Aliases for CD3G Gene
Aliases for CD3G Gene
External Ids for CD3G Gene
- HGNC: 1675
- Entrez Gene: 917
- Ensembl: ENSG00000160654
- OMIM: 186740
- UniProtKB: P09693
Previous GeneCards Identifiers for CD3G Gene
- GC11P120571
- GC11P119726
- GC11P118248
- GC11P117752
- GC11P117720
- GC11P114148
Summaries for CD3G Gene
-
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD3G Gene
CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17 and Enteropathy-Associated T-Cell Lymphoma. Among its related pathways are G-protein signaling N-RAS regulation pathway and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.
UniProtKB/Swiss-Prot for CD3G Gene
-
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Additional gene information for CD3G Gene
- Monarch Initiative
- Search for CD3G at DataMed
- Search for CD3G at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3G Gene
Genomics for CD3G Gene
GeneHancer (GH) Regulatory Elements for CD3G Gene
Promoters and enhancers for CD3G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CD3G on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CD3G Gene
Genomic Locations for CD3G Gene
- chr11:118,344,316-118,355,161
- (GRCh38/hg38)
- Size:
- 10,846 bases
- Orientation:
- Plus strand
- chr11:118,215,059-118,225,876
- (GRCh37/hg19)
Genomic View for CD3G Gene
Genes around CD3G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC
CD3G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD3G Gene
Proteins for CD3G Gene
-
Protein details for CD3G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09693-CD3G_HUMAN
- Recommended name:
- T-cell surface glycoprotein CD3 gamma chain
- Protein Accession:
- P09693
- Q2HIZ6
Protein attributes for CD3G Gene
- Size:
- 182 amino acids
- Molecular mass:
- 20469 Da
- Quaternary structure:
-
- The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Protein Expression for CD3G Gene
Post-translational modifications for CD3G Gene
- Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 (PubMed:2470098). Phosphorylated also by PKC; leading to the TCR complex down-regulation (PubMed:8187769).
- Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
- Ubiquitination at posLast=3232, posLast=7979, Lys93, Lys95, posLast=150150, and Lys164
- Glycosylation at Asn52 and Asn92
- Modification sites at PhosphoSitePlus
Other Protein References for CD3G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Invitrogen Antibodies for CD3G
- GeneTex CD3G antibody for CD3G
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD3G
- Sino Biological Antibodies for CD3G
Protein Products
-
OriGene Purified Proteins for CD3G
- Search Origene for MassSpec and Protein Over-expression Lysates for CD3G
- Origene Custom Protein Services for CD3G
- ProSpec Recombinant Proteins for CD3G
- Search GeneTex for Proteins for CD3G
-
Abcam proteins for CD3G
Assay Products
No data available for DME Specific Peptides for CD3G Gene
Domains & Families for CD3G Gene
Gene Families for CD3G Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD3G Gene
Suggested Antigen Peptide Sequences for CD3G Gene
Graphical View of Domain Structure for InterPro Entry
P09693UniProtKB/Swiss-Prot:
CD3G_HUMAN :- A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
- Domain:
-
- A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
Function for CD3G Gene
Molecular function for CD3G Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD3G (gp26),,gamma polypeptide (see CD3@),including an alternative splicing product pTAC12,component of the pre-T cell antigen receptor complex
- UniProtKB/Swiss-Prot Function:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Phenotypes From GWAS Catalog for CD3G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IMP,IEA | 12794121 |
| GO:0030159 | receptor signaling complex scaffold activity | NAS | 12794121 |
| GO:0042608 | T cell receptor binding | NAS | 11186279 |
| GO:0042803 | protein homodimerization activity | IMP | 14967045 |
| GO:0046982 | protein heterodimerization activity | IPI | 9485181 |
Phenotypes for CD3G Gene
- MGI mutant phenotypes for CD3G:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CD3G:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased viability with neratinib
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD3G gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD3G gene
- Search ViGene Biosciences for CD3G
CRISPR Products
-
OriGene CRISPR knockouts for CD3G
- genomics-online: gRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- Applied Biological Materials CRISPR for CD3G
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD3G
- GenScript: Design CRISPR guide RNA sequences for CD3G
miRNA for CD3G Gene
- miRTarBase miRNAs that target CD3G
-
- hsa-mir-1227-3p (MIRT736144)
- hsa-mir-1273e (MIRT736768)
- hsa-mir-1273f (MIRT736790)
- hsa-mir-1827 (MIRT738088)
- hsa-mir-1910-3p (MIRT738393)
- hsa-mir-2467-3p (MIRT739251)
- hsa-mir-3612 (MIRT741553)
- hsa-mir-377-5p (MIRT742675)
- hsa-mir-4252 (MIRT743325)
- hsa-mir-4257 (MIRT743389)
- hsa-mir-4459 (MIRT744786)
- hsa-mir-4537 (MIRT746080)
- hsa-mir-455-3p (MIRT746166)
- hsa-mir-4695-5p (MIRT747167)
- hsa-mir-6086 (MIRT751829)
- hsa-mir-6499-3p (MIRT752783)
- hsa-mir-650 (MIRT753001)
- hsa-mir-6511a-5p (MIRT753118)
- hsa-mir-6516-5p (MIRT753330)
- hsa-mir-665 (MIRT753622)
- hsa-mir-6840-3p (MIRT757305)
miRNA Products
- Search ViGene Biosciences for CD3G
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CD3G
- Browse OriGene Inhibitory RNA Products For CD3G
- genomics-online: shRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD3G gene
Clone Products
- Sino Biological Human cDNA Clone for CD3G
- VectorBuilder custom plasmid, inducible vectors for CD3G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD3G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CD3G
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD3G (CD3 gamma)
Cell Line Products
-
Horizon Cell Lines for CD3G
-
ViGene Biosciences adenoviral particle packaged cDNA for CD3G gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD3G gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD3G gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD3G Gene
Localization for CD3G Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD3G Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 3 |
| extracellular | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 9485181 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030665 | clathrin-coated vesicle membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD3G Gene
Pathways & Interactions for CD3G Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 2 | Immune response NFAT in immune response | ||
| 3 | ICos-ICosL Pathway in T-Helper Cell | ||
| 4 | TCR Signaling (Qiagen) |
.68
|
|
| 5 | T cell receptor signaling pathway | ||
Pathways by source for CD3G Gene
2 Sino Biological pathways for CD3G Gene
7 BioSystems pathways for CD3G Gene
7 KEGG pathways for CD3G Gene
13 GeneGo (Thomson Reuters) pathways for CD3G Gene
20 Qiagen pathways for CD3G Gene
Interacting Proteins for CD3G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006461 | protein complex assembly | NAS | 12794121 |
| GO:0007163 | establishment or maintenance of cell polarity | IMP | 12407027 |
| GO:0007166 | cell surface receptor signaling pathway | IMP,IEA | 12407027 |
Drugs & Compounds for CD3G Gene
Transcripts for CD3G Gene
mRNA/cDNA for CD3G Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD3G Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD3G
- genomics-online: gRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- Applied Biological Materials CRISPR for CD3G
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD3G
- GenScript: Design CRISPR guide RNA sequences for CD3G
miRNA Products
- Search ViGene Biosciences for CD3G
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CD3G
- Browse OriGene Inhibitory RNA Products For CD3G
- genomics-online: shRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD3G gene
Clone Products
- Sino Biological Human cDNA Clone for CD3G
- VectorBuilder custom plasmid, inducible vectors for CD3G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD3G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CD3G
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD3G (CD3 gamma)
Expression for CD3G Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
- Adipose (Muscoskeletal System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CD3G Gene
This gene is overexpressed in Whole Blood (x22.0), Spleen (x7.1), and Small Intestine - Terminal Ileum (x5.8).
