Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008] See more...

Aliases for CD300LG Gene

Aliases for CD300LG Gene

  • CD300 Molecule Like Family Member G 2 3 5
  • CLM9 2 3 4
  • Triggering Receptor Expressed On Myeloid Cells 4 3 4
  • CD300 Antigen-Like Family Member G 3 4
  • CMRF35-Like Molecule 9 3 4
  • TREM-4 3 4
  • CLM-9 3 4
  • TREM4 3 4
  • CD300 Molecule-Like Family Member G 2
  • CD300 Antigen Like Family Member G 2
  • CD300g Antigen 4
  • Nepmucin 2
  • NEPMUCIN 3
  • CD300LG 5
  • Trem4 2

External Ids for CD300LG Gene

Previous GeneCards Identifiers for CD300LG Gene

  • GC17P039281
  • GC17P041924
  • GC17P037688
  • GC17P043846

Summaries for CD300LG Gene

Entrez Gene Summary for CD300LG Gene

  • Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LG Gene

CD300LG (CD300 Molecule Like Family Member G) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include IgM binding. An important paralog of this gene is CD300A.

UniProtKB/Swiss-Prot Summary for CD300LG Gene

  • Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Additional gene information for CD300LG Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300LG Gene

Genomics for CD300LG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD300LG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD300LG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300LG

Top Transcription factor binding sites by QIAGEN in the CD300LG gene promoter:
  • AML1a
  • AREB6
  • Ik-1
  • NF-E2
  • NF-E2 p45
  • NF-kappaB1
  • Nkx2-5
  • Pax-4a

Genomic Locations for CD300LG Gene

Genomic Locations for CD300LG Gene
chr17:43,847,097-43,863,639
(GRCh38/hg38)
Size:
16,543 bases
Orientation:
Plus strand
chr17:41,924,516-41,940,997
(GRCh37/hg19)
Size:
16,482 bases
Orientation:
Plus strand

Genomic View for CD300LG Gene

Genes around CD300LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LG Gene

Proteins for CD300LG Gene

  • Protein details for CD300LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXG3-CLM9_HUMAN
    Recommended name:
    CMRF35-like molecule 9
    Protein Accession:
    Q6UXG3
    Secondary Accessions:
    • B4DNY5
    • F5H7P9
    • F8W9M3
    • Q8IX38
    • Q8IX39
    • Q8TA95

    Protein attributes for CD300LG Gene

    Size:
    332 amino acids
    Molecular mass:
    36060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD300LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD300LG Gene

Post-translational modifications for CD300LG Gene

  • O-glycosylated with sialylated oligosaccharides.
  • Glycosylation at Asn96, Ser213, Ser214, Thr170, Thr137, Thr171, Ser222, Thr223, Ser224, Thr143, Thr177, Thr228, Thr144, Ser229, Ser237, Thr187, Thr155, Thr161, Thr195, Ser196, Thr199, Thr201, Ser202, Thr207, and Ser208
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD300LG Gene

Domains & Families for CD300LG Gene

Gene Families for CD300LG Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD300LG Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for CD300LG Gene

GenScript: Design optimal peptide antigens:
  • Triggering receptor expressed on myeloid cells 4 (CLM9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXG3

UniProtKB/Swiss-Prot:

CLM9_HUMAN :
  • Ig-like V-type domain mediates binding to lymphocyte.
  • Belongs to the CD300 family.
Domain:
  • Ig-like V-type domain mediates binding to lymphocyte.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LG: view

Function for CD300LG Gene

Molecular function for CD300LG Gene

UniProtKB/Swiss-Prot Function:
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Phenotypes From GWAS Catalog for CD300LG Gene

Gene Ontology (GO) - Molecular Function for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD300LG: view
genes like me logo Genes that share phenotypes with CD300LG: view

Animal Models for CD300LG Gene

MGI Knock Outs for CD300LG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300LG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LG Gene

Localization for CD300LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LG Gene

Apical cell membrane. Single-pass type I membrane protein. Basolateral cell membrane. Single-pass type I membrane protein. Endosome, multivesicular body membrane. Single-pass type I membrane protein. Note=Transcytoses across the cytoplasm. {ECO:0000250 UniProtKB:Q1ERP8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LG gene
Compartment Confidence
plasma membrane 5
endosome 3
extracellular 2
nucleus 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CD300LG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LG Gene

Pathways & Interactions for CD300LG Gene

genes like me logo Genes that share pathways with CD300LG: view

Pathways by source for CD300LG Gene

Interacting Proteins for CD300LG Gene

Gene Ontology (GO) - Biological Process for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LG: view

No data available for SIGNOR curated interactions for CD300LG Gene

Drugs & Compounds for CD300LG Gene

(1) Drugs for CD300LG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with CD300LG: view

Transcripts for CD300LG Gene

mRNA/cDNA for CD300LG Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300LG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LG Gene

No ASD Table

Relevant External Links for CD300LG Gene

GeneLoc Exon Structure for
CD300LG

Expression for CD300LG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300LG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x13.7), Adipose - Subcutaneous (x11.4), and Breast - Mammary Tissue (x8.6).

Protein differential expression in normal tissues from HIPED for CD300LG Gene

This gene is overexpressed in Urine (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LG Gene



Protein tissue co-expression partners for CD300LG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300LG

SOURCE GeneReport for Unigene cluster for CD300LG Gene:

Hs.147313

mRNA Expression by UniProt/SwissProt for CD300LG Gene:

Q6UXG3-CLM9_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for CD300LG Gene

  • Lung(4.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with CD300LG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LG Gene

Orthologs for CD300LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD300LG 30 31
  • 99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD300LG 30 31
  • 78.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD300LG 30 31
  • 73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd300lg 30
  • 72.13 (n)
Mouse
(Mus musculus)
Mammalia Cd300lg 30 17 31
  • 71.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD300LG 31
  • 39 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CD300L-S1 31
  • 27 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 20 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CD300LG (3 of 5) 31
  • 22 (a)
OneToMany
CD300LG (2 of 5) 31
  • 19 (a)
OneToMany
CD300LG (4 of 5) 31
  • 14 (a)
OneToMany
CD300LG (1 of 5) 31
  • 14 (a)
OneToMany
CD300LG (5 of 5) 31
  • 13 (a)
OneToMany
Species where no ortholog for CD300LG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD300LG Gene

ENSEMBL:
Gene Tree for CD300LG (if available)
TreeFam:
Gene Tree for CD300LG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD300LG: view image

Paralogs for CD300LG Gene

(2) SIMAP similar genes for CD300LG Gene using alignment to 2 proteins:

  • CLM9_HUMAN
  • K7EL06_HUMAN
genes like me logo Genes that share paralogs with CD300LG: view

Variants for CD300LG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300LG Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs12453522 - p.Thr228Ala
rs17852267 - p.Asp221Asn

Additional dbSNP identifiers (rs#s) for CD300LG Gene

Structural Variations from Database of Genomic Variants (DGV) for CD300LG Gene

Variant ID Type Subtype PubMed ID
esv3640639 CNV gain 21293372
nsv1146669 OTHER inversion 26484159

Variation tolerance for CD300LG Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300LG Gene

Human Gene Mutation Database (HGMD)
CD300LG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD300LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LG Gene

Disorders for CD300LG Gene

No disorders were found for CD300LG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LG Gene

Publications for CD300LG Gene

  1. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. (PMID: 16876123) Takatsu H … Ohno H (Biochemical and biophysical research communications 2006) 2 3 4 23
  2. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (PMID: 16754720) Umemoto E … Miyasaka M (The Journal of experimental medicine 2006) 2 3
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CD300LG Gene

  • Signalway Proteins for CD300LG

Sources for CD300LG Gene