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Aliases for CD52 Gene

Aliases for CD52 Gene

  • CD52 Molecule 2 3 5
  • Human Epididymis-Specific Protein 5 3 4
  • CD52 Antigen (CAMPATH-1 Antigen) 2 3
  • Epididymal Secretory Protein E5 3 4
  • Cambridge Pathology 1 Antigen 3 4
  • CDW52 3 4
  • He5 3 4
  • Epididymis Secretory Sperm Binding Protein Li 171mP 3
  • CDW52 Antigen (CAMPATH-1 Antigen) 3
  • CAMPATH-1 Antigen 3
  • CD52 Antigen 4
  • HEL-S-171mP 3
  • EDDM5 3
  • CDw52 4
  • HE5 4

External Ids for CD52 Gene

Previous HGNC Symbols for CD52 Gene

  • CDW52

Previous GeneCards Identifiers for CD52 Gene

  • GC01P026329
  • GC01P026516
  • GC01P026644
  • GC01P024898

Summaries for CD52 Gene

GeneCards Summary for CD52 Gene

CD52 (CD52 Molecule) is a Protein Coding gene. Diseases associated with CD52 include Lymphoma, Non-Hodgkin, Familial and T-Cell Prolymphocytic Leukemia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for CD52 Gene

  • May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Additional gene information for CD52 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD52 Gene

Genomics for CD52 Gene

GeneHancer (GH) Regulatory Elements for CD52 Gene

Promoters and enhancers for CD52 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 670.2 +0.3 250 8.4 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 ZNF766 ZNF213 E2F8 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
GH01J026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.9 -34.0 -34026 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A LOC101928324 CD52 GPN2 NPM1P39 UBXN11 CEP85 LIN28A
GH01J026233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.3 -83.3 -83335 2.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CEP85 ARID1A HMGN2 CD52 ZNF593 NPM1P39 UBXN11 ENSG00000261349 LOC101928324 LOC101928728
GH01J026305 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.4 -10.3 -10342 4 HDGF HNRNPUL1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 UBXN11 ARID1A HMGN2 LOC101928324 CD52 RPL17P9 NPM1P39 CEP85 FAM110D CNKSR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD52 gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP
  • GR-alpha
  • GR
  • Evi-1
  • NF-kappaB1

Genomic Locations for CD52 Gene

Genomic Locations for CD52 Gene
2,604 bases
Plus strand
2,604 bases
Plus strand

Genomic View for CD52 Gene

Genes around CD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD52 Gene

Proteins for CD52 Gene

  • Protein details for CD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CAMPATH-1 antigen
    Protein Accession:
    Secondary Accessions:
    • Q5T138
    • Q9BW46

    Protein attributes for CD52 Gene

    61 amino acids
    Molecular mass:
    6614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD52 Gene

Post-translational modifications for CD52 Gene

  • Glycosylation at Asn40 and posLast=2727

Other Protein References for CD52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD52 Gene

Domains & Families for CD52 Gene

Gene Families for CD52 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for CD52 Gene


Suggested Antigen Peptide Sequences for CD52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD52: view

No data available for UniProtKB/Swiss-Prot for CD52 Gene

Function for CD52 Gene

Molecular function for CD52 Gene

UniProtKB/Swiss-Prot Function:
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Phenotypes From GWAS Catalog for CD52 Gene

genes like me logo Genes that share phenotypes with CD52: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD52 Gene

Localization for CD52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD52 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD52 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1711975
GO:0016020 membrane TAS 1711975
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD52: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD52 Gene

Pathways & Interactions for CD52 Gene

genes like me logo Genes that share pathways with CD52: view

Interacting Proteins for CD52 Gene

Gene Ontology (GO) - Biological Process for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8223854
GO:0045730 respiratory burst NAS 8223854
genes like me logo Genes that share ontologies with CD52: view

No data available for SIGNOR curated interactions for CD52 Gene

Drugs & Compounds for CD52 Gene

(7) Drugs for CD52 Gene - From: DrugBank, ClinicalTrials, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alemtuzumab Approved, Investigational Pharma antibody, Target Therapeutic Antibodies 319
Campath Approved May 2001 Pharma 0
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
Immunoglobulins Pharma 7224

(2) Additional Compounds for CD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD52: view

Transcripts for CD52 Gene

mRNA/cDNA for CD52 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD52 Gene

CD52 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD52 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for CD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD52 Gene

This gene is overexpressed in Whole Blood (x16.1) and Spleen (x9.8).

NURSA nuclear receptor signaling pathways regulating expression of CD52 Gene:


SOURCE GeneReport for Unigene cluster for CD52 Gene:


Evidence on tissue expression from TISSUES for CD52 Gene

  • Spleen(4.6)
  • Blood(3.6)
  • Lymph node(3.2)
  • Bone marrow(3.1)
  • Intestine(2.6)
  • Lung(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with CD52: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD52 Gene

Orthologs for CD52 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD52 34 33
  • 99.45 (n)
Species where no ortholog for CD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD52 Gene

Gene Tree for CD52 (if available)
Gene Tree for CD52 (if available)
Evolutionary constrained regions (ECRs) for CD52: view image

Paralogs for CD52 Gene

(1) SIMAP similar genes for CD52 Gene using alignment to 2 proteins:

  • CD52_HUMAN
  • Q9UJ81_HUMAN
genes like me logo Genes that share paralogs with CD52: view

No data available for Paralogs for CD52 Gene

Variants for CD52 Gene

Sequence variations from dbSNP and Humsavar for CD52 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1002242524 -- 26,316,375(+) G/C upstream_transcript_variant
rs1002944347 -- 26,317,123(+) C/G upstream_transcript_variant
rs1002994005 -- 26,317,349(+) G/C upstream_transcript_variant
rs1003278228 -- 26,318,487(+) G/C intron_variant
rs1004241996 -- 26,319,818(+) C/T intron_variant

Variation tolerance for CD52 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD52 Gene

Disorders for CD52 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CD52 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma, non-hodgkin, familial
  • non-hodgkin lymphoma; nhl
t-cell prolymphocytic leukemia
  • leukemia, t-cell, chronic
multiple sclerosis
  • multiple sclerosis, susceptibility to
aplastic anemia
  • aa
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CD52 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD52

genes like me logo Genes that share disorders with CD52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD52 Gene

Publications for CD52 Gene

  1. Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation. (PMID: 11420384) Yeung CH … Cooper TG (Molecular human reproduction 2001) 2 3 22 58
  2. A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. (PMID: 8418821) Kirchhoff C … Ivell R (Molecular reproduction and development 1993) 3 4 22 58
  3. Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. (PMID: 1711975) Xia MQ … Waldmann H (European journal of immunology 1991) 2 3 4 58
  4. The GPI-anchored CD52 antigen of the sperm surface interacts with semenogelin and participates in clot formation and liquefaction of human semen. (PMID: 17624925) Flori F … Giovampaola CD (Molecular reproduction and development 2008) 3 22 58
  5. Different levels of CD52 antigen expression evaluated by quantitative fluorescence cytometry are detected on B-lymphocytes, CD 34+ cells and tumor cells of patients with chronic B-cell lymphoproliferative diseases. (PMID: 17428002) Klabusay M … Mayer J (Cytometry. Part B, Clinical cytometry 2007) 3 22 58

Products for CD52 Gene

Sources for CD52 Gene

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