This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and i... See more...

Aliases for CD47 Gene

Aliases for CD47 Gene

  • CD47 Molecule 2 3 5
  • Antigenic Surface Determinant Protein OA3 2 3 4
  • Leukocyte Surface Antigen CD47 2 3 4
  • IAP 2 3 4
  • CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) 2 3
  • Antigen Identified By Monoclonal Antibody 1D8 2 3
  • Integrin Associated Protein 2 3
  • Rh-Related Antigen 2 3
  • CD47 Glycoprotein 2 3
  • MER6 3 4
  • OA3 2 3
  • Integrin-Associated Signal Transducer 3
  • Integrin-Associated Protein 4
  • Protein MER6 4
  • CD47 Antigen 4
  • CD47 5

External Ids for CD47 Gene

Previous HGNC Symbols for CD47 Gene

  • MER6

Previous GeneCards Identifiers for CD47 Gene

  • GC03M104559
  • GC03M107293
  • GC03M109043
  • GC03M109086
  • GC03M109083
  • GC03M109244
  • GC03M107761
  • GC03M105135

Summaries for CD47 Gene

Entrez Gene Summary for CD47 Gene

  • This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for CD47 Gene

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.

UniProtKB/Swiss-Prot Summary for CD47 Gene

  • Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Gene Wiki entry for CD47 Gene

Additional gene information for CD47 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD47 Gene

Genomics for CD47 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD47 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J108087 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 609.4 +4.0 3983 6.2 CTCF PRDM10 KDM1A ZNF692 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 CD47 lnc-HHLA2-7 MYH15 lnc-IFT57-4 BBX
GH03J108096 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 600.7 -2.7 -2728 1.1 HDAC1 HMBOX1 CTBP1 MEF2D NCOR1 SPI1 TAL1 CBFA2T3 ARID1B SMARCA4 CD47 LOC105374031 LINC01215 IFT57
GH03J108123 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -31.9 -31905 6.2 SP1 LEF1 IKZF1 POLR2A BACH1 LARP7 JUND ZNF143 RELA ZIC2 LINC01215 CD47 IFT57 MYH15 DZIP3 piR-38352-391 LOC105374031
GH03J108219 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.7 -128.0 -128021 5.8 SP1 HNRNPL CREB1 ATF7 ZNF629 RFX1 RFX5 ZNF692 POLR2A TARDBP IFT57 HSALNG0027894 HHLA2 CD47 lnc-CD47-6
GH03J108129 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.2 -38.2 -38226 5 RFX1 FOXA1 ZSCAN4 IKZF2 SP1 JUND CEBPB FOS EP300 FOSL2 CD47 IFT57 MYH15 piR-38352-391 LINC01215
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD47 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD47

Top Transcription factor binding sites by QIAGEN in the CD47 gene promoter:
  • AML1a
  • ATF6
  • c-Myb
  • ER-alpha
  • FOXL1
  • HEN1
  • NF-kappaB1
  • Pax-4a

Genomic Locations for CD47 Gene

Genomic Locations for CD47 Gene
chr3:108,043,091-108,094,200
(GRCh38/hg38)
Size:
51,110 bases
Orientation:
Minus strand
chr3:107,761,941-107,809,935
(GRCh37/hg19)
Size:
47,995 bases
Orientation:
Minus strand

Genomic View for CD47 Gene

Genes around CD47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD47 Gene

Proteins for CD47 Gene

  • Protein details for CD47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08722-CD47_HUMAN
    Recommended name:
    Leukocyte surface antigen CD47
    Protein Accession:
    Q08722
    Secondary Accessions:
    • A8K198
    • D3DN59
    • Q53Y71
    • Q96A60

    Protein attributes for CD47 Gene

    Size:
    323 amino acids
    Molecular mass:
    35214 Da
    Quaternary structure:
    • Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.

    Three dimensional structures from OCA and Proteopedia for CD47 Gene

    Alternative splice isoforms for CD47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD47 Gene

Post-translational modifications for CD47 Gene

  • Glycosylation at Asn23, Asn34, Asn50, Asn73, Asn111, and Asn206
  • Ubiquitination at Lys74, Lys93, Lys314, and Lys317
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

  • Abcam antibodies for CD47

Protein Products

  • Abcam proteins for CD47

No data available for DME Specific Peptides for CD47 Gene

Domains & Families for CD47 Gene

Gene Families for CD47 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CD47 Gene

InterPro:
Blocks:
  • CD47 integrin associated protein
ProtoNet:

Suggested Antigen Peptide Sequences for CD47 Gene

GenScript: Design optimal peptide antigens:
  • Protein MER6 (CD47_HUMAN)
genes like me logo Genes that share domains with CD47: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD47 Gene

Function for CD47 Gene

Molecular function for CD47 Gene

UniProtKB/Swiss-Prot Function:
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
GENATLAS Biochemistry:
cell differentiation antigen 47,identified by monoclonal antibodies BRIC126,CIKM1,BRIC125,same as ovarian tumor marker OH3

Phenotypes From GWAS Catalog for CD47 Gene

Gene Ontology (GO) - Molecular Function for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383453
GO:0070053 thrombospondin receptor activity IBA,IPI 15700281
GO:0086080 protein binding involved in heterotypic cell-cell adhesion ISS --
GO:0098632 cell-cell adhesion mediator activity IPI 11509594
genes like me logo Genes that share ontologies with CD47: view
genes like me logo Genes that share phenotypes with CD47: view

Animal Models for CD47 Gene

MGI Knock Outs for CD47:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD47

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD47 Gene

Localization for CD47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD47 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD47 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA 21873635
GO:0009986 cell surface NAS 25795378
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD47: view

Pathways & Interactions for CD47 Gene

genes like me logo Genes that share pathways with CD47: view

Pathways by source for CD47 Gene

1 R&D Systems pathway for CD47 Gene
2 Qiagen pathways for CD47 Gene
  • Inhibition of Angiogenesis by TSP1
  • Integrin Pathway

SIGNOR curated interactions for CD47 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway TAS 8294396
GO:0008228 opsonization IEA --
GO:0008284 positive regulation of cell proliferation IDA 15383453
genes like me logo Genes that share ontologies with CD47: view

Drugs & Compounds for CD47 Gene

(43) Drugs for CD47 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Atezolizumab Approved, Investigational Pharma 439
Azacitidine Approved, Investigational Pharma 555
Durvalumab Approved, Investigational Pharma 469
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2338

(6) Additional Compounds for CD47 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD47: view

Transcripts for CD47 Gene

mRNA/cDNA for CD47 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD47

Alternative Splicing Database (ASD) splice patterns (SP) for CD47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for CD47 Gene

GeneLoc Exon Structure for
CD47

Expression for CD47 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD47 Gene

This gene is overexpressed in Nasal epithelium (20.2) and Platelet (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD47 Gene



Protein tissue co-expression partners for CD47 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD47

SOURCE GeneReport for Unigene cluster for CD47 Gene:

Hs.446414

mRNA Expression by UniProt/SwissProt for CD47 Gene:

Q08722-CD47_HUMAN
Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Evidence on tissue expression from TISSUES for CD47 Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Liver(4.6)
  • Lymph node(3.4)
  • Spleen(3.4)
  • Bone marrow(3.3)
  • Lung(3.3)
  • Heart(3.1)
  • Intestine(3.1)
  • Skin(3)
  • Muscle(2.9)
  • Kidney(2.8)
  • Stomach(2.5)
  • Thyroid gland(2.5)
  • Pancreas(2.3)
  • Eye(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with CD47: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD47 Gene

Orthologs for CD47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD47 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD47 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD47 30 31
  • 80.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD47 30 31
  • 79.62 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd47 30 17 31
  • 76.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd47 30
  • 75.06 (n)
Oppossum
(Monodelphis domestica)
Mammalia CD47 31
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CD47 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD47 30 31
  • 51.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CD47 31
  • 37 (a)
OneToOne
Species where no ortholog for CD47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD47 Gene

ENSEMBL:
Gene Tree for CD47 (if available)
TreeFam:
Gene Tree for CD47 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD47: view image

Paralogs for CD47 Gene

Pseudogenes.org Pseudogenes for CD47 Gene

genes like me logo Genes that share paralogs with CD47: view

No data available for Paralogs for CD47 Gene

Variants for CD47 Gene

Additional dbSNP identifiers (rs#s) for CD47 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD47 Gene

Variant ID Type Subtype PubMed ID
esv2633277 CNV deletion 19546169
nsv1011158 CNV gain 25217958
nsv241 OTHER inversion 15895083
nsv7355 OTHER inversion 18451855
nsv953243 CNV duplication 24416366

Variation tolerance for CD47 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD47

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD47 Gene

Disorders for CD47 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CD47 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hereditary spherocytosis
  • spherocytosis, type 1
neonatal meningitis
  • meningitis, neonatal
hereditary elliptocytosis
  • congenital elliptocytosis
glanzmann thrombasthenia
  • gt
hemolytic anemia
  • anemia hemolytic
- elite association - COSMIC cancer census association via MalaCards
Search CD47 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD47

genes like me logo Genes that share disorders with CD47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD47 Gene

Publications for CD47 Gene

  1. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. (PMID: 18657508) Hatherley D … Barclay AN (Molecular cell 2008) 3 4 23
  2. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. (PMID: 11509594) Latour S … Sarfati M (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23
  3. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. (PMID: 11454874) Rebres RA … Brown EJ (The Journal of biological chemistry 2001) 3 4 23
  4. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. (PMID: 10549293) Wu AL … Brown EJ (Molecular cell 1999) 3 4 23
  5. Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. (PMID: 7998989) Mawby WJ … Tanner MJ (The Biochemical journal 1994) 3 4 23

Products for CD47 Gene

Sources for CD47 Gene