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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
CD37 (CD37 Molecule) is a Protein Coding gene. Diseases associated with CD37 include Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Osteogenesis Imperfecta, Type Iii. Among its related pathways are Hematopoietic cell lineage. An important paralog of this gene is CD82.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21930792 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001772 | immunological synapse | IDA | 21930792 |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Hematopoietic cell lineage |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
TRU-016 | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD37 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD37 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD37 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd37 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd37 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CD37 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD37 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | CD37 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cd37 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CD37 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Tsp66E 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | tsp-11 31 |
|
ManyToMany | |
tsp-13 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
relapsed/refractory diffuse large b-cell lymphoma |
|
|
osteogenesis imperfecta, type iii |
|
|
leukemia, chronic lymphocytic |
|
|