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Aliases for CD37 Gene

Aliases for CD37 Gene

  • CD37 Molecule 2 3 5
  • Tetraspanin-26 3 4
  • CD37 Antigen 2 4
  • Tspan-26 3 4
  • TSPAN26 3 4
  • Cell Differentiation Antigen 37 3
  • Leukocyte Surface Antigen CD37 3
  • Leukocyte Antigen CD37 3
  • GP52-40 3

External Ids for CD37 Gene

Previous GeneCards Identifiers for CD37 Gene

  • GC19P050496
  • GC19P050206
  • GC19P054514
  • GC19P054531
  • GC19P054532
  • GC19P054533
  • GC19P049838
  • GC19P046215

Summaries for CD37 Gene

Entrez Gene Summary for CD37 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD37 Gene

CD37 (CD37 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage. An important paralog of this gene is CD82.

Gene Wiki entry for CD37 Gene

Additional gene information for CD37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD37 Gene

Genomics for CD37 Gene

GeneHancer (GH) Regulatory Elements for CD37 Gene

Promoters and enhancers for CD37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049332 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655.5 +0.2 188 5 HDGF YBX1 IRF4 ZNF143 ATF7 RUNX3 NCOA1 REST ZNF592 SMARCA4 CD37 SLC6A16 DKKL1 CCDC155 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19J049494 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.2 +163.9 163873 9.7 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D RPS11 SNORD35B GC19P049561 MIR150 GC19M049503 NUP62 PRR12 ALDH16A1 SNORD35A IRF3
GH19J049207 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.7 -126.8 -126839 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ARID2 FOS ATF7 SNRNP70 PPP1R15A PRR12 CD37 PPFIA3 C19orf73 LIN7B CGB7 NTF4 SLC6A16
GH19J049142 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.5 -192.4 -192354 1.1 HDGF PKNOX1 ATF1 SIN3A RFX5 GLIS2 FOS ATF7 CREM ZBTB2 PPFIA3 C19orf73 LIN7B SNRNP70 NTF4 CGB7 KCNA7 SLC6A16 CD37 CCDC155
GH19J049145 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.5 -188.8 -188789 1.6 CLOCK ATF1 ARNT ARID4B SIN3A ETS1 ZNF121 GLIS2 ZNF143 ATF7 SNRNP70 PPFIA3 PRR12 C19orf73 LIN7B KCNA7 NTF4 CGB7 CD37 SLC6A16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD37 gene promoter:
  • USF2
  • USF1
  • USF-1:USF-2
  • USF-1
  • HFH-1
  • RP58
  • Zic3
  • HEN1
  • Lmo2
  • GCNF

Genomic Locations for CD37 Gene

Genomic Locations for CD37 Gene
chr19:49,335,171-49,343,335
(GRCh38/hg38)
Size:
8,165 bases
Orientation:
Plus strand
chr19:49,838,428-49,846,592
(GRCh37/hg19)
Size:
8,165 bases
Orientation:
Plus strand

Genomic View for CD37 Gene

Genes around CD37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD37 Gene

Proteins for CD37 Gene

  • Protein details for CD37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11049-CD37_HUMAN
    Recommended name:
    Leukocyte antigen CD37
    Protein Accession:
    P11049
    Secondary Accessions:
    • B4DVC1
    • Q3KPF9

    Protein attributes for CD37 Gene

    Size:
    281 amino acids
    Molecular mass:
    31703 Da
    Quaternary structure:
    • Interacts with SCIMP.

    Alternative splice isoforms for CD37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD37 Gene

Post-translational modifications for CD37 Gene

  • Glycosylation at posLast=188188, posLast=183183, and Asn170
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD37 Gene

Domains & Families for CD37 Gene

Gene Families for CD37 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P11049

UniProtKB/Swiss-Prot:

CD37_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD37: view

Function for CD37 Gene

Molecular function for CD37 Gene

GENATLAS Biochemistry:
cell differentiation antigen 37 (gp52-40),52-40kDa,membrane glycoprotein,identified by monoclonal antibodies G28-1,Y29/55,RFB-7,MB-1,M-B371,M-B372

Phenotypes From GWAS Catalog for CD37 Gene

Gene Ontology (GO) - Molecular Function for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with CD37: view
genes like me logo Genes that share phenotypes with CD37: view

Animal Models for CD37 Gene

MGI Knock Outs for CD37:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD37

CRISPR Products

miRNA for CD37 Gene

miRTarBase miRNAs that target CD37

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD37

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD37 Gene

Localization for CD37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD37 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD37 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with CD37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD37 Gene

Pathways & Interactions for CD37 Gene

SuperPathway Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD37: view

Pathways by source for CD37 Gene

1 KEGG pathway for CD37 Gene

Gene Ontology (GO) - Biological Process for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CD37: view

No data available for SIGNOR curated interactions for CD37 Gene

Drugs & Compounds for CD37 Gene

(1) Drugs for CD37 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TRU-016 Pharma 0

(1) Additional Compounds for CD37 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD37: view

Transcripts for CD37 Gene

mRNA/cDNA for CD37 Gene

(8) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD37 Gene

CD37 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD37

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:
SP2: -
SP3:

Relevant External Links for CD37 Gene

GeneLoc Exon Structure for
CD37
ECgene alternative splicing isoforms for
CD37

Expression for CD37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD37 Gene

This gene is overexpressed in Whole Blood (x26.1) and Spleen (x5.7).

Protein differential expression in normal tissues from HIPED for CD37 Gene

This gene is overexpressed in Blymphocyte (22.2), Serum (17.0), Peripheral blood mononuclear cells (14.3), and Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD37 Gene



Protein tissue co-expression partners for CD37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD37 Gene:

CD37

SOURCE GeneReport for Unigene cluster for CD37 Gene:

Hs.166556

mRNA Expression by UniProt/SwissProt for CD37 Gene:

P11049-CD37_HUMAN
Tissue specificity: B-lymphocytes.

Evidence on tissue expression from TISSUES for CD37 Gene

  • Spleen(4.1)
  • Blood(3.1)
  • Lymph node(3.1)
  • Bone marrow(3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CD37: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD37 Gene

Orthologs for CD37 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD37 34 33
  • 97.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD37 34 33
  • 84.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD37 34 33
  • 84.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd37 16 34 33
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Cd37 33
  • 81.02 (n)
oppossum
(Monodelphis domestica)
Mammalia CD37 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD37 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CD37 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd37 33
  • 54.84 (n)
zebrafish
(Danio rerio)
Actinopterygii CD37 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-11 34
  • 18 (a)
ManyToMany
tsp-13 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
Species where no ortholog for CD37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD37 Gene

ENSEMBL:
Gene Tree for CD37 (if available)
TreeFam:
Gene Tree for CD37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD37: view image

Paralogs for CD37 Gene

(8) SIMAP similar genes for CD37 Gene using alignment to 7 proteins:

  • CD37_HUMAN
  • B7ZAN3_HUMAN
  • M0QZ33_HUMAN
  • M0QZP6_HUMAN
  • M0R083_HUMAN
  • M0R1J1_HUMAN
  • Q96LM7_HUMAN
genes like me logo Genes that share paralogs with CD37: view

Variants for CD37 Gene

Sequence variations from dbSNP and Humsavar for CD37 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000234674 -- 49,335,668(+) A/G intron_variant
rs1000800657 -- 49,335,347(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001030324 -- 49,339,060(+) A/G intron_variant
rs1001543856 -- 49,334,411(+) G/A upstream_transcript_variant
rs1002019172 -- 49,341,031(+) /A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD37 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for CD37 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD37 Gene

Disorders for CD37 Gene

Additional Disease Information for CD37

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CD37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD37 Gene

Publications for CD37 Gene

  1. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. (PMID: 2388030) Classon BJ … Stamenkovic I (The Journal of experimental medicine 1990) 3 4 22 58
  2. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P … Brdicka T (Molecular and cellular biology 2011) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract. (PMID: 10405235) Okochi H … Furue M (Journal of clinical gastroenterology 1999) 3 22 58

Products for CD37 Gene

Sources for CD37 Gene

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