CD44 Gene (Protein Coding)

CD44 Molecule (Indian Blood Group)

GC11P035139
GIFtS:
49
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation... See more...

Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3 5
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • CD44 Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • MDU2 3 4
  • MDU3 3 4
  • MIC4 3 4
  • LHR 3 4
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Indian Blood Group Antigen 3
  • Phagocytic Glycoprotein I 4
  • Soluble CD44 3
  • CDW44 3
  • CSPG8 3
  • HCELL 3
  • CDw44 4
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3
  • IN 3

External Ids for CD44 Gene

Previous HGNC Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Previous GeneCards Identifiers for CD44 Gene

  • GC11P036713
  • GC11P035838
  • GC11P035199
  • GC11P035124
  • GC11P035125
  • GC11P035116
  • GC11P034858
  • GC11P035168

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

CIViC Summary for CD44 Gene

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Hereditary Gastric Cancer. Among its related pathways are Innate Immune System and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot Summary for CD44 Gene

  • Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).

Gene Wiki entry for CD44 Gene

Additional gene information for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

GeneHancer (GH) Regulatory Elements for CD44 Gene

Promoters and enhancers for CD44 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J035137 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 510.8 +3.7 3696 10.4 ZBTB40 CTCF SP1 PHF8 JUND FOS EP300 ZIC2 REST POLR2A CD44 LOC100507144 ENSG00000251194 APIP PDHX SNORD164-001
GH11J035157 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +27.8 27834 18.4 TCF12 SP1 JUND FOS CTCF EP300 REST TCF7 RFX1 RELA CD44 LOC100507144 MIR1343 APIP PDHX ENSG00000255004 SNORD164-001 HSALNG0083608
GH11J035081 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 35 -53.3 -53304 7.8 TCF12 SP1 FOS ZNF10 EP300 ZNF263 RFX1 RELA MEF2C RCOR1 LOC105376627 lnc-APIP-1 CD44 LOC100507144 APIP lnc-CD44-5 lnc-CD44-7
GH11J035076 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 32.1 -60.6 -60578 4.3 FOS RELA EP300 NFYB BCL11A NR2F2 TCF12 CBFB SMARCC1 POLR2A CD44 LOC100507144 APIP lnc-CD44-5 lnc-APIP-1 LOC105376626 lnc-CD44-7
GH11J035029 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.7 -103.3 -103326 13.1 SIN3A GTF2E2 JUND FOS EP300 REST POLR2A ZBTB11 AFF1 RELA CD44 LOC100507144 APIP lnc-CD44-7 lnc-APIP-1 piR-36378-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD44 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD44

Top Transcription factor binding sites by QIAGEN in the CD44 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CD44 Gene

Genomic Locations for CD44 Gene
chr11:35,138,870-35,232,402
(GRCh38/hg38)
Size:
93,533 bases
Orientation:
Plus strand
chr11:35,160,417-35,253,949
(GRCh37/hg19)
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

Genes around CD44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD44 Gene

Proteins for CD44 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2 (PubMed:15123640). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435, PubMed:25195884). Interacts with UNC119 (PubMed:19381274). Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267). Interacts with RDX, EZR and MSN (By similarity). Interacts with EGFR (PubMed:18757307, PubMed:23589287). Interacts with CD74; this complex is essential for the MIF-induced signaling cascade that results in B cell survival (By similarity).
    Miscellaneous:
    • [Isoform 1]: Corresponds to the largest isoform.
    • [Isoform 3]: Alternative splice donor/acceptor on exon 5.
    • [Isoform 4]: Lacks exon 6.
    • [Isoform 5]: Alternative splice donor/acceptor on exon 7.
    • [Isoform 6]: Lacks exon 10.
    • [Isoform 7]: Lacks exon 13.
    • [Isoform 8]: Lacks exon 14.
    • [Isoform 9]: Lacks exon 19.
    • [Isoform 10]: Lacks exons 6-11.
    • [Isoform 11]: Lacks exons 6-13.
    • [Isoform 12]: Lacks exons 6-14.
    • [Isoform 13]: Lacks exons 6-11 and exon 14.
    • [Isoform 14]: Lacks exons 6-11, exon 13 and exon 14.
    • [Isoform 15]: Lacks exons 6-14 and exon 19.
    • [Isoform 16]: Alternative splice donor/acceptor on exon 5 and lacks exon 10.
    • [Isoform 17]: Alternative splice donor/acceptor on exon 7 and lacks exon 10.
    • [Isoform 19]: Soluble isoform, has enhanced hyaluronan binding.

