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This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Diseases associated with CD300LF include Noonan Syndrome 7 and Noonan Syndrome 6. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LD.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001786 | phosphatidylserine binding | ISS | -- |
GO:0005136 | interleukin-4 receptor binding | ISS | -- |
GO:0008289 | lipid binding | IEA | -- |
GO:0097001 | ceramide binding | IDA | 24035150 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
|
3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0033004 | negative regulation of mast cell activation | IDA | 24035150 |
GO:0034125 | negative regulation of MyD88-dependent toll-like receptor signaling pathway | IMP | 22043923 |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | IMP | 22043923 |
GO:0035772 | interleukin-13-mediated signaling pathway | ISS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD300LF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD300LF 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Cd300lf 30 17 31 |
|
ManyToMany | |
Gm11711 31 |
|
ManyToMany | |||
Cd300lh 31 |
|
ManyToMany | |||
Gm11710 31 |
|
ManyToMany | |||
Cd300ld 31 |
|
ManyToMany | |||
Gm11709 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | CD300LF 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Cd300lf 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2034310 | - | p.Gln218Arg | |||
rs35489971 | - | p.Val19Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3282n100 | CNV | gain | 25217958 |
dgv5768n54 | CNV | gain | 21841781 |
esv2751770 | CNV | gain | 17911159 |
esv33995 | CNV | loss | 17666407 |
esv3573820 | CNV | gain | 25503493 |
esv3641230 | CNV | gain | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome 7 |
|
|
noonan syndrome 6 |
|
|