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This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] See more...
Aliases for CD300A Gene
Aliases for CD300A Gene
External Ids for CD300A Gene
- HGNC: 19319
- Entrez Gene: 11314
- Ensembl: ENSG00000167851
- OMIM: 606790
- UniProtKB: Q9UGN4
Previous GeneCards Identifiers for CD300A Gene
- GC17P069975
- GC17P072462
- GC17P067871
Summaries for CD300A Gene
-
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for CD300A Gene
CD300A (CD300a Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding and signaling receptor activity. An important paralog of this gene is CD300C.
UniProtKB/Swiss-Prot Summary for CD300A Gene
-
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Additional gene information for CD300A Gene
- HGNC(19319)
- Entrez Gene(11314)
- Ensembl(ENSG00000167851)
- OMIM(606790)
- UniProtKB(Q9UGN4)
- Open Targets Platform(ENSG00000167851)
- Search for CD300A at DataMed
- Search for CD300A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD300A Gene
Genomics for CD300A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD300A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD300A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD300A
- Top Transcription factor binding sites by QIAGEN in the CD300A gene promoter:
-
- AML1a
- Bach1
- c-Myc
- E47
- LUN-1
- Max
- MyoD
- Nkx5-1
- Tal-1
Genomic Locations for CD300A Gene
Genomic Locations for CD300A Gene
- chr17:74,466,373-74,484,798
- (GRCh38/hg38)
- Size:
- 18,426 bases
- Orientation:
- Plus strand
- chr17:72,462,522-72,480,933
- (GRCh37/hg19)
- Size:
- 18,412 bases
- Orientation:
- Plus strand
Genomic View for CD300A Gene
Genes around CD300A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
CD300A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD300A Gene
Proteins for CD300A Gene
-
Protein details for CD300A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UGN4-CLM8_HUMAN
- Recommended name:
- CMRF35-like molecule 8
- Protein Accession:
- Q9UGN4
- A8MW96
- O95100
- Q9HD97
- Q9P0F3
- Q9UBK4
- Q9UMS9
- Q9UMT0
Protein attributes for CD300A Gene
- Size:
- 299 amino acids
- Molecular mass:
- 33201 Da
- Quaternary structure:
-
- Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D.
- SequenceCaution:
-
- Sequence=AAF28906.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAF28906.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for CD300A Gene
Post-translational modifications for CD300A Gene
- Phosphorylated on tyrosine.
- N-glycosylated.
-
Glycosylation at Asn83 and Asn92
- NX_Q9UGN4 (NX_Q9UGN4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CD300A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD300A Antibody
- Creative Diagnostics Anti-CD300A monoclonal antibody, clone FQS6337
- Creative Biolabs Recombinant Anti-Human CD300A Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD300A
- Novus Biologicals Antibodies for CD300A
-
Abcam antibodies for CD300A
- Invitrogen Antibodies for CD300A (AFLGC-CD300A)
- antibodies-online: Show 22 available CD300A Antibodies ranked by validation data
- Compare Top CD300A Antibodies
-
Recommended
- 16 FACS Antibodies (anti-mouse)
- 2 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 52 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 9 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 1 WB Antibody (anti-rat)
-
Biorbyt antibodies for CD300A
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD300A
- Sino Biological Antibodies for CD300A
Protein Products
-
OriGene Purified Proteins for CD300A
- Search Origene for MassSpec and Protein Over-expression Lysates for CD300A
- Origene Custom Protein Services for CD300A
- Sino Biological Recombinant Proteins for CD300A
- Sino Biological Cell Lysates for CD300A
- ProSpec Recombinant Proteins for CD300A
-
ProSci Proteins for CD300A
-
Abcam proteins for CD300A
Assay Products
- RayBiotech Custom Human CD300a ELISA
-
Custom Assay ServicesOriGene ELISA Kits for CD300A
- antibodies-online: Show 4 available CD300A Elisa Kits ranked by validation data
- Compare Top CD300A Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CD300A
-
Abcam assays for CD300A
No data available for DME Specific Peptides for CD300A Gene
Domains & Families for CD300A Gene
Gene Families for CD300A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD300A Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- ProtoNet:
Suggested Antigen Peptide Sequences for CD300A Gene
- GenScript: Design optimal peptide antigens:
-
- NK inhibitory receptor (CLM8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UGN4- Family:
-
- Belongs to the CD300 family.
