This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initia... See more...

Aliases for CD4 Gene

Aliases for CD4 Gene

  • CD4 Molecule 2 3 5
  • T-Cell Surface Glycoprotein CD4 2 3 4
  • T-Cell Surface Antigen T4/Leu-3 3 4
  • CD4 Antigen (P55) 2 3
  • CD4 Receptor 3
  • CD4 Antigen 4
  • CD4mut 3

External Ids for CD4 Gene

Previous GeneCards Identifiers for CD4 Gene

  • GC12M007045
  • GC12M007130
  • GC12P006777
  • GC12P006769
  • GC12P006899

Summaries for CD4 Gene

Entrez Gene Summary for CD4 Gene

  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CD4 Gene

CD4 (CD4 Molecule) is a Protein Coding gene. Diseases associated with CD4 include Okt4 Epitope Deficiency and Human Immunodeficiency Virus Infectious Disease. Among its related pathways are Vesicle-mediated transport and TCR signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot Summary for CD4 Gene

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
  • (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Wiki entry for CD4 Gene

Additional gene information for CD4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD4 Gene

Genomics for CD4 Gene

GeneHancer (GH) Regulatory Elements for CD4 Gene

Promoters and enhancers for CD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD4 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • p300
  • STAT3
  • TBP
  • TFIID

Genomic Locations for CD4 Gene

Genomic Locations for CD4 Gene
chr12:6,786,858-6,820,810
(GRCh38/hg38)
Size:
33,953 bases
Orientation:
Plus strand
chr12:6,896,024-6,929,976
(GRCh37/hg19)
Size:
33,953 bases
Orientation:
Plus strand

Genomic View for CD4 Gene

Genes around CD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD4 Gene

Proteins for CD4 Gene

  • Protein details for CD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01730-CD4_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD4
    Protein Accession:
    P01730
    Secondary Accessions:
    • B2R737
    • D3DUS5
    • Q4ZGK2
    • Q5U066
    • Q9UDE5

    Protein attributes for CD4 Gene

    Size:
    458 amino acids
    Molecular mass:
    51111 Da
    Quaternary structure:
    • Forms disulfide-linked homodimers at the cell surface. Interacts with LCK (PubMed:16888650). Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes.
    • (Microbial infection) Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu (PubMed:2214026, PubMed:16331979, PubMed:9641677).
    • (Microbial infection) Interacts with Human Herpes virus 7 surface proteins.

    Three dimensional structures from OCA and Proteopedia for CD4 Gene

neXtProt entry for CD4 Gene

Post-translational modifications for CD4 Gene

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.
  • Glycosylation at Asn296 and Asn325
  • Ubiquitination at Lys453
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD4_HUMAN (587)

Antibody Products

Protein Products

  • Abcam proteins for CD4

No data available for DME Specific Peptides for CD4 Gene

Domains & Families for CD4 Gene

Gene Families for CD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CD4 Gene

GenScript: Design optimal peptide antigens:
  • T-cell surface antigen T4/Leu-3 (CD4_HUMAN)
  • CD4 receptor (Q13969_HUMAN)
  • Surface glycoprotein variant (Q6LCP8_HUMAN)
genes like me logo Genes that share domains with CD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD4 Gene

Function for CD4 Gene

Molecular function for CD4 Gene

UniProtKB/Swiss-Prot Function:
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).
GENATLAS Biochemistry:
cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4

Phenotypes From GWAS Catalog for CD4 Gene

Gene Ontology (GO) - Molecular Function for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 10358157
GO:0005102 signaling receptor binding IEA --
GO:0005201 extracellular matrix structural constituent NAS 12444132
GO:0005515 protein binding IPI 7831289
genes like me logo Genes that share ontologies with CD4: view
genes like me logo Genes that share phenotypes with CD4: view

Human Phenotype Ontology for CD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD4 Gene

MGI Knock Outs for CD4:
  • Cd4 Cd4<tm1Mak>
  • Cd4 Cd4<tm1Dim>
  • Cd4 Cd4<tm1Knw>
  • Cd4 Cd4<tm1Litt>
  • Cd4 Cd4<tm1Doi>
  • Cd4 Cd4<tm2Litt>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CD4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD4 Gene

Localization for CD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 4
endosome 4
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 24942581
genes like me logo Genes that share ontologies with CD4: view

Pathways & Interactions for CD4 Gene

genes like me logo Genes that share pathways with CD4: view