Aliases for CD40LG Gene
- CD40 Ligand 2 3 4 5
- TNF-Related Activation Protein 2 3 4
- Tumor Necrosis Factor (Ligand) Superfamily Member 5 2 3
- T-B Cell-Activating Molecule 2 3
- CD40 Antigen Ligand 2 3
- T-Cell Antigen Gp39 3 4
- TNFSF5 3 4
- CD40-L 3 4
- CD40L 3 4
- TRAP 3 4
- Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome) 2
External Ids for CD40LG Gene
Previous HGNC Symbols for CD40LG Gene
Previous GeneCards Identifiers for CD40LG Gene
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD40LG Gene
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Toxoplasmosis. Among its related pathways are IL4-mediated signaling events and Allograft rejection. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding. An important paralog of this gene is TNFSF11.
UniProtKB/Swiss-Prot for CD40LG Gene
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.