The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma ... See more...

Aliases for CD3E Gene

Aliases for CD3E Gene

  • CD3e Molecule 2 3 5
  • CD3e Antigen, Epsilon Polypeptide (TiT3 Complex) 2 3
  • T-Cell Surface Glycoprotein CD3 Epsilon Chain 3 4
  • T-Cell Surface Antigen T3/Leu-4 Epsilon Chain 3 4
  • CD3e Molecule, Epsilon (CD3-TCR Complex) 2 3
  • T3E 3 4
  • T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3 3
  • CD3e Antigen 4
  • CD3-Epsilon 3
  • IMD18 3
  • TCRE 3

External Ids for CD3E Gene

Previous GeneCards Identifiers for CD3E Gene

  • GC11P120532
  • GC11P119687
  • GC11P118209
  • GC11P117713
  • GC11P117680
  • GC11P114108

Summaries for CD3E Gene

Entrez Gene Summary for CD3E Gene

  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD3E Gene

CD3E (CD3e Molecule) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are TCR signaling (REACTOME) and G-protein signaling N-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and obsolete signal transducer activity. An important paralog of this gene is CD3G.

UniProtKB/Swiss-Prot Summary for CD3E Gene

  • Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

Gene Wiki entry for CD3E Gene

Additional gene information for CD3E Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD3E Gene

Genomics for CD3E Gene

GeneHancer (GH) Regulatory Elements for CD3E Gene

Promoters and enhancers for CD3E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD3E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD3E gene promoter:
  • Cdc5
  • GR
  • GR-alpha
  • GR-beta
  • Hlf
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5B

Genomic Locations for CD3E Gene

Genomic Locations for CD3E Gene
chr11:118,304,545-118,316,175
(GRCh38/hg38)
Size:
11,631 bases
Orientation:
Plus strand
chr11:118,175,260-118,186,890
(GRCh37/hg19)
Size:
11,631 bases
Orientation:
Plus strand

Genomic View for CD3E Gene

Genes around CD3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3E Gene

Proteins for CD3E Gene

  • Protein details for CD3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07766-CD3E_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD3 epsilon chain
    Protein Accession:
    P07766
    Secondary Accessions:
    • A8K997

    Protein attributes for CD3E Gene

    Size:
    207 amino acids
    Molecular mass:
    23147 Da
    Quaternary structure:
    • The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6 (PubMed:15294938). Interacts with NCK1 (PubMed:15972658). Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation (PubMed:26507128).

    Three dimensional structures from OCA and Proteopedia for CD3E Gene

neXtProt entry for CD3E Gene

Post-translational modifications for CD3E Gene

  • Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
  • Ubiquitination at Lys104 and Lys177
  • Modification sites at PhosphoSitePlus

Other Protein References for CD3E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CD3E Gene

Domains & Families for CD3E Gene

Gene Families for CD3E Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • FDA approved drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CD3E Gene

GenScript: Design optimal peptide antigens:
  • CD3E protein (A0N2Z5_HUMAN)
  • T-cell surface antigen T3/Leu-4 epsilon chain (CD3E_HUMAN)
genes like me logo Genes that share domains with CD3E: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD3E Gene

Function for CD3E Gene

Molecular function for CD3E Gene

UniProtKB/Swiss-Prot Function:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
GENATLAS Biochemistry:
cell differentiation antigen CD3E (gp16),16kDa,epsilon polypeptide,TiT3 complex (see CD3@)

Phenotypes From GWAS Catalog for CD3E Gene

Gene Ontology (GO) - Molecular Function for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS,IEA 9485181
GO:0005515 protein binding IPI 7761456
GO:0017124 SH3 domain binding IPI 12110186
GO:0019901 protein kinase binding NAS 12110186
GO:0030159 receptor signaling complex scaffold activity NAS 9886373
genes like me logo Genes that share ontologies with CD3E: view
genes like me logo Genes that share phenotypes with CD3E: view

Human Phenotype Ontology for CD3E Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD3E Gene

MGI Knock Outs for CD3E:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CD3E

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD3E Gene

Localization for CD3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3E Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD3E gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
mitochondrion 0
lysosome 0

Gene Ontology (GO) - Cellular Components for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane NAS 9485181
GO:0005911 cell-cell junction IEA --
GO:0009897 external side of plasma membrane IDA,IEA 11390434
genes like me logo Genes that share ontologies with CD3E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD3E Gene

Pathways & Interactions for CD3E Gene

genes like me logo Genes that share pathways with CD3E: view

Pathways by source for CD3E Gene

SIGNOR curated interactions for CD3E Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion ISS,IEA 12652296
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002669 positive regulation of T cell anergy IEA --
GO:0007166 cell surface receptor signaling pathway IEA,NAS 12110186
genes like me logo Genes that share ontologies with CD3E: view

Drugs & Compounds for CD3E Gene

(10) Drugs for CD3E Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Catumaxomab Approved, Investigational, Withdrawn Pharma Target, agonist, Antibody Others 14
Muromonab Approved, Investigational Pharma Target, binder 0
Otelixizumab Investigational Pharma antibody 0
Teplizumab Investigational Pharma 0
Visilizumab Investigational Pharma 108
genes like me logo Genes that share compounds with CD3E: view

Transcripts for CD3E Gene

mRNA/cDNA for CD3E Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CD3E

Alternative Splicing Database (ASD) splice patterns (SP) for CD3E Gene

No ASD Table

Relevant External Links for CD3E Gene

GeneLoc Exon Structure for
CD3E
ECgene alternative splicing isoforms for
CD3E

Expression for CD3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD3E Gene

mRNA differential expression in normal tissues according to GTEx for CD3E Gene

This gene is overexpressed in Whole Blood (x28.8), Spleen (x6.2), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for CD3E Gene

This gene is overexpressed in Tlymphocyte (21.8), CD8 Tcells (16.0), and Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD3E Gene



Protein tissue co-expression partners for CD3E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD3E Gene:

CD3E

SOURCE GeneReport for Unigene cluster for CD3E Gene:

Hs.3003

Evidence on tissue expression from TISSUES for CD3E Gene

  • Blood(4.6)
  • Lymph node(2.5)
  • Spleen(2.5)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD3E Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
Regions:
Head and neck:
  • brain
  • ear
  • head
  • middle ear
Abdomen:
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
General:
  • blood
  • bone marrow
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with CD3E: view

No data available for mRNA Expression by UniProt/SwissProt for CD3E Gene

Orthologs for CD3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD3E 33 32
  • 99.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD3E 33 32
  • 78.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD3E 33 32
  • 76.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd3e 32
  • 73.73 (n)
mouse
(Mus musculus)
Mammalia Cd3e 17 33 32
  • 72.66 (n)
oppossum
(Monodelphis domestica)
Mammalia CD3E 33
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD3E 33 32
  • 57.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD3E 33
  • 37 (a)
OneToOne