Aliases for CD63 Gene
Aliases for CD63 Gene
External Ids for CD63 Gene
- HGNC: 1692
- Entrez Gene: 967
- Ensembl: ENSG00000135404
- OMIM: 155740
- UniProtKB: P08962
Previous HGNC Symbols for CD63 Gene
- MLA1
Previous GeneCards Identifiers for CD63 Gene
- GC12M056043
- GC12M056192
- GC12M055834
- GC12M054405
- GC12M056119
- GC12M053159
Summaries for CD63 Gene
-
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
GeneCards Summary for CD63 Gene
CD63 (CD63 Molecule) is a Protein Coding gene. Diseases associated with CD63 include Hermansky-Pudlak Syndrome and Melanoma. Among its related pathways are Proteoglycans in cancer and Innate Immune System. An important paralog of this gene is TSPAN33.
UniProtKB/Swiss-Prot for CD63 Gene
-
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD63 Gene
Genomics for CD63 Gene
GeneHancer (GH) Regulatory Elements for CD63 Gene
Promoters and enhancers for CD63 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CD63 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CD63 Gene
Genomic Locations for CD63 Gene
- chr12:55,725,323-55,729,707
- (GRCh38/hg38)
- Size:
- 4,385 bases
- Orientation:
- Minus strand
- chr12:56,119,107-56,123,491
- (GRCh37/hg19)
Genomic View for CD63 Gene
Genes around CD63 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC
- 12q13.2 by Ensembl
CD63 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD63 Gene
Proteins for CD63 Gene
-
Protein details for CD63 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08962-CD63_HUMAN
- Recommended name:
- CD63 antigen
- Protein Accession:
- P08962
- F8VZE2
- Q5TZP3
- Q8N6Z9
- Q9UCG6
Protein attributes for CD63 Gene
- Size:
- 238 amino acids
- Molecular mass:
- 25637 Da
- Quaternary structure:
-
- Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1 (PubMed:16917503, PubMed:24635319). Interacts with CD9. Identified in a complex with CD9 and ITGB3 (PubMed:19640571). Interacts with PMEL (PubMed:21962903). Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes (PubMed:23632027). Interacts with SYT7 (By similarity).
- Miscellaneous:
-
- Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
- This antigen is associated with early stages of melanoma tumor progression.
Protein Expression for CD63 Gene
Post-translational modifications for CD63 Gene
- Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
- Glycosylation at Asn172, posLast=150150, and Asn130
- Ubiquitination at posLast=110110
- Modification sites at PhosphoSitePlus
Other Protein References for CD63 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD63 (CD63)
-
Custom Antibody ServicesOriGene Antibodies for CD63
- AM32335PU-N
- AM33263PU-N
- AM33263PU-S
- AM33263PU-T
- AM33301PU-N
- AM33301PU-S
- AM33301PU-T
- AM50244PU-N
- AM50244PU-S
- AM50244PU-T
- AP20598PU-N
- SM3035APC
- SM3035B
- SM3035F
- SM3035P
- SM3035PP
- SM3035R
- TA327649
- TA350816
- TA353711
- TA802750
- CF802750
- TA802751
- CF802751
- TA802752
- CF802752
- TA802810
- CF802810
- TA802811
- CF802811
- TA802840
- CF802840
- TA802849
- CF802849
- TA802919
- CF802919
- TA803392
- CF803392
- TA803393
- CF803393
- TA803394
- CF803394
- TA803502
- CF803502
- TA803574
- CF803574
- TA803823
- CF803823
- TA804012
- CF804012
- TA804013
- CF804013
- TA804014
- CF804014
- TA804016
- CF804016
- TA890020
- Novus Biologicals Antibodies for CD63
- Invitrogen Antibodies for CD63
- GeneTex CD63 Antibody for CD63
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD63
- Sino Biological Antibodies for CD63
Protein Products
-
OriGene Purified Proteins for CD63
- Search Origene for MassSpec and Protein Over-expression Lysates for CD63
- Origene Custom Protein Services for CD63
- Sino Biological Cell Lysates for CD63
- Sino Biological Recombinant Proteins for CD63
- Search GeneTex for Proteins for CD63
Assay Products
No data available for DME Specific Peptides for CD63 Gene
Domains & Families for CD63 Gene
Gene Families for CD63 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for CD63 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD63 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08962- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for CD63 Gene
Molecular function for CD63 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
- GENATLAS Biochemistry:
- cell differentiation antigen CD63 (melanoma 1 antigen)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16917503 |
Phenotypes for CD63 Gene
- MGI mutant phenotypes for CD63:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CD63:
Animal Models for CD63 Gene
- MGI Knock Outs for CD63:
-
- Cd63 Cd63<tm1Psa>
Animal Model Products
-
Taconic Biosciences Mouse Models for CD63
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD63
-
CRISPR Products
-
OriGene CRISPR knockouts for CD63
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD63
- genomics-online: gRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- Applied Biological Materials CRISPR for CD63
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD63
- GenScript: Design CRISPR guide RNA sequences for CD63
miRNA for CD63 Gene
- miRTarBase miRNAs that target CD63
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CD63
- Browse OriGene Inhibitory RNA Products For CD63
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD63
- genomics-online: shRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD63
- VectorBuilder custom plasmid, inducible vectors for CD63
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD63
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD63
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD63
- Applied Biological Materials Clones for CD63
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD63
Cell Line Products
-
Horizon Cell Lines for CD63
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD63 Gene
Localization for CD63 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD63 Gene
- Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, exosome. Cell surface. Note=Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903). {ECO:0000269 PubMed:10793155, ECO:0000269 PubMed:21962903, ECO:0000269 PubMed:7682577}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| cytoskeleton | 2 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 25645918 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IDA,TAS | 22431521 |
| GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for CD63 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Lysosome |
-
|
|
| 4 | Proteoglycans in cancer | ||
| 5 | Adhesion |
-
|
|
Pathways by source for CD63 Gene
7 Reactome pathways for CD63 Gene
2 KEGG pathways for CD63 Gene
2 Cell Signaling Technology pathways for CD63 Gene
Interacting Proteins for CD63 Gene
Selected Interacting proteins:
P08962-CD63_HUMAN
ENSP00000257857
for CD63 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for CD63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002092 | positive regulation of receptor internalization | IMP | 23632027 |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0007155 | cell adhesion | IBA | -- |
| GO:0007160 | cell-matrix adhesion | IMP | 23632027 |
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for CD63 Gene
Transcripts for CD63 Gene
mRNA/cDNA for CD63 Gene
- (1311) Selected AceView cDNA sequences:
- (12) Additional mRNA sequences :
- (10) REFSEQ mRNAs :
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000257857 1070 bps (uc001shn.5)
- ENST00000420846 981 bps (uc031qhv.1)
- ENST00000546457 607 bps (uc058pbe.1)
- ENST00000546939 779 bps (uc031qht.2)
- ENST00000548117 499 bps (uc058pax.1)
CRISPR Products
-
OriGene CRISPR knockouts for CD63
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD63
- genomics-online: gRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- Applied Biological Materials CRISPR for CD63
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD63
- GenScript: Design CRISPR guide RNA sequences for CD63
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CD63
- Browse OriGene Inhibitory RNA Products For CD63
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD63
- genomics-online: shRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD63
- VectorBuilder custom plasmid, inducible vectors for CD63
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD63
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD63
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD63
- Applied Biological Materials Clones for CD63
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD63
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
Expression for CD63 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Placenta (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
This gene is overexpressed in Nasal epithelium (17.1), Neutrophil (8.7), and Amniocyte (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD63 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD63 Gene:
CD63SOURCE GeneReport for Unigene cluster for CD63 Gene:
Hs.445570mRNA Expression by UniProt/SwissProt for CD63 Gene:
P08962-CD63_HUMAN
Tissue specificity:
Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Evidence on tissue expression from TISSUES for CD63 Gene
- Skin(5)
- Lung(4.9)
- Blood(4.7)
- Liver(4.6)
- Muscle(4.6)
- Nervous system(4.6)
- Pancreas(4.5)
- Intestine(4)
- Heart(3.6)
- Kidney(3.4)
- Spleen(3.4)
- Eye(3.3)
- Bone marrow(3.2)
- Lymph node(3.1)
- Gall bladder(2.6)
- Stomach(2.6)
- Adrenal gland(2.5)
- Thyroid gland(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for CD63
-
OriGene qPCR primer pairs for CD63
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD63 Gene
Orthologs for CD63 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD63 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD63 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD63 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Cd63 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd63 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | CD63 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd63 33 |
|
||
| Str.8003 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cd63 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9569 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tsp29Fa 34 33 |
|
OneToMany | |
| Tsp47F 34 |
|
OneToMany | |||
| Tsp39D 34 |
|
OneToMany | |||
| Tsp29Fb 34 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009651 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tsp-7 34 33 |
|
OneToOne |
- Species where no ortholog for CD63 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CD63 Gene
- ENSEMBL:
- Gene Tree for CD63 (if available)
- TreeFam:
- Gene Tree for CD63 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD63: view image
Paralogs for CD63 Gene
Paralogs for CD63 Gene
(20) SIMAP similar genes for CD63 Gene using alignment to 7 proteins:
