2A_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen gamma chain
- Protein Accession:
- P04233
- A8K7R1
- B4DNE8
- D3DQG3
- D3DQG4
- Q14597
- Q29832
- Q5U0J8
- Q8SNA0
- Q8WLP6
Protein attributes for CD74 Gene
- Size:
- 296 amino acids
- Molecular mass:
- 33516 Da
- Quaternary structure:
-
- Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
- SequenceCaution:
-
- Sequence=AAA36304.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CD74 Gene
Protein Expression for CD74 Gene
Post-translational modifications for CD74 Gene
- N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
- Glycosylation at Ser281, posLast=256256, Thr203, posLast=136136, and posLast=130130
- Ubiquitination at posLast=170170 and Lys159
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- HG2A_HUMAN (659)
Other Protein References for CD74 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD74 (CD74)
-
Custom Antibody ServicesOriGene Antibodies for CD74
- Novus Biologicals Antibodies for CD74
-
Abcam antibodies for CD74
- Invitrogen Antibodies for CD74 (AFLGC-CD74)
- antibodies-online: Search results for 531 available CD74 Antibodies ranked by validation data
- Compare Top CD74 Antibodies
-
Recommended
- 64 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 305 WB Antibodies (anti-human)
- 95 FACS Antibodies (anti-human)
- 38 IHC Antibodies (anti-human)
- 18 IHC (p) Antibodies (anti-human)
- 14 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IF Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 RIA Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 7 WB Antibodies (anti-rat)
- GeneTex CD74 Antibody for CD74
-
Boster Bio Antibodies for CD74
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD74
- Sino Biological Antibodies for CD74
Protein Products
- R&D Systems Proteins and Enzymes for CD74
-
OriGene Purified Proteins for CD74
- Search Origene for MassSpec and Protein Over-expression Lysates for CD74
- Origene Custom Protein Services for CD74
- Sino Biological Recombinant Proteins for CD74
- Sino Biological Cell Lysates for CD74
- ProSpec Recombinant Proteins for CD74
- GeneTex Proteins for CD74
-
ProSci Proteins for CD74
- CD74 molecule, major histocompatibility complex, class II invariant chain [96-110]
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [92-450]
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [92-605]
-
Abcam proteins for CD74
No data available for DME Specific Peptides for CD74 Gene
Domains & Families for CD74 Gene
Gene Families for CD74 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Predicted membrane proteins
Protein Domains for CD74 Gene
Suggested Antigen Peptide Sequences for CD74 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD74 Gene
Function for CD74 Gene
Molecular function for CD74 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
- GENATLAS Biochemistry:
- cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies LN2,BU-43,BU-45,chain Ii,31kDa
Phenotypes From GWAS Catalog for CD74 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001540 | amyloid-beta binding | IPI | 19849849 |
| GO:0004896 | cytokine receptor activity | IDA | 17045821 |
| GO:0005515 | protein binding | IPI | 16242130 |
| GO:0019955 | cytokine binding | IPI,IEA | 12782713 |
| GO:0023026 | MHC class II protein complex binding | IDA | 1448172 |
Phenotypes for CD74 Gene
- MGI mutant phenotypes for CD74:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CD74:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
Animal Models for CD74 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD74
-
CRISPR Products
-
OriGene CRISPR knockouts for CD74
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD74
- genomics-online: gRNA clones - Search results for 155 available CD74 gene related products
- Overview of 155 available CD74 gene related products
- Applied Biological Materials CRISPR for CD74
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD74
- GenScript: Design CRISPR guide RNA sequences for CD74
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD74
- Browse OriGene Inhibitory RNA Products For CD74
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD74
- genomics-online: shRNA clones - Search results for 155 available CD74 gene related products
- Overview of 155 available CD74 gene related products
Clone Products
-
OriGene ORF clones in human for CD74
- RC205824
- RC205824L1
- RC205824L2
- RC205824L3
- RC205824L4
- RC206830
- RC206830L1
- RC206830L2
- RC206830L3
- RC206830L4
- RC212964
- RC212964L1
- RC212964L2
- RC212964L3
- RC212964L4
- RC512964
- RG205824
- RG206830
- RG212964
- RC205824L1V
- RC205824L2V
- RC205824L3V
- RC205824L4V
- RC206830L1V
- RC206830L2V
- RC206830L3V
- RC206830L4V
- RC212964L1V
- RC212964L2V
- RC212964L3V
- RC212964L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD74
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD74
- Applied Biological Materials Clones for CD74
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CD74
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD74 Gene
Localization for CD74 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD74 Gene
- Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| cytoskeleton | 3 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Golgi apparatus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005622 | intracellular | TAS,IEA | 12782713 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for CD74 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection | ||
| 2 | Influenza A | ||
| 3 | Tuberculosis | ||
| 4 | NF-kappaB Signaling | ||
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for CD74 Gene
5 Reactome pathways for CD74 Gene
3 KEGG pathways for CD74 Gene
2 GeneGo (Thomson Reuters) pathways for CD74 Gene
1 Cell Signaling Technology pathway for CD74 Gene
Interacting Proteins for CD74 Gene
Selected Interacting proteins:
P04233-HG2A_HUMAN
ENSP00000009530
for CD74 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CD74
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA | -- |
| GO:0001516 | prostaglandin biosynthetic process | IDA | 12782713 |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 24942581 |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IMP,IEA | 12782713 |
| GO:0002250 | adaptive immune response | IEA | -- |
Drugs & Compounds for CD74 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| milatuzumab | Investigational | Pharma | antibody | Therapeutic Antibodies | 0 |
Drug Products
Transcripts for CD74 Gene
mRNA/cDNA for CD74 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (4731) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000377795 1138 bps (uc003lse.4)
- ENST00000353334 1449 bps (uc003lsd.4)
- ENST00000518797 1727 bps (uc063ire.1)
- ENST00000524315 584 bps (uc063irf.1)
- ENST00000009530 981 bps (uc003lsc.4)
Unigene Clusters for CD74 Gene
- CD74 molecule, major histocompatibility complex, class II invariant chain:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CD74
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD74
- genomics-online: gRNA clones - Search results for 155 available CD74 gene related products
- Overview of 155 available CD74 gene related products
- Applied Biological Materials CRISPR for CD74
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD74
- GenScript: Design CRISPR guide RNA sequences for CD74
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD74
- Browse OriGene Inhibitory RNA Products For CD74
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD74
- genomics-online: shRNA clones - Search results for 155 available CD74 gene related products
- Overview of 155 available CD74 gene related products
Clone Products
-
OriGene ORF clones in human for CD74
- RC205824
- RC205824L1
- RC205824L2
- RC205824L3
- RC205824L4
- RC206830
- RC206830L1
- RC206830L2
- RC206830L3
- RC206830L4
- RC212964
- RC212964L1
- RC212964L2
- RC212964L3
- RC212964L4
- RC512964
- RG205824
- RG206830
- RG212964
- RC205824L1V
- RC205824L2V
- RC205824L3V
- RC205824L4V
- RC206830L1V
- RC206830L2V
- RC206830L3V
- RC206830L4V
- RC212964L1V
- RC212964L2V
- RC212964L3V
- RC212964L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD74
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD74
- Applied Biological Materials Clones for CD74
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - |
Expression for CD74 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Brain (Nervous System)
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
- Adipose (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Umbilical Cord (Extraembryonic Tissues)
- Colon (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Astrocytes (Nervous System)
- Glial Cells
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Tonsil (Hematopoietic System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for CD74 Gene
This gene is overexpressed in Spleen (x5.3) and Whole Blood (x4.6).
This gene is overexpressed in Lymph node (16.0), Blymphocyte (12.6), and Nasal epithelium (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD74 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD74 Gene:
CD74SOURCE GeneReport for Unigene cluster for CD74 Gene:
Hs.436568Evidence on tissue expression from TISSUES for CD74 Gene
- Spleen(5)
- Nervous system(5)
- Heart(4.9)
- Intestine(4.9)
- Lung(4.9)
- Liver(4.8)
- Blood(4.5)
- Stomach(4.5)
- Pancreas(4.4)
- Eye(3.9)
- Lymph node(3.8)
- Bone marrow(3.2)
- Muscle(3.2)
- Bone(3.1)
- Kidney(3.1)
- Skin(3.1)
- Gall bladder(2.9)
- Adrenal gland(2.7)
- Thyroid gland(2.4)
Primer Products
-
OriGene qPCR primer pairs for CD74
-
OriGene qPCR primer pairs and template standards for CD74
- genomics-online: primer clones - Search results for 155 available CD74 gene related products
- Overview of 155 available CD74 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD74 Gene
Orthologs for CD74 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD74 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD74 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cd74 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd74 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CD74 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CD74 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD74 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD74 33 |
|
||
| II 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CD74 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd74 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10251 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cd74a 34 |
|
OneToOne |
- Species where no ortholog for CD74 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CD74 Gene
- ENSEMBL:
- Gene Tree for CD74 (if available)
- TreeFam:
- Gene Tree for CD74 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD74: view image
Paralogs for CD74 Gene
(3) SIMAP similar genes for CD74 Gene using alignment to 6 proteins:
- HG2A_HUMAN
- E7EQJ3_HUMAN
- E7ER71_HUMAN
- E7ESL3_HUMAN
- H0YBZ2_HUMAN
- H0YBZ8_HUMAN
No data available for Paralogs for CD74 Gene
Variants for CD74 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000084815 | -- | 150,408,399(-) | G/A | intron_variant | |
| rs1000442955 | -- | 150,406,816(-) | T/G | intron_variant | |
| rs1000519043 | -- | 150,412,000(-) | T/C | intron_variant | |
| rs1000794707 | -- | 150,408,768(-) | T/C | intron_variant | |
| rs1000860894 | -- | 150,402,894(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
78.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD74 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD74
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD74 Gene
Disorders for CD74 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| undifferentiated pleomorphic sarcoma |
|
|
| mantle cell lymphoma |
|
|
| adenosquamous cell lung carcinoma |
|
|
Search CD74 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HG2A_HUMAN- Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein. {ECO:0000269 PubMed:12661006}.
Additional Disease Information for CD74
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CD74 Gene
Publications for CD74 Gene
- Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PMID: 3001652) Kudo J … Saunders GF (Nucleic acids research 1985) 2 3 4 58
- cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PMID: 6324166) Claesson L … Peterson PA (Proceedings of the National Academy of Sciences of the United States of America 1983) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen LL … Saavalainen P (Tissue antigens 2009) 3 44 58
- CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (PMID: 17045821) Shi X … Bucala R (Immunity 2006) 3 22 58
Products for CD74 Gene
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- Custom Antibody Services
- ProSci Proteins for CD74
- CD74 molecule, major histocompatibility complex, class II invariant chain [96-110]
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [92-450]
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [92-605]
- Horizon Cell Lines for CD74
- genomics-online: cdna clones - Search results for 155 available CD74 gene related products
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Sources for CD74 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
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- (28) ASD
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- (33) HomoloGene
- (34) PanEnsembl
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- (36) SGD
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- (39) Pseudogene
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- (47) Atlas
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- (49) GenBank
- (50) H-invDB
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- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
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- (58) PubMed
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- (65) Sino Biological
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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