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This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Coccidioidomycosis and Eosinophilic Pneumonia. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Kit receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is CLEC2A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | TAS | 8340758 |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16525420 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0042802 | identical protein binding | IDA | 11101293 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005887 | integral component of plasma membrane | TAS | 8340758 |
GO:0009897 | external side of plasma membrane | IEA,IBA | 21873635 |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
2 | Kit receptor signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035690 | cellular response to drug | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
tocilizumab | Approved | Pharma | Immunotherapies | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||
SP2: | - | - | - | ||||||||||||
SP3: | - | ||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD69 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD69 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD69 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd69 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd69 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD69 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD69 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC769354 30 |
|
||
-- 31 |
|
OneToMany | |||
BLEC1 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Y-LEC1 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
17.5 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769384 | Benign: not provided | 9,753,550(-) | T/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759878 | CNV | gain+loss | 17122850 |
nsv1051530 | CNV | gain | 25217958 |
nsv952801 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
coccidioidomycosis |
|
|
eosinophilic pneumonia |
|
|
milk allergy |
|
|
chronic eosinophilic pneumonia |
|
|
allergic asthma |
|