Aliases for CD46 Gene
- CD46 Molecule 2 3 5
- TLX 2 3 4
- Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen) 2 3
- Antigen Identified By Monoclonal Antibody TRA-2-10 2 3
- CD46 Molecule, Complement Regulatory Protein 2 3
- CD46 Antigen, Complement Regulatory Protein 2 3
- Trophoblast Leukocyte Common Antigen 3 4
- Membrane Cofactor Protein 3 4
- TRA2.10 2 3
External Ids for CD46 Gene
Previous HGNC Symbols for CD46 Gene
Previous GeneCards Identifiers for CD46 Gene
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
GeneCards Summary for CD46 Gene
CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Atypical Hemolytic Uremic Syndrome With Complement Gene Abnormality. Among its related pathways are Immune response Lectin induced complement pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is C4BPA.
UniProtKB/Swiss-Prot Summary for CD46 Gene
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
(Microbial infection) Acts as a receptor for cultured Measles virus.
(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).