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This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Richter's Syndrome and Thymic Carcinoma. Among its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005044 | scavenger receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 1711157 |
GO:0038023 | signaling receptor activity | NAS | 1711157 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IDA | 11390434 |
GO:0005887 | integral component of plasma membrane | NAS | 1711157 |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Hematopoietic cell lineage | ||
2 | Hematopoietic Stem Cells and Lineage-specific Markers |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0008037 | cell recognition | NAS | 1711157 |
GO:0031295 | T cell costimulation | IEA,IBA | 21873635 |
GO:0097190 | apoptotic signaling pathway | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100911215 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd5 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD5 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD5 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1212n100 | CNV | gain | 25217958 |
esv2760588 | CNV | gain+loss | 21179565 |
nsv1116676 | CNV | tandem duplication | 24896259 |
nsv428259 | CNV | gain+loss | 18775914 |
nsv509412 | CNV | insertion | 20534489 |
nsv526162 | CNV | loss | 19592680 |
nsv832176 | CNV | gain+loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
richter's syndrome |
|
|
thymic carcinoma |
|
|
prolymphocytic leukemia |
|
|
splenic marginal zone lymphoma |
|
|
nodal marginal zone lymphoma |
|
|