Aliases for CD2BP2 Gene
Aliases for CD2BP2 Gene
- CD2 Cytoplasmic Tail Binding Protein 2 2 3 5
- CD2 Antigen Cytoplasmic Tail-Binding Protein 2 3 4
- Protein Phosphatase 1, Regulatory Subunit 59 2 3
- CD2 Cytoplasmic Domain-Binding Protein 2 3 4
- U5 SnRNP 52K Protein 3 4
- U5-52K 3 4
- CD2 Antigen (Cytoplasmic Tail)-Binding Protein 2 2
- CD2 (Cytoplasmic Tail) Binding Protein 2 2
External Ids for CD2BP2 Gene
- HGNC: 1656
- Entrez Gene: 10421
- Ensembl: ENSG00000169217
- OMIM: 604470
- UniProtKB: O95400
Previous GeneCards Identifiers for CD2BP2 Gene
- GC16P029473
- GC16M030756
- GC16M030359
- GC16M030400
- GC16M030272
- GC16M030273
- GC16M027924
Summaries for CD2BP2 Gene
-
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
GeneCards Summary for CD2BP2 Gene
CD2BP2 (CD2 Cytoplasmic Tail Binding Protein 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include ribonucleoprotein complex binding.
UniProtKB/Swiss-Prot for CD2BP2 Gene
-
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Additional gene information for CD2BP2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2BP2 Gene
Genomics for CD2BP2 Gene
GeneHancer (GH) Regulatory Elements for CD2BP2 Gene
Promoters and enhancers for CD2BP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD2BP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD2BP2 gene promoter:
-
- C/EBPalpha
- FOXJ2
- FOXJ2 (long isoform)
- HFH-1
- p53
Genomic Locations for CD2BP2 Gene
Genomic Locations for CD2BP2 Gene
- chr16:30,350,766-30,355,361
- (GRCh38/hg38)
- Size:
- 4,596 bases
- Orientation:
- Minus strand
- chr16:30,362,087-30,366,682
- (GRCh37/hg19)
- Size:
- 4,596 bases
- Orientation:
- Minus strand
Genomic View for CD2BP2 Gene
Genes around CD2BP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
CD2BP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD2BP2 Gene
Proteins for CD2BP2 Gene
-
Protein details for CD2BP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95400-CD2B2_HUMAN
- Recommended name:
- CD2 antigen cytoplasmic tail-binding protein 2
- Protein Accession:
- O95400
- B2RDX2
- Q9ULP2
Protein attributes for CD2BP2 Gene
- Size:
- 341 amino acids
- Molecular mass:
- 37646 Da
- Quaternary structure:
-
- Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.
Protein Expression for CD2BP2 Gene
Post-translational modifications for CD2BP2 Gene
Other Protein References for CD2BP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-CD2BP2 Antibody (HPA041508) and Anti-CD2BP2 Antibody (HPA061309)
- Novus Biologicals Antibodies for CD2BP2
- Invitrogen Antibodies for CD2BP2 (AFLGC-CD2BP2)
Protein Products
- Atlas Antibodies PrEST Antigen CD2BP2 (APrEST82309) and PrEST Antigen CD2BP2 (APrEST88443)
-
OriGene Purified Proteins for CD2BP2
- Search Origene for MassSpec and Protein Over-expression Lysates for CD2BP2
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-
Abcam proteins for CD2BP2
No data available for DME Specific Peptides for CD2BP2 Gene
Domains & Families for CD2BP2 Gene
Gene Families for CD2BP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CD2BP2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD2BP2 Gene
- GenScript: Design optimal peptide antigens:
-
- CD2 antigen cytoplasmic tail-binding protein 2 (CD2B2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD2BP2 Gene
Function for CD2BP2 Gene
Molecular function for CD2BP2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
Phenotypes From GWAS Catalog for CD2BP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9843987 |
| GO:0043021 | ribonucleoprotein complex binding | IDA | 15840814 |
Phenotypes for CD2BP2 Gene
Animal Model Products
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-
CRISPR Products
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-
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miRNA for CD2BP2 Gene
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miRNA Products
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Clone Products
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- RR210936
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for CD2BP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD2BP2 Gene
Localization for CD2BP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD2BP2 Gene
- Cytoplasm. Nucleus. Note=Predominantly nuclear.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (4)
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IDA,IEA | 15840814 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005682 | U5 snRNP | IDA | 15840814 |
| GO:0005737 | cytoplasm | TAS | 9843987 |
Pathways & Interactions for CD2BP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for CD2BP2 Gene
1 BioSystems pathway for CD2BP2 Gene
4 Reactome pathways for CD2BP2 Gene
Interacting Proteins for CD2BP2 Gene
Selected Interacting proteins:
O95400-CD2B2_HUMAN
ENSP00000304903
for CD2BP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CD2BP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000244 | spliceosomal tri-snRNP complex assembly | NAS | 15840814 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0010923 | negative regulation of phosphatase activity | IDA | 19389623 |
No data available for SIGNOR curated interactions for CD2BP2 Gene
Drugs & Compounds for CD2BP2 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen CD2BP2 (APrEST82309) and PrEST Antigen CD2BP2 (APrEST88443)
Transcripts for CD2BP2 Gene
mRNA/cDNA for CD2BP2 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (393) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000305596 3361 bps (ENST00000305596.7)
- ENST00000569466 1417 bps (ENST00000569466.1)
- ENST00000564525 541 bps (ENST00000564525.1)
