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This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility t... See more...
Aliases for CD6 Gene
Aliases for CD6 Gene
External Ids for CD6 Gene
- HGNC: 1691
- NCBI Entrez Gene: 923
- Ensembl: ENSG00000013725
- OMIM®: 186720
- UniProtKB/Swiss-Prot: P30203
Previous GeneCards Identifiers for CD6 Gene
- GC11P063132
- GC11P062252
- GC11P060990
- GC11P060514
- GC11P060495
- GC11P060743
- GC11P057086
Summaries for CD6 Gene
-
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for CD6 Gene
CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Multiple Sclerosis. Among its related pathways are Cell adhesion molecules. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163.
UniProtKB/Swiss-Prot Summary for CD6 Gene
-
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Additional gene information for CD6 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD6 Gene
Genomics for CD6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD6
- Top Transcription factor binding sites by QIAGEN in the CD6 gene promoter:
-
- AML1a
- AP-1
- ATF-2
- c-Jun
- NF-kappaB
- NF-kappaB1
- YY1
Genomic Locations for CD6 Gene
Latest Assembly
- chr11:60,971,678-61,020,377
- (GRCh38/hg38)
- Size:
- 48,700 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:60,739,152-60,787,849
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 48,698 bases
- Orientation:
- Plus strand
Genomic View for CD6 Gene
Genes around CD6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.2 by HGNC
- 11q12.2 by Entrez Gene
- 11q12.2 by Ensembl
CD6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD6 Gene
Proteins for CD6 Gene
-
Protein details for CD6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30203-CD6_HUMAN
- Recommended name:
- T-cell differentiation antigen CD6
- Protein Accession:
- P30203
- A4KAD4
- A4KAD5
- Q9UMF2
- Q9Y4K7
- Q9Y4K8
- Q9Y4K9
- Q9Y4L0
Protein attributes for CD6 Gene
- Size:
- 668 amino acids
- Molecular mass:
- 71801 Da
- Quaternary structure:
-
- Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185). Interacts with the TCR/CD3 complex subunit CD3E (PubMed:15294938). Interacts (via tyrosine phosphorylated C-terminus) with LCP2 (via SH2 domain) (PubMed:16914752). Interacts with VAV1 (By similarity). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (PubMed:24945728).
- Miscellaneous:
-
- [Isoform 6]: Lacks the third SRCR domain and doesn't bind ALCAM/CD166. Doesn't localize to the immunological synapse.
- [Isoform 7]: Lacks the third SRCR domain and doesn't bind ALCAM/CD166. Doesn't localize to the immunological synapse. Constitutes the only expressed species in a small percentage of T-cells.
Protein Expression for CD6 Gene
Post-translational modifications for CD6 Gene
- After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
- Glycosylated.
-
Glycosylation at Asn28, Asn49, Asn112, Asn118, Asn229, Asn368, Asn339, and Asn345
- NX_P30203 (NX_P30203-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CD6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CD6 Monoclonal Antibody (LS-B12171) and CD6 Monoclonal Antibody (LS-B12863)
- G Biosciences Immunotag™ CD6 Antibody (ITA1431-100u) and Immunotag™ CD6 Antibody (ITA5435-100u)
- NSJ Bioreagents CD6 Antibody (Mouse Monoclonal)
- BioLegend CD6 Antibody (313904) and CD6 Antibody (313906)
- Novus Biologicals Antibodies for CD6
- Invitrogen Antibodies for CD6 (AFLGC-CD6)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD6
- Sino Biological Antibodies for CD6
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CD6
- Origene Custom Protein Services for CD6
- Novus Biologicals lysates for CD6
- Sino Biological Recombinant Proteins for CD6
- Sino Biological Cell Lysates for CD6
- antibodies-online: Show 17 available CD6 Proteins ranked by validation data
- Compare Top CD6 Proteins
-
Abcam proteins for CD6
Assay products for research
- G Biosciences Immunotag™ T-cell differentiation antigen CD6 ELISA Kit
- RayBiotech Custom Human CD6 ELISA
- Novus Biologicals ELISA Kits for CD6
- antibodies-online: Show 21 available CD6 Elisa Kits ranked by validation data
- Compare Top CD6 Elisa Kits
-
Quality Products:
-
Abcam assays for CD6
- Sino Biological Assays for CD6
No data available for DME Specific Peptides for CD6 Gene
Domains & Families for CD6 Gene
Gene Families for CD6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD6 Gene
