The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] See more...

Aliases for CD34 Gene

Aliases for CD34 Gene

  • CD34 Molecule 2 3 5
  • CD34 Antigen 2 3 4
  • Hematopoietic Progenitor Cell Antigen CD34 3 4

External Ids for CD34 Gene

Previous GeneCards Identifiers for CD34 Gene

  • GC01M206701
  • GC01M203770
  • GC01M204701
  • GC01M205143
  • GC01M204432
  • GC01M206116
  • GC01M208057
  • GC01M178734

Summaries for CD34 Gene

Entrez Gene Summary for CD34 Gene

  • The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD34 Gene

CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Gastrointestinal Stromal Tumor. Among its related pathways are C-MYB transcription factor network and Dendritic Cells Developmental Lineage Pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and sulfate binding.

UniProtKB/Swiss-Prot Summary for CD34 Gene

  • Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Gene Wiki entry for CD34 Gene

Additional gene information for CD34 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD34 Gene

Genomics for CD34 Gene

GeneHancer (GH) Regulatory Elements for CD34 Gene

Promoters and enhancers for CD34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J207907 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 762.5 +1.2 1156 5.6 RAD21 KLF14 GLIS2 ZIC2 REST ZBTB8A PRDM10 SP2 EZH2 ZXDB CD34 ENSG00000285719 MIR29B2CHG C4BPA
GH01J207886 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 762.6 +21.6 21605 5.8 ZNF148 SP1 DPF2 IKZF1 PKNOX1 POLR2A RXRA IKZF2 NFE2 MGA CD34 PLXNA2 C4BPA CD46 lnc-PLXNA2-8 MIR29B2CHG
GH01J207747 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.9 +159.6 159636 8.1 ZBTB40 SP1 SREBF1 RBPJ SMARCE1 POLR2A USF2 NR2F6 CREB1 HCFC1 CD46 lnc-CD34-7 CD34 MIR29B2CHG CD55 CR1L lnc-CD34-5
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.9 +884.7 884734 18.4 SIN3A ZBTB40 ZBTB6 FOXA1 RBPJ SMARCE1 POLR2A TCF7L2 NR2F6 CREB1 C1orf116 EIF2D CDCA4P4 C4BPA CD46 CD34 C4BPB FCAMR PIGR FCMR
GH01J207309 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 18.9 +600.1 600113 4.1 ZBTB40 SMARCE1 POLR2A CC2D1A ELF1 MAX L3MBTL2 DACH1 TEAD4 ZNF652 EIF2D CD55 CD34 CR2 piR-50968-013 ENSG00000237074
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD34 gene promoter:
  • AML1a

Genomic Locations for CD34 Gene

Genomic Locations for CD34 Gene
chr1:207,880,972-207,911,402
(GRCh38/hg38)
Size:
30,431 bases
Orientation:
Minus strand
chr1:208,057,594-208,084,747
(GRCh37/hg19)
Size:
27,154 bases
Orientation:
Minus strand

Genomic View for CD34 Gene

Genes around CD34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD34 Gene

Proteins for CD34 Gene

  • Protein details for CD34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28906-CD34_HUMAN
    Recommended name:
    Hematopoietic progenitor cell antigen CD34
    Protein Accession:
    P28906
    Secondary Accessions:
    • A8K664
    • Q15970
    • Q15971
    • Q5JTA3
    • Q5JTA4
    • Q9UJB1

    Protein attributes for CD34 Gene

    Size:
    385 amino acids
    Molecular mass:
    40716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA03181.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CD34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD34 Gene

Post-translational modifications for CD34 Gene

  • Highly glycosylated.
  • Phosphorylated on serine residues by PKC.
  • Glycosylation at Asn36, Asn51, Asn55, Asn85, Asn107, Asn126, Asn142, Asn194, and Asn249
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CD34 Gene

Antibody Products

  • Abcam antibodies for CD34

No data available for DME Specific Peptides for CD34 Gene

Domains & Families for CD34 Gene

Gene Families for CD34 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD34 Gene

Suggested Antigen Peptide Sequences for CD34 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53734, highly similar to Hematopoietic progenitor cell antigen CD34 (B4DG27_HUMAN)
  • cDNA FLJ54166, highly similar to Hematopoietic progenitor cell antigen CD34 (B4DUX4_HUMAN)
  • Hematopoietic progenitor cell antigen CD34 (CD34_HUMAN)
  • CD34 antigen (Q3C1E7_HUMAN)
  • Hematopoietic progenital cell antigen CD34 (Q8IUM0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P28906

UniProtKB/Swiss-Prot:

CD34_HUMAN :
  • Belongs to the CD34 family.
Family:
  • Belongs to the CD34 family.
genes like me logo Genes that share domains with CD34: view

Function for CD34 Gene

Molecular function for CD34 Gene

UniProtKB/Swiss-Prot Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
GENATLAS Biochemistry:
cell differentiation antigen CD34,105-120kDa,transmembrane glycoprotein,single chain,identified by monoclonal antibodies My10,BI-3C5,ICH-3,12.8,cytokine low-responding circulating haemopoietic progenitor,expressed by small vessel endothelial cells

Phenotypes From GWAS Catalog for CD34 Gene

Gene Ontology (GO) - Molecular Function for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 21873977
GO:0030246 carbohydrate binding IDA 15249540
GO:0043199 sulfate binding IEA --
genes like me logo Genes that share ontologies with CD34: view
genes like me logo Genes that share phenotypes with CD34: view

Animal Models for CD34 Gene

MGI Knock Outs for CD34:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CD34

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD34 Gene

Localization for CD34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD34 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD34 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 2
cytosol 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 7525669
GO:0005764 lysosome ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9042286
genes like me logo Genes that share ontologies with CD34: view

Pathways & Interactions for CD34 Gene

genes like me logo Genes that share pathways with CD34: view

SIGNOR curated interactions for CD34 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IDA 12939361
GO:0001935 endothelial cell proliferation IDA 21835908
GO:0003094 glomerular filtration IEP 20354148
GO:0003158 endothelium development IEP 17261663
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD34: view

Drugs & Compounds for CD34 Gene

(25) Drugs for CD34 Gene - From: ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1452
Lenalidomide Approved Pharma Anti-angiogenic. 848
Melphalan Approved Pharma 801
Prednisone Approved, Vet_approved Pharma 1658
Alkylating Agents Pharma 5566

(11) Additional Compounds for CD34 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CD34 Gene

Compound Action Cas Number
UM 171 HSC agonist 1448724-09-1
genes like me logo Genes that share compounds with CD34: view

Transcripts for CD34 Gene

mRNA/cDNA for CD34 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CD34

Alternative Splicing Database (ASD) splice patterns (SP) for CD34 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for CD34 Gene

GeneLoc Exon Structure for
CD34
ECgene alternative splicing isoforms for
CD34

Expression for CD34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD34 Gene

This gene is overexpressed in Seminal vesicle (7.0), Cervix (6.7), and Oral epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD34 Gene



Protein tissue co-expression partners for CD34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD34 Gene:

CD34

SOURCE GeneReport for Unigene cluster for CD34 Gene:

Hs.374990

mRNA Expression by UniProt/SwissProt for CD34 Gene:

P28906-CD34_HUMAN
Tissue specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Evidence on tissue expression from TISSUES for CD34 Gene

  • Bone marrow(4.8)
  • Heart(4.8)
  • Skin(4.7)
  • Blood(3.9)
  • Muscle(3.8)
  • Nervous system(3.8)
  • Lung(3.3)
  • Lymph node(3.3)
  • Spleen(3.3)
  • Intestine(3.2)
  • Kidney(3.1)
  • Liver(2.8)
  • Stomach(2.7)
  • Bone(2.6)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with CD34: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD34 Gene

Orthologs for CD34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD34 33 32
  • 99.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD34 33 32
  • 80.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd34 17 33 32
  • 76.54 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911324 32
  • 76.25 (n)
cow
(Bos Taurus)
Mammalia CD34 33 32
  • 75.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD34 33
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD34 33
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD34 33
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD34 33
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779603 32
  • 49.46 (n)
Species where no ortholog for CD34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD34 Gene

ENSEMBL:
Gene Tree for CD34 (if available)
TreeFam:
Gene Tree for CD34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD34: view image

Paralogs for CD34 Gene

(1) SIMAP similar genes for CD34 Gene using alignment to 6 proteins:

  • CD34_HUMAN
  • B4DG27_HUMAN
  • Q3C1E7_HUMAN
  • Q5JTA5_HUMAN
  • Q8IUM0_HUMAN
  • Q9UH97_HUMAN
genes like me logo Genes that share paralogs with CD34: view

No data available for Paralogs for CD34 Gene

Variants for CD34 Gene

Sequence variations from dbSNP and Humsavar for CD34 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000112813 -- 207,883,282(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000121734 -- 207,903,885(-) G/A intron_variant
rs1000128898 -- 207,890,422(-) C/T intron_variant
rs1000305138 -- 207,910,233(-) G/T intron_variant
rs1000387776 -- 207,893,060(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD34 Gene

Variant ID Type Subtype PubMed ID
nsv1002076 CNV gain 25217958
nsv4243 CNV insertion 18451855

Variation tolerance for CD34 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD34 Gene

Disorders for CD34 Gene

MalaCards: The human disease database

(138) MalaCards diseases for CD34 Gene - From: DISEASES, Novoseek, and GeneCards