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The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008] See more...
Aliases for CD40LG Gene
Aliases for CD40LG Gene
External Ids for CD40LG Gene
- HGNC: 11935
- Entrez Gene: 959
- Ensembl: ENSG00000102245
- OMIM: 300386
- UniProtKB: P29965
Previous HGNC Symbols for CD40LG Gene
- HIGM1
- IMD3
- TNFSF5
Previous GeneCards Identifiers for CD40LG Gene
- GC0XP135456
- GC0XP135558
- GC0XP135730
- GC0XP125001
Summaries for CD40LG Gene
-
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD40LG Gene
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Toxoplasmosis. Among its related pathways are NF-KappaB Family Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding. An important paralog of this gene is TNFSF10.
UniProtKB/Swiss-Prot Summary for CD40LG Gene
-
Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
-
[CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Additional gene information for CD40LG Gene
- HGNC(11935)
- Entrez Gene(959)
- Ensembl(ENSG00000102245)
- OMIM(300386)
- UniProtKB(P29965)
- Open Targets Platform(ENSG00000102245)
- Monarch Initiative
- Search for CD40LG at DataMed
- Search for CD40LG at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD40LG Gene
Genomics for CD40LG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD40LG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD40LG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD40LG
- Top Transcription factor binding sites by QIAGEN in the CD40LG gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- STAT1
- STAT1alpha
- STAT1beta
- TBP
- TFIID
Genomic Locations for CD40LG Gene
Genomic Locations for CD40LG Gene
- chrX:136,648,158-136,660,390
- (GRCh38/hg38)
- Size:
- 12,233 bases
- Orientation:
- Plus strand
- chrX:135,730,336-135,742,549
- (GRCh37/hg19)
- Size:
- 12,214 bases
- Orientation:
- Plus strand
Genomic View for CD40LG Gene
Genes around CD40LG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by HGNC
- Xq26.3 by Entrez Gene
- Xq26.3 by Ensembl
CD40LG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD40LG Gene
Proteins for CD40LG Gene
-
Protein details for CD40LG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29965-CD40L_HUMAN
- Recommended name:
- CD40 ligand
- Protein Accession:
- P29965
Protein attributes for CD40LG Gene
- Size:
- 261 amino acids
- Molecular mass:
- 29274 Da
- Quaternary structure:
-
- Homotrimer (PubMed:8626375, PubMed:11676606, PubMed:8589998). Interacts with isoform 3 of CD28 (PubMed:15067037). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (PubMed:8626375, PubMed:31331973). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (PubMed:31331973).
Protein Expression for CD40LG Gene
Post-translational modifications for CD40LG Gene
- The soluble form derives from the membrane form by proteolytic processing.
- N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
- Not O-glycosylated.
-
Glycosylation at Asn240
- NX_P29965 (NX_P29965-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CD40L_HUMAN (610)
Other Protein References for CD40LG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
BioLegend
- CD154 Antibody (310805)
- CD154 Antibody (310809)
- CD154 Antibody (310810)
- CD154 Antibody (310811)
- CD154 Antibody (310808)
- CD154 Antibody (310812)
- CD154 Antibody (310806)
- CD154 Antibody (310802)
- CD154 Antibody (310804)
- CD154 Antibody (310814)
- CD154 Antibody (310815)
- CD154 Antibody (310818)
- CD154 Antibody (310820)
- APC/Cyanine7 CD154 Antibody (310821)
- APC/Cyanine7 CD154 Antibody (310822)
- CD154 Antibody (310823)
- CD154 Antibody (310827)
- CD154 Antibody (310828)
- CD154 Antibody (310825)
- CD154 Antibody (310829)
- CD154 Antibody (310831)
- CD154 Antibody (310832)
- CD154 Antibody (310824)
- PerCP/Cyanine5.5 CD154 Antibody (310833)
- PerCP/Cyanine5.5 CD154 Antibody (310834)
- CD154 (MaxPar(R) Ready) Antibody
- CD154 Antibody (310838)
- CD154 Antibody (310837)
- CD154 Antibody (310826)
- CD154 Antibody (310830)
- CD154 Antibody (310839)
- CD154 Antibody (310840)
- CD154 Antibody (310841)
- CD154 Antibody (310842)
- TotalSeq(TM)-A0032 CD154 Antibody
- APC/Fire(TM) 750 CD154 Antibody (310848)
- CD154 Antibody (310846)
- APC/Fire(TM) 750 CD154 Antibody (310847)
- CD154 Antibody (310845)
-
Custom Antibody ServicesOriGene Antibodies for CD40LG
- 4CD40-1H4
- 4CD40-2A3
- AM08043BT-N
- AM08043FC-N
- AM08043LE-N
- AM08043PU-N
- AM08043RP-N
- AM26197PU-N
- AM26801LE-N
- AM26801PU-N
- AM26801RP-N
- AM31238AF-N
- AM31238FC-N
- AM31238PU-N
- AM31238RP-N
- AM33407PU-N
- AP00059PU-N
- AP01120BT-N
- AP01120BT-S
- AP01120PU-N
- AP01120PU-S
- AP17806PU-N
- AP18226PU-N
- AP23309PU-N
- DDX0140P-100
- DDX0141A647-100
- DDX0141P-100
- SM057F
- SM1224P
- SM1555A
- SM1555F
- SP2184P
- TA320280
- TA334291
- TA349779
- TA354175
- TA600027
- TA700027
- Novus Biologicals Antibodies for CD40LG
-
Abcam antibodies for CD40LG
- Invitrogen Antibodies for CD40LG (AFLGC-CD40LG)
- antibodies-online: Show 476 available IgM Antibodies ranked by validation data
- Compare Top IgM Antibodies
-
Recommended
- 258 WB Antibodies (anti-human)
- 119 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IF Antibodies (anti-human)
- 7 IF/ICC Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 4 ICC Antibodies (anti-human)
- 3 Inhibition Antibodies (anti-human)
- 3 FM Antibodies (anti-human)
- 3 IHC (fro) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 1 MA Antibody (anti-human)
- 71 FACS Antibodies (anti-mouse)
- 54 WB Antibodies (anti-mouse)
- 40 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 4 Neut Antibodies (anti-mouse)
- 2 in vivo Antibodies (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 41 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD40LG
- Sino Biological Antibodies for CD40LG
Protein Products
- G Biosciences Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN1452), Human CD40L/TNFSF5/CD40 Ligand/T-Cell Antigen Gp39/TNF-Related Activation Protein/TRAP/Tumor Necrosis Factor Ligand Superfamily Member 5/CD154/CD40LG/TRAP, Lyophilized, and Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN0109)
- Search Origene for MassSpec and Protein Over-expression Lysates for CD40LG
- Origene Custom Protein Services for CD40LG
- Sino Biological Recombinant Proteins for CD40LG
- Sino Biological Cell Lysates for CD40LG
- ProSpec Recombinant Proteins for CD40LG
-
Abcam proteins for CD40LG
Assay Products
- RayBiotech Human CD40L ELISA
- Novus Biologicals ELISA Kits for CD40LG
- antibodies-online: Show 112 available IgM Elisa Kits ranked by validation data
- Compare Top IgM Elisa Kits
-
Quality Products:
- ABIN624957
- ABIN1114192
- ABIN411377
- ABIN414917
- ABIN2683742
- ABIN2472082
- ABIN924794
- ABIN3032903
- ABIN1029800
- ABIN5520120
- ABIN1114190
- ABIN415533
- ABIN366338
- ABIN1889305
- ABIN1029801
- ABIN5520122
- ABIN6720243
- ABIN2683744
- ABIN5669726
- ABIN772890
- ABIN1114191
- ABIN416337
- ABIN1568893
- ABIN5520125
- ABIN5670390
- ABIN771567
- ABIN6384334
- ABIN5653024
- ABIN4885852
- ABIN4967930
- ABIN5520121
- ABIN1051839
- ABIN1560584
- ABIN4967934
-
Abcam assays for CD40LG
No data available for DME Specific Peptides for CD40LG Gene
Domains & Families for CD40LG Gene
Gene Families for CD40LG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Disease related genes
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD40LG Gene
- InterPro:
- Blocks:
-
- Tumor Necrosis Factor
- CD40 ligand/CD154 antigen signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CD40LG Gene
- GenScript: Design optimal peptide antigens:
-
- CD40 ligand (C1L3E0_HUMAN)
- Tumor necrosis factor ligand superfamily member 5 (CD40L_HUMAN)
- VH4 heavy chain variable region (O95973_HUMAN)
- Tumor necrosis factor ligand superfamily member 5 (Q45QX2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29965- Family:
-
- Belongs to the tumor necrosis factor family.