- InterPro:
- Blocks:
-
- Speract/scavenger receptor
Suggested Antigen Peptide Sequences for CD6 Gene
- GenScript: Design optimal peptide antigens:
-
- CD6deltaD3 (A4KAD4_HUMAN)
- CD6deltaD3Ex6 (A4KAD5_HUMAN)
- TP120 (CD6_HUMAN)
- CD6 molecule (Q6AZ88_HUMAN)
- CD6 protein (Q8N4Q7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD6 Gene
Function for CD6 Gene
Molecular function for CD6 Gene
- UniProtKB/Swiss-Prot Function:
- Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
- GENATLAS Biochemistry:
- cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed on mature T-cell,B-cell subset,thymocyte
Phenotypes From GWAS Catalog for CD6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IDA | 17601777 |
| GO:0005044 | scavenger receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 24584089 |
| GO:0042802 | identical protein binding | IPI | 26146185 |
| GO:0070891 | lipoteichoic acid binding | IMP | 17601777 |
Phenotypes for CD6 Gene
- MGI mutant phenotypes for CD6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CD6:
Animal Models for CD6 Gene
- MGI Knock Outs for CD6:
-
- Cd6 Cd6<tm1Linf>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CD6 - Starting at $85 >
- * CD6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CD6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD6
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD6
- Browse OriGene Inhibitory RNA Products For CD6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD6
Clone products for research
- Applied Biological Materials (abm): Clones for CD6 - Starting at $45 >
- * CD6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CD6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD6
Cell Lines for research
-
Horizon Cell Lines for CD6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD6 Gene
Localization for CD6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD6 Gene
- Cell membrane. Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269 PubMed:15294938}.
- [Soluble CD6]: Secreted. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IDA | 15294938 |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1919444 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD6 Gene
Pathways & Interactions for CD6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell adhesion molecules | ||
Pathways by source for CD6 Gene
1 KEGG pathway for CD6 Gene
Interacting Proteins for CD6 Gene
Selected Interacting proteins:
P30203-CD6_HUMAN
ENSP00000323280
for CD6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CD6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001771 | immunological synapse formation | IMP | 15294938 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002438 | acute inflammatory response to antigenic stimulus | IDA | 17601777 |
| GO:0006897 | endocytosis | IEA | -- |
No data available for SIGNOR curated interactions for CD6 Gene
Transcripts for CD6 Gene
mRNA/cDNA for CD6 Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313421 3252 nts (view in UCSC)
- ENST00000344931 3022 nts (view in UCSC)
- ENST00000352009 1809 nts (view in UCSC)
- ENST00000419282 486 nts (view in UCSC)
- ENST00000433107 1268 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CD6 - Starting at $85 >
- * CD6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CD6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD6
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD6
- Browse OriGene Inhibitory RNA Products For CD6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD6
Clone products for research
- Applied Biological Materials (abm): Clones for CD6 - Starting at $45 >
- * CD6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CD6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD6
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | - | - | |||||||
| SP5: | - | - | |||||||
| SP6: | - | - | |||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: | |||||||||
| SP15: |
Relevant External Links for CD6 Gene
- GeneLoc Exon Structure for
- CD6
Expression for CD6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Double Positive Thymocytes Thymus
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
mRNA differential expression in normal tissues according to GTEx for CD6 Gene
This gene is overexpressed in Whole Blood (x20.8), Spleen (x7.4), and Small Intestine - Terminal Ileum (x5.9).
This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Lymph node (15.3), CD4 Tcells (14.5), and Tlymphocyte (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD6
SOURCE GeneReport for Unigene cluster for CD6 Gene:
Hs.744366mRNA Expression by UniProt/SwissProt for CD6 Gene:
P30203-CD6_HUMAN
Tissue specificity:
Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Evidence on tissue expression from TISSUES for CD6 Gene
- Lymph node(3.6)
- Spleen(3.6)
- Intestine(3.4)
- Blood(3)
- Bone marrow(2.3)
Primer products for research
-
OriGene qPCR primer pairs for CD6
-
OriGene qPCR primer pairs and template standards for CD6
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD6 Gene
Orthologs for CD6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD6 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD6 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CD6 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd6 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd6 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CD6 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CD6 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | CD6 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497305 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CD6 (2 of 2) 30 |
|
OneToMany | |
| CD6 (1 of 2) 30 |
|
OneToMany |
- Species where no ortholog for CD6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CD6 Gene
- ENSEMBL:
- Gene Tree for CD6 (if available)
- TreeFam:
- Gene Tree for CD6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD6: view image
- Alliance of Genome Resources:
- Additional Orthologs for CD6
Paralogs for CD6 Gene
Paralogs for CD6 Gene
(8) SIMAP similar genes for CD6 Gene using alignment to 16 proteins:
- CD6_HUMAN
- A4KAD4_HUMAN
- A4KAD5_HUMAN
- E7ER04_HUMAN
- F5H835_HUMAN
- F6UFK6_HUMAN
- G5E973_HUMAN
- H0YGL3_HUMAN
- L8E9F6_HUMAN
- Q6AZ88_HUMAN
- Q8N4Q7_HUMAN
- Q8WWJ3_HUMAN
- Q8WWJ4_HUMAN
- Q8WWJ5_HUMAN
- Q8WWJ6_HUMAN
- Q8WWJ7_HUMAN
Variants for CD6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD6 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116662669 | Benign: not provided | 61,017,751(+) |
T/C NM_006725.5(CD6):c.1583-8T>C |
INTRON | |
| rs11230562 | -- |
p.Thr217Met |
|||
| rs11230563 | -- |
p.Arg225Trp |
|||
| rs12360861 | -- |
p.Ala271Thr |
|||
| rs2074225 | -- |
p.Ala257Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1212n100 | CNV | gain | 25217958 |
| esv1472305 | CNV | insertion | 17803354 |
| esv2760588 | CNV | gain+loss | 21179565 |
| esv3365476 | CNV | duplication | 20981092 |
| esv3414510 | CNV | insertion | 20981092 |
| nsv1040352 | CNV | loss | 25217958 |
| nsv1140480 | CNV | tandem duplication | 24896259 |
| nsv39214 | CNV | insertion | 16902084 |
| nsv468580 | CNV | loss | 19166990 |
| nsv555153 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.95;
93.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD6 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD6 Gene
Disorders for CD6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple sclerosis |
|
|
Search CD6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD6
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD6 Gene
Publications for CD6 Gene
- Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PMID: 17371992) Castro MA … Carmo AM (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 22
- CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PMID: 16914752) Hassan NJ … Brown MH (Molecular and cellular biology 2006) 3 4 22
- Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PMID: 9013954) Bowen MA … Aruffo A (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4
- Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. (PMID: 26146185) Chappell PE … Brown MH (Structure (London, England : 1993) 2015) 3 4
- Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. (PMID: 24584089) Roncagalli R … Malissen B (Nature immunology 2014) 3 4
ExternalLinks
Products for CD6 Gene
- View all 18 R&D Systems CD6 (CD6) Products
- View all R&D Systems CD6 (CD6) Proteins and Enzymes
- View all 15 R&D Systems CD6 (CD6) Primary Antibodies
- View all R&D Systems CD6 (CD6) Proteome Profiler Antibody Arrays
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- Learn more about R&D Systems custom CD6 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CD6
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD6
- Browse OriGene Inhibitory RNA Products For CD6
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD6
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- antibodies-online: Show 53 available CD6 Antibodies ranked by validation data
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- antibodies-online: Show 17 available CD6 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for CD6
- Search Santa Cruz Biotechnology (SCBT) for CD6 siRNA/shRNA
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD6
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CD6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD6
Sources for CD6 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
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