- CD63_HUMAN
- C9JV86_HUMAN
- F8VNT9_HUMAN
- F8VV56_HUMAN
- F8VWK8_HUMAN
- F8VX62_HUMAN
- F8W022_HUMAN
Variants for CD63 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs483352715 | uncertain-significance, not provided | 55,726,202(-) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1000274649 | -- | 55,727,489(-) | G/A | intron_variant | |
| rs1000613765 | -- | 55,730,534(-) | G/A | upstream_transcript_variant | |
| rs1000876538 | -- | 55,729,350(-) | G/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000943290 | -- | 55,730,230(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.68;
32.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD63 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD63
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD63 Gene
Disorders for CD63 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hermansky-pudlak syndrome |
|
|
| melanoma |
|
|
| hermansky-pudlak syndrome 9 |
|
|
| quebec platelet disorder |
|
|
| skin melanoma |
|
|
Search CD63 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD63
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD63 Gene
Publications for CD63 Gene
- The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. (PMID: 7682577) Nishibori M … Gerrard JM (The Journal of clinical investigation 1993) 3 4 22 58
- An ocular melanoma-associated antigen. Molecular characterization. (PMID: 1339263) Wang MX … Donoso LA (Archives of ophthalmology (Chicago, Ill. : 1960) 1992) 3 4 22 58
- TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling. (PMID: 24635319) Lee SY … Lee MA (The Biochemical journal 2014) 3 4 58
- Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. (PMID: 23632027) Tugues S … Claesson-Welsh L (The Journal of biological chemistry 2013) 3 4 58
- Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. (PMID: 22660413) Baietti MF … David G (Nature cell biology 2012) 3 4 58
Products for CD63 Gene
- R&D Systems Antibodies for CD63 (CD63)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD63
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD63
- AM32335PU-N
- AM33263PU-N
- AM33263PU-S
- AM33263PU-T
- AM33301PU-N
- AM33301PU-S
- AM33301PU-T
- AM50244PU-N
- AM50244PU-S
- AM50244PU-T
- AP20598PU-N
- SM3035APC
- SM3035B
- SM3035F
- SM3035P
- SM3035PP
- SM3035R
- TA327649
- TA350816
- TA353711
- TA802750
- CF802750
- TA802751
- CF802751
- TA802752
- CF802752
- TA802810
- CF802810
- TA802811
- CF802811
- TA802840
- CF802840
- TA802849
- CF802849
- TA802919
- CF802919
- TA803392
- CF803392
- TA803393
- CF803393
- TA803394
- CF803394
- TA803502
- CF803502
- TA803574
- CF803574
- TA803823
- CF803823
- TA804012
- CF804012
- TA804013
- CF804013
- TA804014
- CF804014
- TA804016
- CF804016
- TA890020
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD63
- Search Origene for MassSpec and Protein Over-expression Lysates for CD63
- Origene Custom Protein Services for CD63
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CD63
- Browse OriGene Inhibitory RNA Products For CD63
- OriGene qPCR primer pairs and template standards for CD63
- OriGene qPCR primer pairs for CD63
- OriGene CRISPR knockouts for CD63
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD63
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD63 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD63
- GenScript Custom Assay Services for CD63
- GenScript Custom overexpressing Cell Line Services for CD63
- GenScript: Design CRISPR guide RNA sequences for CD63
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD63
- Sino Biological Human cDNA Clone for CD63
- Sino Biological Cell Lysates for CD63
- Sino Biological Recombinant Proteins for CD63
- Sino Biological Antibodies for CD63
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD63
- Novus Biologicals proteins and lysates for CD63
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CD63
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for CD63
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD63
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD63
- antibodies-online: Search results for 560 available CD63 Antibodies ranked by validation data
- Compare Top CD63 Antibodies
- antibodies-online: Search results for 28 available CD63 Elisa Kits ranked by validation data
- Compare Top CD63 Elisa Kits
- antibodies-online: Search results for 23 available CD63 Proteins ranked by validation data
- Compare Top CD63 Proteins
- GeneTex CD63 Antibody for CD63
- Search GeneTex for Proteins for CD63
- Santa Cruz Biotechnology (SCBT) Antibodies for CD63
- Search Santa Cruz Biotechnology (SCBT) for CD63 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD63
- Horizon Cell Lines for CD63
- genomics-online: cdna clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- orf clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- genomics-online: gRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- genomics-online: primer clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- genomics-online: shRNA clones - Search results for 175 available CD63 gene related products
- Overview of 175 available CD63 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD63
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD63
- GeneCopoeia miRNA 3'UTR Target clone products for CD63
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD63
Sources for CD63 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio