This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012] See more...

Aliases for CD300E Gene

Aliases for CD300E Gene

  • CD300e Molecule 2 3 5
  • CD300e Antigen 2 3 4
  • IREM2 2 3 4
  • CLM2 2 3 4
  • Immune Receptor Expressed On Myeloid Cells 2 3 4
  • Polymeric Immunoglobulin Receptor 2 3 4
  • CD300 Antigen-Like Family Member E 3 4
  • CMRF35-Like Molecule 2 3 4
  • Poly-Ig Receptor 2 3 4
  • CMRF35-A5 3 4
  • CD300LE 3 4
  • IREM-2 3 4
  • PIgR-2 3 4
  • CLM-2 3 4
  • PIgR2 3 4
  • CD300 Antigen Like Family Member E 2
  • CMRF35A5 4
  • CD300E 5

External Ids for CD300E Gene

Previous HGNC Symbols for CD300E Gene

  • CD300LE

Previous GeneCards Identifiers for CD300E Gene

  • GC17M070119
  • GC17M072606
  • GC17M068017

Summaries for CD300E Gene

Entrez Gene Summary for CD300E Gene

  • This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

GeneCards Summary for CD300E Gene

CD300E (CD300e Molecule) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is CD300C.

UniProtKB/Swiss-Prot Summary for CD300E Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300E Gene

Genomics for CD300E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD300E Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074620 Promoter/Enhancer 0.7 FANTOM5 Ensembl dbSUPER 302.6 +1.3 1261 1.8 CD300E CD300C CD300LB CD300LF ENSG00000261222 TMEM104 CD300A CD300LD SLC16A5 TTYH2
GH17J074623 Promoter/Enhancer 0.7 EPDnew ENCODE dbSUPER 250.7 +0.1 128 0.2 CD300E ENSG00000261222 LOC101928343 CD300LD
GH17J074568 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 39.6 +54.4 54353 1.6 ZNF600 ZBTB10 CEBPB MAX KLF9 STAT3 ZNF316 TBP NFE2 ZNF658 CD300E NAT9 CD300C NUP85 CD300LB NT5C CD300LD MGC16275 CASKIN2 GGA3
GH17J074635 Enhancer 1 FANTOM5 ENCODE dbSUPER 47.2 -12.7 -12717 3.2 ZNF592 MAX BHLHE40 SPI1 IKZF1 PKNOX1 TARDBP ZNF687 IKZF2 RAD51 HSALNG0118672-002 HSALNG0118673 CD300E CD300C CD300LB CD300LF TMEM104 CD300LD RAB37 ENSG00000236770
GH17J074631 Enhancer 1 FANTOM5 ENCODE dbSUPER 49.8 -8.2 -8170 1.6 SPI1 MYC IKZF1 ATF4 REST CEBPG IKZF2 RUNX3 MLLT1 CD300E CD300C CD300LB CD300LF CD300LD RAB37 ENSG00000236770 TMEM104 CD300A SLC16A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD300E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300E

Top Transcription factor binding sites by QIAGEN in the CD300E gene promoter:
  • E47
  • Hand1
  • NRSF form 1
  • NRSF form 2
  • TBP
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CD300E Gene

Latest Assembly
14,074 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
13,854 bases
Minus strand

(GRCh37/hg19 by Ensembl)
13,872 bases
Minus strand

Genomic View for CD300E Gene

Genes around CD300E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300E Gene

Proteins for CD300E Gene

  • Protein details for CD300E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 2
    Protein Accession:
    Secondary Accessions:
    • B4DNS1
    • Q7Z7I3

    Protein attributes for CD300E Gene

    205 amino acids
    Molecular mass:
    22918 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for CD300E Gene

Post-translational modifications for CD300E Gene

Other Protein References for CD300E Gene

No data available for DME Specific Peptides for CD300E Gene

Domains & Families for CD300E Gene

Gene Families for CD300E Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD300E Gene

Suggested Antigen Peptide Sequences for CD300E Gene

GenScript: Design optimal peptide antigens:
  • Polymeric immunoglobulin receptor 2 (CLM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD300 family.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300E: view

Function for CD300E Gene

Molecular function for CD300E Gene

UniProtKB/Swiss-Prot Function:
Probably acts as an activating receptor.