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

    Alternative splice isoforms for CD44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD44 Gene

Protein Expression for CD44 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD44 Gene

  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • N-glycosylated.
  • O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Glycosylation at Asn25, Asn57, Asn100, Asn110, Asn120, Thr174, Thr197, Ser199, Thr200, Thr541, Asn636, Asn548, Ser550, Ser553, Thr554, Thr555, Tyr560, Thr561, Ser562, Thr567, Ser570, Thr572, Thr577, Ser514, Ser578, Thr515, Thr581, Ser583, Thr318, Thr528, Thr529, Thr325, Asn599, Ser330, Ser332, Asn350, Ser422, Thr423, Thr424, Thr426, Ser458, Ser430, Thr433, Ser434, Ser478, Thr480, Thr484, and Thr489
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD44_HUMAN (736)

Other Protein References for CD44 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD44 Gene

Domains & Families for CD44 Gene

Gene Families for CD44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD44 Gene

Blocks:
  • Link domain
  • CD44 antigen precursor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD44 Gene

GenScript: Design optimal peptide antigens:
  • CD44 molecule (C0STK4_HUMAN)
  • CD44 molecule (C1PHC2_HUMAN)
  • CD44 molecule (C1PHC3_HUMAN)
  • CD44 molecule (C1PHC4_HUMAN)
  • CD44 molecule (C1PHE6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16070

UniProtKB/Swiss-Prot:

CD44_HUMAN :
  • The lectin-like LINK domain is responsible for hyaluronan binding.
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD44 Gene

UniProtKB/Swiss-Prot Function:
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).
GENATLAS Biochemistry:
cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas

Phenotypes From GWAS Catalog for CD44 Gene

Gene Ontology (GO) - Molecular Function for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0004896 contributes_to cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 11207560
GO:0005518 collagen binding NAS 2471973
GO:0005540 hyaluronic acid binding NAS,IEA 1991450
genes like me logo Genes that share ontologies with CD44: view
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

Animal Model Products

CRISPR Products

miRNA for CD44 Gene

miRTarBase miRNAs that target CD44

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD44

Clone Products

  • Addgene plasmids for CD44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250 UniProtKB:P15379, ECO:0000269 PubMed:23589287}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
extracellular 4
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
lysosome 3
peroxisome 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane NAS 1991450
GO:0005902 microvillus ISS --
genes like me logo Genes that share ontologies with CD44: view

Pathways & Interactions for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

Pathways by source for CD44 Gene

4 GeneGo (Thomson Reuters) pathways for CD44 Gene
  • Cell adhesion_Cell-matrix glycoconjugates
  • Cell adhesion_ECM remodeling
  • Development Beta-adrenergic receptors regulation of ERK
  • Signal transduction Calcium signaling
2 Qiagen pathways for CD44 Gene
  • Glioma Invasiveness
  • Rac1 Pathway
2 Cell Signaling Technology pathways for CD44 Gene
1 GeneTex pathway for CD44 Gene

SIGNOR curated interactions for CD44 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA 21873635
GO:0007155 cell adhesion IEA,IDA 19703720
GO:0007160 cell-matrix adhesion NAS 1922057
GO:0016477 cell migration IDA 22726066
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CD44: view

Drugs & Compounds for CD44 Gene

Products:

  1. Drug

(57) Drugs for CD44 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 730
Bivatuzumab Investigational Pharma Target 0
HYALURONAN Pharma 0

(43) Additional Compounds for CD44 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD44 Gene

8 REFSEQ mRNAs :
42 NCBI additional mRNA sequence :
39 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD44

Clone Products

  • Addgene plasmids for CD44

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22: -
SP23: - - - - - - - - - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29: - - - - - - - - - - - - - - -
SP30:
SP31: -
SP32:
SP33:

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - -