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This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
CD300E (CD300e Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. An important paralog of this gene is CD300C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 32296183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Class I MHC mediated antigen processing and presentation | ||
3 | RET signaling | ||
4 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0045087 | innate immune response | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD300E 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD300E 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD300E 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd300e 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd300e 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1278044712 | A colorectal cancer sample |
p.Thr27Ala |
|||
rs1878061 | - |
p.Gly158Arg |
|||
rs581157 | - |
p.Lys19Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3282n100 | CNV | gain | 25217958 |
dgv372n27 | CNV | gain | 19166990 |
dgv5768n54 | CNV | gain | 21841781 |
dgv5774n54 | CNV | gain | 21841781 |
esv2604772 | CNV | insertion | 19546169 |
esv2751770 | CNV | gain | 17911159 |
esv2761978 | CNV | gain | 21179565 |
esv33995 | CNV | loss | 17666407 |
esv3573820 | CNV | gain | 25503493 |
esv3641230 | CNV | gain | 21293372 |
esv3641244 | CNV | gain | 21293372 |
nsv517569 | CNV | gain+loss | 19592680 |
No disorders were found for CD300E Gene.