The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokin... See more...

Aliases for CD70 Gene

Aliases for CD70 Gene

  • CD70 Molecule 2 3 5
  • CD27L 2 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 7 3 4
  • CD70 Antigen 3 4
  • CD27 Ligand 3 4
  • CD27-L 3 4
  • CD27LG 3 4
  • TNFSF7 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 7 2
  • Tumor Necrosis Factor Ligand 8A 3
  • Surface Antigen CD70 3
  • Ki-24 Antigen 3
  • TNLG8A 3
  • LPFS3 3
  • CD70 5

External Ids for CD70 Gene

Previous HGNC Symbols for CD70 Gene

  • CD27LG
  • TNFSF7

Previous GeneCards Identifiers for CD70 Gene

  • GC19M006537
  • GC19M006538
  • GC19M006346

Summaries for CD70 Gene

Entrez Gene Summary for CD70 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD70 Gene

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Acute Myocarditis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protease binding.

UniProtKB/Swiss-Prot Summary for CD70 Gene

  • Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD70 Gene

Genomics for CD70 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006588 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 257.3 +13.8 13833 3.1 ZNF207 IKZF1 ZNF600 POLR2A ZBTB10 SIN3A TARDBP TRIM22 SP2 YY1 CD70 PRR22 TNFSF9 PSPN RPL7P50 piR-61101-322
GH19J006599 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 250.7 +1.9 1933 5.1 SP1 ZNF207 NCOR1 IKZF1 MYC SIX5 ZNF592 ZNF10 NFIC CEBPB CD70 piR-51999-004 piR-56133-104 piR-60340-012 SAFB KHSRP GTF2F1 RPL7P50 TNFSF9
GH19J006592 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 18.5 +11.5 11534 0.7 BCLAF1 ATF2 POLR2A ZNF592 TAF1 BHLHE40 IKZF1 HDGF JUNB STAT1 RPL7P50 lnc-TNFSF9-3 CD70 TNFSF9 DENND1C ZNF557 piR-61101-322
GH19J006575 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +25.7 25656 5.5 BCLAF1 SP1 ZNF207 IKZF1 NCOR1 JUND POLR2A NFIC BCL11A ZNF592 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 piR-38129-054 piR-61945-242
GH19J006517 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 7.6 +85.8 85827 1.1 SP1 BCL11A TRIM22 MAFF IRF4 SMC3 ZNF316 EBF1 SMARCA5 MAFK CD70 TNFSF9 RFX2 HSALNG0123556 piR-46662-319 TUBB4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD70 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD70

Top Transcription factor binding sites by QIAGEN in the CD70 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for CD70 Gene

Latest Assembly
chr19:6,581,648-6,604,103
(GRCh38/hg38)
Size:
22,456 bases
Orientation:
Minus strand

Previous Assembly
chr19:6,581,659-6,591,161
(GRCh37/hg19 by Entrez Gene)
Size:
9,503 bases
Orientation:
Minus strand

chr19:6,583,194-6,604,114
(GRCh37/hg19 by Ensembl)
Size:
20,921 bases
Orientation:
Minus strand

Genomic View for CD70 Gene

Genes around CD70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD70 Gene

Proteins for CD70 Gene

  • Protein details for CD70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32970-CD70_HUMAN
    Recommended name:
    CD70 antigen
    Protein Accession:
    P32970
    Secondary Accessions:
    • B4DPR8
    • Q53XX4
    • Q96J57

    Protein attributes for CD70 Gene

    Size:
    193 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for CD70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD70 Gene

Post-translational modifications for CD70 Gene

  • Glycosylation at Asn63, Tyr74, and Asn170
  • Modification sites at PhosphoSitePlus

Other Protein References for CD70 Gene

Antibodies for research

  • Abcam antibodies for CD70

No data available for DME Specific Peptides for CD70 Gene

Domains & Families for CD70 Gene

Gene Families for CD70 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD70 Gene

Suggested Antigen Peptide Sequences for CD70 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60770, highly similar to Tumor necrosis factor ligand superfamilymember 7 (B4DPR8_HUMAN)
  • Tumor necrosis factor ligand superfamily member 7 (CD70_HUMAN)
  • Tumor necrosis factor (Ligand) superfamily, member 7, isoform CRA_a (Q53XX4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32970

UniProtKB/Swiss-Prot:

CD70_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with CD70: view

Function for CD70 Gene

Molecular function for CD70 Gene

UniProtKB/Swiss-Prot Function:
Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Phenotypes From GWAS Catalog for CD70 Gene

Gene Ontology (GO) - Molecular Function for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005102 signaling receptor binding TAS 8120384
GO:0005125 cytokine activity IMP 28011863
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 12324477
genes like me logo Genes that share ontologies with CD70: view
genes like me logo Genes that share phenotypes with CD70: view

Human Phenotype Ontology for CD70 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD70 Gene

MGI Knock Outs for CD70:
  • Cd70 Cd70<tm1.1Jda>

Animal Models for research

  • Taconic Biosciences Mouse Models for CD70

miRNA for CD70 Gene

miRTarBase miRNAs that target CD70

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD70

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD70 Gene

Localization for CD70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD70 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 8120384
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD70: view

Pathways & Interactions for CD70 Gene

PathCards logo

SuperPathways for CD70 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions
4 Akt Signaling
.60
.60
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with CD70: view

Pathways by source for CD70 Gene

1 KEGG pathway for CD70 Gene
1 GeneGo (Thomson Reuters) pathway for CD70 Gene
  • Apoptosis and survival Apoptotic TNF-family pathways
17 Qiagen pathways for CD70 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • CD27 Pathway
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for CD70 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002456 T cell mediated immunity IMP 28011863
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8387892
GO:0007267 cell-cell signaling TAS 8387892
GO:0019724 B cell mediated immunity IMP 28011863
genes like me logo Genes that share ontologies with CD70: view

Drugs & Compounds for CD70 Gene

(7) Drugs for CD70 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDX-1203 Pharma 0
MDX-1411 Pharma 0
SGN-70 Pharma antibody 0
SGN-75 Pharma antibody 0

(1) Additional Compounds for CD70 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD70: view

Transcripts for CD70 Gene

mRNA/cDNA for CD70 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD70

Alternative Splicing Database (ASD) splice patterns (SP) for CD70 Gene

No ASD Table

Relevant External Links for CD70 Gene

GeneLoc Exon Structure for
CD70

Expression for CD70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD70 Gene

This gene is overexpressed in Liver (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD70 Gene



Protein tissue co-expression partners for CD70 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD70

SOURCE GeneReport for Unigene cluster for CD70 Gene:

Hs.501497

Evidence on tissue expression from TISSUES for CD70 Gene

  • Kidney(4.4)
  • Blood(3.2)
  • Lymph node(2.5)
  • Spleen(2.3)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with CD70: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD70 Gene

Orthologs for CD70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD70 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia CD70 29 30
  • 77.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD70 29 30
  • 72.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd70 29
  • 64.59 (n)
Mouse
(Mus musculus)
Mammalia Cd70 29 16 30
  • 64.25 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia CD70 30
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD70 30
  • 35 (a)
OneToOne
Species where no ortholog for CD70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD70 Gene

ENSEMBL:
Gene Tree for CD70 (if available)
TreeFam:
Gene Tree for CD70 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD70: view image
Alliance of Genome Resources:
Additional Orthologs for CD70

Paralogs for CD70 Gene

No data available for Paralogs for CD70 Gene

Variants for CD70 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD70 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1568431102 Pathogenic: Severe combined immunodeficiency due to CD70 deficiency 6,586,044(-) AAAG/A
NM_001252.5(CD70):c.552_554CTT[1] (p.Phe186del)
INFRAME_DELETION,INTRON
rs1568431262 Pathogenic: Severe combined immunodeficiency due to CD70 deficiency 6,586,351(-) GA/G
NM_001252.5(CD70):c.250del (p.Ser84fs)
FRAMESHIFT
rs368303189 Pathogenic: Severe combined immunodeficiency due to CD70 deficiency 6,586,067(-) G/A
NM_001252.5(CD70):c.535C>T (p.Arg179Ter)
NONSENSE,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CD70 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CD70 Gene

Variant ID Type Subtype PubMed ID
esv3893161 CNV gain 25118596
nsv833728 CNV loss 17160897
nsv978762 CNV duplication 23825009

Variation tolerance for CD70 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD70 Gene

Human Gene Mutation Database (HGMD)
CD70
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD70
Leiden Open Variation Database (LOVD)
CD70

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD70 Gene

Disorders for CD70 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CD70 Gene - From: OMI, CVR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
lymphoproliferative syndrome 3
  • lpfs3
acute myocarditis
combined immunodeficiency
  • combined t cell and b cell immunodeficiency
lymphoproliferative syndrome 2
  • lpfs2
macroglobulinemia
  • primary macroglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search CD70 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD70_HUMAN
  • Lymphoproliferative syndrome 3 (LPFS3) [MIM:618261]: An autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections. {ECO:0000269 PubMed:28011863, ECO:0000269 PubMed:28011864}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for CD70

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CD70: view

No data available for Genatlas for CD70 Gene

Publications for CD70 Gene

  1. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. (PMID: 28011864) Abolhassani H … Pan-Hammarström Q (The Journal of experimental medicine 2017) 3 4 72
  2. Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection. (PMID: 28011863) Izawa K … Latour S (The Journal of experimental medicine 2017) 3 4 72
  3. The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman MR … Herrmann S (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4
  4. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PMID: 8387892) Goodwin RG … Hennen K (Cell 1993) 2 3 4
  5. Epigenetic silencing of TNFSF7 (CD70) by DNA methylation during progression to breast cancer. (PMID: 20119871) Yu SE … Jang YK (Molecules and cells 2010) 3 22

Products for CD70 Gene

  • Addgene plasmids for CD70

Sources for CD70 Gene