This gene is overexpressed in CD4 Tcells (26.1), CD8 Tcells (21.0), Peripheral blood mononuclear cells (9.8), and Lymph node (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD3G Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD3G Gene:
CD3GSOURCE GeneReport for Unigene cluster for CD3G Gene:
Hs.2259Evidence on tissue expression from TISSUES for CD3G Gene
- Blood(2.6)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD3G Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- immune
- integumentary
- lymphatic
- nervous
- respiratory
Regions:
Head and neck:
- brain
- head
General:
- blood
- bone marrow
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD3G
-
OriGene qPCR primer pairs and template standards for CD3G
- genomics-online: primer clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for CD3G Gene
Orthologs for CD3G Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD3G 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CD3G 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CD3G 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd3g 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd3g 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD3G 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD3G 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD3D 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for CD3G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD3G Gene
(1) SIMAP similar genes for CD3G Gene using alignment to 6 proteins:
Variants for CD3G Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894199 | pathogenic, Immunodeficiency 17 | 118,344,424(+) | A/G | initiator_codon_variant, missense_variant | |
| rs115851096 | benign, Immunodeficiency 17 | 118,349,060(+) | A/G | intron_variant | |
| rs139781104 | benign, Immunodeficiency 17 | 118,349,035(+) | G/A | coding_sequence_variant, missense_variant | |
| rs142915569 | uncertain-significance, Immunodeficiency due to defect in CD3-gamma | 118,349,821(+) | T/A/C/G | coding_sequence_variant, missense_variant | |
| rs145293635 | uncertain-significance, Immunodeficiency due to defect in CD3-gamma | 118,344,407(+) | G/A/T | 5_prime_UTR_variant |
Residual Variation Intolerance Score:
70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.80;
91.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD3G Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD3G Gene
Disorders for CD3G Gene
(8) MalaCards diseases for CD3G Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 17 |
|
|
| enteropathy-associated t-cell lymphoma |
|
|
| immunodeficiency 19 |
|
|
| immunodeficiency 18 |
|
|
| immune defect due to absence of thymus |
|
|
Search CD3G in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CD3G_HUMAN- Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269 PubMed:1635567, ECO:0000269 PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for CD3G Gene
immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal transduction,through the TCR
Additional Disease Information for CD3G
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for CD3G Gene
- Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K … McManus R (BMC medical genetics 2010) 3 44 58
- Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S … Plenge RM (Nature genetics 2009) 3 44 58
- Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing. (PMID: 17822534) Akl H … Willard-Gallo KE (Virology journal 2007) 3 22 58
- Transcriptional regulation of the human CD3 gamma gene: the TATA-less CD3 gamma promoter functions via an initiator and contiguous Sp-binding elements. (PMID: 15879122) Badran BM … Willard-Gallo KE (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 22 58
- Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. (PMID: 14967045) Sigalov A … Stern L (Biochemistry 2004) 3 22 58
Products for CD3G Gene
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CD3G
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD3G
- VectorBuilder custom plasmid, inducible vectors for CD3G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD3G
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 90 available CD3G Antibodies ranked by validation data
- Compare Top CD3G Antibodies
- antibodies-online: Search results for 9 available CD3G Elisa Kits ranked by validation data
- Compare Top CD3G Elisa Kits
- antibodies-online: Search results for 10 available CD3G Proteins ranked by validation data
- Compare Top CD3G Proteins
- GeneTex CD3G antibody for CD3G
- Search GeneTex for Proteins for CD3G
- ViGene Biosciences adenoviral particle packaged cDNA for CD3G gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD3G gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD3G gene
- Search ViGene Biosciences for CD3G
- Santa Cruz Biotechnology (SCBT) Antibodies for CD3G
- Search Santa Cruz Biotechnology (SCBT) for CD3G siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD3G
- Horizon Cell Lines for CD3G
- genomics-online: cdna clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- orf clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- genomics-online: gRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- genomics-online: primer clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
- genomics-online: shRNA clones - Search results for 132 available CD3G gene related products
- Overview of 132 available CD3G gene related products
Sources for CD3G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
