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Aliases for CD300C Gene

Aliases for CD300C Gene

  • CD300c Molecule 2 3 5
  • CD300c Antigen 2 3 4
  • Immunoglobulin Superfamily Member 16 3 4
  • CD300 Antigen-Like Family Member C 3 4
  • CMRF35-A1 3 4
  • CMRF35A1 3 4
  • CMRF-35 3 4
  • CMRF35A 3 4
  • CMRF35 3 4
  • IGSF16 3 4
  • CLM-6 3 4
  • CMRF35A Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35-Like Molecule 6 3
  • CMRF35 Antigen 3
  • CMRF-35A 3
  • LIR 3

External Ids for CD300C Gene

Previous GeneCards Identifiers for CD300C Gene

  • GC17M070049
  • GC17M072537
  • GC17M067946

Summaries for CD300C Gene

Entrez Gene Summary for CD300C Gene

  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300C Gene

CD300C (CD300c Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD300A.

Gene Wiki entry for CD300C Gene

Additional gene information for CD300C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300C Gene

Genomics for CD300C Gene

GeneHancer (GH) Regulatory Elements for CD300C Gene

Promoters and enhancers for CD300C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I074544 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 562.7 +0.6 630 2.7 ZSCAN4 MAX ZKSCAN1 MTA3 POLR2A NFATC1 ZNF207 HES1 RFX1 SOX6 CD300C CASKIN2 HID1-AS1 SUMO2 SLC9A3R1 CD300LB
GH17I074547 Enhancer 0.6 FANTOM5 dbSUPER 569.7 -1.7 -1716 0.2 MAX MYC CD300C CD300E CD300LB TMEM104 CD300LF CD300LD CD300A TTYH2 ENSG00000236770
GH17I074568 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32.6 -23.4 -23385 1.5 ZNF473 ZSCAN4 SIN3A ZNF195 YBX1 GLI4 EGR1 FOS EGR2 YY2 NAT9 NUP85 CD300E NT5C CD300C CD300LB GGA3 CD300LD MGC16275 HID1
GH17I074526 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.8 +15.9 15870 7.4 HDGF HDAC1 PKNOX1 RB1 BATF IRF4 RAD21 YY1 ZNF143 ZNF207 CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
GH17I074639 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -93.8 -93755 1.7 PKNOX1 CBFB HLF IRF5 CEBPB DPF2 POLR2A IKZF1 MYC RUNX3 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD CD300A ENSG00000236770 SLC9A3R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD300C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD300C gene promoter:

Genomic Locations for CD300C Gene

Genomic Locations for CD300C Gene
chr17:74,541,065-74,546,171
(GRCh38/hg38)
Size:
5,107 bases
Orientation:
Minus strand
chr17:72,537,247-72,542,282
(GRCh37/hg19)

Genomic View for CD300C Gene

Genes around CD300C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300C Gene

Proteins for CD300C Gene

  • Protein details for CD300C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08708-CLM6_HUMAN
    Recommended name:
    CMRF35-like molecule 6
    Protein Accession:
    Q08708

    Protein attributes for CD300C Gene

    Size:
    224 amino acids
    Molecular mass:
    24830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD300C Gene

Post-translational modifications for CD300C Gene

  • Glycosylation at posLast=9090 and Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for CD300C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300C Gene

Domains & Families for CD300C Gene

Gene Families for CD300C Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD300C Gene

Suggested Antigen Peptide Sequences for CD300C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08708

UniProtKB/Swiss-Prot:

CLM6_HUMAN :
  • Belongs to the CD300 family.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300C: view

Function for CD300C Gene

Gene Ontology (GO) - Molecular Function for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 1349532
genes like me logo Genes that share ontologies with CD300C: view
genes like me logo Genes that share phenotypes with CD300C: view

Animal Models for CD300C Gene

MGI Knock Outs for CD300C:

Animal Model Products

CRISPR Products

miRNA for CD300C Gene

miRTarBase miRNAs that target CD300C

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300C Gene

Localization for CD300C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300C gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
lysosome 2
cytoskeleton 1
nucleus 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1349532
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300C Gene

Pathways & Interactions for CD300C Gene

genes like me logo Genes that share pathways with CD300C: view

Pathways by source for CD300C Gene

Gene Ontology (GO) - Biological Process for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 1349532
GO:0007165 signal transduction IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300C: view

No data available for SIGNOR curated interactions for CD300C Gene

Drugs & Compounds for CD300C Gene

No Compound Related Data Available

Transcripts for CD300C Gene

mRNA/cDNA for CD300C Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300C Gene

CD300c molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300C Gene

No ASD Table

Relevant External Links for CD300C Gene

GeneLoc Exon Structure for
CD300C
ECgene alternative splicing isoforms for
CD300C

Expression for CD300C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD300C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300C Gene

This gene is overexpressed in Whole Blood (x25.0) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CD300C Gene:

CD300C

SOURCE GeneReport for Unigene cluster for CD300C Gene:

Hs.2605

mRNA Expression by UniProt/SwissProt for CD300C Gene:

Q08708-CLM6_HUMAN
Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.

Evidence on tissue expression from TISSUES for CD300C Gene

  • Lung(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CD300C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300C Gene

Orthologs for CD300C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300C 33 34
  • 97.77 (n)
cow
(Bos Taurus)
Mammalia LOC526163 33
  • 69.89 (n)
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD300C 33
  • 69 (n)
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RGD1561778 33
  • 67.33 (n)
mouse
(Mus musculus)
Mammalia Cd300c 33 34
  • 65.48 (n)
AF251705 34
  • 46 (a)
ManyToMany
Cd300a 34
  • 26 (a)
ManyToMany
Cd300c2 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for CD300C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300C Gene

ENSEMBL:
Gene Tree for CD300C (if available)
TreeFam:
Gene Tree for CD300C (if available)

Paralogs for CD300C Gene

Paralogs for CD300C Gene

(5) SIMAP similar genes for CD300C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD300C Gene

genes like me logo Genes that share paralogs with CD300C: view

Variants for CD300C Gene

Sequence variations from dbSNP and Humsavar for CD300C Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000239225 -- 74,543,889(-) G/A intron_variant
rs1000343895 -- 74,543,553(-) G/A intron_variant
rs1000539399 -- 74,544,938(-) G/A coding_sequence_variant, missense_variant
rs1000569240 -- 74,538,588(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000573806 -- 74,538,468(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD300C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv470600 CNV loss 18288195
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300C Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD300C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300C Gene

Disorders for CD300C Gene

Additional Disease Information for CD300C

No disorders were found for CD300C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300C Gene

Publications for CD300C Gene

  1. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PMID: 1349532) Jackson DG … Bell JI (European journal of immunology 1992) 2 3 4 22 58
  2. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PMID: 11556966) Clark GJ … Hart DN (Tissue antigens 2001) 3 4 22 58
  3. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark GJ … Hart DN (Tissue antigens 2000) 2 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CD300C Gene

Sources for CD300C Gene

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