Function for CD40LG Gene
Molecular function for CD40LG Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
- UniProtKB/Swiss-Prot Function:
- [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Phenotypes From GWAS Catalog for CD40LG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | -- |
| GO:0005174 | CD40 receptor binding | IEA,IPI | 9468137 |
| GO:0005178 | integrin binding | IMP | 31331973 |
| GO:0005515 | protein binding | IEA,IPI | 15067037 |
Phenotypes for CD40LG Gene
- MGI mutant phenotypes for CD40LG:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- renal/urinary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for CD40LG:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased viability
- Strongly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased ionizing radiation sensitivity
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for CD40LG Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD40LG - Select products 50% OFF >
- * CD40LG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD40LG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD40LG
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40LG
miRNA for CD40LG Gene
- miRTarBase miRNAs that target CD40LG
-
- hsa-miR-146a-5p (MIRT005463)
- hsa-miR-4665-5p (MIRT619107)
- hsa-miR-1275 (MIRT619108)
- hsa-miR-5010-5p (MIRT619109)
- hsa-miR-4525 (MIRT619110)
- hsa-miR-7111-5p (MIRT619111)
- hsa-miR-6870-5p (MIRT619112)
- hsa-miR-5698 (MIRT619113)
- hsa-miR-4723-5p (MIRT619114)
- hsa-miR-625-5p (MIRT619115)
- hsa-miR-6825-5p (MIRT619116)
- hsa-miR-6883-5p (MIRT619117)
- hsa-miR-6785-5p (MIRT619118)
- hsa-miR-4728-5p (MIRT619119)
- hsa-miR-149-3p (MIRT619120)
- hsa-miR-6797-5p (MIRT619121)
- hsa-miR-1249-5p (MIRT619122)
- hsa-miR-6077 (MIRT619123)
- hsa-miR-873-3p (MIRT619124)
- hsa-miR-6855-3p (MIRT619125)
- hsa-miR-4513 (MIRT619126)
- hsa-miR-637 (MIRT619127)
- hsa-miR-9500 (MIRT619128)
- hsa-miR-4499 (MIRT619129)
- hsa-miR-888-3p (MIRT619130)
- hsa-miR-574-5p (MIRT663020)
- hsa-miR-4455 (MIRT663021)
- hsa-miR-3152-3p (MIRT663022)
- hsa-miR-6867-5p (MIRT663023)
- hsa-miR-5681a (MIRT663024)
- hsa-miR-34a-5p (MIRT733981)
- hsa-miR-345-5p (MIRT784903)
- hsa-miR-3664-5p (MIRT785073)
- hsa-miR-4522 (MIRT786094)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD40LG
- Browse OriGene Inhibitory RNA Products For CD40LG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD40LG
Clone Products
- Applied Biological Materials (abm): Clones for CD40LG - Select products 50% OFF >
- * CD40LG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD40LG
- Addgene plasmids for CD40LG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD40LG
Cell Line Products
-
Horizon Cell Lines for CD40LG
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD40LG Gene
Localization for CD40LG Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD40LG Gene
- Cell membrane. Single-pass type II membrane protein. Cell surface.
- [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269 PubMed:15193700}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| lysosome | 3 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 7678552 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD40LG Gene
Pathways & Interactions for CD40LG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 2 | Allograft rejection |
.44
|
THC Differentiation Pathway
.39
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
| 4 | T cell receptor signaling pathway | ||
| 5 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
Pathways by source for CD40LG Gene
8 BioSystems pathways for CD40LG Gene
6 Reactome pathways for CD40LG Gene
13 KEGG pathways for CD40LG Gene
1 GeneGo (Thomson Reuters) pathway for CD40LG Gene
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
2 R&D Systems pathways for CD40LG Gene
23 Qiagen pathways for CD40LG Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- CD40 Signaling
- Endothelin-1 Signaling Pathway
2 Cell Signaling Technology pathways for CD40LG Gene
Interacting Proteins for CD40LG Gene
GPS-Prot Interaction Network for CD40LG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | IEA,IDA | 9468137 |
| GO:0006955 | immune response | IEA | -- |
| GO:0007159 | leukocyte cell-cell adhesion | NAS | 9468137 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007229 | integrin-mediated signaling pathway | IMP | 31331973 |
Drugs & Compounds for CD40LG Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN1452), Human CD40L/TNFSF5/CD40 Ligand/T-Cell Antigen Gp39/TNF-Related Activation Protein/TRAP/Tumor Necrosis Factor Ligand Superfamily Member 5/CD154/CD40LG/TRAP, Lyophilized, and Human CD40 Ligand/TNFSF5/CD40L/CD154/T-cell antigen Gp39/gp39, Lyophilized (BAN0109)
Transcripts for CD40LG Gene
mRNA/cDNA for CD40LG Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370629 1852 nts (view in UCSC)
- ENST00000370628 1720 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD40LG - Select products 50% OFF >
- * CD40LG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD40LG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD40LG
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40LG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD40LG
- Browse OriGene Inhibitory RNA Products For CD40LG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD40LG
Clone Products
- Applied Biological Materials (abm): Clones for CD40LG - Select products 50% OFF >
- * CD40LG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD40LG
- Addgene plasmids for CD40LG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD40LG
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | - |
Relevant External Links for CD40LG Gene
- GeneLoc Exon Structure for
- CD40LG
Expression for CD40LG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Maturated and electroporated dendritic cells
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CD40LG Gene
This gene is overexpressed in Whole Blood (x19.7), Small Intestine - Terminal Ileum (x6.4), and Spleen (x5.7).
This gene is overexpressed in Blymphocyte (53.1) and NK cells (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD40LG Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD40LG
SOURCE GeneReport for Unigene cluster for CD40LG Gene:
Hs.592244mRNA Expression by UniProt/SwissProt for CD40LG Gene:
P29965-CD40L_HUMAN
Tissue specificity:
Specifically expressed on activated CD4+ T-lymphocytes.
Evidence on tissue expression from TISSUES for CD40LG Gene
- Blood(4.8)
- Lymph node(3.8)
- Spleen(3.8)
- Bone marrow(3.6)
- Kidney(3.5)
- Intestine(3.3)
- Liver(3.3)
- Nervous system(3.3)
- Urine(3.3)
- Heart(3.1)
- Skin(3.1)
- Muscle(2.9)
- Saliva(2.9)
- Lung(2.8)
- Bone(2.6)
- Stomach(2.6)
- Thyroid gland(2.5)
- Eye(2.5)
- Pancreas(2.4)
- Gall bladder(2.2)
- Adrenal gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD40LG Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
Regions:
Head and neck:
- face
- head
- lip
- mouth
Abdomen:
- intestine
- large intestine
- liver
- small intestine
- spleen
General:
- blood
- bone marrow
- coagulation system
- lymph node
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD40LG
-
OriGene qPCR primer pairs and template standards for CD40LG
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for CD40LG Gene
Orthologs for CD40LG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD40LG 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CD40LG 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD40LG 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd40lg 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd40lg 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CD40LG 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CD40LG 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CD40LG 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CD40LG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cd40lg 30 |
|
- Species where no ortholog for CD40LG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD40LG Gene
- ENSEMBL:
- Gene Tree for CD40LG (if available)
- TreeFam:
- Gene Tree for CD40LG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD40LG: view image
Paralogs for CD40LG Gene
Variants for CD40LG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD40LG Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 636364 | Likely Pathogenic: not provided | 136,659,305(+) | G/A | MISSENSE_VARIANT | |
| 636391 | Likely Pathogenic: not provided | 136,650,315(+) | TAC/T | FRAMESHIFT_VARIANT | |
| 636846 | Uncertain Significance: X-linked hyper-IgM syndrome; not provided | 136,656,388(+) | A/G | MISSENSE_VARIANT | |
| 648466 | Uncertain Significance: X-linked hyper-IgM syndrome | 136,656,382(+) | C/T | MISSENSE_VARIANT | |
| 650284 | Likely Pathogenic: X-linked hyper-IgM syndrome | 136,659,149(+) | C/T | NONSENSE |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.34;
26.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD40LG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD40LG Gene
Disorders for CD40LG Gene
(569) MalaCards diseases for CD40LG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency with hyper-igm, type 1 |
|
|
| toxoplasmosis |
|
|
| rubella |
|
|
| cryoglobulinemia |
|
|
| congenital toxoplasmosis |
|
Search CD40LG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CD40L_HUMAN- Immunodeficiency with hyper-IgM, type 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. {ECO:0000269 PubMed:26545377, ECO:0000269 PubMed:31331973, ECO:0000269 PubMed:7532185, ECO:0000269 PubMed:7678782, ECO:0000269 PubMed:7679206, ECO:0000269 PubMed:7679801, ECO:0000269 PubMed:7717401, ECO:0000269 PubMed:8094231, ECO:0000269 PubMed:8550833, ECO:0000269 PubMed:8889581, ECO:0000269 PubMed:9150729, ECO:0000269 PubMed:9746782}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CD40LG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for CD40LG Gene
Publications for CD40LG Gene
- The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. (PMID: 7678782) Aruffo A … Neubauer M (Cell 1993) 2 3 4 23
- Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (PMID: 19421221) Malheiros D … Petzl-Erler ML (Genes and immunity 2009) 3 23 41
- Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions. (PMID: 19735272) Kim SH … Adverse Drug Reaction Research Group in Korea (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009) 3 23 41
- Immune response gene polymorphisms in renal transplant recipients. (PMID: 16378074) Dmitrienko S … Keown PA (Transplantation 2005) 3 23 41
- Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. (PMID: 11676606) Khandekar SS … Fishman-Lobell J (Protein expression and purification 2001) 3 4 23
ExternalLinks
Products for CD40LG Gene
- View all 39 R&D Systems CD40LG (CD40 Ligand/TNFSF5) Products
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- 4CD40-1H4
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- AP00059PU-N
- AP01120BT-N
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- DDX0140P-100
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- SM057F
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- antibodies-online: Show 476 available IgM Antibodies ranked by validation data
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- 6 IP Antibodies (anti-human)
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- 3 FM Antibodies (anti-human)
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- 2 in vivo Antibodies (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 41 WB Antibodies (anti-rat)
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Sources for CD40LG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB