CD6 Gene (Protein Coding)

CD6 Molecule

GC11P060971
GIFtS:
41
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility t... See more...

Aliases for CD6 Gene

Aliases for CD6 Gene

  • CD6 Molecule 2 3 5
  • CD6 Antigen 2 3 4
  • T-Cell Differentiation Antigen CD6 3 4
  • TP120 3 4
  • T12 3 4

External Ids for CD6 Gene

Previous GeneCards Identifiers for CD6 Gene

  • GC11P063132
  • GC11P062252
  • GC11P060990
  • GC11P060514
  • GC11P060495
  • GC11P060743
  • GC11P057086

Summaries for CD6 Gene

Entrez Gene Summary for CD6 Gene

  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CD6 Gene

CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Inflammatory Bowel Disease 16 and Finger Agnosia. Among its related pathways are Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.

UniProtKB/Swiss-Prot Summary for CD6 Gene

  • Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).

Gene Wiki entry for CD6 Gene

Additional gene information for CD6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD6 Gene

Genomics for CD6 Gene

GeneHancer (GH) Regulatory Elements for CD6 Gene

Promoters and enhancers for CD6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J060970 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 770.2 +2.0 1960 6 CTCF RAD21 REST TRIM22 ZNF143 EED RUNX3 BCLAF1 SMC3 MAZ CD6 CD5 SLC15A3 TMEM132A VPS37C CCDC86 PTGDR2 FTH1 SDHAF2 piR-35674-071
GH11J060972 Enhancer 0.7 ENCODE dbSUPER 750.6 -1.1 -1050 0 CTCF RAD21 REST TRIM22 ZNF143 BCLAF1 SMC3 MAZ XRCC5 RB1 CD6 SLC15A3
GH11J060971 Enhancer 0.7 ENCODE dbSUPER 750.6 -1.1 -1137 0.2 CTCF RAD21 REST TRIM22 ZNF143 BCLAF1 SMC3 MAZ XRCC5 RB1 CD6 SLC15A3
GH11J061101 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.9 +131.8 131764 4 CDC5L NFRKB ZSCAN4 HES1 FOXK2 MNT SCRT2 HDGF BCOR ZNF18 CD5 CD6 RNU6-933P VPS37C SDHAF2 ENSG00000279549
GH11J061040 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 33.6 +70.8 70821 3 ETV6 RELA POLR2A MLLT1 ZNF687 CREM IKZF1 RNF2 BACH1 SMAD5 CD6 CD5 SLC15A3 TMEM132A SDHAF2 RF00017-927 ENSG00000256733 lnc-VPS37C-3 LOC105369325
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD6 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1
  • YY1

Genomic Locations for CD6 Gene

Genomic Locations for CD6 Gene
chr11:60,971,641-61,020,377
(GRCh38/hg38)
Size:
48,737 bases
Orientation:
Plus strand
chr11:60,739,115-60,787,849
(GRCh37/hg19)
Size:
48,735 bases
Orientation:
Plus strand

Genomic View for CD6 Gene

Genes around CD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD6 Gene

Proteins for CD6 Gene

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  • Protein details for CD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30203-CD6_HUMAN
    Recommended name:
    T-cell differentiation antigen CD6
    Protein Accession:
    P30203
    Secondary Accessions:
    • A4KAD4
    • A4KAD5
    • Q9UMF2
    • Q9Y4K7
    • Q9Y4K8
    • Q9Y4K9
    • Q9Y4L0

    Protein attributes for CD6 Gene

    Size:
    668 amino acids
    Molecular mass:
    71801 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185). Interacts with the TCR/CD3 complex subunit CD3E (PubMed:15294938). Interacts (via tyrosine phosphorylated C-terminus) with LCP2 (via SH2 domain) (PubMed:16914752). Interacts with VAV1 (By similarity). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (PubMed:24945728).

    Three dimensional structures from OCA and Proteopedia for CD6 Gene

    Alternative splice isoforms for CD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD6 Gene

Protein Expression for CD6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD6 Gene

  • After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
  • Glycosylated.
  • Glycosylation at Asn28, Asn49, Asn112, Asn118, Asn229, Asn368, Asn339, and Asn345
  • Modification sites at PhosphoSitePlus

Other Protein References for CD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Assay Products

  • Abcam assays for CD6

No data available for DME Specific Peptides for CD6 Gene

Domains & Families for CD6 Gene

Gene Families for CD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD6 Gene

GenScript: Design optimal peptide antigens:
  • CD6deltaD3 (A4KAD4_HUMAN)
  • CD6deltaD3Ex6 (A4KAD5_HUMAN)
  • TP120 (CD6_HUMAN)
  • CD6 molecule (Q6AZ88_HUMAN)
  • CD6 protein (Q8N4Q7_HUMAN)
genes like me logo Genes that share domains with CD6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD6 Gene

Function for CD6 Gene

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Molecular function for CD6 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
GENATLAS Biochemistry:
cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed on mature T-cell,B-cell subset,thymocyte

Phenotypes From GWAS Catalog for CD6 Gene

Gene Ontology (GO) - Molecular Function for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 17601777
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 24584089
GO:0042802 identical protein binding IPI 26146185
GO:0070891 lipoteichoic acid binding IMP 17601777
genes like me logo Genes that share ontologies with CD6: view
genes like me logo Genes that share phenotypes with CD6: view

Animal Models for CD6 Gene

MGI Knock Outs for CD6:
  • Cd6 Cd6<tm1Linf>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD6 Gene

