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This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] See more...
Aliases for CD300LF Gene
Aliases for CD300LF Gene
External Ids for CD300LF Gene
- HGNC: 29883
- Entrez Gene: 146722
- Ensembl: ENSG00000186074
- OMIM: 609807
- UniProtKB: Q8TDQ1
Previous GeneCards Identifiers for CD300LF Gene
- GC17M070204
- GC17M072690
- GC17M068099
Summaries for CD300LF Gene
-
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for CD300LF Gene
CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Diseases associated with CD300LF include Noonan Syndrome 7 and Noonan Syndrome 6. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LD.
UniProtKB/Swiss-Prot Summary for CD300LF Gene
-
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Additional gene information for CD300LF Gene
- HGNC(29883)
- Entrez Gene(146722)
- Ensembl(ENSG00000186074)
- OMIM(609807)
- UniProtKB(Q8TDQ1)
- Open Targets Platform(ENSG00000186074)
- Search for CD300LF at DataMed
- Search for CD300LF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300LF Gene
Genomics for CD300LF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD300LF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD300LF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300LF
- Top Transcription factor binding sites by QIAGEN in the CD300LF gene promoter:
-
- AREB6
- ER-alpha
- GR
- GR-alpha
- GR-beta
- Olf-1
- Pax-5
- STAT5A
- STAT5B
- ZID
Genomic Locations for CD300LF Gene
Genomic Locations for CD300LF Gene
- chr17:74,694,308-74,713,000
- (GRCh38/hg38)
- Size:
- 18,693 bases
- Orientation:
- Minus strand
- chr17:72,690,452-72,709,117
- (GRCh37/hg19)
- Size:
- 18,666 bases
- Orientation:
- Minus strand
Genomic View for CD300LF Gene
Genes around CD300LF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
CD300LF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD300LF Gene
Proteins for CD300LF Gene
-
Protein details for CD300LF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDQ1-CLM1_HUMAN
- Recommended name:
- CMRF35-like molecule 1
- Protein Accession:
- Q8TDQ1
- B2RCL2
- C9JDN3
- Q3Y6P0
- Q6UX24
- Q7Z6A6
- Q7Z7I4
- Q7Z7I5
- Q8N6D0
- Q8NAF5
Protein attributes for CD300LF Gene
- Size:
- 290 amino acids
- Molecular mass:
- 32335 Da
- Quaternary structure:
-
- Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner (PubMed:15184070, PubMed:15549731). Interacts with IL4R (By similarity).
Protein Expression for CD300LF Gene
Post-translational modifications for CD300LF Gene
- Phosphorylated on tyrosine.
-
Glycosylation at Asn88
- NX_Q8TDQ1 (NX_Q8TDQ1-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CD300LF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CLM-1 Antibody
- Creative Diagnostics Anti-CD300LF Monoclonal antibody, clone 3I6 [PE]
-
Creative Biolabs
- Recombinant Mouse Anti-Human CD300LF Antibody (clone NFN-370)
- Recombinant Mouse Anti-CD300LF Antibody scFv Fragment (DCR-2)
- Recombinant Anti-CD300LF Antibody (D12)
- Recombinant Anti-CD300LF Antibody scFv Fragment (D12)
- Recombinant Mouse Anti-CD300LF Antibody (DCR-2)
- Recombinant Anti-CD300LF Antibody Fab Fragment (D12)
-
Custom Antibody ServicesOriGene Antibodies for CD300LF
- Novus Biologicals Antibodies for CD300LF
-
Abcam antibodies for CD300LF
- Invitrogen Antibodies for CD300LF (AFLGC-CD300LF)
-
Boster Bio Antibodies for CD300LF
- Sino Biological Antibodies for CD300LF
Protein Products
- Creative Biomart Recombinant Human CD300 Molecule-Like Family Member F, Fc-tagged
-
OriGene Purified Proteins for CD300LF
- Search Origene for MassSpec and Protein Over-expression Lysates for CD300LF
- Origene Custom Protein Services for CD300LF
- Sino Biological Recombinant Proteins for CD300LF
- Sino Biological Cell Lysates for CD300LF
Assay Products
- RayBiotech Custom Human CD300f ELISA
-
Custom Assay ServicesOriGene ELISA Kits for CD300LF
- antibodies-online: Show 17 available IREM1 Elisa Kits ranked by validation data
- Compare Top IREM1 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CD300LF
-
Signalway ELISA kits for CD300LF
No data available for DME Specific Peptides for CD300LF Gene
Domains & Families for CD300LF Gene
Gene Families for CD300LF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD300LF Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for CD300LF Gene
- GenScript: Design optimal peptide antigens:
-
- NK inhibitory receptor (CLM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TDQ1- Family:
-
- Belongs to the CD300 family.
Function for CD300LF Gene
Molecular function for CD300LF Gene
- UniProtKB/Swiss-Prot Function:
- Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Phenotypes From GWAS Catalog for CD300LF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | phosphatidylserine binding | ISS | -- |
| GO:0005136 | interleukin-4 receptor binding | ISS | -- |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0097001 | ceramide binding | IDA | 24035150 |
Phenotypes for CD300LF Gene
- MGI mutant phenotypes for CD300LF:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD300LF:
Animal Models for CD300LF Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CD300LF
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD300LF - Select products 50% OFF >
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miRNA for CD300LF Gene
- miRTarBase miRNAs that target CD300LF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300LF
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Clone Products
- Applied Biological Materials (abm): Clones for CD300LF - Select products 50% OFF >
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- MG204865
- MG217822
- MR204865
- MR204865L3
- MR204865L4
- MR217822
- MR217822L3
- MR217822L4
- RC222248
- RC222248L1
- RC222248L2
- RC222248L3
- RC222248L4
- RC236471
- RC236685
- RC236836
- RC236893
- RC237251
- RC237340
- RG222248
- RR200569
- RR200569L3
- RR200569L4
- MR204865L3V
- MR204865L4V
- MR217822L3V
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- RC222248L1V
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- RR200569L3V
- RR200569L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD300LF
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Cell Line Products
-
Horizon Cell Lines for CD300LF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LF Gene
Localization for CD300LF Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD300LF Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LF Gene
Pathways & Interactions for CD300LF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for CD300LF Gene
3 Reactome pathways for CD300LF Gene
Interacting Proteins for CD300LF Gene
Selected Interacting proteins:
Q8TDQ1-CLM1_HUMAN
ENSP00000462309
for CD300LF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CD300LF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0033004 | negative regulation of mast cell activation | IDA | 24035150 |
| GO:0034125 | negative regulation of MyD88-dependent toll-like receptor signaling pathway | IMP | 22043923 |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | IMP | 22043923 |
| GO:0035772 | interleukin-13-mediated signaling pathway | ISS | -- |
No data available for SIGNOR curated interactions for CD300LF Gene
Drugs & Compounds for CD300LF Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human CD300 Molecule-Like Family Member F, Fc-tagged
Transcripts for CD300LF Gene
mRNA/cDNA for CD300LF Gene
- 7 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000326165 1709 nts (view in UCSC)
- ENST00000469092 1825 nts (view in UCSC)
- ENST00000301573 1785 nts (view in UCSC)
- ENST00000583937 1275 nts (view in UCSC)
- ENST00000464910 996 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD300LF - Select products 50% OFF >
- * CD300LF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD300LF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD300LF
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD300LF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300LF
- Browse OriGene Inhibitory RNA Products For CD300LF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300LF
Clone Products
- Applied Biological Materials (abm): Clones for CD300LF - Select products 50% OFF >
- * CD300LF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204865
- MG217822
- MR204865
- MR204865L3
- MR204865L4
- MR217822
- MR217822L3
- MR217822L4
- RC222248
- RC222248L1
- RC222248L2
- RC222248L3
- RC222248L4
- RC236471
- RC236685
- RC236836
- RC236893
- RC237251
- RC237340
- RG222248
- RR200569
- RR200569L3
- RR200569L4
- MR204865L3V
- MR204865L4V
- MR217822L3V
- MR217822L4V
- RC222248L1V
- RC222248L2V
- RC222248L3V
- RC222248L4V
- RR200569L3V
- RR200569L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD300LF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD300LF
Relevant External Links for CD300LF Gene
- GeneLoc Exon Structure for
- CD300LF
Expression for CD300LF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CD300LF Gene
This gene is overexpressed in Whole Blood (x35.0) and Spleen (x7.0).
This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (27.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LF Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300LF
SOURCE GeneReport for Unigene cluster for CD300LF Gene:
Hs.567706mRNA Expression by UniProt/SwissProt for CD300LF Gene:
Q8TDQ1-CLM1_HUMAN
Tissue specificity:
Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
Evidence on tissue expression from TISSUES for CD300LF Gene
- Lung(4.9)
- Intestine(4.8)
- Blood(4.7)
- Skin(4.3)
- Nervous system(4.3)
- Eye(4.1)
- Pancreas(3.8)
- Liver(3.4)
- Muscle(3.3)
- Spleen(2.6)
- Kidney(2.6)
- Bone marrow(2.3)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD300LF
-
OriGene qPCR primer pairs and template standards for CD300LF
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LF Gene
Orthologs for CD300LF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD300LF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD300LF 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Cd300lf 30 17 31 |
|
ManyToMany | |
| Gm11711 31 |
|
ManyToMany | |||
| Cd300lh 31 |
|
ManyToMany | |||
| Gm11710 31 |
|
ManyToMany | |||
| Cd300ld 31 |
|
ManyToMany | |||
| Gm11709 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | CD300LF 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Cd300lf 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CD300LF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD300LF Gene
- ENSEMBL:
- Gene Tree for CD300LF (if available)
- TreeFam:
- Gene Tree for CD300LF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD300LF: view image
Paralogs for CD300LF Gene
Paralogs for CD300LF Gene
(5) SIMAP similar genes for CD300LF Gene using alignment to 2 proteins:
- CLM1_HUMAN
- J3KS52_HUMAN
Variants for CD300LF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300LF Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2034310 | - | p.Gln218Arg | |||
| rs35489971 | - | p.Val19Ala |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3282n100 | CNV | gain | 25217958 |
| dgv5768n54 | CNV | gain | 21841781 |
| esv2751770 | CNV | gain | 17911159 |
| esv33995 | CNV | loss | 17666407 |
| esv3573820 | CNV | gain | 25503493 |
| esv3641230 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD300LF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LF Gene
Disorders for CD300LF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noonan syndrome 7 |
|
|
| noonan syndrome 6 |
|
|
Search CD300LF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD300LF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD300LF Gene
Publications for CD300LF Gene
- IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PMID: 15184070) Sui L … Cao X (Biochemical and biophysical research communications 2004) 3 4 23
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
- Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. (PMID: 24035150) Izawa K … Kitaura J (The Journal of allergy and clinical immunology 2014) 3 4
- CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. (PMID: 22043923) Kim EJ … Lee WH (Immunology 2012) 3 4
- Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik JS … Ridker PM (Circulation. Cardiovascular genetics 2009) 3 41
ExternalLinks
Products for CD300LF Gene
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300LF
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- OriGene qPCR primer pairs for CD300LF
- OriGene qPCR primer pairs and template standards for CD300LF
- OriGene CRISPR knockouts for CD300LF
- MG204865
- MG217822
- MR204865
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- MR204865L4
- MR217822
- MR217822L3
- MR217822L4
- RC222248
- RC222248L1
- RC222248L2
- RC222248L3
- RC222248L4
- RC236471
- RC236685
- RC236836
- RC236893
- RC237251
- RC237340
- RG222248
- RR200569
- RR200569L3
- RR200569L4
- MR204865L3V
- MR204865L4V
- MR217822L3V
- MR217822L4V
- RC222248L1V
- RC222248L2V
- RC222248L3V
- RC222248L4V
- RR200569L3V
- RR200569L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Taconic Biosciences Mouse Models for CD300LF
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- VectorBuilder Custom and pre-made DNA vectors for CD300LF (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 16 available IREM1 Antibodies ranked by validation data
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- Horizon Cell Lines for CD300LF
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Sources for CD300LF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
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- (143) Applied Biosystems
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- (154) Biorbyt
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- (156) Mastermind
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- (158) CraniofacialAtlas
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- (160) Synthego
- (161) ENA
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- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB