CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008] See more...

Aliases for CD302 Gene

Aliases for CD302 Gene

  • CD302 Molecule 2 3 5
  • CD302 Antigen 2 3 4
  • CLEC13A 2 3 4
  • Type I Transmembrane C-Type Lectin Receptor DCL-1 3 4
  • C-Type Lectin Domain Family 13, Member A 2 3
  • DEC205-Associated C-Type Lectin 1 3 4
  • KIAA0022 2 4
  • BIMLEC 2 3
  • DCL-1 2 3
  • DCL1 3 4
  • C-Type Lectin Domain Family 13 Member A 4
  • C-Type Lectin BIMLEC 4
  • CD302 5

External Ids for CD302 Gene

Previous GeneCards Identifiers for CD302 Gene

  • GC02M160451
  • GC02M160333
  • GC02M160625
  • GC02M152509

Summaries for CD302 Gene

Entrez Gene Summary for CD302 Gene

  • CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]

GeneCards Summary for CD302 Gene

CD302 (CD302 Molecule) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is MRC1.

UniProtKB/Swiss-Prot Summary for CD302 Gene

  • Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

Gene Wiki entry for CD302 Gene

Additional gene information for CD302 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD302 Gene

Genomics for CD302 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD302 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD302 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD302

Top Transcription factor binding sites by QIAGEN in the CD302 gene promoter:
  • C/EBPalpha
  • CUTL1
  • En-1
  • FAC1
  • IRF-7A
  • LUN-1
  • Pbx1a
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for CD302 Gene

Genomic Locations for CD302 Gene
chr2:159,768,628-159,798,255
(GRCh38/hg38)
Size:
29,628 bases
Orientation:
Minus strand
chr2:160,625,139-160,654,766
(GRCh37/hg19)
Size:
29,628 bases
Orientation:
Minus strand

Genomic View for CD302 Gene

Genes around CD302 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD302 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD302 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD302 Gene

Proteins for CD302 Gene

  • Protein details for CD302 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX05-CD302_HUMAN
    Recommended name:
    CD302 antigen
    Protein Accession:
    Q8IX05
    Secondary Accessions:
    • A8K5G4
    • B4E2T9
    • Q15009

    Protein attributes for CD302 Gene

    Size:
    232 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.
    • [Isoform 1]: Produced by intergenic splicing of LY75 and CD302.

    Three dimensional structures from OCA and Proteopedia for CD302 Gene

    Alternative splice isoforms for CD302 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD302 Gene

Post-translational modifications for CD302 Gene

  • May be heterogeneously N-glycosylated in some cell types.
  • Glycosylation at Asn109
  • Modification sites at PhosphoSitePlus

Other Protein References for CD302 Gene

No data available for DME Specific Peptides for CD302 Gene

Domains & Families for CD302 Gene

Gene Families for CD302 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD302 Gene

Suggested Antigen Peptide Sequences for CD302 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57445, moderately similar to Homo sapiens CD302 antigen (CD302), mRNA (B4E2T9_HUMAN)
  • Type I transmembrane C-type lectin receptor DCL-1 (CD302_HUMAN)
genes like me logo Genes that share domains with CD302: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD302 Gene

Function for CD302 Gene

Molecular function for CD302 Gene

UniProtKB/Swiss-Prot Function:
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

Phenotypes From GWAS Catalog for CD302 Gene

Gene Ontology (GO) - Molecular Function for CD302 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with CD302: view
genes like me logo Genes that share phenotypes with CD302: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD302

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD302

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD302 Gene

Localization for CD302 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD302 Gene

Membrane. Single-pass type I membrane protein. Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD302 gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CD302 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005902 microvillus IEA --
GO:0005938 cell cortex IDA 17947679
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with CD302: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD302 Gene

Pathways & Interactions for CD302 Gene

PathCards logo

SuperPathways for CD302 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD302 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IDA 17947679
genes like me logo Genes that share ontologies with CD302: view

No data available for Pathways by source and SIGNOR curated interactions for CD302 Gene

Drugs & Compounds for CD302 Gene

No Compound Related Data Available

Transcripts for CD302 Gene

mRNA/cDNA for CD302 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD302

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD302 Gene

No ASD Table

Relevant External Links for CD302 Gene

GeneLoc Exon Structure for
CD302

Expression for CD302 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD302 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD302 Gene

This gene is overexpressed in Liver (x6.5) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for CD302 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.8) and Lymph node (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD302 Gene



Protein tissue co-expression partners for CD302 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD302

SOURCE GeneReport for Unigene cluster for CD302 Gene:

Hs.130014

mRNA Expression by UniProt/SwissProt for CD302 Gene:

Q8IX05-CD302_HUMAN
Tissue specificity: Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

Evidence on tissue expression from TISSUES for CD302 Gene

  • Liver(4.5)
  • Bone marrow(4.4)
  • Nervous system(2.4)
  • Spleen(2.3)
  • Blood(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with CD302: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD302 Gene

Orthologs for CD302 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD302 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia CD302 30 31
  • 90.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD302 30 31
  • 89.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd302 30 17 31
  • 82.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd302 30
  • 82.05 (n)
Lizard
(Anolis carolinensis)
Reptilia CD302 31
  • 41 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100333685 30
  • 47.69 (n)
CABZ01055500.1 31
  • 27 (a)
OneToOne
Species where no ortholog for CD302 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD302 Gene

ENSEMBL:
Gene Tree for CD302 (if available)
TreeFam:
Gene Tree for CD302 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD302: view image

Paralogs for CD302 Gene

Paralogs for CD302 Gene

genes like me logo Genes that share paralogs with CD302: view

Variants for CD302 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD302 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs34068933 - p.Arg200Ser

Additional dbSNP identifiers (rs#s) for CD302 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD302 Gene

Variant ID Type Subtype PubMed ID
esv1001679 CNV deletion 20482838
nsv1010774 CNV gain 25217958
nsv470497 CNV loss 18288195
nsv834436 CNV loss 17160897

Variation tolerance for CD302 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD302 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD302

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD302 Gene

Disorders for CD302 Gene

Additional Disease Information for CD302

No disorders were found for CD302 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD302 Gene

Publications for CD302 Gene

  1. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. (PMID: 17947679) Kato M … Hart DN (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 23
  2. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M … Hart DN (The Journal of biological chemistry 2003) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CD302 Gene

Sources for CD302 Gene