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This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
CD300E (CD300e Molecule) is a Protein Coding gene. Diseases associated with CD300E include Tungiasis. Among its related pathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is CD300H.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
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|
|
2 | Class I MHC mediated antigen processing and presentation | ||
3 | RET signaling | ||
4 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0045087 | innate immune response | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CD300E 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CD300E 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CD300E 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Cd300e 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cd300e 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1278044712 | A colorectal cancer sample | 74,617,427(-) | T/C | coding_sequence_variant, missense_variant | |
rs1000060453 | -- | 74,621,853(-) | C/A | intron_variant | |
rs1000594562 | -- | 74,614,857(-) | T/C | coding_sequence_variant, intron_variant, missense_variant | |
rs1000705097 | -- | 74,620,462(-) | T/A | intron_variant | |
rs1000844062 | -- | 74,624,646(-) | T/C | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3282n100 | CNV | gain | 25217958 |
dgv372n27 | CNV | gain | 19166990 |
dgv5768n54 | CNV | gain | 21841781 |
dgv5774n54 | CNV | gain | 21841781 |
esv2604772 | CNV | insertion | 19546169 |
esv2751770 | CNV | gain | 17911159 |
esv2761978 | CNV | gain | 21179565 |
esv33995 | CNV | loss | 17666407 |
esv3573820 | CNV | gain | 25503493 |
esv3641230 | CNV | gain | 21293372 |
esv3641244 | CNV | gain | 21293372 |
nsv517569 | CNV | gain+loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
tungiasis |
|
|