Unigene Clusters for CD2BP2 Gene
- CD2 (cytoplasmic tail) binding protein 2:
- Representative Sequences:
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD2BP2 - Now 50% OFF >
- * CD2BP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for CD2BP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD2BP2
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CD2BP2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CD2BP2
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Clone Products
- Applied Biological Materials (abm): Clones for CD2BP2 - Now 50% OFF >
- * CD2BP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
- MG205131
- MR205131
- MR205131L1
- MR205131L1V
- MR205131L2
- MR205131L2V
- MR205131L3
- MR205131L3V
- MR205131L4
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- MR229360
- MR229361
- MR229362
- RC201352
- RC201352L1
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- RC201352L3
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- RC233819
- RG201352
- RG233819
- RR210936
- RR210936L1
- RR210936L1V
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- RR210936L2V
- RR210936L3
- RR210936L3V
- RR210936L4
- RR210936L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD2BP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD2BP2
- genomics-online: cdna clones - Search results for available CD2BP2 gene related products
- orf clones - Search results for available CD2BP2 gene related products
Expression for CD2BP2 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD2BP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD2BP2 Gene:
CD2BP2SOURCE GeneReport for Unigene cluster for CD2BP2 Gene:
Hs.202677Evidence on tissue expression from TISSUES for CD2BP2 Gene
- Nervous system(4.8)
- Lung(4.6)
- Blood(4.4)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for CD2BP2
-
OriGene qPCR primer pairs and template standards for CD2BP2
- genomics-online: primer clones - Search results for available CD2BP2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD2BP2 Gene
Orthologs for CD2BP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD2BP2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD2BP2 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD2BP2 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cd2bp2 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd2bp2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD2BP2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD2BP2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD2BP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | clip4 34 |
|
||
| MGC76157 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cd2bp2-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cd2bp2 35 34 |
|
OneToOne | |
| zgc56165 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011494 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | holn1 35 34 |
|
OneToOne | |
| CG5198 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | teg-1 35 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4310 35 |
|
OneToOne |
- Species where no ortholog for CD2BP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CD2BP2 Gene
- ENSEMBL:
- Gene Tree for CD2BP2 (if available)
- TreeFam:
- Gene Tree for CD2BP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD2BP2: view image
Paralogs for CD2BP2 Gene
Pseudogenes.org Pseudogenes for CD2BP2 Gene
No data available for Paralogs for CD2BP2 Gene
Variants for CD2BP2 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000267867 | -- | 30,352,463(-) | A/G/T | 3_prime_UTR_variant | |
| rs1000671819 | -- | 30,356,398(-) | T/C | upstream_transcript_variant | |
| rs1000848578 | -- | 30,351,491(-) | A/C | 3_prime_UTR_variant | |
| rs1001652822 | -- | 30,353,151(-) | C/G | intron_variant | |
| rs1001890416 | -- | 30,356,707(-) | C/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758642 | CNV | gain | 17122850 |
Residual Variation Intolerance Score:
27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.00;
74.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD2BP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD2BP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD2BP2 Gene
Disorders for CD2BP2 Gene
Additional Disease Information for CD2BP2
No disorders were found for CD2BP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD2BP2 Gene
Publications for CD2BP2 Gene
- Investigating the functional role of CD2BP2 in T cells. (PMID: 17906334) Heinze M … Freund C (International immunology 2007) 3 4 23 58
- The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. (PMID: 15840814) Laggerbauer B … Lührmann R (RNA (New York, N.Y.) 2005) 3 4 23 58
- Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. (PMID: 9843987) Nishizawa K … Reinherz EL (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
- Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). (PMID: 17467737) Nielsen TK … Ficner R (Journal of molecular biology 2007) 3 4 58
- Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library. (PMID: 16941565) Monos D … Kamoun M (Journal of molecular recognition : JMR 2006) 3 23 58
ExternalLinks
Products for CD2BP2 Gene
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- MG205131
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- MR205131L1
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- MR205131L2
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- MR205131L3
- MR205131L3V
- MR205131L4
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- MR229360
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Sources for CD2BP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
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