Free for academic non-profit institutions. Other users need a Commercial license
This gene belongs to the CD300 gene family, which in turn, belongs to the immunoglobulin (Ig) superfamily. This gene is located within a CD300 cluster on chromosome 17. The encoded protein may be involved in innate immunity as well as autoimmune response. A G>A mutation, represented by the single nucleotide polymorphism (SNP) rs905709, at the splice donor site of the 5' terminal exon may be associated with lack of expression of this gene in homozygous (AA) individuals. The human reference assembly (GRCh38.p2) represents the 'A' allele at this SNP. [provided by RefSeq, Apr 2016]
CD300H (CD300H Molecule (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is CD300C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 26221034 |
GO:0042803 | NOT protein homodimerization activity | IDA | 26221034 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001816 | cytokine production | IDA | 26221034 |
GO:0030593 | neutrophil chemotaxis | IDA | 26221034 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | LOC100686047 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC614141 30 |
|
No disorders were found for CD300H Gene.