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The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17 and Immunodeficiency 19. Among its related pathways are TCR signaling in naive CD4+ T cells and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IMP | 12794121 |
GO:0005515 | protein binding | IPI | 32296183 |
GO:0030159 | receptor signaling complex scaffold activity | NAS | 12794121 |
GO:0042608 | T cell receptor binding | NAS | 11186279 |
GO:0042802 | identical protein binding | IDA | 14967045 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | NAS | 9485181 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
2 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
3 | T cell receptor signaling pathway | ||
4 | ICos-ICosL Pathway in T-Helper Cell |
CD28 Signaling in T-Helper Cell
.66
ICos-ICosL Pathway in T-Helper Cell
.66
|
Calcium Mediated T-Cell Apoptosis
.31
|
5 | TCR Signaling (Qiagen) |
PKC-Theta Pathway
.68
TCR Signaling
.68
|
ITK and TCR Signaling
.54
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0007163 | establishment or maintenance of cell polarity | IMP | 12407027 |
GO:0007166 | cell surface receptor signaling pathway | IMP | 12407027 |
GO:0015031 | protein transport | IMP | 12794121 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Muromonab | Approved, Investigational | Pharma | Target, binder | 0 | ||
Catumaxomab | Approved, Investigational, Withdrawn | Pharma | Antibody | Others | 15 | |
Otelixizumab | Investigational | Pharma | antibody | 0 | ||
Visilizumab | Investigational | Pharma | 14 | |||
ANTI-CD3 MONOCLONAL ANTIBODY | Pharma | 0 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD3G 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD3G 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD3G 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd3g 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd3g 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CD3G 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD3G 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD3D 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
845191 | Uncertain Significance: Immunodeficiency 17 | 118,344,460(+) |
G/A NM_000073.3(CD3G):c.37G>A (p.Ala13Thr) |
MISSENSE | |
849416 | Uncertain Significance: Immunodeficiency 17 | 118,350,597(+) |
T/C NM_000073.3(CD3G):c.353T>C (p.Phe118Ser) |
MISSENSE | |
863273 | Uncertain Significance: Immunodeficiency 17 | 118,349,054(+) |
G/A NM_000073.3(CD3G):c.79+4G>A |
INTRON | |
877939 | Uncertain Significance: Immunodeficiency 17 | 118,353,717(+) |
G/T NM_000073.3(CD3G):c.*617G>T |
THREE_PRIME_UTR | |
877940 | Uncertain Significance: Immunodeficiency 17 | 118,353,750(+) |
C/T NM_000073.3(CD3G):c.*650C>T |
THREE_PRIME_UTR |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 17 |
|
|
immunodeficiency 19 |
|
|
enteropathy-associated t-cell lymphoma |
|
|
immunodeficiency 18 |
|
|
cd3zeta deficiency |
|
|