Localization for CD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD6 Gene

Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269 PubMed:15294938}.
Soluble CD6: Secreted. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD6 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
nucleus 1
cytosol 1
endoplasmic reticulum 0
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 15294938
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 1919444
GO:0009897 external side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with CD6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD6 Gene

Pathways & Interactions for CD6 Gene

PathCards logo

SuperPathways for CD6 Gene

genes like me logo Genes that share pathways with CD6: view

Pathways by source for CD6 Gene

1 KEGG pathway for CD6 Gene

Gene Ontology (GO) - Biological Process for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 immunological synapse formation IMP 15294938
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002438 acute inflammatory response to antigenic stimulus IDA 17601777
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with CD6: view

No data available for SIGNOR curated interactions for CD6 Gene

Drugs & Compounds for CD6 Gene

Products:

  1. Drug

(1) Drugs for CD6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CD6: view

Transcripts for CD6 Gene

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mRNA/cDNA for CD6 Gene

(3) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:
SP15:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CD6 Gene

GeneLoc Exon Structure for
CD6
ECgene alternative splicing isoforms for
CD6

Expression for CD6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD6 Gene

mRNA expression in normal human tissues for CD6 Gene
mRNA expression by BioGPS for CD6 GenemRNA expression by GTEx for CD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD6 Gene

This gene is overexpressed in Whole Blood (x20.8), Spleen (x7.4), and Small Intestine - Terminal Ileum (x5.9).

Protein differential expression in normal tissues from HIPED for CD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Lymph node (15.3), CD4 Tcells (14.5), and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD6 Gene



Protein tissue co-expression partners for CD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD6 Gene:

CD6

SOURCE GeneReport for Unigene cluster for CD6 Gene:

Hs.744366

mRNA Expression by UniProt/SwissProt for CD6 Gene:

P30203-CD6_HUMAN
Tissue specificity: Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Evidence on tissue expression from TISSUES for CD6 Gene

  • Lymph node(3.9)
  • Intestine(3.5)
  • Spleen(3.3)
  • Blood(2.9)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with CD6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD6 Gene

Orthologs for CD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD6 33 32
  • 99.05 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CD6 33 32
  • 82.14 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CD6 33 32
  • 80.69 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cd6 32
  • 77.06 (n)
mouse
(Mus musculus)
 Mammalia Cd6 17 33 32
  • 76.9 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CD6 33
  • 51 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CD6 33
  • 50 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 33
  • 23 (a)
 OneToMany
-- 33
  • 12 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia CD6 33
  • 33 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100497305 32
  • 49.33 (n)
zebrafish
(Danio rerio)
 Actinopterygii CD6 (2 of 2) 33
  • 24 (a)
 OneToMany
CD6 (1 of 2) 33
  • 13 (a)
 OneToMany
Species where no ortholog for CD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD6 Gene

ENSEMBL:
Gene Tree for CD6 (if available)
TreeFam:
Gene Tree for CD6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD6: view image

Paralogs for CD6 Gene

Paralogs for CD6 Gene

(8) SIMAP similar genes for CD6 Gene using alignment to 16 proteins:

  • CD6_HUMAN
  • A4KAD4_HUMAN
  • A4KAD5_HUMAN
  • E7ER04_HUMAN
  • F5H835_HUMAN
  • F6UFK6_HUMAN
  • G5E973_HUMAN
  • H0YGL3_HUMAN
  • L8E9F6_HUMAN
  • Q6AZ88_HUMAN
  • Q8N4Q7_HUMAN
  • Q8WWJ3_HUMAN
  • Q8WWJ4_HUMAN
  • Q8WWJ5_HUMAN
  • Q8WWJ6_HUMAN
  • Q8WWJ7_HUMAN
genes like me logo Genes that share paralogs with CD6: view

Variants for CD6 Gene

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Sequence variations from dbSNP and Humsavar for CD6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000084417 -- 60,999,750(+) T/C intron_variant
rs1000090924 -- 60,975,947(+) C/A intron_variant
rs1000231461 -- 60,977,613(+) C/T intron_variant
rs1000232495 -- 61,006,026(+) C/T intron_variant
rs1000254197 -- 60,970,499(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD6 Gene

Variant ID Type Subtype PubMed ID
dgv1212n100 CNV gain 25217958
esv1472305 CNV insertion 17803354
esv2760588 CNV gain+loss 21179565
esv3365476 CNV duplication 20981092
esv3414510 CNV insertion 20981092
nsv1040352 CNV loss 25217958
nsv1140480 CNV tandem duplication 24896259
nsv39214 CNV insertion 16902084
nsv468580 CNV loss 19166990
nsv555153 CNV loss 21841781

Variation tolerance for CD6 Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.95; 93.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD6 Gene

Human Gene Mutation Database (HGMD)
CD6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD6 Gene

Disorders for CD6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 16
  • ibd16
finger agnosia
dyscalculia
  • disorder of arithmetical skills
supraglottis cancer
  • ca larynx - supraglottis
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CD6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD6 Gene

Publications for CD6 Gene

  1. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PMID: 17371992) Castro MA … Carmo AM (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 23 56
  2. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PMID: 16914752) Hassan NJ … Brown MH (Molecular and cellular biology 2006) 3 4 23 56
  3. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PMID: 9013954) Bowen MA … Aruffo A (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 56
  4. Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. (PMID: 26146185) Chappell PE … Brown MH (Structure (London, England : 1993) 2015) 3 4 56
  5. Modulation of CD6 function through interaction with Galectin-1 and -3. (PMID: 24945728) Escoda-Ferran C … Lozano F (FEBS letters 2014) 3 4 56

ExternalLinks

View latest publications for CD6 gene in Mastermind

Products for CD6 Gene

Sources for CD6 Gene