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Aliases for CD4 Gene

Aliases for CD4 Gene

  • CD4 Molecule 2 3 5
  • T-Cell Surface Glycoprotein CD4 2 3
  • T-Cell Surface Antigen T4/Leu-3 3 4
  • CD4 Antigen (P55) 2 3
  • CD4 Receptor 3
  • CD4 Antigen 4
  • CD4mut 3

External Ids for CD4 Gene

Previous GeneCards Identifiers for CD4 Gene

  • GC12M007045
  • GC12M007130
  • GC12P006777
  • GC12P006769
  • GC12P006899

Summaries for CD4 Gene

Entrez Gene Summary for CD4 Gene

  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CD4 Gene

CD4 (CD4 Molecule) is a Protein Coding gene. Diseases associated with CD4 include Okt4 Epitope Deficiency and Pilonidal Sinus. Among its related pathways are Akt Signaling and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CD4 Gene

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

  • (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Wiki entry for CD4 Gene

Additional gene information for CD4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD4 Gene

Genomics for CD4 Gene

GeneHancer (GH) Regulatory Elements for CD4 Gene

Promoters and enhancers for CD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006788 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 671.4 +4.2 4218 5 HDGF FOXA2 MLX ARID4B SIN3A ZNF48 YY1 SLC30A9 ZFP91 SP5 CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12J006784 Enhancer 1 Ensembl ENCODE dbSUPER 666.9 -0.9 -943 3.3 ZNF223 MAFG ZFHX2 MAFF ZNF316 ZNF341 MAFK EMSY SPI1 CD4 RN7SL380P GPR162 P3H3 ZNF384 ENSG00000219410 ING4 ACRBP PIANP LPAR5
GH12J006722 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 -62.8 -62805 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 COPS7A ENSG00000270068 ZNF384 CHD4 ENSG00000219410 NOP2 ENSG00000247853 NCAPD2 ING4 SPSB2
GH12J006735 Enhancer 1 Ensembl ENCODE 11.6 -51.0 -51010 1.1 INSM2 ARID4B RAD21 YY1 ZNF335 SCRT2 ZNF143 ZFP91 RUNX3 MIXL1 PTMS MLF2 LAG3 CD4 GPR162 P3H3 ENSG00000219410 ING4 ACRBP CHD4
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.8 +166.8 166800 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 EMG1 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 SCARNA12 NCAPD2 ENSG00000256967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD4 gene promoter:

Genomic Locations for CD4 Gene

Genomic Locations for CD4 Gene
chr12:6,786,858-6,820,810
(GRCh38/hg38)
Size:
33,953 bases
Orientation:
Plus strand
chr12:6,896,024-6,929,976
(GRCh37/hg19)

Genomic View for CD4 Gene

Genes around CD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD4 Gene

Proteins for CD4 Gene

  • Protein details for CD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01730-CD4_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD4
    Protein Accession:
    P01730
    Secondary Accessions:
    • B2R737
    • D3DUS5
    • Q4ZGK2
    • Q5U066
    • Q9UDE5

    Protein attributes for CD4 Gene

    Size:
    458 amino acids
    Molecular mass:
    51111 Da
    Quaternary structure:
    • Forms disulfide-linked homo-dimers at the cell surface. Interacts with LCK (PubMed:16888650). Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes.
    • (Microbial infection) Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu (PubMed:2214026, PubMed:16331979, PubMed:9641677).
    • (Microbial infection) Interacts with Human Herpes virus 7 surface proteins.

    Three dimensional structures from OCA and Proteopedia for CD4 Gene

neXtProt entry for CD4 Gene

Post-translational modifications for CD4 Gene

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.
  • Glycosylation at posLast=325325 and Asn296
  • Ubiquitination at posLast=453453
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD4_HUMAN (587)

Antibody Products

No data available for DME Specific Peptides for CD4 Gene

Domains & Families for CD4 Gene

Gene Families for CD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CD4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD4: view

No data available for UniProtKB/Swiss-Prot for CD4 Gene

Function for CD4 Gene

Molecular function for CD4 Gene

UniProtKB/Swiss-Prot Function:
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).
GENATLAS Biochemistry:
cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4

Phenotypes From GWAS Catalog for CD4 Gene

Gene Ontology (GO) - Molecular Function for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 10358157
GO:0005201 extracellular matrix structural constituent NAS 12444132
GO:0005515 protein binding IPI 7831289
GO:0008270 zinc ion binding IDA 9668045
genes like me logo Genes that share ontologies with CD4: view
genes like me logo Genes that share phenotypes with CD4: view

Human Phenotype Ontology for CD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD4 Gene

MGI Knock Outs for CD4:
  • Cd4 Cd4<tm1Mak>
  • Cd4 Cd4<tm1Dim>
  • Cd4 Cd4<tm1Litt>
  • Cd4 Cd4<tm1Knw>
  • Cd4 Cd4<tm2Litt>
  • Cd4 Cd4<tm1Doi>

Animal Model Products

Clone Products

  • Addgene plasmids for CD4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD4 Gene

Localization for CD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 4
extracellular 2
peroxisome 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 24942581
genes like me logo Genes that share ontologies with CD4: view

Pathways & Interactions for CD4 Gene

genes like me logo Genes that share pathways with CD4: view

Gene Ontology (GO) - Biological Process for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 24942581
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006948 induction by virus of host cell-cell fusion IDA 9166430
genes like me logo Genes that share ontologies with CD4: view

No data available for SIGNOR curated interactions for CD4 Gene

Drugs & Compounds for CD4 Gene

(141) Drugs for CD4 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Primaquine Approved Pharma 80
Zidovudine Approved Pharma 497
Antithymocyte immunoglobulin (rabbit) Approved Pharma Target 0
Ibalizumab Approved, Investigational Pharma Target, antagonist 0
Abacavir Approved, Investigational Pharma 222

(32) Additional Compounds for CD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for CD4 Gene

Compound Action Cas Number
BMS-378806 Gp120/CD4 inhibitor 357263-13-9
YYA-021 Competitive gp120-CD4 interaction inhibitor 144217-65-2
genes like me logo Genes that share compounds with CD4: view

Drug Products

Transcripts for CD4 Gene

mRNA/cDNA for CD4 Gene

(4) Selected AceView cDNA sequences:
(16) Additional mRNA sequences :
(6) REFSEQ mRNAs :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD4 Gene

CD4 molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for CD4

Alternative Splicing Database (ASD) splice patterns (SP) for CD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CD4 Gene

GeneLoc Exon Structure for
CD4
ECgene alternative splicing isoforms for
CD4

Expression for CD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD4 Gene

This gene is overexpressed in Spleen (x8.4) and Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for CD4 Gene

This gene is overexpressed in Lymph node (26.9), Tlymphocyte (15.4), Peripheral blood mononuclear cells (13.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD4 Gene



Protein tissue co-expression partners for CD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD4 Gene:

CD4

SOURCE GeneReport for Unigene cluster for CD4 Gene:

Hs.631659

mRNA Expression by UniProt/SwissProt for CD4 Gene:

P01730-CD4_HUMAN
Tissue specificity: Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

Evidence on tissue expression from TISSUES for CD4 Gene

  • Blood(4.7)
  • Nervous system(4.7)
  • Liver(4.5)
  • Pancreas(4.1)
  • Spleen(3.4)
  • Kidney(3.1)
  • Lung(2.9)
  • Lymph node(2.8)
  • Intestine(2.4)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD4 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Regions:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CD4: view

Orthologs for CD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD4 34 33
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD4 33
  • 74.68 (n)
cow
(Bos Taurus)
Mammalia CD4 34 33
  • 72.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd4 16 34 33
  • 69.48 (n)
rat
(Rattus norvegicus)
Mammalia Cd4 33
  • 68.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CD4 34
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD4 34
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD4 34 33
  • 43.76 (n)
OneToOne
Species where no ortholog for CD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD4 Gene

ENSEMBL:
Gene Tree for CD4 (if available)
TreeFam:
Gene Tree for CD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD4: view image

Paralogs for CD4 Gene

No data available for Paralogs for CD4 Gene

Variants for CD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD4 Gene

CD4_HUMAN-P01730
The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood T-lymphocytes. OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is polymorphic in white, black, and Japanese populations. The variable phenotypic expression is due a CD4 polymorphism. OKT4 positive individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949].

Sequence variations from dbSNP and Humsavar for CD4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs28919570 pathogenic, Okt4 epitope deficiency 6,816,241(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000078109 -- 6,790,490(+) G/C intron_variant
rs1000166755 -- 6,787,857(+) A/G upstream_transcript_variant
rs1000457374 -- 6,793,088(+) G/A/T intron_variant
rs1000481071 -- 6,815,177(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD4 Gene

Variant ID Type Subtype PubMed ID
dgv2323n54 CNV loss 21841781
dgv757n106 CNV deletion 24896259
esv2663865 CNV deletion 23128226
esv2745479 CNV deletion 23290073
esv3548686 CNV deletion 23714750
esv3548687 CNV deletion 23714750
nsv1069635 CNV deletion 25765185
nsv1127245 CNV deletion 24896259
nsv1152779 CNV deletion 26484159
nsv52513 CNV deletion 16902084
nsv593 CNV deletion 18451855
nsv832323 CNV loss 17160897
nsv832324 CNV loss 17160897
nsv957248 CNV deletion 24416366

Variation tolerance for CD4 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD4 Gene

Human Gene Mutation Database (HGMD)
CD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD4

SNP Genotyping and Copy Number Assay Products

Disorders for CD4 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CD4 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
okt4 epitope deficiency
  • t4 epitope deficiency
pilonidal sinus
pneumocystosis
  • pneumocystis carinii pneumonia
ventilation pneumonitis
  • air-conditioner and humidifier lung
immune system organ benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD4 Gene

Publications for CD4 Gene

  1. Structural basis for the interaction between focal adhesion kinase and CD4. (PMID: 18078954) Garron ML … Arold ST (Journal of molecular biology 2008) 3 4 22 58
  2. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PMID: 12517957) Fragoso R … Jin YJ (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 22 58
  3. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. (PMID: 24942581) Zhen A … Kitchen SG (Journal of virology 2014) 3 4 58
  4. CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. (PMID: 20924289) Hennig BJ … Sirugo G (Journal of acquired immune deficiency syndromes (1999) 2011) 3 44 58
  5. Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population. (PMID: 19843086) Zamani M … Mansouri P (Clinical and experimental dermatology 2010) 3 44 58

Products for CD4 Gene