CD72 Gene (Protein Coding)

CD72 Molecule

GC09M035610
GIFtS:
40
See more...

Aliases for CD72 Gene

Aliases for CD72 Gene

  • CD72 Molecule 2 3 5
  • CD72 Antigen 2 3 4
  • B-Cell Differentiation Antigen CD72 3 4
  • CD72b 2 3
  • Lyb-2 3 4
  • LYB2 2 3
  • CD72 5

External Ids for CD72 Gene

Previous GeneCards Identifiers for CD72 Gene

  • GC09M035922
  • GC09M035779
  • GC09M035599

Summaries for CD72 Gene

GeneCards Summary for CD72 Gene

CD72 (CD72 Molecule) is a Protein Coding gene. Diseases associated with CD72 include Small Intestine Lymphoma and Systemic Lupus Erythematosus. Among its related pathways are B cell receptor signaling pathway (KEGG) and Developmental Biology. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and carbohydrate binding.

UniProtKB/Swiss-Prot Summary for CD72 Gene

Additional gene information for CD72 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD72 Gene

Genomics for CD72 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CD72 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD72 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD72

Top Transcription factor binding sites by QIAGEN in the CD72 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • GATA-2
  • ITF-2
  • MRF-2
  • RP58
  • Tal-1beta
  • ZIC2
  • Zic3

Genomic Locations for CD72 Gene

Genomic Locations for CD72 Gene
chr9:35,609,979-35,646,810
(GRCh38/hg38)
Size:
36,832 bases
Orientation:
Minus strand
chr9:35,609,530-35,646,807
(GRCh37/hg19)
Size:
37,278 bases
Orientation:
Minus strand

Genomic View for CD72 Gene

Genes around CD72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD72 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD72 Gene

Proteins for CD72 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21854-CD72_HUMAN
    Recommended name:
    B-cell differentiation antigen CD72
    Protein Accession:
    P21854

    Protein attributes for CD72 Gene

    Size:
    359 amino acids
    Molecular mass:
    40220 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

neXtProt entry for CD72 Gene

Protein Expression for CD72 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD72 Gene

  • Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).
  • Glycosylation at Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for CD72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD72 Gene

Domains & Families for CD72 Gene

Gene Families for CD72 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD72 Gene

GenScript: Design optimal peptide antigens:
  • Lyb-2 (CD72_HUMAN)
  • CD72b (Q0H7P2_HUMAN)
  • CD72 antigen (Q5TLF7_HUMAN)
  • CD72 antigen (Q5TLF8_HUMAN)
  • CD72 antigen (Q5TLF9_HUMAN)
genes like me logo Genes that share domains with CD72: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD72 Gene

Function for CD72 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD72 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in B-cell proliferation and differentiation.
GENATLAS Biochemistry:
cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies S-HCL2,Bu-40,Bu-41,J3-109;homologous to mouse Lyb-2

Phenotypes From GWAS Catalog for CD72 Gene

Gene Ontology (GO) - Molecular Function for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA,NAS 1711157
GO:0005102 signaling receptor binding TAS 1711157
GO:0005515 protein binding IPI 1711157
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD72: view
genes like me logo Genes that share phenotypes with CD72: view

Animal Models for CD72 Gene

MGI Knock Outs for CD72:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD72

Clone Products

  • Addgene plasmids for CD72

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD72 Gene

Localization for CD72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD72 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD72 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 1711157
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD72: view

Pathways & Interactions for CD72 Gene

genes like me logo Genes that share pathways with CD72: view

Pathways by source for CD72 Gene

1 BioSystems pathway for CD72 Gene
1 KEGG pathway for CD72 Gene

SIGNOR curated interactions for CD72 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 1711157
genes like me logo Genes that share ontologies with CD72: view

Drugs & Compounds for CD72 Gene

Products:

  1. Drug

(2) Drugs for CD72 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CD72: view

Transcripts for CD72 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD72 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD72

Clone Products

  • Addgene plasmids for CD72

Alternative Splicing Database (ASD) splice patterns (SP) for CD72 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9:

Relevant External Links for CD72 Gene

GeneLoc Exon Structure for
CD72

Expression for CD72 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD72 Gene

mRNA expression in normal human tissues for CD72 Gene
mRNA expression by BioGPS for CD72 GenemRNA expression by GTEx for CD72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD72 Gene

This gene is overexpressed in Spleen (x20.9) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for CD72 Gene

This gene is overexpressed in Blymphocyte (35.2), Peripheral blood mononuclear cells (20.8), and Spleen (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD72 Gene



Protein tissue co-expression partners for CD72 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD72

SOURCE GeneReport for Unigene cluster for CD72 Gene:

Hs.116481

mRNA Expression by UniProt/SwissProt for CD72 Gene:

P21854-CD72_HUMAN
Tissue specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Evidence on tissue expression from TISSUES for CD72 Gene

  • Spleen(4.6)
  • Pancreas(4.1)
  • Lymph node(3.1)
  • Blood(2.6)
  • Bone marrow(2.5)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CD72: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD72 Gene

Orthologs for CD72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD72 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CD72 30 31
  • 99.35 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CD72 30 31
  • 77.4 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CD72 30 31
  • 76.95 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cd72 30 17 31
  • 70.35 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cd72 30
  • 68.48 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia CD72 31
  • 42 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CD72 31
  • 41 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CHB1 31
  • 23 (a)
 OneToMany
CD72 31
  • 11 (a)
 OneToMany
-- 31
  • 11 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 31 (a)
 OneToMany
-- 31
  • 29 (a)
 OneToMany
Species where no ortholog for CD72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD72 Gene

ENSEMBL:
Gene Tree for CD72 (if available)
TreeFam:
Gene Tree for CD72 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD72: view image

Paralogs for CD72 Gene

No data available for Paralogs for CD72 Gene

Variants for CD72 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD72 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs34791102 - p.Pro234Leu

Additional dbSNP identifiers (rs#s) for CD72 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD72 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv528256 CNV loss 19592680

Variation tolerance for CD72 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD72 Gene

Human Gene Mutation Database (HGMD)
CD72
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD72

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD72 Gene

Disorders for CD72 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD72 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
small intestine lymphoma
  • small intestinal lymphoma
systemic lupus erythematosus
  • sle
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CD72 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD72

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD72: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD72 Gene

Publications for CD72 Gene

  1. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. (PMID: 15459183) Hitomi Y … Tokunaga K (Human molecular genetics 2004) 3 23 41
  2. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PMID: 1711157) Van de Velde H … Thielemans K (Nature 1991) 2 3 23
  3. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. (PMID: 2044654) Von Hoegen I … Parnes JR (European journal of immunology 1991) 2 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. (PMID: 18071878) Xu J … Yang R (Journal of clinical immunology 2008) 3 41

ExternalLinks

View latest publications for CD72 gene in Mastermind

Products for CD72 Gene

  • Addgene plasmids for CD72
  • Signalway ELISA kits for CD72
  • Signalway Proteins for CD72

Sources for CD72 Gene