Function for CD300A Gene
Molecular function for CD300A Gene
- UniProtKB/Swiss-Prot Function:
- Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Phenotypes From GWAS Catalog for CD300A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001786 | phosphatidylserine binding | IDA | 22302738 |
| GO:0005515 | protein binding | IPI | 10540326 |
| GO:0008429 | phosphatidylethanolamine binding | IDA | 22302738 |
| GO:0038023 | signaling receptor activity | IDA | 16339535 |
Phenotypes for CD300A Gene
- MGI mutant phenotypes for CD300A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD300A:
Animal Models for CD300A Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CD300A
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD300A - Select products 50% OFF >
- * CD300A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for CD300A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD300A
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD300A
miRNA for CD300A Gene
- miRTarBase miRNAs that target CD300A
-
- hsa-miR-148b-3p (MIRT019435)
- hsa-miR-128-3p (MIRT022030)
- mmu-miR-5101 (MIRT587705)
- mmu-miR-653-5p (MIRT587706)
- mmu-miR-1896 (MIRT587707)
- mmu-miR-3085-3p (MIRT587708)
- mmu-miR-3064-5p (MIRT587709)
- mmu-miR-3087-3p (MIRT587710)
- mmu-miR-30a-5p (MIRT587711)
- mmu-miR-30d-5p (MIRT587712)
- mmu-miR-30b-5p (MIRT587713)
- mmu-miR-30e-5p (MIRT587714)
- mmu-miR-30c-5p (MIRT587715)
- mmu-miR-384-5p (MIRT587716)
- mmu-miR-3470b (MIRT587717)
- mmu-miR-1194 (MIRT591418)
- mmu-miR-546 (MIRT591419)
- mmu-miR-24-3p (MIRT591420)
- mmu-miR-3106-5p (MIRT591421)
- mmu-miR-3471 (MIRT591422)
- mmu-miR-713 (MIRT599484)
- mmu-miR-5102 (MIRT599485)
- mmu-miR-129-2-3p (MIRT605834)
- mmu-miR-129-1-3p (MIRT605835)
- mmu-miR-5125 (MIRT605836)
- mmu-miR-5127 (MIRT605837)
- mmu-miR-3110-5p (MIRT605838)
- mmu-miR-150-5p (MIRT605839)
- mmu-miR-105 (MIRT605840)
- mmu-miR-302b-3p (MIRT605841)
- mmu-miR-302d-3p (MIRT605842)
- mmu-miR-302a-3p (MIRT605843)
- mmu-miR-295-3p (MIRT605844)
- mmu-miR-294-3p (MIRT605845)
- mmu-miR-291a-3p (MIRT605846)
- mmu-miR-291a-5p (MIRT605847)
- mmu-miR-291b-5p (MIRT605848)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300A
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300A
Clone Products
- Applied Biological Materials (abm): Clones for CD300A - Select products 50% OFF >
- * CD300A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD300A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD300A
Cell Line Products
-
Horizon Cell Lines for CD300A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300A Gene
Localization for CD300A Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD300A Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,IDA | 10540326 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
| GO:0070821 | tertiary granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300A Gene
Pathways & Interactions for CD300A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for CD300A Gene
5 Reactome pathways for CD300A Gene
Interacting Proteins for CD300A Gene
Selected Interacting proteins:
Q9UGN4-CLM8_HUMAN
ENSP00000353259
for CD300A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD300A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0030889 | negative regulation of B cell proliferation | IMP | 21482706 |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity | IDA | 16339535 |
| GO:0033007 | negative regulation of mast cell activation involved in immune response | IDA | 16339535 |
No data available for SIGNOR curated interactions for CD300A Gene
Transcripts for CD300A Gene
mRNA/cDNA for CD300A Gene
- 4 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000648095 1785 nts (view in UCSC)
- ENST00000360141 1638 nts (view in UCSC)
- ENST00000392625 1163 nts (view in UCSC)
- ENST00000310828 631 nts (view in UCSC)
- ENST00000361933 382 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD300A - Select products 50% OFF >
- * CD300A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD300A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD300A
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD300A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300A
- Browse OriGene Inhibitory RNA Products For CD300A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300A
Clone Products
- Applied Biological Materials (abm): Clones for CD300A - Select products 50% OFF >
- * CD300A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD300A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD300A
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - |
Relevant External Links for CD300A Gene
- GeneLoc Exon Structure for
- CD300A
Expression for CD300A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CD300A Gene
This gene is overexpressed in Whole Blood (x28.7) and Spleen (x5.6).
