The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008] See more...

Aliases for CD300C Gene

Aliases for CD300C Gene

  • CD300c Molecule 2 3 5
  • CD300c Antigen 2 3 4
  • CMRF35A 2 3 4
  • CMRF35 2 3 4
  • IGSF16 2 3 4
  • Immunoglobulin Superfamily Member 16 3 4
  • CD300 Antigen-Like Family Member C 3 4
  • CMRF35-Like Molecule 6 3 4
  • CMRF35-A1 3 4
  • CMRF-35A 2 3
  • CMRF35A1 3 4
  • CMRF-35 3 4
  • CLM-6 3 4
  • LIR 2 3
  • CMRF35A Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Antigen 3
  • CD300C 5
  • IgSF16 4

External Ids for CD300C Gene

Previous GeneCards Identifiers for CD300C Gene

  • GC17M070049
  • GC17M072537
  • GC17M067946

Summaries for CD300C Gene

Entrez Gene Summary for CD300C Gene

  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300C Gene

CD300C (CD300c Molecule) is a Protein Coding gene. Diseases associated with CD300C include Alzheimer Disease 12 and Post-Vaccinal Encephalitis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD300A.

Gene Wiki entry for CD300C Gene

Additional gene information for CD300C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300C Gene

Genomics for CD300C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD300C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074545 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 612.6 +0.4 374 2.3 CREB1 TARDBP RFX1 ZSCAN4 POLR2A ZNF311 MNT HES1 ZNF207 ZKSCAN1 CD300C CASKIN2 HID1-AS1 SLC9A3R1 lnc-CD300C-1 CD300LB LOC107985074
GH17J074544 Promoter/Enhancer 0.6 Ensembl dbSUPER 600.7 +1.8 1814 0.2 NR3C1 CD300C lnc-CD300C-1 CD300LB LOC107985074
GH17J074547 Enhancer 0.5 FANTOM5 dbSUPER 619.6 -1.8 -1772 0.2 MYC MAX CD300C CD300E CD300LB TMEM104 CD300LF CD300LD CD300A TTYH2 ENSG00000236770 lnc-CD300C-3
GH17J074568 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32.6 -23.5 -23490 1.6 ZBTB33 YBX1 ZNF629 ZSCAN4 REST ZNF747 ZNF600 MNT KLF9 ZNF211 CD300E NAT9 CD300C NUP85 CD300LB NT5C CD300LD ENSG00000246731 HID1 CASKIN2
GH17J074635 Enhancer 1 FANTOM5 ENCODE dbSUPER 23 -90.6 -90560 3.2 IKZF2 PKNOX1 DPF2 RELB GATAD2B ZBTB40 ZNF592 ARNT NBN IKZF1 HSALNG0118673 CD300E CD300C CD300LB CD300LF TMEM104 CD300LD RAB37 ENSG00000236770 SLC9A3R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD300C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300C

Top Transcription factor binding sites by QIAGEN in the CD300C gene promoter:
  • AREB6
  • NF-1
  • NF-1/L
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1

Genomic Locations for CD300C Gene

Genomic Locations for CD300C Gene
chr17:74,534,359-74,546,115
(GRCh38/hg38)
Size:
11,757 bases
Orientation:
Minus strand
chr17:72,537,247-72,542,282
(GRCh37/hg19)
Size:
5,036 bases
Orientation:
Minus strand

Genomic View for CD300C Gene

Genes around CD300C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300C Gene

Proteins for CD300C Gene

  • Protein details for CD300C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08708-CLM6_HUMAN
    Recommended name:
    CMRF35-like molecule 6
    Protein Accession:
    Q08708

    Protein attributes for CD300C Gene

    Size:
    224 amino acids
    Molecular mass:
    24830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD300C Gene

Post-translational modifications for CD300C Gene

  • Glycosylation at Asn90 and Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for CD300C Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Boster Bio ELISA Kits for CD300C

No data available for DME Specific Peptides for CD300C Gene

Domains & Families for CD300C Gene

Gene Families for CD300C Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD300C Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for CD300C Gene

GenScript: Design optimal peptide antigens:
  • Immunoglobulin superfamily member 16 (CLM6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08708

UniProtKB/Swiss-Prot:

CLM6_HUMAN :
  • Belongs to the CD300 family.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300C: view

Function for CD300C Gene

Phenotypes From GWAS Catalog for CD300C Gene

Gene Ontology (GO) - Molecular Function for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 1349532
genes like me logo Genes that share ontologies with CD300C: view
genes like me logo Genes that share phenotypes with CD300C: view

Animal Models for CD300C Gene

MGI Knock Outs for CD300C:

Animal Model Products

CRISPR Products

miRNA for CD300C Gene

miRTarBase miRNAs that target CD300C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300C Gene

Localization for CD300C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300C Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300C gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
lysosome 3
extracellular 2
cytoskeleton 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Mitochondria (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1349532
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300C: view

Pathways & Interactions for CD300C Gene

genes like me logo Genes that share pathways with CD300C: view

Pathways by source for CD300C Gene

Gene Ontology (GO) - Biological Process for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 1349532
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300C: view

No data available for SIGNOR curated interactions for CD300C Gene

Drugs & Compounds for CD300C Gene

No Compound Related Data Available

Transcripts for CD300C Gene

mRNA/cDNA for CD300C Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300C

Alternative Splicing Database (ASD) splice patterns (SP) for CD300C Gene

No ASD Table

Relevant External Links for CD300C Gene

GeneLoc Exon Structure for
CD300C

Expression for CD300C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300C Gene

This gene is overexpressed in Whole Blood (x25.0) and Spleen (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300C

SOURCE GeneReport for Unigene cluster for CD300C Gene:

Hs.2605

mRNA Expression by UniProt/SwissProt for CD300C Gene:

Q08708-CLM6_HUMAN
Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.

Evidence on tissue expression from TISSUES for CD300C Gene

  • Lung(4.4)
  • Nervous system(2.9)
  • Spleen(2.4)
  • Blood(2.3)
  • Liver(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with CD300C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300C Gene

Orthologs for CD300C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD300C 30 31
  • 97.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC526163 30
  • 69.89 (n)
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia CD300C 30
  • 69 (n)
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia RGD1561778 30
  • 67.33 (n)
Mouse
(Mus musculus)
Mammalia Cd300c 30 17 31
  • 65.48 (n)
ManyToMany
AF251705 31
  • 46 (a)
ManyToMany
Cd300a 31
  • 26 (a)
ManyToMany
Cd300c2 17
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 30 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for CD300C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD300C Gene

ENSEMBL:
Gene Tree for CD300C (if available)
TreeFam:
Gene Tree for CD300C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD300C: view image

Paralogs for CD300C Gene

(5) SIMAP similar genes for CD300C Gene using alignment to 1 proteins:

  • CLM6_HUMAN

Pseudogenes.org Pseudogenes for CD300C Gene

genes like me logo Genes that share paralogs with CD300C: view

Variants for CD300C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300C Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs11870245 - p.Thr71Ile

Additional dbSNP identifiers (rs#s) for CD300C Gene

Structural Variations from Database of Genomic Variants (DGV) for CD300C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv470600 CNV loss 18288195
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300C Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD300C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD300C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300C Gene

Disorders for CD300C Gene

MalaCards: The human disease database

(4) MalaCards diseases for CD300C Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 12
  • ad12
post-vaccinal encephalitis
  • encephalitis following immunization procedures
cone-rod dystrophy 20
  • cord20
hyperoxaluria, primary, type ii
  • hp2
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CD300C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD300C Gene

Publications for CD300C Gene

  1. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PMID: 1349532) Jackson DG … Bell JI (European journal of immunology 1992) 2 3 4 23
  2. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PMID: 11556966) Clark GJ … Hart DN (Tissue antigens 2001) 3 4 23
  3. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark GJ … Hart DN (Tissue antigens 2000) 2 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CD300C Gene

Sources for CD300C Gene