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This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
CD300A (CD300a Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding and signaling receptor activity. An important paralog of this gene is CD300C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001786 | phosphatidylserine binding | IDA | 22302738 |
GO:0005515 | protein binding | IPI | 10540326 |
GO:0008429 | phosphatidylethanolamine binding | IDA | 22302738 |
GO:0038023 | signaling receptor activity | IDA | 16339535 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA,IDA | 10540326 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
GO:0070821 | tertiary granule membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0007155 | cell adhesion | IEA | -- |
GO:0030889 | negative regulation of B cell proliferation | IMP | 21482706 |
GO:0032516 | positive regulation of phosphoprotein phosphatase activity | IDA | 16339535 |
GO:0033007 | negative regulation of mast cell activation involved in immune response | IDA | 16339535 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD300A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD300A 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | CD300A 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Cd300a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd300a 30 17 31 |
|
ManyToMany | |
Cd300c 31 |
|
ManyToMany | |||
AF251705 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2272111 | - | p.Arg111Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12e196 | CNV | duplication | 17116639 |
dgv3282n100 | CNV | gain | 25217958 |
dgv372n27 | CNV | gain | 19166990 |
dgv5768n54 | CNV | gain | 21841781 |
dgv5774n54 | CNV | gain | 21841781 |
esv2751770 | CNV | gain | 17911159 |
esv2761978 | CNV | gain | 21179565 |
esv33995 | CNV | loss | 17666407 |
esv3573820 | CNV | gain | 25503493 |
esv3641230 | CNV | gain | 21293372 |
nsv470600 | CNV | loss | 18288195 |
nsv517569 | CNV | gain+loss | 19592680 |
No disorders were found for CD300A Gene.