This gene is overexpressed in Urine (42.0) and Monocytes (13.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD300A
SOURCE GeneReport for Unigene cluster for CD300A Gene:
Hs.9688mRNA Expression by UniProt/SwissProt for CD300A Gene:
Q9UGN4-CLM8_HUMAN
Tissue specificity:
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Evidence on tissue expression from TISSUES for CD300A Gene
- Blood(4.6)
- Spleen(2.8)
- Lymph node(2.6)
- Bone marrow(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD300A
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300A Gene
Orthologs for CD300A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD300A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD300A 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | CD300A 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Cd300a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd300a 30 17 31 |
|
ManyToMany | |
| Cd300c 31 |
|
ManyToMany | |||
| AF251705 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CD300A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD300A Gene
- ENSEMBL:
- Gene Tree for CD300A (if available)
- TreeFam:
- Gene Tree for CD300A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD300A: view image
Paralogs for CD300A Gene
Paralogs for CD300A Gene
(2) SIMAP similar genes for CD300A Gene using alignment to 2 proteins:
- CLM8_HUMAN
- J3QKQ4_HUMAN
Pseudogenes.org Pseudogenes for CD300A Gene
Variants for CD300A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD300A Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2272111 | - | p.Arg111Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12e196 | CNV | duplication | 17116639 |
| dgv3282n100 | CNV | gain | 25217958 |
| dgv372n27 | CNV | gain | 19166990 |
| dgv5768n54 | CNV | gain | 21841781 |
| dgv5774n54 | CNV | gain | 21841781 |
| esv2751770 | CNV | gain | 17911159 |
| esv2761978 | CNV | gain | 21179565 |
| esv33995 | CNV | loss | 17666407 |
| esv3573820 | CNV | gain | 25503493 |
| esv3641230 | CNV | gain | 21293372 |
| nsv470600 | CNV | loss | 18288195 |
| nsv517569 | CNV | gain+loss | 19592680 |
Residual Variation Intolerance Score:
61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD300A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD300A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300A Gene
Disorders for CD300A Gene
Additional Disease Information for CD300A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CD300A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300A Gene
Publications for CD300A Gene
- The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. (PMID: 16339535) Bachelet I … Levi-Schaffer F (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 23
- The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark GJ … Hart DN (Tissue antigens 2000) 2 3 4
- Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PMID: 10540326) Cantoni C … Moretta A (European journal of immunology 1999) 3 4 23
- The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. (PMID: 9701027) Green BJ … Hart DN (International immunology 1998) 2 3 4
- CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. (PMID: 22043923) Kim EJ … Lee WH (Immunology 2012) 3 4
ExternalLinks
Products for CD300A Gene
- View all 23 R&D Systems CD300A (CD300a/LMIR1) Products
- View all R&D Systems CD300A (CD300a/LMIR1) Proteins and Enzymes
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- Learn more about R&D Systems custom CD300A antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CD300A
- Custom Assay ServicesOriGene ELISA Kits for CD300A
- OriGene Purified Proteins for CD300A
- Search Origene for MassSpec and Protein Over-expression Lysates for CD300A
- Origene Custom Protein Services for CD300A
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD300A
- Browse OriGene Inhibitory RNA Products For CD300A
- OriGene qPCR primer pairs for CD300A
- OriGene CRISPR knockouts for CD300A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD300A
- Sino Biological Human cDNA Clone for CD300A
- Sino Biological Recombinant Proteins for CD300A
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- Sino Biological Antibodies for CD300A
- Browse Sino Biological Assays
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CD300A
- Novus Biologicals proteins and lysates for CD300A
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- Browse Peptides and Proteins
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- Abcam antibodies for CD300A
- Abcam proteins for CD300A
- Abcam assays for CD300A
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for CD300A
- Taconic Biosciences Mouse Models for CD300A
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CD300A (AFLGC-CD300A)
- VectorBuilder Custom and pre-made DNA vectors for CD300A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CD300A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CD300A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CD300A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CD300A
- antibodies-online: Show 22 available CD300A Antibodies ranked by validation data
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- Recommended
- 16 FACS Antibodies (anti-mouse)
- 2 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 52 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 9 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 1 WB Antibody (anti-rat)
- antibodies-online: Show 4 available CD300A Elisa Kits ranked by validation data
- Compare Top CD300A Elisa Kits
- Quality Products:
- antibodies-online: Show 20 available CD300A Proteins ranked by validation data
- Compare Top CD300A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CD300A
- Search Santa Cruz Biotechnology (SCBT) for CD300A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD300A
- Horizon Cell Lines for CD300A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD300A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD300A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CD300A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD300A
- Biorbyt antibodies for CD300A
Sources for CD300A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB