Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule Like Family Member D 2 3 5
  • CMRF35A4 2 3 4
  • CD300D 2 3 4
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-Like Molecule 5 3 4
  • CMRF35-A4 3 4
  • CLM-5 3 4
  • CD300 Molecule-Like Family Member D 2
  • CMRF35-Like Molecule 4 3
  • Immune Receptor CD300d 3
  • CD300d Antigen 4
  • CD300LD 5
  • CLM-4 3

External Ids for CD300LD Gene

Previous GeneCards Identifiers for CD300LD Gene

  • GC17M070088
  • GC17M072576
  • GC17M067985

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule Like Family Member D) is a Protein Coding gene. Diseases associated with CD300LD include 46,Xy Sex Reversal 8 and Schopf-Schulz-Passarge Syndrome. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is CD300LF.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD300LD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074593 Promoter 0.4 EPDnew 250.7 0.0 -4 0.1 SPI1 CD300LD C17orf77 ENSG00000261222 CD300E
GH17J074592 Promoter 0.4 Ensembl 250.7 +0.2 182 0.2 SPI1 CD300LD SUMO2 C17orf77 piR-51845-001 CD300H
GH17J074568 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +22.7 22678 1.6 ZBTB10 CEBPB MAX KLF9 ZNF658 STAT3 TBP ZNF316 FOSL1 GLI4 CD300E NAT9 CD300C NUP85 CD300LB NT5C CD300LD MGC16275 CASKIN2 GGA3
GH17J074451 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +138.4 138352 4.1 ZBTB10 IKZF1 ZEB1 NONO ZIC2 THAP11 SIN3A VEZF1 SMAD4 SAP130 GPR142 CD300E CD300LD GPRC5C ENSG00000265800 HSALNG0118650 HSALNG0118652 CD300A RF00017-2537
GH17J074442 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +147.2 147217 5.7 CHD2 MXD4 CEBPA ZIC2 HOMEZ KDM6A THAP11 ZNF395 FOXA2 ZNF511 GPRC5C NT5C NUP85 GGA3 NAT9 CD300A GPR142 CD300E CD300LD HSALNG0118650
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD300LD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300LD

Top Transcription factor binding sites by QIAGEN in the CD300LD gene promoter:
  • AREB6
  • Bach1
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • HNF-4alpha2
  • RORalpha1
  • Tal-1

Genomic Locations for CD300LD Gene

Latest Assembly
12,919 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
12,919 bases
Minus strand

(GRCh37/hg19 by Ensembl)
12,919 bases
Minus strand

Genomic View for CD300LD Gene

Genes around CD300LD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 5
    Protein Accession:

    Protein attributes for CD300LD Gene

    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains & Families for CD300LD Gene

Gene Families for CD300LD Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:
  • CMRF35-A4 (CLM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD300 family.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Phenotypes From GWAS Catalog for CD300LD Gene

Gene Ontology (GO) - Molecular Function for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD300LD: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300LD

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane. Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0
cytosol 0
lysosome 0

Gene Ontology (GO) - Cellular Components for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LD Gene

Pathways & Interactions for CD300LD Gene

genes like me logo Genes that share pathways with CD300LD: view

Pathways by source for CD300LD Gene

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q6UXZ3-CLM5_HUMAN ENSP00000364501 for CD300LD Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for SIGNOR curated interactions for CD300LD Gene

Drugs & Compounds for CD300LD Gene

No Compound Related Data Available

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300LD

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for

Expression for CD300LD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (x45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LD Gene

Protein tissue co-expression partners for CD300LD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300LD

SOURCE GeneReport for Unigene cluster for CD300LD Gene:


mRNA Expression by UniProt/SwissProt for CD300LD Gene:

Tissue specificity: Expression seems restricted to cells of myeloid lineage.

Evidence on tissue expression from TISSUES for CD300LD Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with CD300LD: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300LD 30 31
  • 98.11 (n)
(Bos Taurus)
Mammalia LOC509881 30
  • 69.93 (n)
-- 31
  • 41 (a)
-- 31
  • 35 (a)
-- 31
  • 25 (a)
(Mus musculus)
Mammalia Cd300ld 30 17 31
  • 67.65 (n)
Gm11711 31
  • 31 (a)
Gm11710 31
  • 31 (a)
Cd300lh 31
  • 31 (a)
Gm11709 31
  • 26 (a)
Cd300lf 31
  • 22 (a)
Cd300ld3 17
Cd300ld4 17
Cd300ld5 17
(Rattus norvegicus)
Mammalia Cd300le 30
  • 65.7 (n)
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
-- 31
  • 39 (a)
-- 31
  • 37 (a)
-- 31
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 38 (a)
-- 31
  • 37 (a)
-- 31
  • 25 (a)
-- 31
  • 25 (a)
-- 31
  • 17 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 19 (a)
(Gallus gallus)
Aves -- 31
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 34 (a)
-- 31
  • 23 (a)
Species where no ortholog for CD300LD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD300LD Gene

Gene Tree for CD300LD (if available)
Gene Tree for CD300LD (if available)
Evolutionary constrained regions (ECRs) for CD300LD: view image

Paralogs for CD300LD Gene

(4) SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300LD Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs493430 - p.Ser6Ala
rs783239 - p.Val89Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CD300LD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300LD Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300LD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD300LD Gene - From: COP

Disorder Aliases PubMed IDs
46,xy sex reversal 8
  • srxy8
schopf-schulz-passarge syndrome
  • ssps
46,xy sex reversal
  • 46 xy gonadal dysgenesis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CD300LD

genes like me logo Genes that share disorders with CD300LD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E … Sayós J (The Journal of biological chemistry 2012) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski RE … Clark GJ (Immunology letters 2013) 3
  5. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani SR … Gonzalez LC (Analytical biochemistry 2012) 3

Products for CD300LD Gene

Sources for CD300LD Gene