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Aliases for CD72 Gene

Aliases for CD72 Gene

  • CD72 Molecule 2 3 5
  • CD72 Antigen 2 3 4
  • Lyb-2 3 4
  • B-Cell Differentiation Antigen CD72 3
  • CD72b 3
  • LYB2 3

External Ids for CD72 Gene

Previous GeneCards Identifiers for CD72 Gene

  • GC09M035922
  • GC09M035779
  • GC09M035599

Summaries for CD72 Gene

GeneCards Summary for CD72 Gene

CD72 (CD72 Molecule) is a Protein Coding gene. Diseases associated with CD72 include Small Intestine Lymphoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Developmental Biology and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and carbohydrate binding.

UniProtKB/Swiss-Prot for CD72 Gene

  • Plays a role in B-cell proliferation and differentiation.

Additional gene information for CD72 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD72 Gene

Genomics for CD72 Gene

GeneHancer (GH) Regulatory Elements for CD72 Gene

Promoters and enhancers for CD72 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J035644 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 666.5 -2.0 -1998 9 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF207 CD72 SIT1 ARHGEF39 TMEM8B CCDC107 CA9 IL11RA LOC101926948
GH09J035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 660.5 +27.6 27603 6.4 HDGF PKNOX1 ATF1 SMAD1 RB1 SIN3A STAT5A BATF RFX5 ETS1 CD72 ARHGEF39 RGP1 CCDC107 RN7SL22P SIT1 CA9 RECK FAM166B TLN1
GH09J035602 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 23.9 +42.2 42220 3.6 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 E2F8 ZNF143 GC09M035603 TESK1 FAM166B CD72 ENSG00000231393 LOC101926948 CCDC107 RN7SL22P ARHGEF39 VCP
GH09J035811 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10 -165.3 -165254 1.9 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SPAG8 TPM2 CD72 HINT2 ENSG00000227388
GH09J035634 Enhancer 1.1 Ensembl ENCODE dbSUPER 16 +9.6 9623 6.1 HDGF MEIS2 CEBPG PAX8 BMI1 EGR1 NFATC1 EED ATF7 IKZF2 ARHGEF39 CA9 CCDC107 CD72 RN7SL22P GBA2 RGP1 MSMP ENSG00000228843 VCP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD72 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD72 gene promoter:
  • RP58
  • MRF-2
  • Tal-1beta
  • ITF-2
  • deltaCREB
  • Zic3
  • CREB
  • AML1a
  • GATA-2
  • ZIC2

Genomic Locations for CD72 Gene

Genomic Locations for CD72 Gene
chr9:35,609,533-35,646,857
(GRCh38/hg38)
Size:
37,325 bases
Orientation:
Minus strand
chr9:35,609,530-35,646,807
(GRCh37/hg19)
Size:
37,278 bases
Orientation:
Minus strand

Genomic View for CD72 Gene

Genes around CD72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD72 Gene

Proteins for CD72 Gene

  • Protein details for CD72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21854-CD72_HUMAN
    Recommended name:
    B-cell differentiation antigen CD72
    Protein Accession:
    P21854

    Protein attributes for CD72 Gene

    Size:
    359 amino acids
    Molecular mass:
    40220 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

neXtProt entry for CD72 Gene

Post-translational modifications for CD72 Gene

  • Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).
  • Glycosylation at Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for CD72 Gene

No data available for DME Specific Peptides for CD72 Gene

Domains & Families for CD72 Gene

Gene Families for CD72 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD72 Gene

Suggested Antigen Peptide Sequences for CD72 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD72: view

No data available for UniProtKB/Swiss-Prot for CD72 Gene

Function for CD72 Gene

Molecular function for CD72 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in B-cell proliferation and differentiation.
GENATLAS Biochemistry:
cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies S-HCL2,Bu-40,Bu-41,J3-109;homologous to mouse Lyb-2

Phenotypes From GWAS Catalog for CD72 Gene

Gene Ontology (GO) - Molecular Function for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 1711157
GO:0005102 signaling receptor binding TAS 1711157
GO:0005515 protein binding IPI 1711157
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD72: view
genes like me logo Genes that share phenotypes with CD72: view

Animal Models for CD72 Gene

MGI Knock Outs for CD72:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD72 Gene

Localization for CD72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD72 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD72 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 1711157
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD72: view

Pathways & Interactions for CD72 Gene

genes like me logo Genes that share pathways with CD72: view

Pathways by source for CD72 Gene

1 BioSystems pathway for CD72 Gene
1 KEGG pathway for CD72 Gene

SIGNOR curated interactions for CD72 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CD72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 1711157
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with CD72: view

Drugs & Compounds for CD72 Gene

(2) Drugs for CD72 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CD72: view

Transcripts for CD72 Gene

mRNA/cDNA for CD72 Gene

Unigene Clusters for CD72 Gene

CD72 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD72 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: - -
SP9:

Relevant External Links for CD72 Gene

GeneLoc Exon Structure for
CD72
ECgene alternative splicing isoforms for
CD72

Expression for CD72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD72 Gene

This gene is overexpressed in Spleen (x20.9) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for CD72 Gene

This gene is overexpressed in Blymphocyte (35.2), Peripheral blood mononuclear cells (20.8), and Spleen (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD72 Gene



Protein tissue co-expression partners for CD72 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD72 Gene:

CD72

SOURCE GeneReport for Unigene cluster for CD72 Gene:

Hs.116481

mRNA Expression by UniProt/SwissProt for CD72 Gene:

P21854-CD72_HUMAN
Tissue specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Evidence on tissue expression from TISSUES for CD72 Gene

  • Spleen(4.5)
  • Pancreas(4)
  • Lymph node(2.5)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CD72: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD72 Gene

Orthologs for CD72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD72 34 33
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD72 34 33
  • 77.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD72 34 33
  • 76.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd72 16 34 33
  • 70.35 (n)
rat
(Rattus norvegicus)
Mammalia Cd72 33
  • 68.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD72 34
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD72 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHB1 34
  • 23 (a)
OneToMany
CD72 34
  • 11 (a)
OneToMany
-- 34
  • 11 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
Species where no ortholog for CD72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD72 Gene

ENSEMBL:
Gene Tree for CD72 (if available)
TreeFam:
Gene Tree for CD72 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD72: view image

Paralogs for CD72 Gene

No data available for Paralogs for CD72 Gene

Variants for CD72 Gene

Sequence variations from dbSNP and Humsavar for CD72 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000058731 -- 35,638,800(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000096557 -- 35,632,070(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000105675 -- 35,640,585(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000513122 -- 35,610,046(-) G/A 3_prime_UTR_variant
rs1000528127 -- 35,615,217(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD72 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv528256 CNV loss 19592680

Variation tolerance for CD72 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD72 Gene

Human Gene Mutation Database (HGMD)
CD72
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD72

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD72 Gene

Disorders for CD72 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD72 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
small intestine lymphoma
  • small intestinal lymphoma
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CD72 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD72

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD72: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD72 Gene

Publications for CD72 Gene

  1. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. (PMID: 15459183) Hitomi Y … Tokunaga K (Human molecular genetics 2004) 3 22 44 58
  2. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PMID: 1711157) Van de Velde H … Thielemans K (Nature 1991) 2 3 22 58
  3. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. (PMID: 2044654) Von Hoegen I … Parnes JR (European journal of immunology 1991) 2 3 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. (PMID: 18071878) Xu J … Yang R (Journal of clinical immunology 2008) 3 44 58

Products for CD72 Gene

Sources for CD72 Gene

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