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CD36 Gene(Protein Coding)

CD36 Molecule

GCID:
GC07P080369
GIFtS:
55
Genes Participants
UDN Logo

Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule 2 3 5
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • GPIIIB 3 4
  • PAS IV 3 4
  • GP3B 3 4
  • GPIV 3 4
  • FAT 3 4
  • GP4 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Platelet Glycoprotein 4 3
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • BDPLT10 3
  • SCARB3 3
  • CHDS7 3
  • PASIV 3
  • PAS-4 4

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule) is a Protein Coding gene. Diseases associated with CD36 include Platelet Glycoprotein Iv Deficiency and Coronary Heart Disease 7. Among its related pathways are Activated TLR4 signalling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB1.

UniProtKB/Swiss-Prot for CD36 Gene

  • Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).

  • (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Wiki entry for CD36 Gene

Additional gene information for CD36 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CD36 Gene

Promoters and enhancers for CD36 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J080635 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.1 +268.4 268427 5.2 PKNOX1 FOXA2 STAT5A BATF ZNF507 RELA NFATC1 EED ETV6 IKZF2 CD36 GC07P080641 GNAT3
GH07J080646 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 650.1 +277.1 277102 1 PRDM10 CD36 GC07P080641 ENSG00000229436
GH07J080607 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 650.1 +232.6 232605 0.2 CUX1 CD36 GC07P080641 GNAT3
GH07J080602 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.1 +232.7 232740 0.1 CD36 GC07P080641 GNAT3
GH07J080369 Promoter 0.5 EPDnew 650.7 0.0 -25 0.1 CD36 GC07P080351 ENSG00000232667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD36 gene promoter:

Genomic Locations for CD36 Gene

Genomic Locations for CD36 Gene
chr7:80,369,575-80,679,277
(GRCh38/hg38)
Size:
309,703 bases
Orientation:
Plus strand
chr7:79,998,891-80,308,593
(GRCh37/hg19)

Genomic View for CD36 Gene

Genes around CD36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).
    • (Microbial infection) Binds to Plasmodium falciparum EMP1.
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD36 Gene

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Protein Expression for CD36 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).
  • Glycosylation at posLast=417417, posLast=321321, Asn247, Asn235, Asn220, Asn205, posLast=163163, Asn134, Asn102, and posLast=7979
  • Modification sites at PhosphoSitePlus

Other Protein References for CD36 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD36 Gene

Domains & Families for CD36 Gene

Gene Families for CD36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for CD36 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD36 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.
GENATLAS Biochemistry:
cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes

Phenotypes From GWAS Catalog for CD36 Gene

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding TAS 20037584
GO:0005041 low-density lipoprotein particle receptor activity TAS 9568716
GO:0005044 scavenger receptor activity TAS 11240025
GO:0005515 protein binding IPI 16880211
GO:0008035 high-density lipoprotein particle binding IEA --
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Human Phenotype Ontology for CD36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

Animal Model Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD36

Clone Products

  • Addgene plasmids for CD36

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Golgi apparatus. Apical cell membrane. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
mitochondrion 2
peroxisome 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005622 intracellular IPI 20037584
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CD36: view

Pathways & Interactions for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with CD36: view

No data available for SIGNOR curated interactions for CD36 Gene

Drugs & Compounds for CD36 Gene

Products:

  1. Drug

(79) Drugs for CD36 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric Acid Approved, Vet_approved Nutra Agonist, Activator 1243
ABT-510 Investigational Pharma 0
Anticholesteremic Agents Pharma 2147
Anticoagulants Pharma 2862
Antimetabolites Pharma 12587

(58) Additional Compounds for CD36 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Triglycerides Group B
  • 1-Myristoyl-2-pentadecanoyl-3-nervonoyl-glycerol
  • 1-Tetradecanoyl-2-pentadecanoyl-3-(15Z-tetracosanoyl)-glycerol
  • TAG(14:0/15:0/24:1)
  • TAG(53:1)
  • TG(14:0/15:0/24:1)
 555-45-3, 30719-27-8, 2190-24-1, 18641-57-1, 56933-26-7
Triglycerides Group D
  • 2,3-Di(octadecanoyloxy)propyl octadecanoate
  • Glyceryl tristearate
  • Stearic acid triglycerin ester
  • Stearin
  • Trioctadecanoin
 620-64-4
genes like me logo Genes that share compounds with CD36: view

Transcripts for CD36 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD36 Gene

(391) Selected AceView cDNA sequences:
(20) Additional mRNA sequences :
(13) REFSEQ mRNAs :
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD36 Gene

CD36 molecule (thrombospondin receptor):
Representative Sequences:

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD36

Clone Products

  • Addgene plasmids for CD36

Alternative Splicing Database (ASD) splice patterns (SP) for CD36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 14e · 14f ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:

Relevant External Links for CD36 Gene

GeneLoc Exon Structure for
CD36
ECgene alternative splicing isoforms for
CD36

Expression for CD36 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD36 Gene

mRNA expression in normal human tissues for CD36 Gene
mRNA expression by GTEx for CD36 GenemRNA expression by BioGPS for CD36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD36 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x11.0), Adipose - Subcutaneous (x9.6), Heart - Left Ventricle (x8.8), and Breast - Mammary Tissue (x6.2).

Protein differential expression in normal tissues from HIPED for CD36 Gene

This gene is overexpressed in Adipocyte (24.5), Nasopharynx (20.6), and Milk (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD36 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD36 Gene:

CD36

SOURCE GeneReport for Unigene cluster for CD36 Gene:

Hs.120949

Evidence on tissue expression from TISSUES for CD36 Gene

  • Heart(4.8)
  • Blood(4.7)
  • Muscle(4.7)
  • Liver(4.6)
  • Spleen(3.8)
  • Intestine(2.5)
  • Bone marrow(2.2)
  • Lung(2.1)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD36 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
Regions:
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with CD36: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CD36 Gene

Orthologs for CD36 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD36 34 33
  • 99.65 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CD36 34 33
  • 86.98 (n)
 OneToMany
-- 34
  • 73 (a)
 OneToMany
-- 34
  • 67 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia CD36 34 33
  • 86.35 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cd36 16 34 33
  • 83.83 (n)
rat
(Rattus norvegicus)
 Mammalia Cd36 33
  • 83.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia CD36 34
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CD36 34
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CD36 34 33
  • 65.53 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CD36 34
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cd36 33
  • 63.08 (n)
zebrafish
(Danio rerio)
 Actinopterygii cd36 34 33
  • 60.07 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG3829 35
  • 27 (a)
BEST:CK01577 35
  • 26 (a)
CG7227 35
  • 26 (a)
Snmp2 34
  • 24 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea scav-2 34 33
  • 45.03 (n)
 ManyToMany
Y76A2B.6 35
  • 28 (a)
scav-1 34
  • 24 (a)
 ManyToMany
C03F11.3 35
  • 24 (a)
Species where no ortholog for CD36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD36 Gene

ENSEMBL:
Gene Tree for CD36 (if available)
TreeFam:
Gene Tree for CD36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD36: view image

Paralogs for CD36 Gene

Paralogs for CD36 Gene

(2) SIMAP similar genes for CD36 Gene using alignment to 20 proteins:

  • CD36_HUMAN
  • A4D1B1_HUMAN
  • D9IX63_HUMAN
  • D9IX64_HUMAN
  • D9IX65_HUMAN
  • D9IX66_HUMAN
  • D9IX67_HUMAN
  • D9IX68_HUMAN
  • D9IX69_HUMAN
  • E7ERZ9_HUMAN
  • E7EU05_HUMAN
  • E7EVU1_HUMAN
  • E7EWI4_HUMAN
  • E7EX47_HUMAN
  • E9PC45_HUMAN
  • E9PJX8_HUMAN
  • E9PLT1_HUMAN
  • H0YEE7_HUMAN
  • Q13965_HUMAN
  • V5M404_HUMAN
genes like me logo Genes that share paralogs with CD36: view

Variants for CD36 Gene

Products:

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Polymorphic Variants from UniProtKB/Swiss-Prot for CD36 Gene

CD36_HUMAN-P16671
Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].

Sequence variations from dbSNP and Humsavar for CD36 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1049654 likely-benign, Platelet glycoprotein IV deficiency 80,646,139(+) A/C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1194182 likely-benign, Platelet glycoprotein IV deficiency 80,602,188(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs121918035 pathogenic, Platelet glycoprotein IV deficiency, Platelet glycoprotein IV deficiency (PG4D) [MIM:608404] 80,673,392(+) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs142186404 pathogenic, Platelet glycoprotein IV deficiency, Platelet glycoprotein IV deficiency (PG4D) [MIM:608404] 80,669,964(+) T/C/G coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs143304806 uncertain-significance, Platelet glycoprotein IV deficiency 80,674,349(+) G/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD36 Gene

Variant ID Type Subtype PubMed ID
dgv6514n100 CNV loss 25217958
dgv6515n100 CNV loss 25217958
esv2761341 CNV loss 21179565
esv3571939 CNV loss 25503493
esv3613863 CNV loss 21293372
esv3613865 CNV loss 21293372
esv3891151 CNV loss 25118596
nsv1025144 CNV gain 25217958
nsv464606 CNV gain 19166990
nsv464607 CNV loss 19166990
nsv525704 CNV loss 19592680
nsv607682 CNV gain 21841781
nsv607683 CNV loss 21841781
nsv607684 CNV loss 21841781
nsv607685 CNV loss 21841781
nsv831043 CNV loss 17160897
nsv971195 CNV deletion 23825009

Variation tolerance for CD36 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD36 Gene

Human Gene Mutation Database (HGMD)
CD36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD36

SNP Genotyping and Copy Number Assay Products

Disorders for CD36 Gene

MalaCards: The human disease database

(54) MalaCards diseases for CD36 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
platelet glycoprotein iv deficiency
  • bleeding disorder, platelet-type, 10; bdplt10
coronary heart disease 7
  • coronary heart disease, susceptibility to, 7
malaria
  • malaria, susceptibility to
hypertrophic scars
  • scars hypertrophic
chancroid
  • ulcus molle, skin
- elite association - COSMIC cancer census association via MalaCards
Search CD36 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD36_HUMAN
  • Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:15282206}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269 PubMed:11950861, ECO:0000269 PubMed:7533783}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk. {ECO:0000269 PubMed:18753675}.

Genatlas disease for CD36 Gene

platelet CD36 deficiency,type I,with no expression at cell surface

Additional Disease Information for CD36

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD36: view

Publications for CD36 Gene

  1. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. (PMID: 19864601) Erdman LK … Kain KC (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 22 58
  2. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. (PMID: 15282206) Ma X … Doria A (Human molecular genetics 2004) 3 4 44 58
  3. CD36 polymorphism is associated with protection from cerebral malaria. (PMID: 12506336) Omi K … Tokunaga K (American journal of human genetics 2003) 3 4 44 58
  4. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. (PMID: 7503937) Fernández-Ruiz E … Vega MA (Genomics 1993) 2 3 4 58
  5. The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. (PMID: 25822988) Mrizak I … Khan NA (The British journal of nutrition 2015) 3 4 58

Products for CD36 Gene

  • Addgene plasmids for CD36

Sources for CD36 Gene