Aliases for CD58 Gene
External Ids for CD58 Gene
Previous HGNC Symbols for CD58 Gene
Previous GeneCards Identifiers for CD58 Gene
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for CD58 Gene
CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Oral Lichen Planus and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.
UniProtKB/Swiss-Prot Summary for CD58 Gene
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.