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Aliases for CD300LB Gene

Aliases for CD300LB Gene

  • CD300 Molecule Like Family Member B 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells 5 2 3 4
  • Immune Receptor Expressed On Myeloid Cells 3 3 4
  • CD300 Antigen Like Family Member B 2 3
  • Leukocyte Mono-Ig-Like Receptor 5 3 4
  • CMRF35-A2 3 4
  • CD300b 3 4
  • IREM-3 3 4
  • TREM-5 3 4
  • CLM-7 3 4
  • IREM3 3 4
  • TREM5 3 4
  • CLM7 3 4
  • CD300 Molecule-Like Family Member B 2
  • CD300 Antigen-Like Family Member B 4
  • CMRF35-Like Molecule 7 3
  • CD300b Antigen 4
  • EC 56
  • EC 56
  • CMRF35A2 4
  • LMIR5 4

External Ids for CD300LB Gene

Previous GeneCards Identifiers for CD300LB Gene

  • GC17M070029
  • GC17M072517
  • GC17M067926

Summaries for CD300LB Gene

Entrez Gene Summary for CD300LB Gene

  • CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LB Gene

CD300LB (CD300 Molecule Like Family Member B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD300LF.

UniProtKB/Swiss-Prot for CD300LB Gene

  • Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

Additional gene information for CD300LB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LB Gene

Genomics for CD300LB Gene

GeneHancer (GH) Regulatory Elements for CD300LB Gene

Promoters and enhancers for CD300LB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I074526 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 577.2 +1.2 1173 7.4 HDGF HDAC1 PKNOX1 RB1 BATF IRF4 RAD21 YY1 ZNF143 ZNF207 CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
GH17I074568 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -38.1 -38082 1.5 ZNF473 ZSCAN4 SIN3A ZNF195 YBX1 GLI4 EGR1 FOS EGR2 YY2 NAT9 NUP85 CD300E NT5C CD300C CD300LB GGA3 CD300LD MGC16275 HID1
GH17I074461 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +65.7 65705 9.3 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 YBX1 IRF4 ZNF766 ZNF207 ZNF143 CD300A NUP85 NAT9 NT5C GGA3 MGC16275 GPR142 CD300LB ARMC7 BTBD17
GH17I074639 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20 -108.5 -108452 1.7 PKNOX1 CBFB HLF IRF5 CEBPB DPF2 POLR2A IKZF1 MYC RUNX3 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD CD300A ENSG00000236770 SLC9A3R1
GH17I074477 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 21.2 +52.6 52561 3.7 BACH1 MAX ZMYM3 EBF1 ZNF664 CTBP1 ATF7 IKZF2 RUNX3 SMARCE1 GPRC5C CD300LB CD300E CD300C BTBD17 CD300LD CD300LF TMEM104 CD300A TTYH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD300LB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD300LB gene promoter:

Genomic Locations for CD300LB Gene

Genomic Locations for CD300LB Gene
10,301 bases
Minus strand

Genomic View for CD300LB Gene

Genes around CD300LB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LB Gene

Proteins for CD300LB Gene

  • Protein details for CD300LB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 7
    Protein Accession:
    Secondary Accessions:
    • Q1EG73
    • Q8IX40
    • Q8N6D1

    Protein attributes for CD300LB Gene

    201 amino acids
    Molecular mass:
    22689 Da
    Quaternary structure:
    • Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.
    • Sequence=AAH28091.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF83614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW89170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CD300LB Gene

Selected DME Specific Peptides for CD300LB Gene


Post-translational modifications for CD300LB Gene

  • Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD300LB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CD300LB Gene

Gene Families for CD300LB Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD300LB Gene

Suggested Antigen Peptide Sequences for CD300LB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD300 family.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LB: view

Function for CD300LB Gene

Molecular function for CD300LB Gene

UniProtKB/Swiss-Prot Function:
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

Enzyme Numbers (IUBMB) for CD300LB Gene

genes like me logo Genes that share phenotypes with CD300LB: view

Animal Models for CD300LB Gene

MGI Knock Outs for CD300LB:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LB Gene

Localization for CD300LB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LB Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LB gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD300LB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LB Gene

Pathways & Interactions for CD300LB Gene

genes like me logo Genes that share pathways with CD300LB: view

Interacting Proteins for CD300LB Gene

Gene Ontology (GO) - Biological Process for CD300LB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LB: view

No data available for SIGNOR curated interactions for CD300LB Gene

Drugs & Compounds for CD300LB Gene

No Compound Related Data Available

Transcripts for CD300LB Gene

mRNA/cDNA for CD300LB Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300LB Gene

CD300 molecule-like family member b:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LB Gene

No ASD Table

Relevant External Links for CD300LB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300LB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD300LB Gene

mRNA differential expression in normal tissues according to GTEx for CD300LB Gene

This gene is overexpressed in Whole Blood (x37.1).

Protein differential expression in normal tissues from HIPED for CD300LB Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD300LB Gene

Protein tissue co-expression partners for CD300LB Gene

NURSA nuclear receptor signaling pathways regulating expression of CD300LB Gene:


SOURCE GeneReport for Unigene cluster for CD300LB Gene:


mRNA Expression by UniProt/SwissProt for CD300LB Gene:

Tissue specificity: Expressed exclusively in myeloid lineages.

Evidence on tissue expression from TISSUES for CD300LB Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with CD300LB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LB Gene

Orthologs for CD300LB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300LB 33 34
  • 98.51 (n)
(Rattus norvegicus)
Mammalia Cd300lb 33
  • 71.83 (n)
(Mus musculus)
Mammalia Cd300lb 33 16 34
  • 70.67 (n)
(Canis familiaris)
Mammalia CD300LB 34
  • 59 (a)
(Bos Taurus)
Mammalia CD300LB 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
-- 34
  • 40 (a)
-- 34
  • 30 (a)
-- 34
  • 26 (a)
-- 34
  • 24 (a)
-- 34
  • 20 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 24 (a)
(Gallus gallus)
Aves -- 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
-- 34
  • 28 (a)
-- 34
  • 23 (a)
Species where no ortholog for CD300LB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LB Gene

Gene Tree for CD300LB (if available)
Gene Tree for CD300LB (if available)

Paralogs for CD300LB Gene

Paralogs for CD300LB Gene

(5) SIMAP similar genes for CD300LB Gene using alignment to 2 proteins: Pseudogenes for CD300LB Gene

genes like me logo Genes that share paralogs with CD300LB: view

Variants for CD300LB Gene

Sequence variations from dbSNP and Humsavar for CD300LB Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000120558 -- 74,528,703(-) T/C intron_variant
rs1000227885 -- 74,532,275(-) G/A upstream_transcript_variant
rs1000343500 -- 74,532,457(-) G/T upstream_transcript_variant
rs1000477831 -- 74,521,782(-) C/T 3_prime_UTR_variant, intron_variant
rs1000615145 -- 74,530,960(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LB Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv470600 CNV loss 18288195
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300LB Gene

Gene Damage Index Score: 0.67; 14.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300LB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LB Gene

Disorders for CD300LB Gene

Additional Disease Information for CD300LB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CD300LB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LB Gene

Publications for CD300LB Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. (PMID: 17928527) Yamanishi Y … Kitamura T (Blood 2008) 3 4 58
  4. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. (PMID: 16920917) Martínez-Barriocanal A … Sayós J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 58
  5. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58

Products for CD300LB Gene

Sources for CD300LB Gene

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