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Aliases for CD55 Gene

Aliases for CD55 Gene

  • CD55 Molecule (Cromer Blood Group) 2 3 5
  • CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group) 2 3
  • CD55 Antigen 3 4
  • DAF 3 4
  • CR 3 4
  • Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System) 2
  • Complement Decay-Accelerating Factor 3
  • Cromer Blood Group Antigen 3
  • CHAPLE 3
  • CROM 3
  • TC 3

External Ids for CD55 Gene

Previous HGNC Symbols for CD55 Gene

  • DAF

Previous GeneCards Identifiers for CD55 Gene

  • GC01P205561
  • GC01P207494
  • GC01P178191

Summaries for CD55 Gene

Entrez Gene Summary for CD55 Gene

  • This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD55 Gene

CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy and Blood Group, Cromer System. Among its related pathways are Creation of C4 and C2 activators and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include lipid binding and virus receptor activity. An important paralog of this gene is C4BPA.

UniProtKB/Swiss-Prot for CD55 Gene

  • This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).

  • (Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).

Gene Wiki entry for CD55 Gene

Additional gene information for CD55 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD55 Gene

Genomics for CD55 Gene

GeneHancer (GH) Regulatory Elements for CD55 Gene

Promoters and enhancers for CD55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I207319 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 569.8 +0.3 317 5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF143 SP3 MEF2D SSRP1 GLIS1 CD55 EIF2D CD46 CR2 C4BPA LOC105372881
GH01I207333 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.2 +14.2 14240 5.4 HDGF PKNOX1 FOXA2 SMAD1 YBX1 IRF4 POLR2B E2F8 FOS ATF7 CD55 EIF2D CR2 CR1 CD46 LOC105372881
GH01I207239 Enhancer 1.5 FANTOM5 Ensembl ENCODE 23.1 -79.1 -79109 5.1 PKNOX1 FOXA2 MLX ARID4B YY1 FOS DEK SP5 REST KAT8 CD55 CR2 IL19 C4BPA ENSG00000237074
GH01I207316 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -4.1 -4103 2.6 HDGF PKNOX1 CLOCK ARNT NEUROD1 SIN3A ZBTB7B ZNF766 ZNF207 FOS CD55 CD46 EIF2D RPL7AP20 CDCA4P4 CR2 CR1 ENSG00000237074
GH01I207204 Enhancer 1.2 Ensembl ENCODE 27.8 -116.1 -116061 1.4 PKNOX1 FOXA2 MLX ARNT SIN3A YBX1 ZNF766 CBX5 E2F8 FOS CD55 C4BPAP3 C4BPAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD55 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD55 gene promoter:

Genomic Locations for CD55 Gene

Genomic Locations for CD55 Gene
chr1:207,321,472-207,386,804
(GRCh38/hg38)
Size:
65,333 bases
Orientation:
Plus strand
chr1:207,494,817-207,534,311
(GRCh37/hg19)

Genomic View for CD55 Gene

Genes around CD55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD55 Gene

Proteins for CD55 Gene

  • Protein details for CD55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08174-DAF_HUMAN
    Recommended name:
    Complement decay-accelerating factor
    Protein Accession:
    P08174
    Secondary Accessions:
    • B1AP14
    • D3DT83
    • D3DT84
    • E7ER69
    • P09679
    • P78361
    • Q14UF2
    • Q14UF3
    • Q14UF4
    • Q14UF5
    • Q14UF6

    Protein attributes for CD55 Gene

    Size:
    381 amino acids
    Molecular mass:
    41400 Da
    Quaternary structure:
    • Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
    • (Microbial infection) Interacts with coxsackievirus A21, coxsackieviruses B1, B3 and B5 capsid proteins.
    • (Microbial infection) Interacts with human enterovirus 70 and D68 capsid proteins (Probable).
    • (Microbial infection) Interacts with human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for CD55 Gene

    Alternative splice isoforms for CD55 Gene

neXtProt entry for CD55 Gene

Post-translational modifications for CD55 Gene

  • The Ser/Thr-rich domain is heavily O-glycosylated.
  • Glycosylation at posLast=9595, Thr343, and posLast=344344

No data available for DME Specific Peptides for CD55 Gene

Domains & Families for CD55 Gene

Gene Families for CD55 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD55 Gene

Graphical View of Domain Structure for InterPro Entry

P08174

UniProtKB/Swiss-Prot:

DAF_HUMAN :
  • The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
  • Belongs to the receptors of complement activation (RCA) family.
Domain:
  • The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
Family:
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CD55: view

Function for CD55 Gene

Molecular function for CD55 Gene

UniProtKB/Swiss-Prot Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).

Phenotypes From GWAS Catalog for CD55 Gene

Gene Ontology (GO) - Molecular Function for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA,IDA 7525274
GO:0005515 protein binding IPI 9064337
GO:0008289 lipid binding IDA 12731067
genes like me logo Genes that share ontologies with CD55: view
genes like me logo Genes that share phenotypes with CD55: view

Human Phenotype Ontology for CD55 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD55 Gene

MGI Knock Outs for CD55:

Animal Model Products

miRNA for CD55 Gene

miRTarBase miRNAs that target CD55

Clone Products

  • Addgene plasmids for CD55

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD55 Gene

Localization for CD55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD55 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 7: Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD55 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 4
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody ring (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2433596
GO:0009986 cell surface IDA 15907827
genes like me logo Genes that share ontologies with CD55: view

Pathways & Interactions for CD55 Gene

genes like me logo Genes that share pathways with CD55: view

SIGNOR curated interactions for CD55 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006958 complement activation, classical pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8223854
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CD55: view

Drugs & Compounds for CD55 Gene

(37) Drugs for CD55 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved, Vet_approved Pharma Target, other 7
COXSACKIEVIRUS TYPE A21 Pharma 0
ONYVAX-105 (105AD7) Pharma 0

(20) Additional Compounds for CD55 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD55: view

Transcripts for CD55 Gene

Unigene Clusters for CD55 Gene

CD55 molecule, decay accelerating factor for complement (Cromer blood group):
Representative Sequences:

Clone Products

  • Addgene plasmids for CD55

Alternative Splicing Database (ASD) splice patterns (SP) for CD55 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for CD55 Gene

GeneLoc Exon Structure for
CD55
ECgene alternative splicing isoforms for
CD55

Expression for CD55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD55 Gene

mRNA differential expression in normal tissues according to GTEx for CD55 Gene

This gene is overexpressed in Whole Blood (x14.6).

Protein differential expression in normal tissues from HIPED for CD55 Gene

This gene is overexpressed in Cerebrospinal fluid (23.6), Cervix (9.7), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD55 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD55 Gene:

CD55

SOURCE GeneReport for Unigene cluster for CD55 Gene:

Hs.126517

mRNA Expression by UniProt/SwissProt for CD55 Gene:

P08174-DAF_HUMAN
Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

Evidence on tissue expression from TISSUES for CD55 Gene

  • Lung(4.9)
  • Nervous system(4.8)
  • Liver(4.6)
  • Urine(4.1)
  • Blood(3.6)
  • Intestine(3.6)
  • Heart(2.9)
  • Bone marrow(2.8)
  • Kidney(2.6)
  • Muscle(2.6)
  • Pancreas(2.4)
  • Spleen(2.4)
  • Skin(2.2)
  • Adrenal gland(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CD55: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD55 Gene

Orthologs for CD55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD55 33 34
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia CD55 33 34
  • 72.34 (n)
dog
(Canis familiaris)
Mammalia CD55 33 34
  • 72.31 (n)
rat
(Rattus norvegicus)
Mammalia Cd55 33
  • 64.9 (n)
mouse
(Mus musculus)
Mammalia Cd55 33 34
  • 62.35 (n)
Daf2 34
  • 41 (a)
OneToMany
Cd55b 16
platypus
(Ornithorhynchus anatinus)
Mammalia CD55 34
  • 43 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD55 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 18 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rca2.1 34
  • 22 (a)
ManyToMany
rca2.2 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 6 (a)
OneToMany
Species where no ortholog for CD55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD55 Gene

ENSEMBL:
Gene Tree for CD55 (if available)
TreeFam:
Gene Tree for CD55 (if available)

Paralogs for CD55 Gene

genes like me logo Genes that share paralogs with CD55: view

Variants for CD55 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD55 Gene

DAF_HUMAN-P08174
Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8 high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have any associated hematologic or other abnormalities (PubMed:12675719).

Sequence variations from dbSNP and Humsavar for CD55 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs121909603 affects, Cromer blood group system 207,322,542(+) G/A coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs869312818 affects, Cromer blood group system 207,322,484(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_079373 Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) [MIM:226300] p.Cys267Ser
rs1000090941 -- 207,354,905(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000117414 -- 207,344,979(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD55 Gene

Variant ID Type Subtype PubMed ID
nsv508688 CNV deletion 20534489
nsv4221 CNV deletion 18451855
nsv1002014 CNV gain 25217958
esv2722084 CNV deletion 23290073

Variation tolerance for CD55 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 27.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD55 Gene

Human Gene Mutation Database (HGMD)
CD55
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD55

Disorders for CD55 Gene

MalaCards: The human disease database

(23) MalaCards diseases for CD55 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD55 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DAF_HUMAN
  • Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) [MIM:226300]: An autosomal recessive disease characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease. Patients T lymphocytes show increased complement activation causing surface deposition of complement and the generation of soluble C5a. {ECO:0000269 PubMed:28657829, ECO:0000269 PubMed:28657861}. Note=The disease is caused by mutations affecting the gene represented in this entry. CHAPLE is caused by biallelic mutations in the CD55 gene.

Additional Disease Information for CD55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD55: view

No data available for Genatlas for CD55 Gene

Publications for CD55 Gene

  1. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PMID: 7519480) Lublin DM … Tanner MJ (Blood 1994) 3 4 22 58
  2. Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). (PMID: 1377029) Nakano Y … Tomita M (Biochimica et biophysica acta 1992) 3 4 22 58
  3. Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PMID: 1712233) Nakano Y … Tomita M (Biochimica et biophysica acta 1991) 3 4 22 58
  4. CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. (PMID: 28657829) Ozen A … Lenardo MJ (The New England journal of medicine 2017) 3 4 58
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for CD55 Gene

Sources for CD55 Gene

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