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CD44 Gene(Protein Coding)

CD44 Molecule (Indian Blood Group)

GCID:
GC11P035168
GIFtS:
54
Genes Participants
UDN Logo

Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3 5
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • CD44 Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • MDU2 3 4
  • MDU3 3 4
  • MIC4 3 4
  • LHR 3 4
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Phagocytic Glycoprotein I 4
  • Soluble CD44 3
  • CDW44 3
  • CSPG8 3
  • HCELL 3
  • CDw44 4
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3
  • IN 3

External Ids for CD44 Gene

Previous HGNC Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Previous GeneCards Identifiers for CD44 Gene

  • GC11P036713
  • GC11P035838
  • GC11P035199
  • GC11P035124
  • GC11P035125
  • GC11P035116
  • GC11P034858

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

CIViC summary for CD44 Gene

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Lichen Sclerosus. Among its related pathways are Cell adhesion_ECM remodeling and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot for CD44 Gene

  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Gene Wiki entry for CD44 Gene

Additional gene information for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CD44 Gene

Promoters and enhancers for CD44 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J035137 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.9 +3.7 3696 10.4 HDGF SIN3A YBX1 IRF4 GLIS2 ZNF143 ATF7 FOS RUNX3 MCM3 CD44 LOC100507144 APIP PDHX GC11P035210
GH11J035081 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 35 -53.3 -53304 7.8 PKNOX1 SIN3A IRF4 ZNF143 ATF7 FOS RUNX3 ZNF263 MAFF PBX2 LOC105376627 CD44 LOC100507144 NAT10 APIP GC11P035081
GH11J035042 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 33 -92.9 -92939 6.9 SOX13 PKNOX1 FOXA2 MAX CEBPG ZBTB40 ZNF644 FOSL1 ZNF614 GATA3 CD44 LOC100507144 APIP LOC105376626 GC11M035023
GH11J035076 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 32.1 -60.6 -60578 4.3 PKNOX1 BATF IRF4 FOS ETV6 BCLAF1 IKZF2 RUNX3 CREM SMARCC1 CD44 LOC100507144 APIP GC11P035081 LOC105376626
GH11J035157 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +27.9 27886 18.5 PKNOX1 FOXA2 IRF4 YY1 ATF7 FOS RUNX3 RXRA REST PPARG CD44 LOC100507144 MIR1343 APIP PDHX ENSG00000255004 GC11P035210
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD44 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CD44 Gene

Genomic Locations for CD44 Gene
chr11:35,138,870-35,232,402
(GRCh38/hg38)
Size:
93,533 bases
Orientation:
Plus strand
chr11:35,160,417-35,253,949
(GRCh37/hg19)
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

Genes around CD44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD44 Gene

Proteins for CD44 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with UNC119 (PubMed:19381274). Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267). Interacts with RDX, EZR and MSN (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

    Alternative splice isoforms for CD44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD44 Gene

Protein Expression for CD44 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD44 Gene

  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Glycosylation at Thr638, Thr637, posLast=636636, posLast=599599, posLast=578578, posLast=572572, Ser570, Thr567, Ser562, Thr561, posLast=560560, Asn548, posLast=541541, posLast=514514, Thr484, Thr480, Ser458, Ser434, posLast=433433, posLast=430430, Thr426, posLast=424424, Thr423, posLast=422422, posLast=350350, Ser330, Thr325, posLast=318318, posLast=200200, posLast=174174, posLast=120120, Asn110, Asn100, Asn57, and Asn25
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD44_HUMAN (736)

Other Protein References for CD44 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD44 Gene

Domains & Families for CD44 Gene

Gene Families for CD44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD44 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16070

UniProtKB/Swiss-Prot:

CD44_HUMAN :
  • The lectin-like LINK domain is responsible for hyaluronan binding.
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD44 Gene

UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
GENATLAS Biochemistry:
cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas

Phenotypes From GWAS Catalog for CD44 Gene

Gene Ontology (GO) - Molecular Function for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 contributes_to cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 11207560
GO:0005518 collagen binding NAS 2471973
GO:0005540 hyaluronic acid binding IEA,NAS 1991450
genes like me logo Genes that share ontologies with CD44: view
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

Animal Model Products

CRISPR Products

miRNA for CD44 Gene

miRTarBase miRNAs that target CD44

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD44

Clone Products

  • Addgene plasmids for CD44

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250 UniProtKB:P15379}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 5
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
endosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane NAS 1991450
GO:0005902 microvillus ISS --
genes like me logo Genes that share ontologies with CD44: view

Pathways & Interactions for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

SIGNOR curated interactions for CD44 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 1922057
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030214 hyaluronan catabolic process TAS --
genes like me logo Genes that share ontologies with CD44: view

Drugs & Compounds for CD44 Gene

Products:

  1. Drug

(58) Drugs for CD44 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 535
Bivatuzumab Investigational Pharma Target 0
HYALURONAN Pharma 0

(42) Additional Compounds for CD44 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD44 Gene

(27) REFSEQ mRNAs :
(36) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(39) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD44 Gene

CD44 molecule (Indian blood group):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD44

Clone Products

  • Addgene plasmids for CD44

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
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SP26: - - - -
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SP30:
SP31: -
SP32:
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ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - -
SP21: - -
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SP23: - - - - - - - - - - - - - - - - - -
SP24:
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - -
SP27: - - - - - - - - - - - - - - -
SP28:
SP29: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP30: - - -
SP31:
SP32:
SP33:

ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
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SP11:
SP12: -
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SP21: -
SP22:
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SP26:
SP27:
SP28: -
SP29: - -
SP30:
SP31:
SP32:
SP33: - - - - -

Relevant External Links for CD44 Gene

GeneLoc Exon Structure for
CD44
ECgene alternative splicing isoforms for
CD44

Expression for CD44 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD44 Gene

mRNA expression in normal human tissues for CD44 Gene
mRNA expression by BioGPS for CD44 GenemRNA expression by GTEx for CD44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery