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Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule Like Family Member D 2 3 5
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-A4 3 4
  • CMRF35A4 3 4
  • CD300D 3 4
  • CLM-4 3 4
  • CD300 Molecule-Like Family Member D 2
  • CMRF35-Like Molecule 4 3
  • Immune Receptor CD300d 3
  • CD300d Antigen 4

External Ids for CD300LD Gene

Previous GeneCards Identifiers for CD300LD Gene

  • GC17M070088
  • GC17M072576
  • GC17M067985

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule Like Family Member D) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LF.

Additional gene information for CD300LD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

GeneHancer (GH) Regulatory Elements for CD300LD Gene

Promoters and enhancers for CD300LD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I074592 Promoter/Enhancer 0.8 EPDnew Ensembl 550.8 +0.1 82 0.4 SPI1 CD300LD SUMO2 PIR53017 C17orf77
GH17I074526 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.1 +62.0 61982 7.4 HDGF HDAC1 PKNOX1 RB1 BATF IRF4 RAD21 YY1 ZNF143 ZNF207 CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
GH17I074568 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +22.7 22727 1.5 ZNF473 ZSCAN4 SIN3A ZNF195 YBX1 GLI4 EGR1 FOS EGR2 YY2 NAT9 NUP85 CD300E NT5C CD300C CD300LB GGA3 CD300LD MGC16275 HID1
GH17I074511 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +78.7 78679 3.3 YBX1 FEZF1 ZNF213 ZNF416 ZNF548 SP3 ZFP41 MEF2D ZNF610 GLIS1 NUP85 NAT9 NT5C GGA3 RN7SL573P HID1-AS1 CD300E SLC16A5 MIF4GD CDR2L
GH17I074639 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -47.6 -47643 1.7 PKNOX1 CBFB HLF IRF5 CEBPB DPF2 POLR2A IKZF1 MYC RUNX3 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD CD300A ENSG00000236770 SLC9A3R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD300LD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD300LD gene promoter:

Genomic Locations for CD300LD Gene

Genomic Locations for CD300LD Gene
12,919 bases
Minus strand

Genomic View for CD300LD Gene

Genes around CD300LD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 4
    Protein Accession:

    Protein attributes for CD300LD Gene

    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains & Families for CD300LD Gene

Gene Families for CD300LD Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD300 family.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Gene Ontology (GO) - Molecular Function for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD300LD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LD Gene

Pathways & Interactions for CD300LD Gene

genes like me logo Genes that share pathways with CD300LD: view

Pathways by source for CD300LD Gene

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6UXZ3-CLM4_HUMAN ENSP00000364501 for CD300LD Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for SIGNOR curated interactions for CD300LD Gene

Drugs & Compounds for CD300LD Gene

No Compound Related Data Available

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300LD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (x45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LD Gene

Protein tissue co-expression partners for CD300LD Gene

NURSA nuclear receptor signaling pathways regulating expression of CD300LD Gene:


SOURCE GeneReport for Unigene cluster for CD300LD Gene:


mRNA Expression by UniProt/SwissProt for CD300LD Gene:

Tissue specificity: Expression seems restricted to cells of myeloid lineage.

Evidence on tissue expression from TISSUES for CD300LD Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with CD300LD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300LD 33 34
  • 98.11 (n)
(Bos Taurus)
Mammalia LOC509881 33
  • 69.93 (n)
-- 34
  • 41 (a)
-- 34
  • 35 (a)
-- 34
  • 25 (a)
(Mus musculus)
Mammalia Cd300ld 33 34
  • 67.65 (n)
Cd300lh 34
  • 31 (a)
Gm11710 34
  • 31 (a)
Gm11711 34
  • 31 (a)
Gm11709 34
  • 26 (a)
Cd300lf 34
  • 22 (a)
Cd300ld5 16
(Rattus norvegicus)
Mammalia Cd300le 33
  • 65.7 (n)
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
-- 34
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
-- 34
  • 37 (a)
-- 34
  • 25 (a)
-- 34
  • 25 (a)
-- 34
  • 17 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
(Gallus gallus)
Aves -- 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
-- 34
  • 23 (a)
Species where no ortholog for CD300LD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LD Gene

Gene Tree for CD300LD (if available)
Gene Tree for CD300LD (if available)

Paralogs for CD300LD Gene

Paralogs for CD300LD Gene

(4) SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations from dbSNP and Humsavar for CD300LD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000238531 -- 74,589,102(-) C/G intron_variant
rs1000650393 -- 74,585,147(-) G/T intron_variant
rs1000765123 -- 74,584,916(-) T/A intron_variant
rs1001324339 -- 74,594,035(-) A/G upstream_transcript_variant
rs1001522897 -- 74,583,591(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300LD Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300LD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

Additional Disease Information for CD300LD

No disorders were found for CD300LD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E … Sayós J (The Journal of biological chemistry 2012) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski RE … Clark GJ (Immunology letters 2013) 3 58
  4. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani SR … Gonzalez LC (Analytical biochemistry 2012) 3 58
  5. The CD300 molecules regulate monocyte and dendritic cell functions. (PMID: 19592130) Clark GJ … Hart DN (Immunobiology 2009) 3 58

Products for CD300LD Gene

Sources for CD300LD Gene

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