Phenotypes From GWAS Catalog for CD300E Gene

Gene Ontology (GO) - Molecular Function for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with CD300E: view
genes like me logo Genes that share phenotypes with CD300E: view

Animal Models for CD300E Gene

MGI Knock Outs for CD300E:
  • Cd300e Cd300e<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300E Gene

Localization for CD300E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300E Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300E gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300E Gene

Pathways & Interactions for CD300E Gene

genes like me logo Genes that share pathways with CD300E: view

Gene Ontology (GO) - Biological Process for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300E: view

No data available for SIGNOR curated interactions for CD300E Gene

Drugs & Compounds for CD300E Gene

No Compound Related Data Available

Transcripts for CD300E Gene

mRNA/cDNA for CD300E Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300E

Alternative Splicing Database (ASD) splice patterns (SP) for CD300E Gene

No ASD Table

Relevant External Links for CD300E Gene

GeneLoc Exon Structure for

Expression for CD300E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300E Gene

mRNA differential expression in normal tissues according to GTEx for CD300E Gene

This gene is overexpressed in Whole Blood (x35.8).

Protein differential expression in normal tissues from HIPED for CD300E Gene

This gene is overexpressed in Monocytes (46.9) and Urine (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300E Gene

Protein tissue co-expression partners for CD300E Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300E

SOURCE GeneReport for Unigene cluster for CD300E Gene:


mRNA Expression by UniProt/SwissProt for CD300E Gene:

Tissue specificity: Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).

Evidence on tissue expression from TISSUES for CD300E Gene

  • Blood(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CD300E: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300E Gene

Orthologs for CD300E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300E 29 30
  • 99.16 (n)
(Canis familiaris)
Mammalia CD300E 29 30
  • 75.61 (n)
(Bos Taurus)
Mammalia CD300E 29 30
  • 74.63 (n)
(Mus musculus)
Mammalia Cd300e 29 16 30
  • 71.65 (n)
(Rattus norvegicus)
Mammalia Cd300e 29
  • 70.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 42 (a)
-- 30
  • 35 (a)
-- 30
  • 33 (a)
-- 30
  • 32 (a)
-- 30
  • 29 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 31 (a)
(Gallus gallus)
Aves -- 30
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 36 (a)
-- 30
  • 27 (a)
Species where no ortholog for CD300E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD300E Gene

Gene Tree for CD300E (if available)
Gene Tree for CD300E (if available)
Evolutionary constrained regions (ECRs) for CD300E: view image
Alliance of Genome Resources:
Additional Orthologs for CD300E

Paralogs for CD300E Gene

(7) SIMAP similar genes for CD300E Gene using alignment to 4 proteins:

  • J3KR39_HUMAN
genes like me logo Genes that share paralogs with CD300E: view

Variants for CD300E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300E Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs127804471 A colorectal cancer sample p.Thr27Ala
rs1878061 -- p.Gly158Arg
rs581157 -- p.Lys19Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CD300E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CD300E Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2604772 CNV insertion 19546169
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300E Gene

Gene Damage Index Score: 0.89; 18.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300E Gene

Disorders for CD300E Gene

Additional Disease Information for CD300E

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for CD300E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300E Gene

Publications for CD300E Gene

  1. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. (PMID: 15557162) Aguilar H … López-Botet M (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4
  2. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. (PMID: 15549731) Alvarez-Errico D … López-Botet M (European journal of immunology 2004) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. (PMID: 33020563) Coletta S … de Bernard M (Scientific reports 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for CD300E Gene

Sources for CD300E Gene