CD36 Gene (Protein Coding)

CD36 Molecule

GC07P080369
GIFtS:
49
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, a... See more...

Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule 2 3 5
  • GP3B 2 3 4
  • GPIV 2 3 4
  • FAT 2 3 4
  • GP4 2 3 4
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Platelet Glycoprotein 4 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • SCARB3 2 3
  • GPIIIB 3 4
  • PAS IV 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • BDPLT10 3
  • CHDS7 3
  • PASIV 3
  • PAS-4 4
  • CD36 5

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule) is a Protein Coding gene. Diseases associated with CD36 include Platelet Glycoprotein Iv Deficiency and Coronary Heart Disease 7. Among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB2.

UniProtKB/Swiss-Prot Summary for CD36 Gene

  • Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
  • (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Wiki entry for CD36 Gene

Additional gene information for CD36 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CD36 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J080635 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 257.9 +270.5 270489 8.7 BCL11A CEBPA HOMEZ FOXA2 SMAD4 SAP130 CTBP1 BCL6 RAD21 CBFB CD36 RF00017-6414 lnc-GNAI1-4 lnc-GNAI1-5 GNAT3 SEMA3C
GH07J080607 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 250.1 +233.5 233526 2.2 CUX1 lnc-GNAI1-5 CD36 lnc-GNAI1-4 GNAT3 SEMA3C
GH07J080646 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 250.1 +277.4 277414 1.6 PRDM10 RF00017-6414 CD36 HSALNG0059204 lnc-GNAI1-5 GNAT3 SEMA3C
GH07J080369 Promoter 0.3 EPDnew 250.7 0.0 -25 0.1 CD36 hsa-miR-5095-463 ENSG00000232667 GNAI1
GH07J080370 Enhancer 0.2 FANTOM5 250.7 +1.3 1309 0.3 CD36 GNAI1 LOC101927269 ENSG00000232667 GNAT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD36

Top Transcription factor binding sites by QIAGEN in the CD36 gene promoter:
  • AP-1
  • GATA-1
  • NF-kappaB
  • STAT1

Genomic Locations for CD36 Gene

Latest Assembly
chr7:80,369,575-80,679,277
(GRCh38/hg38)
Size:
309,703 bases
Orientation:
Plus strand

Previous Assembly
chr7:80,231,523-80,308,593
(GRCh37/hg19 by Entrez Gene)
Size:
77,071 bases
Orientation:
Plus strand

chr7:79,998,891-80,308,593
(GRCh37/hg19 by Ensembl)
Size:
309,703 bases
Orientation:
Plus strand

Genomic View for CD36 Gene

Genes around CD36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

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  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).
    • (Microbial infection) Binds to Plasmodium falciparum EMP1.
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD36 Gene

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Protein Expression for CD36 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).
  • Glycosylation at Asn79, Asn102, Asn134, Asn205, Asn220, Asn163, Asn235, Asn247, Asn321, and Asn417
  • Ubiquitination at Lys469 and Lys472
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CD36 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CD36

No data available for DME Specific Peptides for CD36 Gene

Domains & Families for CD36 Gene

Gene Families for CD36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for CD36 Gene

InterPro:
Blocks:
  • Adhesion molecule CD36 family signature
  • Adhesion molecule CD36 signature
ProtoNet:

Suggested Antigen Peptide Sequences for CD36 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA (A4D1B1_HUMAN)
  • Thrombospondin receptor (CD36_HUMAN)
  • Platelet glycoprotein IV variant (D9IX63_HUMAN)
  • Platelet glycoprotein IV variant (D9IX64_HUMAN)
  • Platelet glycoprotein IV variant (D9IX65_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

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  6. Cell Lines for research

Molecular function for CD36 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248, ChEBI:CHEBI:17968; Evidence={ECO:0000269|PubMed:21395585};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; Evidence={ECO:0000269|PubMed:21395585};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; Evidence={ECO:0000269|PubMed:21395585};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=tetradecanoate(out) = tetradecanoate(in); Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807; Evidence={ECO:0000269|PubMed:21395585};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, ChEBI:CHEBI:7896; Evidence={ECO:0000269|PubMed:21395585};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=tetracosanoate(out) = tetracosanoate(in); Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014; Evidence={ECO:0000269|PubMed:21395585};.
GENATLAS Biochemistry:
cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes

Phenotypes From GWAS Catalog for CD36 Gene

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding TAS 20037584
GO:0005041 low-density lipoprotein particle receptor activity TAS 9568716
GO:0005044 scavenger receptor activity IBA,TAS 11240025
GO:0005324 long-chain fatty acid transporter activity IMP 21395585
GO:0005515 protein binding IPI 16880211
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Human Phenotype Ontology for CD36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD36

Clone products for research

  • Addgene plasmids for CD36

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane. Multi-pass membrane protein. Membrane raft. Golgi apparatus. Apical cell membrane. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
extracellular 4
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CD36: view

Pathways & Interactions for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002532 production of molecular mediator involved in inflammatory response TAS 29111364
genes like me logo Genes that share ontologies with CD36: view

No data available for SIGNOR curated interactions for CD36 Gene

Drugs & Compounds for CD36 Gene

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(82) Drugs for CD36 Gene - From: ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma 919
Sodium citrate Approved, Investigational Pharma 1584
Citric acid Approved, Vet_approved Nutra 1584
ABT-510 Investigational Pharma 0
Trierucin Investigational Pharma 0

(56) Additional Compounds for CD36 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Torvoside G
  • 1,2,3-Propanetriyl tripentadecanoate, 9ci
  • 1-Pentadecanoyl-2-pentadecanoyl-3-pentadecanoyl-glycerol
  • Glycerol tripentadecanoate
  • TAG(15:0/15:0/15:0)
  • TAG(45:0)
 184777-22-8, 30719-27-8
Triglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-3-myristoleoyl-glycerol
  • 1-Tetradecanoyl-2-pentadecanoyl-3-(9Z-tetradecenoyl)-glycerol
  • TAG(14:0/15:0/14:1)
  • TAG(43:1)
  • TG(14:0/15:0/14:1)
 555-45-3, 2190-24-1, 18641-57-1, 56933-26-7
Triglycerides Group C
  • 2,3-Di(octadecanoyloxy)propyl octadecanoate
  • Glyceryl tristearate
  • Stearic acid triglycerin ester
  • Stearin
  • Trioctadecanoin
 620-64-4
genes like me logo Genes that share compounds with CD36: view

Transcripts for CD36 Gene

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mRNA/cDNA for CD36 Gene

15 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD36

Clone products for research

  • Addgene plasmids for CD36

Alternative Splicing Database (ASD) splice patterns (SP) for CD36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 14e · 14f ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:

Relevant External Links for CD36 Gene

GeneLoc Exon Structure for
CD36

Expression for CD36 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD36 Gene

mRNA expression in normal human tissues for CD36 Gene
mRNA expression by GTEx for CD36 GenemRNA expression by BioGPS for CD36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD36 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x11.0), Adipose - Subcutaneous (x9.6), Heart - Left Ventricle (x8.8), and Breast - Mammary Tissue (x6.2).

Protein differential expression in normal tissues from HIPED for CD36 Gene

This gene is overexpressed in Adipocyte (24.5), Nasopharynx (20.6), and Milk (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD36 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD36

SOURCE GeneReport for Unigene cluster for CD36 Gene:

Hs.120949

Evidence on tissue expression from TISSUES for CD36 Gene

  • Heart(4.8)
  • Blood(4.7)
  • Muscle(4.7)
  • Liver(4.6)
  • Spleen(4.1)
  • Intestine(2.9)
  • Lung(2.7)
  • Bone marrow(2.6)
  • Gall bladder(2.5)
  • Thyroid gland(2.5)
  • Kidney(2.5)
  • Nervous system(2.5)
  • Skin(2.4)
  • Pancreas(2.3)
  • Lymph node(2.3)
  • Stomach(2.2)
  • Adrenal gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD36 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
Regions:
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with CD36: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CD36 Gene

Orthologs for CD36 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CD36 30 31
  • 99.65 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CD36 30 31
  • 86.98 (n)
 OneToMany
-- 31
  • 73 (a)
 OneToMany
-- 31
  • 67 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia CD36 30 31
  • 86.35 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cd36 30 17 31
  • 83.83 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cd36 30
  • 83.33 (n)
Oppossum
(Monodelphis domestica)
 Mammalia CD36 31
  • 80 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CD36 31
  • 73 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CD36 30 31
  • 65.53 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CD36 31
  • 61 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cd36 30
  • 63.08 (n)
Zebrafish
(Danio rerio)
 Actinopterygii cd36 30 31
  • 60.07 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG3829 32
  • 27 (a)
BEST:CK01577 32
  • 26 (a)
CG7227 32
  • 26 (a)
Snmp2 31
  • 24 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea scav-2 30 31
  • 45.03 (n)
 ManyToMany
Y76A2B.6 32
  • 28 (a)
scav-1 31
  • 24 (a)
 ManyToMany
C03F11.3 32
  • 24 (a)
Species where no ortholog for CD36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CD36 Gene

ENSEMBL:
Gene Tree for CD36 (if available)
TreeFam:
Gene Tree for CD36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD36: view image

Paralogs for CD36 Gene

Paralogs for CD36 Gene

(2) SIMAP similar genes for CD36 Gene using alignment to 20 proteins:

  • CD36_HUMAN
  • A4D1B1_HUMAN
  • D9IX63_HUMAN
  • D9IX64_HUMAN
  • D9IX65_HUMAN
  • D9IX66_HUMAN
  • D9IX67_HUMAN
  • D9IX68_HUMAN
  • D9IX69_HUMAN
  • E7ERZ9_HUMAN
  • E7EU05_HUMAN
  • E7EVU1_HUMAN
  • E7EWI4_HUMAN
  • E7EX47_HUMAN
  • E9PC45_HUMAN
  • E9PJX8_HUMAN
  • E9PLT1_HUMAN
  • H0YEE7_HUMAN
  • Q13965_HUMAN
  • V5M404_HUMAN
genes like me logo Genes that share paralogs with CD36: view

Variants for CD36 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Polymorphic Variants from UniProtKB/Swiss-Prot for CD36 Gene

CD36_HUMAN-P16671
Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD36 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
13538 Pathogenic, Protective: Platelet glycoprotein IV deficiency; Malaria, cerebral, resistance to 80,647,259(+) TGTGTGTGTGTGTGTG
NM_001001547.2(CD36):c.120+399TG[12] 		INTRON
873470 Likely Pathogenic: Platelet glycoprotein IV deficiency 80,669,989(+) AGGTATTGCAGTTCTT
NM_001001547.3(CD36):c.787_808del (p.Val263fs) 		FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
908922 Uncertain Significance: Platelet glycoprotein IV deficiency 80,656,694(+) C/T
NM_001001547.3(CD36):c.275C>T (p.Thr92Met) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
908923 Uncertain Significance: Platelet glycoprotein IV deficiency 80,656,700(+) G/A
NM_001001547.3(CD36):c.281G>A (p.Arg94Lys) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
908987 Uncertain Significance: Platelet glycoprotein IV deficiency 80,666,469(+) G/A
NM_001001547.3(CD36):c.728G>A (p.Cys243Tyr) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CD36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CD36 Gene

Variant ID Type Subtype PubMed ID
dgv6514n100 CNV loss 25217958
dgv6515n100 CNV loss 25217958
esv2761341 CNV loss 21179565
esv3571939 CNV loss 25503493
esv3613863 CNV loss 21293372
esv3613865 CNV loss 21293372
esv3891151 CNV loss 25118596
nsv1025144 CNV gain 25217958
nsv464606 CNV gain 19166990
nsv464607 CNV loss 19166990
nsv525704 CNV loss 19592680
nsv607682 CNV gain 21841781
nsv607683 CNV loss 21841781
nsv607684 CNV loss 21841781
nsv607685 CNV loss 21841781
nsv831043 CNV loss 17160897
nsv971195 CNV deletion 23825009

Variation tolerance for CD36 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD36 Gene

Human Gene Mutation Database (HGMD)
CD36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD36

SNP Genotyping and Copy Number Assays for research

Disorders for CD36 Gene

MalaCards: The human disease database

(62) MalaCards diseases for CD36 Gene - From: OMI, CVR, GTR, SWI, COP, and GCD

Disorder Aliases PubMed IDs
platelet glycoprotein iv deficiency
  • bleeding disorder, platelet-type, 10; bdplt10
coronary heart disease 7
  • coronary heart disease, susceptibility to, 7
malaria
  • malaria, susceptibility to
blood platelet disease
  • platelet disorder
osteogenesis imperfecta, type i
  • oi1
- elite association - COSMIC cancer census association via MalaCards
Search CD36 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD36_HUMAN
  • Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269 PubMed:11950861, ECO:0000269 PubMed:7533783}. Note=The disease is caused by variants affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk. {ECO:0000269 PubMed:18753675}.
  • Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:15282206}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Genatlas disease for CD36 Gene

platelet CD36 deficiency,type I,with no expression at cell surface

Additional Disease Information for CD36

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CD36: view

Publications for CD36 Gene